Contribuições da história da matemática para a construção dos saberes do professor de matemática

Este artigo apresenta os resultados de uma investigação a respeito da relevância dos conhecimentos advindos de estudos da história da matemática para o processo de formação dos saberes docentes. As investigações evidenciam que os conhecimentos teóricos e metodológicos da história da matemática são importantes para a formação do professor. Tivemos como objetivo analisar e evidenciar como tais conhecimentos colaboram para a estruturação dos saberes do professor de matemática. Para isso, entrevistamos professores que vivenciaram o processo de construção e aplicação de uma proposta pedagógica, apoiada na história da matemática, em sala de aula. Por meio da análise de conteúdo, estruturamos seis categorias que evidenciam alguns saberes docentes, que fazem parte ou vão além daqueles saberes já explicitados pela literatura

Evaluation of antioxidant capacity of endemic plant Marrubium astracanicum subsp. macrodon: Identification of its phenolic contents by using HPLC-MS/MS

PubMed: 29842794Antioxidant properties of Marrubium astracanicum subsp. macrodon solvent extracts were measured by both cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods. According to the results, ethanol extract of the plant has high potential of reducing antioxidant activity on CUPRAC method. However, water extract of the plant has lower antioxidant potential. Furthermore, both water and ethanol extracts showed lower reducing antioxidant activity compare to standards on FRAP method. Moreover, the composition and content of plant leaves were detected by UHPLC-ESI-MS/MS. High concentrations of quinic acid, p-coumaric acid and malic acid were determined. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group

False profile radiography for the evaluation of Legg-Calvé-Perthes disease.

False profile radiography (FPR), as proposed by Lequesne and de Sèze, depicts the pathology on the anterolateral acetabular wall and femoral head. A study was conducted to find out the differences between normal anteroposterior radiography and FPR. Twenty-seven patients with Legg-Calvé-Perthes disease who had not been operated on previously and 50 recruits without any pathology were studied for the acetabulum-head index of Heyman-Herndon (HHI) and center-edge angles (CEs) in antero-posterior radiographs and VCA angles in FPR. The VCA angle is most useful to detect anterolateral coverage of the femoral head in lateral pillar C hips. FPR is an easy, reliable and cheap technique to evaluate the anterolateral parts of the femoral head, and the acetabulum

UHPLC-ESI-MS/MS analyses for quantification of phenolic compounds of Nepeta nuda subsp. Lydiae

Phenolic compounds of Nepeta nuda subsp. Lydiae leaves were identified by UHPLC-ESI-MS/MS. To the best of our knowledge, phenolic compounds in N. nuda subsp. Lydiae are reported for the first time. Chlorogenic acid, rosmarinic acid and quinic acid, were found to be the most abundant compound in the methanol extract of N. nuda subsp. Lydiae, among the twenty-seven compounds studied by LC-MS/MS. Also, smaller amounts of kaempferol, p-coumaric acid, tr-caffeic acid, apigenin, luteolin and rhamnetin were identified, quantitatively. In conclusion, leaves of N. nuda subsp. Lydiae have high potential of phenolic contents that mainly attributed with biological activities. © 2016 Abdulmelik Aras et al

Spectroscopic and Structural Characterization, Enzyme Inhibitions, and Antioxidant Effects of New Ru(II) and Ni(II) Complexes of Schiff Base

PubMed ID: 31207061The new complex compounds [RuLCl(p-cymene)] ? 3H2O and [NiL2(H2O)2] ? 3H2O (L: 1-{4-[(2-hydroxy-3-methoxybenzylidene)amino]phenyl}ethanone) were prepared and characterized using FT-IR, 1H- and 13C-NMR, mass spectroscopy, TGA, elemental analysis, X-ray powder diffraction and magnetic moment techniques. Octahedral geometry for new Ni(II) and Ru(II) complexes was proposed. Thermal decomposition confirmed the existence of lattice and coordinated water molecule in the complexes. To determine the antioxidant properties of Schiff base ligand and its Ni(II), Ru(II) metal complexes, FRAP, CUPRAC, ABTS and DPPH methods of antioxidant assays were used. Moreover, enzyme inhibition of complexes was evaluated against carbonic anhydrase I and II isoenzymes (CA I and CA II) and acetylcholinesterase (AChE). For CA I and CA II, the best inhibition enzymes, was the Ni(II) complex with 62.98±18.41, 86.17±23.62 Ki values, whereas this inhibition effect showed ligand with 24.53±2.66 Ki value for the AChE enzyme. © 2019 Wiley-VHCA AG, Zurich, Switzerlan

ICP-MS and HPLC analyses, enzyme inhibition and antioxidant potential of Achillea schischkinii Sosn.

PubMed: 31677859Achillea schischkinii Sosn. is an endemic plant species and it belongs to Asteraceae family. It is distributed widely in the Central and East Anatolia. This study was carried out for evaluation of the antioxidant activity, enzyme inhibition effect, elemental and phenolic content of A. schischkinii. Briefly, acetylcholinesterase (AChE), butyrylcholinesterase (BChE), ?-glycosidase (?-Gly), and glutathione S-transferase (GST) enzymes were strongly inhibited by A. schischkinii. IC50 values for AChE, BChE, ?-Gly, and GST enzymes were found as 19.3 mg/mL, 15.4 mg/mL, 69.3 mg/mL, and 34.7 mg/mL respectively. The antioxidant activity of the sample was evaluated by four different in vitro bioanalytical methods. Besides, the concentrations of twelve elements in A. schischkinii were analyzed by ICP-MS technique. Zn (50.6 ppm), Mn (23.0 ppm), and Cu (12.7 ppm) were found as major elements. Furthermore, catechin (20.8 µg/mg extract), trans-ferulic acid (18.3 µg/mg extract), and gallic acid (11.2 µg/mg extract) were characterized as major phenolic compounds by using HPLC. Practical applications: Acetylcholinesterase, butyrylcholinesterase, ?-glycosidase, and glutathione s-transferase enzymes have crucial functions on metabolism. Enzyme inhibition or activation mostly attributed to some health disorders such as Alzheimer's disease, Diabetes mellitus, cancer and hyperglycemia. Phenolic contents are responsible for effective biological activity. This study evaluated the phenolic content and antioxidant activity of Achillea schischkinii as well as the inhibition effect against four metabolic enzymes. The results would be beneficial for using the plant in the food industry and pharmacological process. © 2019 Elsevier Inc

Spectroscopic and Structural Characterization, Enzyme Inhibitions, and Antioxidant Effects of New Ru(II) and Ni(II) Complexes of Schiff Base

PubMed: 31207061The new complex compounds [RuLCl(p-cymene)] · 3H2O and [NiL2(H2O)2] · 3H2O (L: 1-{4-[(2-hydroxy-3-methoxybenzylidene)amino]phenyl}ethanone) were prepared and characterized using FT-IR, 1H- and 13C-NMR, mass spectroscopy, TGA, elemental analysis, X-ray powder diffraction and magnetic moment techniques. Octahedral geometry for new Ni(II) and Ru(II) complexes was proposed. Thermal decomposition confirmed the existence of lattice and coordinated water molecule in the complexes. To determine the antioxidant properties of Schiff base ligand and its Ni(II), Ru(II) metal complexes, FRAP, CUPRAC, ABTS and DPPH methods of antioxidant assays were used. Moreover, enzyme inhibition of complexes was evaluated against carbonic anhydrase I and II isoenzymes (CA I and CA II) and acetylcholinesterase (AChE). For CA I and CA II, the best inhibition enzymes, was the Ni(II) complex with 62.98±18.41, 86.17±23.62 Ki values, whereas this inhibition effect showed ligand with 24.53±2.66 Ki value for the AChE enzyme. © 2019 Wiley-VHCA AG, Zurich, Switzerlan

PERBANDINGAN TITER ANTIBODI ANTARA AYAM LAYER YANG DIVAKSIN IBD MONOVALEN INAKTIF DENGAN IBD POLIVALEN INAKTIF (IBD-IB-ND) MENGGUNAKAN INDIRECT ELISA

Infectious Bursal Disease is caused by Birnavirus, has a mortality rate up to 100% and immunosuppressive. The aim of this study was determine antibody titer difference of layer chicken vaccinated with IBD monovalent inactive vaccine and IBD polyvalent inactive (IBD-IB-ND) and to know the relationship between two types of vaccine administration with weeks of treatment vaccination. A total of 24 chicks were divided into four groups. Group 1 (P1), six chickens was vaccinated with IBD monovalent inactive (LV3UA) at the age of two weeks given 0.3 ml /chick with a dose of 103 TCID50/0,3ml virus. Group 2 (P2), six chickens was vaccinated with IBD polyvalent inactive (LV8UA) at the age of two weeks are given 0.5 ml /chick with a dose of IBD virus 103 TCID50/0,5ml, 1035 EID50/0,5ml IB, ND 1050 EID50 /0,5 ml. Group 3 (P3), six chickens as a control IBD monovalent inactive vaccine given 0.3 ml physiological NaCl /chick. Group 4 (P4), six chickens as a control vaccine IBD polyvalent inactive (IBD-IB-ND) given 0.3 ml physiological NaCl/chick. Blood sampling for antibody titer observations was performed four times in all age groups for two weeks, four week, six week and eight week. Measurement of antibody titers was used in indirect ELISA. Data analysis used the General Linear Models (GLM) and ANOVA. The results showed that 1) there is no difference antibody titers of vaccinated layer chickens with IBD monovalent inactive and IBD polyvalent inactive (IBD-IB-ND) vaccine, 2) There is a relation between the used of both vaccine treatment and weeks of vaccination