74 research outputs found
Inner Shell Ionization with High Velocity Positive Ions
This work was supported by National Science Foundation Grant PHY 76-84033 and Indiana Universit
L-Subshell Ionization with High Velocity Positive Ions
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
Study of the (d->,6-Li) Reaction
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
Radiative Proton Capture Studies at Intermediate Energies
This work was supported by National Science Foundation Grants PHY 76-84033A01, PHY 78-22774, and Indiana Universit
Radiative Proton Capture: Recent Results
Supported by the National Science Foundation and Indiana Universit
The Isovector Quadrupole Resonance in 16-O
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates
Protein energy malnutrition (PEM) is a syndrome that often results in immunodeficiency coupled with pancytopenia. Hemopoietic tissue requires a high nutrient supply and the proliferation, differentiation and maturation of cells occur in a constant and balanced manner, sensitive to the demands of specific cell lineages and dependent on the stem cell population. In the present study, we evaluated the effect of PEM on some aspects of hemopoiesis, analyzing the cell cycle of bone marrow cells and the percentage of progenitor cells in the bone marrow. Two-month-old male Swiss mice (N = 7-9 per group) were submitted to PEM with a low-protein diet (4%) or were fed a control diet (20% protein) ad libitum. When the experimental group had lost about 20% of their original body weight after 14 days, we collected blood and bone marrow cells to determine the percentage of progenitor cells and the number of cells in each phase of the cell cycle. Animals of both groups were stimulated with 5-fluorouracil. Blood analysis, bone marrow cell composition and cell cycle evaluation was performed after 10 days. Malnourished animals presented anemia, reticulocytopenia and leukopenia. Their bone marrow was hypocellular and depleted of progenitor cells. Malnourished animals also presented more cells than normal in phases G0 and G1 of the cell cycle. Thus, we conclude that PEM leads to the depletion of progenitor hemopoietic populations and changes in cellular development. We suggest that these changes are some of the primary causes of pancytopenia in cases of PEM.FAPESPCNP
The (d,6-Li) Reaction Studies
Supported by the National Science Foundation and Indiana Universit
Radiative Capture Reactions at Intermediate Energies
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
Proton Radiative Capture at E_p = 150 MeV
This research was sponsored by the National Science Foundation Grant NSF PHY 87-1440
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