61 research outputs found
Ultrafractionated Radiation Therapy (3 Daily Doses of 0.75 Gy) - A New and Promising Radiotherapy Schedule for Glioblastoma Patients
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Evidence for Teeth-as-Tools and Palliative Oral Hygiene at Late Medieval Villamagna
Scaffolding Course Research Assignments to Incorporate Information Literacy Skill Development: An Interdisciplinary Pilot Project
Presentation from the Workshop for Information Literacy Use (WILU) 2016 Conference in Vancouver, Canada. Embedding librarians and systematic, multiple Information Literacy (IL) sessions into courses is gaining popularity. However, this is time-intensive for both faculty and librarians; faculty have to find time in their courses for multiple IL sessions, and librarians have to find time to teach all of these sessions across the curriculum. How can we embed librarian expertise and IL skill development into courses in a more sustainable way?
This presentation will describe a cross-disciplinary partnership between the Behavioral Sciences librarian and four faculty in Anthropology, Psychology, and Sociology at the University of Michigan-Dearborn on a pilot project which addresses this challenge. This pilot project began because faculty were finding that many of the students in their courses seemed to be getting overwhelmed by their research papers and projects, which was reflected in poor performance on these assignments. The pilot project team took an assignment scaffolding approach to address these issues. Assignment scaffolding involves taking complex assignments, such as research papers and projects, and breaking them down into smaller components. The pilot project team systematically restructured the research papers and projects in their courses to create scaffolded assignments reflecting the steps of the research process. IL skill development was integrated into these graded assignments, which built towards final research papers and projects. These scaffolded assignments were then piloted in six courses across Behavioral Sciences disciplines, with assessments to measure the overall effectiveness of this pilot project.
This presentation walks through the process of restructuring and rewriting research papers and projects to incorporate IL skill development in a systematic, meaningful way. This presentation also discusses the benefits of adopting the assignment scaffolding method to integrate librarian expertise and systematic IL skill development into a course and across the curriculum, as well as the sustainability of this method.Presentation from the Workshop for Information Literacy Use (WILU) 2016 Conference in Vancouver, Canada.https://deepblue.lib.umich.edu/bitstream/2027.42/150196/1/Anderson, Nadine - Scaffolding Course Research Assignments to Incorporate Information Literacy Skill Development - An Interdisciplinary Pilot Project .pdfDescription of Anderson, Nadine - Scaffolding Course Research Assignments to Incorporate Information Literacy Skill Development - An Interdisciplinary Pilot Project .pdf : Presentation Slide
Evidence for discrimination between feeding sounds of familiar fish and unfamiliar mammal-eating killer whale ecotypes by long-finned pilot whales
Research funding was provided by the US Office of Naval Research, the DGA/TN (France), the UK Natural Environmental Research Council, and the Ministries of Defence of Norway and The Netherlands. PLT acknowledges funding received from the MASTS pooling initiative (The Marine Alliance for Science and Technology for Scotland). MASTS is funded by the Scottish Funding Council (Grant reference HR09011) and contributing institutions. CC acknowledges statistical support provided by the Multi-study OCean acoustics Human effects Analysis (MOCHA) project funded by the United States Office of Naval Research (Grant N00014-12-1-0204).Killer whales (KW) may be predators or competitors of other cetaceans. Since their foraging behavior and acoustics differ among populations ('ecotypes'), we hypothesized that other cetaceans can eavesdrop on KW sounds and adjust their behavior according to the KW ecotype. We performed playback experiments on long-finned pilot whales (Globicephala melas) in Norway using familiar fish-eating KW sounds (fKW) simulating a sympatric population that might compete for foraging areas, unfamiliar mammal-eating KW sounds (mKW) simulating a potential predator threat, and two control sounds. We assessed behavioral responses using animal-borne multi-sensor tags and surface visual observations. Pilot whales barely changed behavior to a broadband noise (CTRL-), whereas they were attracted and exhibited spyhops to fKW, mKW, and to a repeated-tonal upsweep signal (CTRL+). Whales never stopped nor started feeding in response to fKW, whereas they reduced or stopped foraging to mKW and CTRL+. Moreover, pilot whales joined other subgroups in response to fKW and CTRL+, whereas they tightened individual spacing within group and reduced time at surface in response to mKW. Typical active intimidation behavior displayed to fKW might be an antipredator strategy to a known low-risk ecotype or alternatively a way of securing the habitat exploited by a heterospecific sympatric population. Cessation of feeding and more cohesive approach to mKW playbacks might reflect an antipredator behavior towards an unknown KW ecotype of potentially higher risk. We conclude that pilot whales are able to acoustically discriminate between familiar and unfamiliar KW ecotypes, enabling them to adjust their behavior according to the perceived disturbance type.PostprintPeer reviewe
Numerical modelling of dislocations and deformation mechanisms in CaIrO3 and MgGeO3 post-perovskites—Comparison with MgSiO3 post-perovskite
Irradiation of the potential cancer stem cell niches in the adult brain improves progression-free survival of patients with malignant glioma
<p>Abstract</p> <p>Background</p> <p>Glioblastoma is the most common brain tumor in adults. The mechanisms leading to glioblastoma are not well understood but animal studies support that inactivation of tumor suppressor genes in neural stem cells (NSC) is required and sufficient to induce glial cancers. This suggests that the NSC niches in the brain may harbor cancer stem cells (CSCs), Thus providing novel therapy targets. We hypothesize that higher radiation doses to these NSC niches improve patient survival by eradicating CSCs.</p> <p>Methods</p> <p>55 adult patients with Grade 3 or Grade 4 glial cancer treated with radiotherapy at UCLA between February of 2003 and May of 2009 were included in this retrospective study. Using radiation planning software and patient radiological records, the SVZ and SGL were reconstructed for each of these patients and dosimetry data for these structures was calculated.</p> <p>Results</p> <p>Using Kaplan-Meier analysis we show that patients whose bilateral subventricular zone (SVZ) received greater than the median SVZ dose (= 43 Gy) had a significant improvement in progression-free survival if compared to patients who received less than the median dose (15.0 vs 7.2 months PFS; P = 0.028). Furthermore, a mean dose >43 Gy to the bilateral SVZ yielded a hazard ratio of 0.73 (P = 0.019). Importantly, similarly analyzing total prescription dose failed to illustrate a statistically significant impact.</p> <p>Conclusions</p> <p>Our study leads us to hypothesize that in glioma targeted radiotherapy of the stem cell niches in the adult brain could yield significant benefits over radiotherapy of the primary tumor mass alone and that damage caused by smaller fractions of radiation maybe less efficiently detected by the DNA repair mechanisms in CSCs.</p
Paper 1: The JWST PEARLS View of the El Gordo Galaxy Cluster and of the Structure It Magnifies
The massive galaxy cluster El Gordo (z=0.87) imprints multitudes of
gravitationally lensed arcs onto James Webb Space Telescope (JWST)
Near-Infrared Camera (NIRCam) images. Eight bands of NIRCam imaging were
obtained in the ``Prime Extragalactic Areas for Reionization and Lensing
Science'' (``PEARLS'') program. PSF-matched photometry across Hubble Space
Telescope (HST) and NIRCam filters supplies new photometric redshifts. A new
light-traces-mass lens model based on 56 image multiplicities identifies the
two mass peaks and yields a mass estimate within 500 kpc of ~(7.0 +/- 0.30) x
10^14 Msun. A search for substructure in the 140 cluster members with
spectroscopic redshifts confirms the two main mass components. The southeastern
mass peak that contains the BCG is more tightly bound than the northwestern
one. The virial mass within 1.7 Mpc is (5.1 +/- 0.60) x 10^14 Msun, lower than
the lensing mass. A significant transverse velocity component could mean the
virial mass is underestimated. We contribute one new member to the previously
known z=4.32 galaxy group. Intrinsic (delensed) positions of the five secure
group members span a physical extent of ~60 kpc. Thirteen additional candidates
selected by spectroscopic/photometric constraints are small and faint with a
mean intrinsic luminosity ~2.2 mag fainter than L*. NIRCam imaging admits a
fairly wide range of brightnesses and morphologies for the group members,
suggesting a more diverse galaxy population in this galaxy overdensity.Comment: 24 pages, accepted by Ap
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