59 research outputs found
Potent neutralization of SARS-CoV-2 by human antibody heavy-chain variable domains isolated from a large library with a new stable scaffold
- Author
- Publication venue
- Publication date
- 01/01/2020
- Field of study
Effective therapies are urgently needed for COVID-19. Here we describe the identification of a new stable
human immunoglobulin G1 heavy-chain variable (VH) domain scaffold that was used for the construction
of a large library, lCAT6, of engineered human VHs. This library was panned against the receptor-binding
domain (RBD) of the SARS-CoV-2 spike (S) glycoprotein. Two VH domains (VH ab6 and VH m397) were
selected and fused to Fc for increased half-life in circulation. The VH-Fc ab6 and m397 specifically
neutralized SARS-CoV-2 with high potencies (50% neutralization at 0.35 μg/ml and 1.5 μg/ml, respectively)
as measured by two independent replication-competent virus neutralization assays. Ab6 and m397
competed with ACE2 for binding to RBD, suggesting a competitive mechanism of virus neutralization.
These VH domains may have potential applications for prophylaxis and therapy of COVID-19 alone or in
combination, as well as for diagnosis and as tools for research
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)
- Author
- A. -G. Wu
- A. C. Ma
- A. K. Au
- Abdel-Aziz A. K.
- Abdelfatah S.
- Abdellatif M.
- Abdoli A.
- Abel S.
- Abeliovich H.
- Abildgaard M. H.
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- Adamopoulos I. E.
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.
- Author
- A Aouacheria
- A Aouacheria
- A Aranovich
- A Ashkenazi
- A Ashkenazi
- A Ashkenazi
- A Bernet
- A Buque
- A Chiche
- A Conte
- A Costanzo
- A Crockford
- A Degterev
- A Degterev
- A Dey
- A Gast
- A Gross
- A Hakkim
- A Hamacher-Brady
- A Hunger
- A Kaczmarek
- A Kamb
- A Koenig
- A Kotschy
- A Letai
- A Linkermann
- A Linkermann
- A Linkermann
- A Linkermann
- A Mousa
- A Muir
- A Mukherjee
- A Nilsson
- A Oberst
- A Oberst
- A Pagotto
- A Pyakurel
- A Rongvaux
- A Rubartelli
- A Sahaboglu
- A Seiler
- A Serrano-Puebla
- A Shamas-Din
- A Sistigu
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Strasser
- A Sumoza-Toledo
- A Sundararaman
- A Tittarelli
- A Trautmann
- A Villunger
- A Witt
- A Zychlinsky
- AA Fatokun
- AA Mailleux
- Aaron Ciechanover
- AB Pardee
- Abhishek D. Garg
- AC Bellail
- AC Schinzel
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- AD Garg
- Adi Kimchi
- AE Alsop
- AE Feldstein
- AJ Schile
- AL Anding
- AL Genevois
- Alexey V. Antonov
- AM Chinnaiyan
- AM Distefano
- AM Dudek
- AM Verhagen
- AN Antony
- AN Barclay
- Ana J. García-Sáez
- Andreas Linkermann
- Andreas Strasser
- Andreas Villunger
- Andrew Oberst
- Andrew Thorburn
- Antonella Sistigu
- AP West
- AR Delbridge
- AT Schneider
- AT Ting
- AT Ting
- Atan Gross
- AV Follis
- AV Jacobsen
- AV Vaseva
- AV Vaseva
- AW Roberts
- B Antonsson
- B Aslan
- B Conradt
- B Fadeel
- B Gerlach
- B Gibert
- B Gooptu
- B McDonald
- B Schellenberg
- B Van Do
- B Xia
- BA Carlson
- BA Hilton
- BA Napier
- BB Aggarwal
- BC Barnhart
- Bertrand Joseph
- Beth Levine
- BG Childs
- BG Childs
- BG Childs
- BG Lambrus
- BG Yipp
- Boris Turk
- Boris Zhivotovsky
- BP Eckelman
- BP Eckelman
- BR Stockwell
- Brent R. Stockwell
- Brian D. Dynlacht
- BT Cookson
- C Bergmann
- C Dominguez-Brauer
- C Du
- C Frezza
- C Gerle
- C Guenebeaud
- C Gunther
- C Gunther
- C Helmke
- C Hernandez
- C Hockings
- C Lood
- C Lopez-Garcia
- C Lopez-Otin
- C Lopez-Otin
- C Louandre
- C Louandre
- C Nelson
- C Oberle
- C Piot
- C Rogers
- C Scaffidi
- C Vanpouille-Box
- C White
- C Xie
- Carlos López-Otín
- Carmen Garrido
- Catherine Brenner
- CC Wu
- CD Simpson
- CD Wiley
- Cecilia M.P. Rodrigues
- CF Wenceslau
- Christoph Borner
- CJ Kearney
- CK Ea
- CK Lam
- CK McPhee
- CL Buchheit
- CL Buchheit
- CL Buchheit
- CL Case
- Claudio Hetz
- CM Henry
- CN Casson
- Colin S. Duckett
- CP Baines
- CP Baines
- CP Dillon
- CP Dillon
- CP Dillon
- Cristina Muñoz-Pinedo
- CT Tan
- D Brenner
- D Brough
- D Chen
- D Crighton
- D Denton
- D Denton
- D Denton
- D Denton
- D Denton
- D Denton
- D Gatica
- D Goldschneider
- D Kranz
- D Li
- D Malin
- D Martin-Sanchez
- D Merino
- D Munoz-Espin
- D Piani
- D Ren
- D Stojkov
- D Tang
- D Tang
- D Vercammen
- D Vercammen
- D Wallach
- D Weaver
- D Yang
- DA Flusberg
- DA Rodriguez
- Daniel J. Klionsky
- Daolin Tang
- David C. Rubinsztein
- David M. Pereira
- David W. Andrews
- David Wallach
- DC Gray
- DH Cho
- Didac Carmona-Gutierrez
- Dieter Adam
- DJ Baker
- DJ Baker
- DJ Klionsky
- DJ McIlroy
- DL Berry
- DL Vaux
- DM Moquin
- DM Moujalled
- DM Pilla
- DM Rothwarf
- Domagoj Vucic
- Douglas R. Green
- DR Green
- DR Green
- DR Green
- DR Green
- DR Green
- DR Green
- DR Green
- DS Kempe
- DV Krysko
- E Arama
- E Basso
- E Buytaert
- E Candi
- E Fouquerel
- E Gavathiotis
- E Gavathiotis
- E Giampazolias
- E Kip
- E Lachaier
- E Lafont
- E Meunier
- E Perez
- E Vacchelli
- E Varfolomeev
- E Venereau
- E Zandi
- E Zandi
- EA Miao
- Edward A. Miao
- EF Lee
- EH Cheng
- EH Cheng
- EH Hinchcliffe
- EJ Park
- Eleonora Candi
- Eli Arama
- Emad S. Alnemri
- Emily H. Cheng
- Emre Sayan
- Enrico Lugli
- Eric H. Baehrecke
- Erwin F. Wagner
- Evripidis Gavathiotis
- EY Bassoy
- Eyal Gottlieb
- F Basit
- F Chalmin
- F Chen
- F Edlich
- F Ghiringhelli
- F Ke
- F Ke
- F Ke
- F Llambi
- F Llambi
- F Llambi
- F Loison
- F Madeo
- F Martin-Sanchez
- F McNab
- F Meitinger
- F Mille
- F Pietrocola
- F Todt
- F Wartha
- FB Chekeni
- FC Kischkel
- Feng Shao
- FK Chan
- FK Chan
- FL Scott
- FM Menzies
- FM Menzies
- FR Greten
- Francesca Bernassola
- Francesco Cecconi
- Francesco Di Virgilio
- Francis K.-M. Chan
- Frank Madeo
- G Brumatti
- G Casinelli
- G Denecker
- G Dewson
- G Droga-Mazovec
- G Ichim
- G Ichim
- G Kroemer
- G Kroemer
- G Kroemer
- G Monaco
- G Nunez
- G Quarato
- G Sun
- Gabriel A. Rabinovich
- Gabriel Nuñez
- Gerald M. Cohen
- Gerry Melino
- Gian Maria Fimia
- GO Latunde-Dada
- GP Sims
- GS Salvesen
- Guido Kroemer
- GW Dorn 2nd
- Gwenola Manic
- Gyorgy Hajnoczky
- Gyorgy Szabadkai
- H Appelqvist
- H Dai
- H Dai
- H Du
- H Hsu
- H Imai
- H Inoue
- H Inuzuka
- H Kazama
- H Kim
- H Kim
- H Li
- H Li
- H Otera
- H Parker
- H Puthalakath
- H Puthalakath
- H Sakahira
- H Wajant
- H Wang
- H Wang
- H Wang
- H Wang
- H Wang
- H Wang
- H Yang
- H Yang
- H Yuan
- H Yuan
- H Yuan
- H Zhang
- H Zhang
- HA Park
- Hamsa Puthalakath
- Hans-Uwe Simon
- HC Chen
- HE Kamber Kaya
- Henning Walczak
- Herbert W. Virgin
- Hidenori Ichijo
- Hinrich Gronemeyer
- HL Tang
- I Adkins
- I Amelio
- I Jaco
- I Jorgensen
- I Jorgensen
- I Jorgensen
- I Maejima
- I Martins
- I Marzo
- I Poursaitidis
- I Sturmlechner
- I Vitale
- I Vitale
- I Vitale
- I Vitale
- I Vitale
- I Vitale
- I Zanoni
- IC Low
- IE Dumitriu
- IE Gentle
- IE Wertz
- Ilio Vitale
- IP Nezis
- IP Nezis
- IR Powley
- Isaac S. Harris
- Ivano Amelio
- J Alanko
- J Bove
- J Brojatsch
- J Campisi
- J Cedervall
- J Chai
- J Chai
- J Chang
- J Desai
- J Desai
- J Ding
- J Ding
- J Fitamant
- J Fombonne
- J Fucikova
- J Fullgrabe
- J Fullgrabe
- J Geng
- J Gilloteaux
- J He
- J He
- J Hitomi
- J Huai
- J Huun
- J Karch
- J Kaur
- J Kers
- J Kim
- J Li
- J Lin
- J Liu
- J Maelfait
- J Majkut
- J Michels
- J Nunnari
- J Nylandsted
- J Parrish
- J Pecot
- J Puccini
- J Seo
- J Shi
- J Shi
- J Shi
- J Silke
- J Sosna
- J Suzuki
- J Suzuki
- J Suzuki
- J Warne
- J Wu
- J Xu
- J Yang
- J Yu
- J Zhang
- J Zhao
- J Zou
- J. Marie Hardwick
- JA DiDonato
- JA Ewald
- JA Hagar
- JA Mason
- JA Rickard
- James A. Wells
- Jan Paul Medema
- JC Acosta
- JC Hamann
- JD Bernet
- JE Chipuk
- JE Chipuk
- JE Kokoszka
- JE Vince
- JE Vince
- Jean-Christophe Marine
- Jean-Claude Martinou
- Jeffery D. Molkentin
- Jerry E. Chipuk
- JH Woo
- JI Jun
- JJ Guan
- JJ Schulman
- JL Lin
- JM Bravo-San Pedro
- JM Brouwer
- JM Deursen van
- JM Gump
- JM Hildebrand
- JM Jamison
- JM Mulcahy Levy
- JM Murphy
- JMM Levy
- Jochen H.M. Prehn
- John A. Cidlowski
- John J. Lemasters
- John M. Abrams
- John Silke
- John W. Elrod
- Josef M. Penninger
- JP Coppe
- JP Friedmann Angeli
- JPF Angeli
- JQ Kwong
- JQ Kwong
- JT Sockolosky
- JU Schweichel
- Juan R. Cubillos-Ruiz
- Junying Yuan
- JV Brower
- JV Lu
- JW Harper
- JW Upton
- JW Upton
- K Csomos
- K Eichholz
- K Huang
- K Kawane
- K Li
- K Martinod
- K Mills
- K Moriwaki
- K Moriwaki
- K Newton
- K Newton
- K Newton
- K Ruckdeschel
- K Schleich
- K Schleich
- K Segawa
- K Segawa
- K Sharma
- K Shimada
- K Tada
- K Tracy
- K Vlantis
- K Wang
- K Yacobi-Sharon
- K Zhang
- Karen H. Vousden
- Katiuscia Bianchi
- KD Metzler
- KD Metzler
- KE Gascoigne
- KE Lawlor
- Kevin M. Ryan
- KF Hsu
- KG Fleten
- KH Jang
- KH Szymczyk
- KJ Mackenzie
- KJ Neelsen
- KJ Oh
- KJ Weigel
- KK David
- KK David
- KL Lu
- KL O’Neill
- Klas Blomgren
- Klaus-Michael Debatin
- KM Backus
- KN Alavian
- KN Alavian
- KS Lang
- L Antonioli
- L Apetoh
- L Aram
- L Bezu
- L Broutier
- L Burri
- L Chen
- L Chen
- L Corrales
- L Dara
- L Deng
- L Dorstyn
- L Duprez
- L Fazal
- L Franchi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Galluzzi
- L Garcia-Prat
- L Grosse
- L Groth-Pedersen
- L Jiang
- L Jiang
- L Kaestner
- L Lin
- L Luo
- L Mosteiro
- L Sborgi
- L Scorrano
- L Scorrano
- L Sun
- L Tortola
- L Virag
- L Zitvogel
- L Zitvogel
- LA Barclay
- LA Gillies
- LA O’ Reilly
- LA Timmerman
- Laurence Zitvogel
- LG Yu
- LH Ho
- LJ Siskind
- LJ Yant
- LL Fava
- Lloyd A. Greene
- LM Kutscher
- Lorenzo Galluzzi
- LS Dickens
- LS Dickens
- LS Hinojosa
- Luca Scorrano
- Lucia Altucci
- LY Li
- M Aziz
- M Bonora
- M Bonora
- M Bonora
- M Castedo
- M Castedo
- M Castedo
- M Castedo
- M Castets
- M Colombini
- M Conrad
- M Dannappel
- M Demaria
- M Demaria
- M Demers
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- Y Li
- Y Li
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- Y Liu
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- Y Ma
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- Y Shlyakhtina
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- Y Tsujimoto
- Y Wang
- Y Wang
- Y Wang
- Y Wang
- Y Xie
- Y Xie
- Y Xie
- Y Zaltsman
- Y Zermati
- Y Zhang
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- Y Zhu
- Y Zhu
- YB Chen
- YC Hou
- YH Liao
- YI Nakajima
- Ying Wang
- YN Gong
- Yoshihide Tsujimoto
- YS Cho
- Yufang Shi
- Z Cai
- Z Cai
- Z Wang
- Z Wang
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- Z You
- Z Zhang
- Z Zhong
- Zahra Zakeri
- ZG Liu
- ZN Oltvai
- ZT Schafer
- ZX Chen
- ZX Chen
- Publication venue
- Cell Death Differ
- Publication date
- 01/01/2018
- Field of study
Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
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- Publication venue
- Publication date
- 22/09/2015
- Field of study
In 2008 we published the first set of guidelines for standardizing research in autophagy. Since then, research on this topic has continued to accelerate, and many new scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Accordingly, it is important to update these guidelines for monitoring autophagy in different organisms. Various reviews have described the range of assays that have been used for this purpose. Nevertheless, there continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes. For example, a key point that needs to be emphasized is that there is a difference between measurements that monitor the numbers or volume of autophagic elements (e.g., autophagosomes or autolysosomes) at any stage of the autophagic process versus those that measure fl ux through the autophagy pathway (i.e., the complete process including the amount and rate of cargo sequestered and degraded). In particular, a block in macroautophagy that results in autophagosome accumulation must be differentiated from stimuli that increase autophagic activity, defi ned as increased autophagy induction coupled with increased delivery to, and degradation within, lysosomes (inmost higher eukaryotes and some protists such as Dictyostelium ) or the vacuole (in plants and fungi). In other words, it is especially important that investigators new to the fi eld understand that the appearance of more autophagosomes does not necessarily equate with more autophagy. In fact, in many cases, autophagosomes accumulate because of a block in trafficking to lysosomes without a concomitant change in autophagosome biogenesis, whereas an increase in autolysosomes may reflect a reduction in degradative activity. It is worth emphasizing here that lysosomal digestion is a stage of autophagy and evaluating its competence is a crucial part of the evaluation of autophagic flux, or complete autophagy. Here, we present a set of guidelines for the selection and interpretation of methods for use by investigators who aim to examine macroautophagy and related processes, as well as for reviewers who need to provide realistic and reasonable critiques of papers that are focused on these processes. These guidelines are not meant to be a formulaic set of rules, because the appropriate assays depend in part on the question being asked and the system being used. In addition, we emphasize that no individual assay is guaranteed to be the most appropriate one in every situation, and we strongly recommend the use of multiple assays to monitor autophagy. Along these lines, because of the potential for pleiotropic effects due to blocking autophagy through genetic manipulation it is imperative to delete or knock down more than one autophagy-related gene. In addition, some individual Atg proteins, or groups of proteins, are involved in other cellular pathways so not all Atg proteins can be used as a specific marker for an autophagic process. In these guidelines, we consider these various methods of assessing autophagy and what information can, or cannot, be obtained from them. Finally, by discussing the merits and limits of particular autophagy assays, we hope to encourage technical innovation in the field
Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Aaron Joffe
- Aaron Mark Hernandez
- Aaron Mark Hernandez
- Abby Lewis
- Abdelhamid Hachimi
- Abdualhamid I Alshrif
- Abel Viveiros
- Abhijit Duggal
- Abidin Oner Balbay
- Achilleas Chovas
- Ade Susanti
- Adi Hadzibegovic
- Adonis Dungca
- Adrian Belii
- Adrian Belii
- Adriana Onelli
- Afolabi Owojuyigbe
- Agnieszka Kubisz-Pudelko
- Agnès Blanc
- Ahmed Ali Aboufray
- Ahmed Elhadi
- Ahmed Ramadan Triki
- Ahmed Subhy Alsheikhly
- Ahmed Zaki
- Ahmet Eroglu
- Aidan O'Shea
- Aikaterini Dimoula
- Aikaterini Efthimiou
- Aikaterini Flevari
- Ailesh Corcoran
- AiPing Bi
- Aiua Ren
- Aizhi Zhang
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- Xiuying Yao
- Xiyan Wei
- Xu Peipei
- Xue Lin
- Xue Qin Li
- Xuejuan Liang
- XueLian Liu
- Xuelian Pang
- Xuelian Xu
- Xueping Jiao
- Yajun Ding
- Yakubu H Yakubu
- Yali Zhang
- Yalım Dikmen
- Yalım Dikmen
- Yalim Dikmen
- Yan Gao
- Yan Li
- Yan Liu
- Yan Liu
- Yan Long
- Yan Wan
- Yan Wang
- Yan Xiao
- Yan Xie
- Yan Xu
- Yan Yan
- Yanfei Long
- Yang Lei
- Yang Liu
- Yang Wu
- Yang Xiaoyan
- Yanhong Di
- Yanhua Hao
- Yani Tian
- Yanlan Yao
- Yanling Shen
- Yanman Jian
- Yanmei Gu
- Yanming Ding
- Yann Le Guen
- Yanping Yang
- Yasser Mandourah
- Yenny Cardenas
- Yenny Cardenas
- Yesim Serife Bayraktar
- Yin He
- Ying Cao
- Ying Li
- Ying Liu
- Ying Wang
- Ying Wei
- Ying Zhang
- Yingjuan Zhao
- Yingli Wang
- Yinhua Guo
- Yolanda Mendiara
- YongXia Yang
- Yoshimasa Nishime
- Yoshiro Hayashi
- Youjin Chang
- Youru Jiang
- Youssef Zied Elhechmi
- Ysica Acosta
- Yu Chao
- Yu Han
- Yu Liu
- Yu Liu
- Yue Sun
- Yue Ying Gong
- Yuming Zhou
- Yun Su Sim
- Yun Wu
- Yunchun Dong
- Yunfeng Xiong
- Yupeng Liu
- Yuping Wang
- Yuxia Huo
- Yuxia Wang
- Yuxia Yuan
- Yvan Fleury
- Yvonne Andersen
- Zainab Ateya
- Zaneta Bogoevska-Miteva
- Zeya Shi
- Zhang Zhigang
- ZhangShuangzi Li
- ZhangXia Feng
- Zhaoxia Feng
- Zhaoxing Dai
- Zhenxia Zhang
- Zhihong Chen
- Zhiru Yao
- Zhixia Jiang
- ZhiXia Jiang
- Zhixia Tian
- Zhu Jun Yu
- Zhuqing Li
- Zied Hajjej
- Zijing Wu
- Zsuzsann Ágoston
- Zu Qing Cao
- Zulkifli Zulkifli
- Ângela Lima
- Publication venue
- Intensive Care Medicine
- Publication date
- 29/08/2020
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
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Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
- Atchade Enora
- Ateya Zainab
- Attwood Ben
- Aucapina Alejandra
- Avalos Fernando
- Aves Emma
- Avogadro Prune
- Avramopoulou Lamprini
- Ay Mustafa
- Ay Serap Avcı
- Aya Umeda
- Ayala Maria
- Aydemir Semih
- Aydin Demet Tok
- Azencot Mazal
- Azoia Joao
- Baasanjav Battsetseg
- Babych Volodymyr
- Baccaro Fernando
- Badariotti Gustavo
- Bae Jung-Min
- Baek Jonghyun
- Baftiu Nehat
- Bagshaw Sean
- Bahrin Laila Kamaliah Kamalul
- Bai Dongmei
- Bai Xiaowu
- Baini Matías
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- Baker Nerilee
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- Balbay Abidin Oner
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- Banwarie Preveen
- Bao Guijun
- Baptiste-Savoie Jacqueline
- Barakat-Johnson Michelle
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- Baronia Arvind
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- Barreiro Emma Moreno
- Barros Elaine
- Barrowcliffe Suzanne
- Barrueco-Francioni Jesus Emilio
- Bartoli Julio Ricardo
- Baruah Rosaleen
- Bascary Carlos Alejandro
- Baskakov Danil
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- Ben-Hamouda Nawfel
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- Bertoletti Fernando Pablo
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- Eller Philipp
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- Wahab Sherliza
- Wahlbom Ewa
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- White Joanne
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- Xiao Lina
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- Xiaoyan Yang
- Xie Yan
- Xing Cynthia
- Xiong Yunfeng
- Xixi Li
- Xu Lina
- Xu Xiao
- Xu Xuelian
- Xu Yan
- Xue Xiujuan
- Yaghi Aktham
- Yakubu Yakubu H.
- Yamamoto Ryohey
- Yan Howe
- Yan Xiaoli
- Yan Yan
- Yang Fan
- Yang Fengling
- Yang Huai
- Yang Jing
- Yang Lei
- Yang Qiao
- Yang Shunzhu
- Yang Yanping
- Yang YongXia
- Yao Xiuying
- Yao Yanlan
- Yao Zhiru
- Ye Man
- Ye Mei
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- Yeon-Joo Lee
- Yildiz İsmail
- Yilmaz Hakan
- Yin Hai
- Yin Li
- Young Charlotte
- Young-Jae Cho
- Yu Jing
- Yu Min
- Yu Tingting
- Yu Zhu Jun
- Yuan Cui
- Yuan Weilian
- Yuan Yuxia
- Yuchen Wu
- Yuemen Ly
- Yumei Chen
- Zahra Hajer Ben
- Zainudin Asmah
- Zakalik Graciela
- Zaki Ahmed
- Zalba-Etayo Begoña
- Zamora Purificacion Sanchez
- Zamorano Matias Jesús Flamm
- Zan Tao
- Zand Farid
- Zarei Fatemeh
- Zeng Jing Mei
- Zeng Qi
- Zepoy Sofia
- Zerman Avşar
- Zermeno Jorge Macias
- Zgrzheblovska Lesia
- Zhang Aizhi
- Zhang Baoke
- Zhang Feifei
- Zhang Guiping
- Zhang Hong
- Zhang Hongsu
- Zhang Hui
- Zhang Jing
- Zhang Jundi
- Zhang Libing
- Zhang Ling
- Zhang Na
- Zhang Wei
- Zhang Yali
- Zhang Ying
- Zhang Zhenxia
- Zhao Hui Min
- Zhao Lijuan
- Zhao Lina
- Zhao Qian
- Zhao Qingli
- Zhao Rong Hua
- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- 'Organisation for Economic Co-Operation and Development (OECD)'
- Publication date
- 26/02/2021
- Field of study
Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat
Recommended from our members
Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study
- Author
- Abdala Antonio
- Abidi Khalid
- Abillama Fayez François
- Abos Francisco Javier Saenz
- Aboufray Ahmed Ali
- Abregal Giancarlo
- Abroug Fekri
- Achilleos Eleni
- Acosta Ysica
- Adam Višnja Nesek
- Adamina Ileana
- Adams John
- Adamuz Jordi
- Adejumo Prisca Olabisi
- Adekola Oyebola
- Ademokun Jane
- Adenekan Anthony
- Adib Nik Azman Nik
- Adipa Faustina Excel
- Afonso Elsa
- Aganon Ferdinand
- Agarwal Sonika
- Aguirre Joaquin
- Aguirre Lydia Gallego
- Aguirre-Bermeo Hernan
- Ahmad Fatima Kasem El
- Ahmad Meraj
- Ahmed Hazem
- Ahn Jong-Joon
- Ahtiala Maarit
- Akbas Turkay
- Akdağ Devrim
- Akker Mustafa
- Akselsen Gro Ringstad
- Al-Alawi Maram Milud Said
- Alabuzidi Aya
- Alampi Daniela
- Albaiceta Guillermo Muñiz
- Albert Patricia
- Albrecht Lea
- Albrett Jonathan
- Alexandropoulou Paraskevi
- Alexandrou Anna
- Ali Ashwaq
- Ali Mohd Nazri
- Alias Anita
- Alkhumsi Soad Imhmed R.
- Allaert Silvie
- Allison Nicola
- Almekhlafi Ghaleb
- Alonso Helena Fernandez
- Alsheikhly Ahmed Subhy
- Alshrif Abdualhamid I
- Alvarenga Gloria
- Alvarez Diana
- Alvarez Gonzalo Martín
- Alvarez Gustavo Andres
- Alvarez Jorge Duerto
- Alvarez Josep Trenado
- Alvarez Raquel Garcia
- Alves Paulo
- Andersen Marit Hildegunn
- Andersen Yvonne
- Andresen Hanne
- Anisoglou Souzana
- Antonio Maria Gracia San
- Antunes Nelson
- Anvelt Eneli
- Aperocho Cristal April Jane
- Aponte Cesar
- Araya Paola
- Arcas María Luisa Bravo
- Arikan Huseyin
- Arntsen Wenche
- Arteta Arteta Donaldo S.
- Ashour Firas
- Assiri Amer
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- Zermeno Jorge Macias
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- Zhao Ronghua
- Zhao Wenwen
- Zhao Yingjuan
- Zhedaeva Marina
- Zheng Hong
- Zheng Jing
- Zheng Xianhong
- Zhigang Zhang
- Zhijuan Wang
- Zhiping Sun
- Zhivotneva Trina
- Zhou Yuming
- Zhu Guoyan
- Zhu JiFen
- Zhu Jin Yu
- Zivanovic-Posilovic Gordana
- Zorko Nika
- Zubareva Nadezhda
- Zuev Evgeniy
- Zueva Oksana
- Zulkifli Zulkifli
- Ágoston Zsuzsann
- Åkerman Eva
- Çelik Jale Bengi
- Ñamendys-Silva Silvio A.
- Özcan Beysim
- Özserezli Boğaç
- Ünlü Nurdan
- Čuljak Hemena
- Şentürk Evren
- Šuput Aleksandar
- Publication venue
- Intensive Care Medicine
- Publication date
- 09/04/2021
- Field of study
The original version of this article unfortunately contained a mistake
Ordered Mesoporous Metal Carbide-Derived Electrocatalysts for the Alkaline Hydrogen Evolution Reaction
- Author
- Publication venue
- Ulsan National Institute of Science and Technology
- Publication date
- 01/08/2021
- Field of study
School of Energy and Chemical Engineering (Chemical Engineering)ope
Self-Supported Ordered Mesoporous Molybdenum Carbides as an Efficient Electrocatalysts for Alkaline Hydrogen Evolution Reaction
- Author
- Publication venue
- 'Korean Chemical Society'
- Publication date
- 06/07/2020
- Field of study
- …