Pengembangan Modul Pembelajaran Fisika Berbasis Inkuiri Terbimbing Pada Materi Pokok Suhu Dan Kalor

The research development aimed to produce physics learning module based on guided inquiry in the main subject of temperature and heat to student in X class. The research method used Research and Development approach. The development procedure of this module include: potential problems, data collection to meet the need, product design, the validation design, the revised design, the friendly match products include, trial internal: feasibility test products, trial external: trial utility products, revision and final stage, the production. After doing the trial learning module that developed was interesting, easy, and beneficial for the students. The learning module is also effective used as a learning media.Penelitian pengembangan ini bertujuan untuk menghasilkan modul pembelajaran fisika berbasis inkuiri terbimbing pada materi pokok suhu dan kalor untuk siswa kelas X. Metode penelitian ini menggunakan pendekatan penelitian dan pengembangan (Research and Development). Prosedur pengembangan modul ini meliputi: potensi masalah, pengumpulan data untuk memenuhi kebutuhan, desain produk, validasi desain, revisi desain, uji coba produk meliputi, uji internal: uji kelayakan produk, uji eksternal: uji kemanfaatan produk, revisi dan tahap terakhir, produksi. Setelah melakukan uji coba lapangan modul pembelajaran yang dikembangkan menarik, mudah, dan bermanfaat bagi siswa. Modul pembelajaran tersebut juga efektif digunakan sebagai media pembelajaran

Constraints of the Clumpyness of Dark Matter Halos Through Heating of the Disk Galaxies

Motivated by the presence of numerous dark matter clumps in the Milky Way's halo as expected from the cold dark matter cosmological model, we conduct numerical simulations to examine the heating of the disk. We construct an initial galaxy model in equilibrium, with a stable thin disk. The disk interacts with dark matter clumps for about 5 Gyr. Three physical effects are examined : first the mass spectrum of the dark matter clumps, second the initial thickness of the galactic disk, and third the spatial distribution of the clumps. We find that the massive end of the mass spectrum determines the amount of disk heating. Thicker disks suffer less heating. There is a certain thickness at which the heating owing to the interaction with the clumps becomes saturates. We also find that the heating produced by the model which mimics the distribution found in Standard CDM cosmology is significant and too high to explain the observational constraints. On the other hand, our model that corresponds to the clump distribution in a $\Lambda$CDM cosmology produces no significant heating. This result suggests that the $\Lambda$CDM cosmology is preferable with respect to the Standard CDM cosmology in explaining the thickness of the Milky Way.Comment: 28 pages, 13 figures, submitted to Ap

Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

Telomere length is a risk factor in disease and the dynamics of telomere length are crucial to our understanding of cell replication and vitality. The proliferation of whole genome sequencing represents an unprecedented opportunity to glean new insights into telomere biology on a previously unimaginable scale. To this end, a number of approaches for estimating telomere length from whole-genome sequencing data have been proposed. Here we present Telomerecat, a novel approach to the estimation of telomere length. Previous methods have been dependent on the number of telomeres present in a cell being known, which may be problematic when analysing aneuploid cancer data and non-human samples. Telomerecat is designed to be agnostic to the number of telomeres present, making it suited for the purpose of estimating telomere length in cancer studies. Telomerecat also accounts for interstitial telomeric reads and presents a novel approach to dealing with sequencing errors. We show that Telomerecat performs well at telomere length estimation when compared to leading experimental and computational methods. Furthermore, we show that it detects expected patterns in longitudinal data, repeated measurements, and cross-species comparisons. We also apply the method to a cancer cell data, uncovering an interesting relationship with the underlying telomerase genotype

Publisher Correction: Telomerecat: A ploidy-agnostic method for estimating telomere length from whole genome sequencing data.

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Functional role of cell surface CUB domain-containing protein 1 in tumour cell dissemination

The function of CUB domain-containing protein 1 (CDCP1), a recently described transmembrane protein expressed on the surface of hematopoietic stem cells and normal and malignant cells of different tissue origin, is not well defined. The contribution of CDCP1 to tumor metastasis was analyzed by using HeLa carcinoma cells overexpressing CDCP1 (HeLa-CDCP1) and a high-disseminating variant of prostate carcinoma PC-3 naturally expressing high levels of CDCP1 (PC3-hi/diss). CDCP1 expression rendered HeLa cells more aggressive in experimental metastasis in immunodeficient mice. Metastatic colonization by HeLa-CDCP1 was effectively inhibited with subtractive immunization-generated, CDCP1-specific monoclonal antibody (mAb) 41-2, suggesting that CDCP1 facilitates relatively late stages of the metastatic cascade. In the chick embryo model, time- and dose-dependent inhibition of HeLa-CDCP1 colonization by mAb 41-2 was analyzed quantitatively to determine when and where CDCP1 functions during metastasis. Quantitative PCR and immunohistochemical analyses indicated that CDCP1 facilitated tumor cell survival soon after vascular arrest. Live cell imaging showed that the function-blocking mechanism of mAb 41-2 involved enhancement of tumor cell apoptosis, confirmed by attenuation of mAb 41-2–mediated effects with the caspase inhibitor z-VAD-fmk. Under proapoptotic conditions in vitro, CDCP1 expression conferred HeLa-CDCP1 cells with resistance to doxorubicin-induced apoptosis, whereas ligation of CDCP1 with mAb 41-2 caused additional enhancement of the apoptotic response. The functional role of naturally expressed CDCP1 was shown by mAb 41-2–mediated inhibition of both experimental and spontaneous metastasis of PC3-hi/diss. These findings confirm that CDCP1 functions as an antiapoptotic molecule and indicate that during metastasis CDCP1 facilitates tumor cell survival likely during or soon after extravasation

Structure of Dark Triad Dirty Dozen Across Eight World Regions

The Dark Triad (i.e., narcissism, psychopathy, Machiavellianism) has garnered intense attention over the past 15 years. We examined the structure of these traits’ measure—the Dark Triad Dirty Dozen (DTDD)—in a sample of 11,488 participants from three W.E.I.R.D. (i.e., North America, Oceania, Western Europe) and five non-W.E.I.R.D. (i.e., Asia, Middle East, nonWestern Europe, South America, sub-Saharan Africa) world regions. The results confirmed the measurement invariance of the DTDD across participants’ sex in all world regions, with men scoring higher than women on all traits (except for psychopathy in Asia, where the difference was not significant). We found evidence for metric (and partial scalar) measurement invariance within and between W.E.I.R.D. and non-W.E.I.R.D. world regions. The results generally support the structure of the DTDD