Density slope of the nuclear symmetry energy from the neutron skin thickness of heavy nuclei

Expressing explicitly the parameters of the standard Skyrme interaction in terms of the macroscopic properties of asymmetric nuclear matter, we show in the Skyrme-Hartree-Fock approach that unambiguous correlations exist between observables of finite nuclei and nuclear matter properties. We find that existing data on neutron skin thickness $\Delta r_{np}$ of Sn isotopes give an important constraint on the symmetry energy $E_{sym}({\rho _{0}})$ and its density slope $L$ at saturation density ${\rho _{0}}$. Combining these constraints with those from recent analyses of isospin diffusion and double neutron/proton ratio in heavy-ion collisions at intermediate energies leads to a more stringent limit on $L$ approximately independent of $E_{sym}({\rho _{0}})$. The implication of these new constraints on the $\Delta r_{np}$ of $^{208}$Pb as well as the core-crust transition density and pressure in neutron stars is discussed.Comment: 18 pages, 9 figures, 1 table. Significantly expanded to include a number of details and discussions. Title shortened. Accepted version to appear in PR

Transition density and pressure in hot neutron stars

Using the momentum-dependent MDI effective interaction for nucleons, we have studied the transition density and pressure at the boundary between the inner crust and liquid core of hot neutron stars. We find that their values are larger in neutrino-trapped neutron stars than in neutrino-free neutron stars. Furthermore, both are found to decrease with increasing temperature of a neutron star as well as increasing slope parameter of the nuclear symmetry energy, except that the transition pressure in neutrino-trapped neutron stars for the case of small symmetry energy slope parameter first increases and then decreases with increasing temperature. We have also studied the effect of the nuclear symmetry energy on the critical temperature above which the inner crust in a hot neutron star disappears and found that with increasing value of the symmetry energy slope parameter, the critical temperature decreases slightly in neutrino-trapped neutron stars but first decreases and then increases in neutrino-free neutron stars.Comment: 7 pages, 6 figures, version to appear in Phys. Rev.

Isospin- and momentum-dependent effective interactions for the baryon octet and the properties of hybrid stars

The isospin- and momentum-dependent MDI interaction, which has been extensively used in intermediate-energy heavy-ion reactions to study the properties of asymmetric nuclear matter, is extended to include the nucleon-hyperon and hyperon-hyperon interactions by assuming same density, momentum and isospin dependence as for the nucleon-nucleon interaction. The parameters in these interactions are determined from the empirical hyperon single-particle potentials in symmetric nuclear matter at saturation density. The extended MDI interaction is then used to study in the mean-field approximation the equation of state of hypernuclear matter and also the properties of hybrid stars by including the phase transition from the hypernuclear matter to the quark matter at high densities. In particular, the effects of attractive and repulsive $\Sigma$N interactions and different values of symmetry energies on the hybrid star properties are investigated.Comment: 13 pages, 12 figures, version to appear in Phys. Rev.

Effects of momentum-dependent nuclear potential on two-nucleon correlation functions and light cluster production in intermediate energy heavy-ion collisions

Using an isospin- and momentum-dependent transport model, we study the effects due to the momentum dependence of isoscalar nuclear potential as well as that of symmetry potential on two-nucleon correlation functions and light cluster production in intermediate energy heavy-ion collisions induced by neutron-rich nuclei. It is found that both observables are affected significantly by the momentum dependence of nuclear potential, leading to a reduction of their sensitivity to the stiffness of nuclear symmetry energy. However, the t/$^{3}$He ratio remains a sensitive probe of the density dependence of nuclear symmetry energy.Comment: 20 pages, 11 figure

Probing the equation of state of neutron-rich matter with intermediate energy heavy-ion collisions

Nuclear reactions induced by stable and/or radioactive neutron-rich nuclei provide the opportunity to pin down the equation of state of neutron-rich matter, especially the density ($\rho$) dependence of its isospin-dependent part, i.e., the nuclear symmetry energy $E_{\rm sym}$. A conservative constraint, $32(\rho /\rho_{0})^{0.7} < E_{\rm sym}(\rho ) < 32(\rho /\rho _{0})^{1.1}$, around the nuclear matter saturation density $\rho_0$ has recently been obtained from the isospin diffusion data in intermediate energy heavy-ion collisions. We review this exciting result and discuss its consequences and implications on nuclear effective interactions, radii and cooling mechanisms of neutron stars.Comment: 10 pages. Invited talks at (1) International Workshop on Nuclear Multifragmentation, Nov. 28-Dec. 1, 2005, Catania, Italy and (2) XXIX Symposium on Nuclear Physics, Jan. 3-6, 2006, Cocoyoc, Morelos, Mexic

High-energy behavior of the nuclear symmetry potential in asymmetric nuclear matter

Using the relativistic impulse approximation with empirical NN scattering amplitude and the nuclear scalar and vector densities from the relativistic mean-field theory, we evaluate the Dirac optical potential for neutrons and protons in asymmetric nuclear matter. From the resulting Schr\"{o}% dinger-equivalent potential, the high energy behavior of the nuclear symmetry potential is studied. We find that the symmetry potential at fixed baryon density is essentially constant once the nucleon kinetic energy is greater than about 500 MeV. Moreover, for such high energy nucleon, the symmetry potential is slightly negative below a baryon density of about $$ fm$^{-3}$ and then increases almost linearly to positive values at high densities. Our results thus provide an important constraint on the energy and density dependence of nuclear symmetry potential in asymmetric nuclear matter.Comment: 6 pages, 5 figures, revised version, to appear in PR

Probing isospin- and momentum-dependent nuclear effective interactions in neutron-rich matter

The single-particle potentials for nucleons and hyperons in neutron-rich matter generally depends on the density and isospin asymmetry of the medium as well as the momentum and isospin of the particle. It further depends on the temperature of the matter if the latter is in thermal equilibrium. We review here the extension of a Gogny-type isospin- and momentum-dependent interaction in several aspects made in recent years and their applications in studying intermediate-energy heavy ion collisions, thermal properties of asymmetric nuclear matter and properties of neutron stars. The importance of the isospin- and momentum-dependence of the single-particle potential, especially the momentum dependence of the isovector potential, is clearly revealed throughout these studies.Comment: 27 pages, 19 figures, 1 table, accepted version to appear in EPJA special volume on Nuclear Symmetry Energ

Test on Existence of Histology Subtype-Specific Prognostic Signatures Among Early Stage Lung Adenocarcinoma and Squamous Cell Carcinoma Patients Using a Cox-Model Based Filter

BACKGROUND: Non-small cell lung cancer (NSCLC) is the predominant histological type of lung cancer, accounting for up to 85% of cases. Disease stage is commonly used to determine adjuvant treatment eligibility of NSCLC patients, however, it is an imprecise predictor of the prognosis of an individual patient. Currently, many researchers resort to microarray technology for identifying relevant genetic prognostic markers, with particular attention on trimming or extending a Cox regression model. Adenocarcinoma (AC) and squamous cell carcinoma (SCC) are two major histology subtypes of NSCLC. It has been demonstrated that fundamental differences exist in their underlying mechanisms, which motivated us to postulate the existence of specific genes related to the prognosis of each histology subtype. RESULTS: In this article, we propose a simple filter feature selection algorithm with a Cox regression model as the base. Applying this method to real-world microarray data identifies a histology-specific prognostic gene signature. Furthermore, the resulting 32-gene (32/12 for AC/SCC) prognostic signature for early-stage AC and SCC samples has superior predictive ability relative to two relevant prognostic signatures, and has comparable performance with signatures obtained by applying two state-of-the art algorithms separately to AC and SCC samples. CONCLUSIONS: Our proposal is conceptually simple, and straightforward to implement. Furthermore, it can be easily adapted and applied to a range of other research settings. REVIEWERS: This article was reviewed by Leonid Hanin (nominated by Dr. Lev Klebanov), Limsoon Wong and Jun Yu

Shear viscosity of neutron-rich nucleonic matter near its liquid-gas phase transition

Within a relaxation time approach using free nucleon-nucleon cross sections modified by the in-medium nucleon masses that are determined from an isospin- and momentum-dependent effective nucleon-nucleon interaction, we investigate the specific shear viscosity ($\eta/s$) of neutron-rich nucleonic matter near its liquid-gas phase transition. It is found that as the nucleonic matter is heated at fixed pressure or compressed at fixed temperature, its specific shear viscosity shows a valley shape in the temperature or density dependence, with the minimum located at the boundary of the phase transition. Moreover, the value of $\eta/s$ drops suddenly at the first-order liquid-gas phase transition temperature, reaching as low as $4\sim5$ times the KSS bound of $\hbar/4\pi$. However, it varies smoothly for the second-order liquid-gas phase transition. Effects of the isospin degree of freedom and the nuclear symmetry energy on the value of $\eta/s$ are also discussed.Comment: 6 pages, 5 figure

Energy dependence of pion in-medium effects on \pi^-/\pi^+ ratio in heavy-ion collisions

Within the framework of a thermal model with its parameters fitted to the results from an isospin-dependent Boltzmann-Uehling-Uhlenbeck (IBUU) transport model, we study the pion in-medium effect on the charged-pion ratio in heavy-ion collisions at various energies. We find that due to the cancellation between the effects from pion-nucleon s-wave and p-wave interactions in nuclear medium, the \pi^-/\pi^+ ratio generally decreases after including the pion in-medium effect. The effect is larger at lower collision energies as a result of narrower pion spectral functions at lower temperatures.Comment: 4 pages, 4 figures, 1 table, minor modifications, version to appear in Physical Review