8 research outputs found

    Científicas españolas: un mundo por descubrir

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    Objetivos: La UniĂłn Europea sugiere, entre otros puntos, que la formaciĂłn universitaria sea complementada con los avances que se vayan produciendo en la investigaciĂłn cientĂ­fica y, ademĂĄs, pone un especial Ă©nfasis en la digitalizaciĂłn de contenidos y en la difusiĂłn a travĂ©s de internet en la EducaciĂłn Superior. Por ello, el objetivo del proyecto llevado a cabo fue realizar una actividad en la que los alumnos entrevistaran a una mujer cientĂ­fica española que trabajara en alguno de los temas estudiados en clases e ir creando un blog, vinculado a Facebook, con las entrevistas realizadas. De esta forma, ademĂĄs de dar visibilidad a las cientĂ­ficas de nuestro paĂ­s, ya que en muchos casos la mujer estĂĄ infravalorada por la sociedad en el ĂĄmbito cientĂ­fico, se pretendĂ­a conseguir la participaciĂłn activa del alumnado y favorecer y fomentar su aprendizaje activo, desarrollar la capacidad del alumno de profundizar en un tema de investigaciĂłn y de plantearse y de que tomaran conciencia del relevante nivel cientĂ­fico que existe en nuestro paĂ­s y, en concreto, de la importancia que tienen las mujeres. MetodologĂ­a: Se propuso la actividad a alumnos de 5 Grados diferentes (Farmacia, Doble Grado de NutriciĂłn y DietĂ©tica, Ciencia y TecnologĂ­a de los Alimentos, Terapia Ocupacional y Óptica y OptometrĂ­a). Los alumnos interesados en participar formaron grupos de trabajo y eligieron el tema sobre el que querĂ­an trabajar del listado propuesto por los profesores. Buscaron una mujer cientĂ­fica española de reconocido prestigio que trabajara en el tema elegido y, despuĂ©s de comunicĂĄrselo al profesor, se pusieron en contacto con ella para solicitarles la realizaciĂłn de la entrevista. Una vez que esta accedĂ­a a su realizaciĂłn, los alumnos prepararon un dossier de preguntas basĂĄndose en los trabajos publicados de la misma, y, tras ser supervisado y corregido por el profesor, eran formuladas a la cientĂ­fica elegida. Una vez realizada la entrevista, los alumnos redactaron un artículo y tras su revisiĂłn por el profesor, se hacĂ­a público en el blog. Para dar mayor visibilidad al blog, se creĂł una cuenta abierta de Facebook en la que se iba vinculando el mismo. Al final de todo el proceso se realizĂł una valoraciĂłn de la actividad global por parte de los alumnos mediante una encuesta de opiniĂłn tipo Likert. Resultados: Se ofertĂł la actividad a 581 alumnos y participaron 195 (33,6%). Con la actividad propuesta se ha conseguido la participaciĂłn activa de un porcentaje considerable del alumnado, destacando en los Grados de CYTA (78,4%), Doble Grado de Farmacia y NutriciĂłn (72,3%) y Farmacia (24,1%). Dentro de los que participaron en la actividad, el porcentaje de aprobados fue mayor que el de suspensos (78 vs. 22%; p<0,05, respectivamente). Por otra parte, la valoraciĂłn otorgada a la actividad fue bastante buena (3,8 sobre 5 puntos), aunque muchos estudiantes manifestaron que les llevĂł bastante tiempo su realizaciĂłn. Por Ășltimo, segĂșn los alumnos, la actividad les hizo tomar conciencia del alto nivel cientĂ­fico de muchas cientĂ­ficas españolas (4,5 puntos sobre 5)

    COVID-19 outbreaks in a transmission control scenario: challenges posed by social and leisure activities, and for workers in vulnerable conditions, Spain, early summer 2020

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    Severe acute respiratory syndrome coronavirus 2 community-wide transmission declined in Spain by early May 2020, being replaced by outbreaks and sporadic cases. From mid-June to 2 August, excluding single household outbreaks, 673 outbreaks were notified nationally, 551 active (>6,200 cases) at the time. More than half of these outbreaks and cases coincided with: (i) social (family/friends’ gatherings or leisure venues) and (ii) occupational (mainly involving workers in vulnerable conditions) settings. Control measures were accordingly applied

    Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

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    Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

    Quorum sensing network in clinical strains of A. baumannii : AidA is a new quorum quenching enzyme

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    Acinetobacter baumannii is an important pathogen that causes nosocomial infections generally associated with high mortality and morbidity in Intensive Care Units (ICUs). Currently, little is known about the Quorum Sensing (QS)/Quorum Quenching (QQ) systems of this pathogen. We analyzed these mechanisms in seven clinical isolates of A. baumannii. Microarray analysis of one of these clinical isolates, Ab1 (A. baumannii ST-2-clon-2010), previously cultured in the presence of 3-oxo-C12-HSL (a QS signalling molecule) revealed a putative QQ enzyme (α/ÎČ hydrolase gene, AidA). This QQ enzyme was present in all nonmotile clinical isolates (67% of which were isolated from the respiratory tract) cultured in nutrient depleted LB medium. Interestingly, this gene was not located in the genome of the only motile clinical strain growing in this medium (A. baumannii strain Ab421-GEIH-2010 [Ab7], isolated from a blood sample). The AidA protein expressed in E. coli showed QQ activity. Finally, we observed downregulation of the AidA protein (QQ system attenuation) in the presence of HO (ROS stress). In conclusion, most of the A. baumannii clinical strains were not surface motile (84%) and were of respiratory origin (67%). Only the pilT gene was involved in surface motility and related to the QS system. Finally, a new QQ enzyme (α/ÎČ hydrolase gene, AidA protein) was detected in these strains

    Influence of the length of hospitalisation in post-discharge outcomes in patients with acute heart failure: Results of the LOHRCA study.

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    To investigate the relationship between length of hospitalisation (LOH) and post-discharge outcomes in acute heart failure (AHF) patients and to ascertain whether there are different patterns according to department of initial hospitalisation. Consecutive AHF patients hospitalised in 41 Spanish centres were grouped based on the LOH (15 days). Outcomes were defined as 90-day post-discharge all-cause mortality, AHF readmissions, and the combination of both. Hazard ratios (HRs), adjusted by chronic conditions and severity of decompensation, were calculated for groups with LOH >6 days vs. LOH 6 days vs. LOH We included 8563 patients (mean age: 80 (SD = 10) years, 55.5% women), with a median LOH of 7 days (IQR 4-11): 2934 (34.3%) had a LOH 15 days. The 90-day post-discharge mortality was 11.4%, readmission 32.2%, and combined endpoint 37.4%. Mortality was increased by 36.5% (95%CI = 13.0-64.9) when LOH was 11-15 days, and by 72.0% (95%CI = 42.6-107.5) when >15 days. Conversely, no differences were found in readmission risk, and the combined endpoint only increased 21.6% (95%CI = 8.4-36.4) for LOH >15 days. Stratified analysis by hospitalisation departments rendered similar post-discharge outcomes, with all exhibiting increased mortality for LOH >15 days and no significant increments in readmission risk. Short hospitalisations are not associated with worse outcomes. While post-discharge readmissions are not affected by LOH, mortality risk increases as the LOH lengthens. These findings were similar across hospitalisation departments

    Influence of the length of hospitalisation in post-discharge outcomes in patients with acute heart failure: Results of the LOHRCA study

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