Evaluation of buried faults in Konya region using steerable filters

Bu makalede, yönlendirmeli filtreler jeofizik verilerin değerlendirilmesinde kullanılmışlardır. Yönlendirmeli filtreler belirli bir doğrultuda band geçiren filtrelerdir. Yönlendirmeli filtreler de, giriş görüntüsündeki farklı yönlerdeki kenarların elde edilmesi için, görüntü ilk önce farklı yönlere sahip temel filtrelerden geçirilir ve daha sonra yönelim alt-bandlarına ayrılır. Bu çalışmada, yönlendirmeli filtrelerin başarımını görebilmek için, çeşitli açılara sahip sentetik datalar ele alınmış ve kenar belirlemesi yapılmıştır. Arazi çalışması olarak, Konya bölgesinin gravite anomali haritasını kullandık. Gömülü durumda bulunan fayların oluşturduğu anomaliler farklı yönler için incelenmiş ve bölgenin oluşturulan fay haritası jeolojik bilgilerle karşılaştırılmıştır.In this paper, steerable filters are used in the evaluation of geophysical data. Steerable filters are band-pass filters having direction property. In extraction of directional properties, input data is passed through various directed band pass filters and then grouped into sub-bands. Here, to present the performance of steerable filters, we have chosen synthetic examples having various direction properties and tried to find out the borders of these samples. As a field study, we have used gravity anomaly map of Konya region. The anomalies caused by buried faults are evaluated for different angles and obtained fault map of the region is compared to previous geological results

The effects of servicescape on the emotional states and behavioural responses of hotel guests

The aim of this paper is to reveal the influence of servicescape of hotel businesses on the emotional states and behavioural responses of guests. Data collected from 211 participants, was tested by using Regression Analysis to determine the interaction among identified variables (servicescape, emotional states and behavioural responses). It was found that the servicescape component had a positive effect on behavioural responses, and emotional states of guests played a mediating role between servicescape and behavioural response components. It is important to determine what kind of emotional states along with the influence of servicescape result in behavioural changes in hotels. Hence, determining the emotional states that individuals experience in hotels will make it possible to design a servicescape by considering those emotional states

In vitro anticancer and apoptotic activity of edible mushroom Lepista nuda (Bull.) Cooke on leukemia and breast cancer compared with protocatechuic acid, paclitaxel and doxorubicin

Macro fungi are used as food and for therapy for centuries. One such fungus Lepista nuda (Bull.) Cooke is reported to exhibit many biological activities while other species viz. Lepista inversa and L. sordida possess active substances. In this study, we prepared extractions depended on polarity increase from the edible mushroom Lepista nuda and studied its action on HL60 (leukemia) and MCF7 (breast cancer) cancer cell lines., We used PCA (protocatechuic acid), paclitaxel and doxorubicin as positive controls. Methanol extract was found effective on both cell lines. The extract showed fairly significant (IC50 ~15 mg/mL) of biologic activity compared with drugs protocatechuic acid, paclitaxel and doxorubicin against HL-60 cell line with regard to both proliferation and apoptotic effects (>%75)

In vitro anticancer and apoptotic activity of edible mushroom Lepista nuda (Bull.) Cooke on leukemia and breast cancer compared with protocatechuic acid, paclitaxel and doxorubicin

147-152Macro fungi are used as food and for therapy for centuries. One such fungus Lepista nuda (Bull.) Cooke is reported to exhibit many biological activities while other species viz. Lepista inversa and L. sordida possess active substances. In this study, we prepared extractions depended on polarity increase from the edible mushroom Lepista nuda and studied its action on HL60 (leukemia) and MCF7 (breast cancer) cancer cell lines., We used PCA (protocatechuic acid), paclitaxel and doxorubicin as positive controls. Methanol extract was found effective on both cell lines. The extract showed fairly significant (IC50 ~15 mg/mL) of biologic activity compared with drugs protocatechuic acid, paclitaxel and doxorubicin against HL-60 cell line with regard to both proliferation and apoptotic effects (>%75)

Diagnosis of Paratuberculosis in Histopathological Images Based on Explainable Artificial Intelligence and Deep Learning

Artificial intelligence holds great promise in medical imaging, especially histopathological imaging. However, artificial intelligence algorithms cannot fully explain the thought processes during decision-making. This situation has brought the problem of explainability, i.e., the black box problem, of artificial intelligence applications to the agenda: an algorithm simply responds without stating the reasons for the given images. To overcome the problem and improve the explainability, explainable artificial intelligence (XAI) has come to the fore, and piqued the interest of many researchers. Against this backdrop, this study examines a new and original dataset using the deep learning algorithm, and visualizes the output with gradient-weighted class activation mapping (Grad-CAM), one of the XAI applications. Afterwards, a detailed questionnaire survey was conducted with the pathologists on these images. Both the decision-making processes and the explanations were verified, and the accuracy of the output was tested. The research results greatly help pathologists in the diagnosis of paratuberculosis.Comment: 7 page

Factors associated with livebirth in couples undergoing their first in vitro fertilization cycle: An internally validated prediction model

Objective: The aim of the study is to create a new model to predict successful outcome in assisted reproductive techniques

Label reading habits and views on genetically modified organisms of adults during food shoppingErişkinlerin gıda alışverişi sırasında etiket okuma alışkanlıkları ve genetiği değiştirilmiş organizmalar konusundaki görüşleri

Food label makes it possible to use the rights training, access to information, selection for consumer. It is possible to eat healthy by having more information on food labels. This study was planned to determine food label reading habit and the views on GMOs of adults. The population of the research consists of adults who shpping at supermarket in Manisa. The sample was 658 people (n=658). The descriptive and cross-sectional survey was done October between and December 2014. The data collection form includes socio-demographic information, opinions on label reading and GMOs. It was found that 80.1% of respondents' source of information on GMOs is the media.It was found that socio-demographical characteristics of the participants affected food labels reading habits and views on GMOs. It was found that most of respondents that disagreed in production with genetically modified seeds in Turkey is correct. Furthermore most of respondents thought that did not comply with the ban which prevents entry of genetically modified foods to Turkey and did not make necessary checks in there. The results of this study show that adults are not having much knowledge about GMOs and risk perseption scale on GMOs is great. the media has the bigggest effect about GMOs. This study once again showed the need for the educational role of the public health nurse in terms of community nutrition. Extended English abstract is in the end of PDF (TURKISH) file.ÖzetGıda etiketi tüketicinin bilgi edinme, eğitilme, seçme hakkını kullanmasını mümkün kılar. Gıda etiketleri hakkında daha fazla bilgiye sahip olarak sağlıklı beslenmek mümkündür. Çalışma erişkinlerin gıda etiketi okuma alışkanlığı ve GDO konusundaki görüşlerinin belirlenmesi amacıyla planlanmıştır. Araştırmanın evrenini Manisa il merkezinde bulunan süpermarketlerden alışveriş yapan erişkinler oluşturmuştur. Örneklem ise 568 kişidir (n=658). Tanımlayıcı-kesitsel tipteki çalışmanın verileri Ekim-Aralık 2014 tarihleri arasında toplanmıştır. Veriler GDO’ ya ilişkin soruların olduğu form ve sosyo-demografik bilgi formu kullanılarak toplanmıştır. GDO’ ya ilişkin bilgiye ulaşmada en sık kullanılan kaynak medyadır (%80.1).Katılımcıların sosyo-demografik özelliklerinin   etiket okuma alışkanlığı ve GDO’ ya ilişkin görüşlerini etkilediği bulunmuştur. Katılımcıların çoğu Türkiye’de GD tohumlarla üretim yapılmasını doğru bulmadığını, Türkiye’de GDO’ lu gıda girişini engelleyen yasağa uyulmadığını ve gerekli kontrollerin yapılmadığını düşünmektedir. Çalışma sonuçlarına göre erişkinler GDO hakkında pek fazla bilgi sahibi değildir ve medya en büyük etkiye sahiptir. Katılımcıların GDO risk algısı yüksektir. Bu çalışma toplum beslenmesi açısından halk sağlığı hemşiresinin eğitici rolüne olan ihtiyacı bir kez daha gözler önüne sermiştir

The Effects of azadrachtin on mitotic division in root tip meristem cells of Allium cepa L.

Ülkemizde park ve bahçelerde yetiştirilen, Meliaceae familyasına ait olan Melia azedarach' tan elde edilen ve bir biopestisit olarak kullanılan Azadirachtin'in genotoksik etkileri bir bitkisel test sistemi ile araştırılmıştır. Tohumlar Aydın'daki Melia azedarach türlerinin meyvelerinden elde edilmiştir. 25 gr tohum/İt, 50 gr tohum/İt ve 75 gr tohum/İt olmak üzere 3 ayrı konsantrasyondaki ekstraktlann etkileri Allium test ile belirlenmiştir. Elde edilen kökler mikroskobik gözlemler için kullanılmıştır. Azadirachtin, kontrol grubu ile karşılaştınldığında hücre bölünmesi ve kromozomlar üzerinde etkili bulunmuştur. Ancak tarımsal uygulamada tavsiye edilen 50 gr tohum/lt'lik dozda en düşük etkiyi göstermiştir. Yapılan sayımlar neticesinde Azdirachtin'in mitotik indeksi düşürdüğü görülmüştür. Azadirachtin'in zararlı etkilerinin düşük olacağı ve geleneksel kimyasal pestish kullanımını azaltacağı düşünülmektedir. Azadirachtin, which is used as a biopesticide obtained from Melia azedarach. Melia azedarach belongs to the Meliaceae family and grown in the parks and gardens of our country. Genotoxic effects of Azadirachtin have been investigated with a plant test system. The kernels were obtained from the fruits of Melia azedarach species in Aydın. The effects of the extracts at 25 gr kernel/It, 50 gr kernel/It and 75 gr kernel/It have been investigated with Allium test, which is a plant test system. The roots that were obtained, have been used in microscopic observations. Azadirachtin was found to be effective on cell division and chromosomes with respect to control group. But at the 50 gr kernel per It. concentration, which is recommended in the agricultural application, Azadirachtin showed the lowest effect. As a result of the countings, it was found that Azadirachtin decreases the mitotic indexs. It was thought that the harmful effects of Azadirachtin would be low and Azadirachtin would decrease the use of traditional chemical pestisides

Determining the cytotoxic activities of extracts derived from some endemic plants that are growing in aydin vicinity

Bu arastırma Aydın yöresinde yetisen bazı endemik bitkilerden (Crocus olivieri ssp. balansae, Scutellaria orientalis ssp. carica, Scrophularia floribunda ve Hypericum adenotrichum) elde edilen ekstraktların sitotoksik aktivitelerinin belirlenmesi amacıyla yapılmıstır. Bu amaçla cins özellikleri göz önüne alınarak 4 farklı endemik bitki seçilmistir. Seçilen bitkilerden farklı yöntemlerle (petrol eteri, etil asetat, diklormetan ve metanol) elde edilen ekstraktların farklı konsantrasyonları (0,5 mg/ml, 1 mg/ml, 4 mg/ml, 20 mg/ml ve 40 mg/ml) bir lösemi hücre hattı olan HL-60 hücrelerine uygulanarak ekstraktların sitotoksik aktiviteleri arastırılmıstır. Ayrıca sitotoksik aktivite sonuçlarına göre etkili olan 3 adet bitkinin HL-60 hücreleri üzerindeki apoptotik ve nekrotik etkileri de Hoechst 33258/Propidium Iodide (HO/PI) boyama yöntemi ile arastırılmıstır. Çalısma sonucunda seçilen bitkilerden özellikle H. adenotrichum bitkisinin hem sitotoksik aktivite hem de apoptotik etki bakımından ön plana çıktıgı gözlenmistir. Sitotoksik aktivite bakımından S. orientalis ssp. carica ve S. floribunda’ da etkili olmustur. Ancak bu iki bitki apoptotik ve nekrotik etki bakımından degerlendirildiginde, S. orientalis ssp. carica’ nın apoptotik etki bakımından, S. floribunda’dan daha etkili oldugu bulunmustur. S. floribunda ise güçlü sitotoksik aktivite göstermesine ragmen, HL-60 hücreleri üzerinde yüksek oranda nekrotik etkiye yol açmıstır. Çalısma kapsamında seçilen endemik bitkiler sitotoksik aktivite bakımından ilk kez bu tez kapsamında arastırılmıstır. Elde ettigimiz veriler kanser tedavisinde kullanılabilecek yeni bitkisel kökenli bilesiklerin arastırılmasına ısık tutması açısından önem tasımaktadır. Daha ileri çalısmalarla bitkilerden elde edilen etkili ekstraktlar içerisindeki etken madde grupları veya bilesikler belirlenerek hücre içerisinde hangi mekanizmalarla ve hangi düzeylerde etkinlik gösterdikleri ortaya konmalıdır.This study has been carried out to determine the cytototxic activities of the extracts derived from some endemic plants (Crocus olivieri ssp. balansae, Scutellaria orientalis ssp. carica, Scrophularia floribunda ve Hypericum adenotrichum) that are growing in Aydın vicinity. For this purpose 4 different endemic plants have been selected in consideration of genus properties. The cytotoxic activities of different concentrations (0,5 mg/ml, 1 mg/ml, 4 mg/ml, 20 mg/ml and 40 mg/ml) from various extract types (petroleum ether, ethyl acetate, dichloromethane and methanol) of selected plants has been tested against HL-60 leukaemia cell line. In addition the apoptotic and necrotic effects on HL-60 cells of 3 plants which were effective according to the cytotoxic activity results have been investigated with Hoechst 33258/Propidium Iodide (HO/PI) staining. At the end of the study, it was examined that from the selected plants especially H. adenotrichum is coming on surface in both of cytotoxic activity and apoptotic effect. S. orientalis ssp. carica and S. floribunda has been found also cytotoxic. But, when this two plant have utilized in terms of apoptotic and necrotic effect, it was found that S.orientalis ssp. carica was more effective than S. floribunda, related to apoptotic effect. But S. floribunda showed a high ratio of necrotic effect on HL-60 cells in spite of its strong cytotoxic activity. Selected endemic plants in the scope of the study were investigated for the first time in this Thesis in terms of their cytotoxic activity. The results of this study is important in lighting up the investigation for new plant sources that can be used in cancer therapy. Furthermore the act of mechanisms must be shown and the chemical groups or compounds must be determined in the derived effective extracts