Vaginal clear cell adenocarcinoma with associated Mullerian duct anomalies, renal agenesis and situs inversus: report of a case with no known in-utero exposure with diethyl stilboestrol

A 27 year old female presented with two months history of continuous vaginal bleeding. On evaluation, she was diagnosed as a case of vaginal clear cell adenocarcinoma (VCCA) along with associated Mullerian duct anomalies including didelphys uterus with double vagina; left sided renal agenesis and situs inversus. Although VCCA is strongly linked to in-utero exposure with Diethyl stillboestrol (DES), this patient had no known history regarding such exposure. Also, only a few cases have been described in the literature in which this tumour was seen in association with Mullerian duct anomalies and renal agenesis; in the absence of known DES exposure

Diffusion weighted image (DWI) findings in methanol intoxication

Methanol is a toxic substance with extremely devastating effects upon exposure. The case described suffered from such kind of poisoning. MRI brain demonstrated necrosis bilaterally in the Putamen areas which is a classic hallmark finding. Additional Diffusion weighted imaging showed abnormal signal bilaterally in the putamen areas along with Diffusion positive bilateral lesions (possibly infarctions) in both the frontal and occipital lobes that were not evident on MRI with or without contrast

Characteristics of Nanosilver Ink (UTDAg) Microdroplets and Lines on Polyimide During Inkjet Printing at High Stage Velocity

The performance of printed electronics strongly depends on printing techniques and printing resolution that enhance their electrical and mechanical properties. In this research paper, a Jetlab 4xl was used to control and dispense microdroplets of highly conductive nanosilver ink (UTDAg) on a polyimide substrate. The waveform effect on the droplet generation is characterized by measuring the size and the speed of the drops. The behavior of ejected drops on the substrate is studied by printing lines at different drop spacing and stage velocity. The jetting parameters that drive the piezoelectric actuator were properly determined and two waveforms (bipolar) were created to generate two different droplet characteristics in terms of speed and size. Then, printing on the fly using commands in a script file (called ‘in script’ hereafter) with burst mode (a single burst) was used to print lines with different droplet spacings of 50 μm, 60 μm, 70 μm, 80 μm, 90 μm and 100 μm and stage velocities of 20 mm s−1, 30 mm s−1, 40 mm s−1, and 50 mm s−1. The spreading behavior of the ejected droplets was investigated as well by printing lines with 250 μm spacing at the different stage velocities mentioned above. The physical characteristics of the printed lines were studied by optical microscopy and surface profilometry. Finally, the resistance of the printed line at 100 μm droplet spacing and 50 mm s−1 stage velocity was measured at curing temperatures of 140 °C and 160 °C

Impact of Brand Label on Purchase Intention of a Customer

Main target of this research is examining the relationship between the purchase intention of cosmetics and brand label. The image of the store mediates the relationship between purchase intention and brand label in the cosmetics sector of Pakistan. To check the direct or indirect effect of brand label on purchase intention, data was collected from 200 customers of different stores. Snow ball sampling technique is used for the collection of data from respondents, and PLS-SEM 3 was used to test the hypothesis. The findings indicate that brand label positively and significantly impact customer purchase intention of cosmetics and store image is also positively linked with brand label and mediating the relationship between purchase intention and brand label. Findings will help the retail service sector to understand the importance of store image and how to enhance the consumers purchase intentions. Over long term, customer retention is better and business profitability is greater

Primary cutaneous B cell lymphoma--leg type (NEW EORTC--WHO classification), with nasal sinuses involvement

Primary Cutaneous lymphomas of B cell origin are rare, there remains a controversy in truly classifying these lymphomas and an updated EORTC classification divides them on the basis of their distinct histopthological grounds rather than on the basis of their anatomic location as in WHO classification, while the new WHO- EORTC joint classification maintains some characteristics of both systems, We report an elderly gentleman who primarily had a typical Leg dominant Cutaneous lymphoma of B cell origin uniquely with involvement of nasal Sinusues, bearing the Immunohistochemical staining features of Cutaneous lymphoma - Leg Type befitting the new joint WHO-EORTC classification of Cutaneous B cell Lymphoma

Subependymal giant cell astrocytoma

Subependymal giant cell astrocytomas (SEGAs) are slowly growing tumours corresponding to WHO grade I. They are intraventricular and usually occur in the setting of tuberous sclerosis complex. They often result in obstructive hydrocephalus. Treatment is usually restricted to surgical resection, recurrences are rare and long term prognosis is excellent. We present a series of three cases

Clear cell papillary cystadenoma of epididymis, a mimic of metastatic renal cell carcinoma

We discuss a case of 25 year old male who was evaluated for primary infertility following marriage. He had no previous history of urogenital complaints or abnormalities. In fact, his past medical history was unremarkable. On examination epididymal masses were found. Semen analysis showed azoospermia. Right epididymal mass was surgically excised. Histopathology showed an epididymal neoplasm composed of simple and complex papillary processes lining and filling the ducts. The tumor cells were clear and positive for cytoplasmic glycogen. Immunohistochemistry was also supportive. Diagnosis of clear cell papillary cystedenoma was made based on histopathological and immunohistochemical features

Angiokeratoma of tongue:a series of 14 cases

Angiokeratomas (AC) are vascular lesions which are defined histologically as one or more dilated blood vessels lying directly subepidermal and showing an epidermal proliferative reaction with ectatic capillaries in the papillary dermis. Only three other cases of isolated mucosal angiokeratoma have been reported in the indexed literature. We reviewed all cases of angiokeratoma located on the tongue, diagnosed in our department during a study period of 10 years (1995-2005). Histologically all 14 cases showed dilated and congested blood vessels in the upper papillary dermis. They lack deep dermal involvement. Hyperkeratosis and acanthosis were also seen in most of the cases. No clinical data was available to assess systemic disease. A higher incidence of of AC in tongue is seen in our study

Frequency of primary solid malignant neoplasms in both sexes, as seen in our practice

Background: To determine the frequency of various histologic types of primary solid malignant neoplasms in males and females, in our practice, in a large series of surgical biopdies. Method: A retrospective study of 20,000 consecutive surgical biopsies in the section of Histopathology, Aga Khan University Hospital (AKU), Karachi, in 2004. Results: Squamous cell carcinoma of oral cavity was the commonest malignant neoplasm in males followed by diffuse Large B cell, Non-Hodgkin\u27s lymphoma and Prostatic adenocarcinoma. In females, infiltrating Ductal carcinoma of the breast was overwhelmingly the commonest malignant neoplasm followed by Squamous cell carcinoma of the oral cavity and esophagus. Conclusion: Out of 20,000 biopsies, there were 4616(23.08%) malignant neplasms. Carcinoma of oral cavity is very common in our population in both sexes