222 research outputs found
Frequency of hyperglycemia and polymorphism of TNF and TP53 genes in patients with acute pancreatitis, chronic pancreatitis, pancreatic cancer
BACKGROUND: Β«The vicious circleΒ» of associations of diabetes mellitus (DM) with pancreatic pathology, when pancreatic diseases can initiate DM, and type 2 DM β cause functional and organic pancreatic pathology, determines the search for possible associations. Some studies have established a relationship between TNF or TP53 polymorphisms with DM or with pancreatic diseases.AIMS: to determine and compare fasting plasma glucose and the frequency of hyperglycemia in patients with acute pancreatitis (APp), chronic pancreatitis (CPp), pancreatic cancer (PCp) depending on gender, etiology or stage of the disease, polymorphism -308G/A TNF gene in all patients, and polymorphism 72Arg/Pro gene TP53 in PCp..MATERIALS AND METHODS: At the observational multicenter clinical cross-sectional uncontrolled case-study 44 APp, 97 CPp and 45 PCp were examined; the groups were comparable by sex/age. Informed consent form for participate in the study was obtained from all patients. The main outcome of the study: frequency of hyperglycemia in APp, CPp, PCp, considering the polymorphism TNF and TP53 genes.Β RESULTS: The lowest age-standardized fasting plasma glucose (FPG) was found in CPp (6,2Β±0,2 mmol/l) than in APp (6,7Β±0,2 mmol/l, p=0,041). In PCp (6,6Β±0,2 mmol/l), the average levels of FPG did not differ substantially when compared with APp (p=0,749) or CPp (p=0,092). In APp, the norm of GP was detected less frequently (31,8%) than in CPp (54,6%, Ο2 =6,3, p=0,012), and the frequency of the norm of GP in PCp (48,9%) did not differ with that in APp or CPp. The frequency of FPGβ₯6,1<7,0 mmol/l did not differ in APp (20,5%), CPp (9,3%) or PCp (17,8%). The frequency of FGPβ₯7.0 mmol/l did not differ in APp CPp and PCp: 47,7, 36,1, 33,3%. Logistic regression analysis revealed a tendency for an increased chance of having stage 3β4 PC with FPGβ₯7,0 mmol/l (Exp (B)=3,205 95%CI 0,866β11,855, p=0,081) in PCp, but not in patients with pancreatic necrosis or βdefiniteΒ» Π‘P.The frequencies of G/G (71,4, 74,7, 76,2%), G/A (26,2, 24,1, 23,8%) of TNF genotypes did not differ in APp, CPp or PCp, p>0,05. In PCp genotypes Arg/Arg, Arg/Pro, Pro/Pro polymorphism gene 72Arg/Pro TP53 in 2,4, 35,7, 61,9% of cases. No associations of GPβ₯7,0 mmol/l with TNF polymorphism in APp, CPp, PCp and with TP53 polymorphism in PCp were obtained.CONCLUSIONS: The frequency of FGPβ₯7,0 mmol/l did not differ for various pancreatic disease and was not associated with the risk of pancreatic necrosis and βdefinedβ CP. The -308G/A polymorphism TNF gene did not differ in APp, CPp or PCp and was not associated with impaired carbohydrate metabolism. The 72Arg/Pro polymorphism TP53 gene in PCp was not associated with impaired carbohydrate metabolism
Π’ΠΊΠ°Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΏΡΠΎΡΠ΅ΠΎΠ³Π»ΠΈΠΊΠ°Π½ΠΎΠ² Π² ΡΠ°Π·Π»ΠΈΡΠ½ΡΡ ΡΠΈΠΏΠ°Ρ ΠΎΠΏΡΡ ΠΎΠ»Π΅ΠΉ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ°
Background. Proteoglycans (PGs) are complex glycosylated molecules playing an important role in cell-cell and cell-matrix interactions and signaling. Expression of PGs and their expression pattern change considerably during malignant transformation of mammalian cells and tissues.Objective. The aim of our work was to investigate tissue-specificity of main PGs expression (glypican-1, perlecan, syndecan-1, aggrecan, versican, CSPG4/NG2, brevican, decorin, lumican) in normal cells (fibroblasts and normal epithelial prostate cells PNT2) and in different human cancer cell lines (prostate, breast, lung, brain, kidney). Expression patterns of main PGs were determined in these cells using reverse transcription polymerase chain reaction analysis and immunocytochemical staining.Results. It was shown that fibroblasts actively expressed PGs, and PNT2 cells had lower (5β6-fold) expression levels of a limited set of PG. In different cancer cell lines, overall transcriptional activities of PGs varied up to 10-fold, although their expression patterns had tissue-specific properties (for example, expression of syndecan-1 is more specific for prostate cancer cells, while perlecan is typical for lung cancer cell lines).Conclusions. Along with this, variability of the PG expression patterns in cell lines of the same tissue of origin was shown, suggesting a possible contribution of the variable PGs expression to intratumoural heterogeneity of cancer cells and their potential as perspective biomarker (s) for personalised cancer diagnostics.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. ΠΡΠΎΡΠ΅ΠΎΠ³Π»ΠΈΠΊΠ°Π½Ρ (ΠΠ) β Π±Π΅Π»ΠΊΠΎΠ²ΠΎ-ΡΠ³Π»Π΅Π²ΠΎΠ΄Π½ΡΠ΅ ΠΌΠΎΠ»Π΅ΠΊΡΠ»Ρ, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΠ΅ Π² ΠΌΠ΅ΠΆΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π²Π·Π°ΠΈΠΌΠΎΠ΄Π΅ΠΉΡΡΠ²ΠΈΡΡ
ΠΈ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠ°Π½ΠΈΠΈ ΡΡΡΡΠΊΡΡΡΡ Π²Π½Π΅ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΌΠ°ΡΡΠΈΠΊΡΠ°. ΠΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΠ ΠΈ ΠΈΡ
ΡΠΎΡΡΠ°Π² Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΈΠ·ΠΌΠ΅Π½ΡΡΡΡΡ ΠΏΡΠΈ Π·Π»ΠΎΠΊΠ°ΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎΠΉ ΡΡΠ°Π½ΡΡΠΎΡΠΌΠ°ΡΠΈΠΈ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠΊΠ°Π½Π΅ΠΉ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΈΠ·ΡΡΠΈΡΡ ΡΠΊΠ°Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΠΎΡΡΡ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΎΡΠ½ΠΎΠ²Π½ΡΡ
ΠΠ (Π³Π»ΠΈΠΏΠΈΠΊΠ°Π½Π°-1, ΠΏΠ΅ΡΠ»Π΅ΠΊΠ°Π½Π°, ΡΠΈΠ½Π΄Π΅ΠΊΠ°Π½Π°-1, Π°Π³Π³ΡΠ΅ΠΊΠ°Π½Π°, Π²Π΅ΡΡΠΈ- ΠΊΠ°Π½Π°, Π₯Π‘ΠΠ4/NG2, Π±ΡΠ΅Π²ΠΈΠΊΠ°Π½Π°, Π΄Π΅ΠΊΠΎΡΠΈΠ½Π° ΠΈ Π»ΡΠΌΠΈΠΊΠ°Π½Π°) Π² Π½ΠΎΡΠΌΠ°Π»ΡΠ½ΡΡ
(ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΡ, ΡΠΏΠΈΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΡΠ΅ ΠΊΠ»Π΅ΡΠΊΠΈ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ PNT2) ΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ
ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΈΠ½ΠΈΡΡ
ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° (ΡΠ°ΠΊ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, ΠΌΠΎΠ»ΠΎΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, Π»Π΅Π³ΠΊΠΎΠ³ΠΎ, ΠΌΠΎΠ·Π³Π°, ΠΏΠΎΡΠΊΠΈ) ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ°Π·Π½ΠΎΠΉ ΡΠ΅ΠΏΠ½ΠΎΠΉ ΡΠ΅Π°ΠΊΡΠΈΠΈ c ΠΎΠ±ΡΠ°ΡΠ½ΠΎΠΉ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠ΅ΠΉ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΡΠ»ΠΎ ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΠΈΠ±ΡΠΎΠ±Π»Π°ΡΡΡ Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ Π°ΠΊΡΠΈΠ²Π½ΠΎ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΡΡ ΠΠ, Π° ΠΊΠ»Π΅ΡΠΊΠΈ PNT2 Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π±ΠΎΠ»Π΅Π΅ Π½ΠΈΠ·ΠΊΠΎΠΉ (Π² 5β6 ΡΠ°Π·) ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠ΅ΠΉ ΠΎΠ³ΡΠ°Π½ΠΈΡΠ΅Π½Π½ΠΎΠ³ΠΎ Π½Π°Π±ΠΎΡΠ° ΠΠ. ΠΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠ΅ ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΠ΅ Π»ΠΈΠ½ΠΈΠΈ ΠΎΡΠ»ΠΈΡΠ°ΡΡΡΡ ΠΏΠΎ ΠΎΠ±ΡΠ΅ΠΉ ΡΡΠ°Π½ΡΠΊΡΠΈΠΏΡΠΈΠΎΠ½Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΠ (Π΄ΠΎ 10 ΡΠ°Π·) ΠΈ ΠΏΠ°ΡΡΠ΅ΡΠ½Ρ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΠΌΡΡ
ΠΠ, ΠΎΠ±Π»Π°Π΄Π°Ρ ΠΏΡΠΈ ΡΡΠΎΠΌ ΡΠΊΠ°Π½Π΅ΡΠΏΠ΅ΡΠΈΡΠΈΡΠ½ΡΠΌΠΈ ΠΏΡΠΈΠ·Π½Π°ΠΊΠ°ΠΌΠΈ (Π½Π°ΠΏΡΠΈΠΌΠ΅Ρ, ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΡΠΈΠ½Π΄Π΅ΠΊΠ°Π½Π°-1 Π±ΠΎΠ»Π΅Π΅ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠ½Π° Π΄Π»Ρ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ ΠΏΡΠ΅Π΄ΡΡΠ°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΠΆΠ΅Π»Π΅Π·Ρ, Π° ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡ ΠΏΠ΅ΡΠ»Π΅ΠΊΠ°Π½Π° β Π΄Π»Ρ ΡΠ°ΠΊΠ° Π»Π΅Π³ΠΊΠΎΠ³ΠΎ).ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. ΠΠ°ΡΠΈΠ°Π±Π΅Π»ΡΠ½ΠΎΡΡΡ ΠΏΠ°ΡΡΠ΅ΡΠ½ΠΎΠ² ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΠΈ ΠΠ Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΡΡ
Π»ΠΈΠ½ΠΈΡΡ
ΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΈΠΏΠ° ΠΎΠΏΡΡ
ΠΎΠ»ΠΈ ΠΌΠΎΠΆΠ΅Ρ Π²Π½ΠΎΡΠΈΡΡ Π²ΠΊΠ»Π°Π΄ Π²ΠΎ Π²Π½ΡΡΡΠΈΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΡ Π³Π΅ΡΠ΅ΡΠΎΠ³Π΅Π½Π½ΠΎΡΡΡ ΠΈ ΡΠ»ΡΠΆΠΈΡΡ ΠΏΠΎΡΠ΅Π½ΡΠΈΠ°Π»ΡΠ½ΡΠΌ Π±ΠΈΠΎΠΌΠ°ΡΠΊΠ΅ΡΠΎΠΌ Π΄Π»Ρ ΠΏΠ΅ΡΡΠΎΠ½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Π½ΠΎΠΉ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅ΠΉ
Mineralogy of alluvial sediments of Avzyan gold region (the Southern Urals)
The Avzyan gold region is located within the Bashkirian anticlinorium and includes lode gold deposits and placers. The Gorny Priisk, Bogryashka and Ulyuk-Bar gold deposits are hosted in the Riphean metamorphosed carbonaceous sequence. The article describes the mineralogy of the heavy concentrates from alluvial sediments of the streams of Bolshoy Avzyan basin which drains the Gorny Priisk, Bogryashka and Ulyuk-Bar gold ore deposits. The comparison of mineralogical and chemical feature of the studied heavy concentrates is done. Samples and Methods. Samples from the streams were collected every 50-100 m. Hand specimens of ore and host rocks from the lode gold deposits were collected from outcrops and dumps. The content of metals in the heavy concentrates estimated using X-ray fluorescence analyzer Innov-X alfa. Chemical composition of the accessory minerals was studied using electron microscope Vega-3 Tescan with EDA X-Act Oxford. Discussion and Results. The source of the alluvial sediments was the lode gold deposits located in the immediate vicinity of placers. Heavy concentrates of the Kamenny stream are characterized by a high content of As and Cu while ones of the Bogryashka and Bolshoy Klyuch streams show a high content of Cr and Ba. Goethite is major ore mineral for all studied samples. Ilmenite, rutile, epidote and barite are also widespread in the samples from the Bogryashka and Bolshoy Klyuch streams. Native gold is present in the sediments of all studied stream. The greatest number of gold grains was found in the samples from the Bolshoy Klyuch stream. The weak roundness of the golds and the presence of unoxidized sulfides (pyrite, chalcopyrite and pyrrhotite) indicate a relatively small age of placers. Monazite and xenotime morphology suggests autigenic catagenetic and/or metamorphic origin. Monazite contains (apfu) Ce (0.27-0.56), Nd (0.10-0.37) and La (0.09-0.33), minor Pr, Sm, Gd, Eu and Dy; ThO2 up to 9.78 wt. % (0.08 apfu). It is similar with monazite composition from other streams of the east part of the Bashkirian anticlinorium and can be evidence of their similar origin. Xenotime contains major Gd, Dy and Er and minor Tb and Ho. Xenotime from the Bogryashka stream is characterized by the increased concentration of (apfu) Gd (0.10-0.24), Nd (0.01-0.02), Sm (0.03-0.06), Eu (0.02-0.06) and absence of Ho and Yb. Xenotime composition from the Kamenny and Bolshoy Klyuch streams is similar with ones from east part of the Bashkirian anticlinorium. Galena inclusions in REE phosphates, monazite inclusions in goethite and xenotime inclusions in pyrite can be evidence about similar conditions and time of formation gold-sulfide and REE mineralization
Results of Modeling Experiments in Designing Immuno-Enzyme Test-System for the Detection of Antibodies to <I>Yersinia pestis</I> F1 (ELISA-Ab-F1 <I>Yersinia pestis</I>)
Designed is immuno-enzyme test-system for the detection of antibodies to Yersinia pestis capsular antigen F1 β βELISA-Ab-F1
Yersinia pestisβ. On the model of laboratory mice it is demonstrated that this test-system is highly specific, its diagnostic titer being 1/320.Diagnostic value of the test-system is 83.3β88.9 % as revealed through investigations of sera and blood suspension samples, swabs of thoracic organs of animals, inoculated with live plague vaccine, strains of plague microbe, containing and deprived of pFra, as well as with heterologous bacteria
Constructing and Medical Trials of a Monoclonal Dot-Immuno-Enzyme Test-System βDIATul-Mβ for Tularemia Microbe Detection
mc/ml. Additionally, this test-system has been proving for acquisition of sustainable results after 6 months of storing (the observation period). Medical trials of the panel of reagents βMonoclonal dot-immuno-enzyme test-system for tularemia microbe detectionβ have shown it to be a prospective preparation for implementation into the national healthcare practices both under stationary and field conditions
ΠΡΠΎΠ±Π»Π΅ΠΌΠ° ΡΠ°Π½Π½Π΅Π³ΠΎ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΡΡΠ°ΡΡΠΊΡΠΎΠΌΠΈΠΈ
Background. The highest rate of incontinence after radical prostatectomy (RP) is observed in the first 2β6 months after surgery. In orderΒ to decrease the period of incontinence, virous surgical methods aimed at preservation and reconstruction of structures participatingΒ in the mechanism of urine retention has been developed and improved.The study objective is to evaluate effectiveness of an original method of formation of an urethral anastomosis in the early continence recovery.Materials and methods. Data on 126 patients who underwent retropubic RP were analyzed. Depending on the method of urethral anastomosis formation, patients were divided into 2 groups: in the 1st group (n = 52) the patients underwent PR with urethra suspension m. levator ani, in the 2nd (n = 74) β standard RP. In the 1st group, 6 ligatures were applied to the anterior and posterior urethra walls: at the 12 and 6 hour projections through the mucosa, submucosa, and smooth muscle; at the 10, 2, 4, and 8 hour projections β more laterally with capture of the m. levator ani medial margins. Continence recovery was evaluated on days 1, 7, and 14 after urinary catheter removal and then at days 30, 90, 180, and 365 after RP. The criteria of continence were absence of urine leakage at rest and during physical activity and a necessity of using a safety liner.Results. There werenβt any significant differences at day 1 after urinary catheter removal between the two groups (Ρ > 0.05). In the 1st group, continence values at days 30, 90, and 180 after RP were significantly higher (57.7, 69.2, and 71.1 %, respectively) compared to the 2nd group (35.1, 41.9, and 51.3 %, respectively) (Ρ <0.05).Conclusion. Results of this work show significant benefits of RP with urethra suspension m. levator ani compared to standard RP per continence recovery criteria at days 7, 14, 30, 90, and 180 after the surgery. The technique of urethra suspension m. levator ani is easy to perform and ensures early continence recovery after RP.ΠΠ²Π΅Π΄Π΅Π½ΠΈΠ΅. Π§Π°ΡΡΠΎ Π½Π΅Π΄Π΅ΡΠΆΠ°Π½ΠΈΠ΅ ΠΌΠΎΡΠΈ ΠΏΠΎΡΠ»Π΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ ΡΠ°Π΄ΠΈΠΊΠ°Π»ΡΠ½ΠΎΠΉ ΠΏΡΠΎΡΡΠ°ΡΡΠΊΡΠΎΠΌΠΈΠΈ (Π ΠΠ) ΡΠ΅Π³ΠΈΡΡΡΠΈΡΡΡΡ Π² ΠΏΠ΅ΡΠ²ΡΠ΅ 2β6 ΠΌΠ΅Ρ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠ²Π½ΠΎΠ³ΠΎ Π²ΠΌΠ΅ΡΠ°ΡΠ΅Π»ΡΡΡΠ²Π°. Π ΡΠ΅Π»ΡΡ
ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΈΡ ΠΏΠ΅ΡΠΈΠΎΠ΄Π° ΠΈΠ½ΠΊΠΎΠ½ΡΠΈΠ½Π΅Π½ΡΠΈΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½Ρ ΠΈ ΡΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½Ρ ΡΠ°Π·Π»ΠΈΡΠ½ΡΠ΅ Ρ
ΠΈΡΡΡΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΌΠ΅ΡΠΎΠ΄Ρ, Π½Π°ΠΏΡΠ°Π²Π»Π΅Π½Π½ΡΠ΅ Π½Π° ΡΠΎΡ
ΡΠ°Π½Π΅Π½ΠΈΠ΅ ΠΈ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΡΡΠΊΡΡΡ, ΡΡΠ°ΡΡΠ²ΡΡΡΠΈΡ
Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ β ΠΎΡΠ΅Π½ΠΈΡΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ ΠΎΡΠΈΠ³ΠΈΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅ΡΡΠΎΡΠΈΡΡΠΎΠ°Π½Π°ΡΡΠΎΠΌΠΎΠ·Π° Π² ΡΠ°Π½Π½Π΅ΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠΈ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°Π½Ρ Π΄Π°Π½Π½ΡΠ΅ 126 ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠΎΠ΄Π²Π΅ΡΠ³Π½ΡΡΡΡ
ΠΏΠΎΠ·Π°Π΄ΠΈΠ»ΠΎΠ½Π½ΠΎΠΉ Π ΠΠ. Π Π·Π°Π²ΠΈΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡ ΠΌΠ΅ΡΠΎΠ΄Π° ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΡ ΡΡΠ΅ΡΡΠΎΡΠΈΡΡΠΎΠ°Π½Π°ΡΡΠΎΠΌΠΎΠ· Π±ΠΎΠ»ΡΠ½ΡΠ΅ Π±ΡΠ»ΠΈ ΡΠ°Π·Π΄Π΅Π»Π΅Π½Ρ Π½Π° 2 Π³ΡΡΠΏΠΏΡ: ΠΏΠ°ΡΠΈΠ΅Π½ΡΠ°ΠΌ 1-ΠΉ Π³ΡΡΠΏΠΏΡ (n = 52) Π²ΡΠΏΠΎΠ»Π½Π΅Π½Π° Π ΠΠ Ρ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠ΅ΠΉ ΡΡΠ΅ΡΡΡ m. levator ani, 2-ΠΉ (n = 74) β ΡΡΠ°Π½Π΄Π°ΡΡΠ½Π°Ρ Π ΠΠ. Π 1-ΠΉ Π³ΡΡΠΏΠΏΠ΅ Π½Π° ΠΏΠ΅ΡΠ΅Π΄Π½ΡΡ ΠΈ Π·Π°Π΄Π½ΡΡ ΡΡΠ΅Π½ΠΊΠΈ ΡΡΠ΅ΡΡΡ Π½Π°ΠΊΠ»Π°Π΄ΡΠ²Π°Π»ΠΈ 6 Π»ΠΈΠ³Π°ΡΡΡ: Π² ΠΏΡΠΎΠ΅ΠΊΡΠΈΠΈ 12 ΠΈ 6 Ρ ΡΡΠ»ΠΎΠ²Π½ΠΎΠ³ΠΎ ΡΠΈΡΠ΅ΡΠ±Π»Π°ΡΠ° ΡΠ΅ΡΠ΅Π· ΡΠ»ΠΈΠ·ΠΈΡΡΡΡ, ΠΏΠΎΠ΄ΡΠ»ΠΈΠ·ΠΈΡΡΡΡ ΠΎΠ±ΠΎΠ»ΠΎΡΠΊΠΈ ΠΈ Π³Π»Π°Π΄ΠΊΠΎΠΌΡΡΠ΅ΡΠ½ΡΠΉ ΡΠ»ΠΎΠΉ; Π½Π° 10, 2, 4 ΠΈ 8 Ρ β Π±ΠΎΠ»Π΅Π΅ Π»Π°ΡΠ΅ΡΠ°Π»ΡΠ½ΠΎ Ρ Π·Π°Ρ
Π²Π°ΡΠΎΠΌ ΠΌΠ΅Π΄ΠΈΠ°Π»ΡΠ½ΡΡ
ΠΊΡΠ°Π΅Π² m. levator ani. ΠΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ ΠΎΡΠ΅Π½ΠΈΠ²Π°Π»ΠΈ ΡΠ΅ΡΠ΅Π· 1, 7 ΠΈ 14 ΡΡΡ Ρ ΠΌΠΎΠΌΠ΅Π½ΡΠ° ΡΠ΄Π°Π»Π΅Π½ΠΈΡ ΡΡΠ΅ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ΅ΡΠ΅ΡΠ° ΠΈ Π΄Π°Π»Π΅Π΅ ΡΠ΅ΡΠ΅Π· 30, 90, 180 ΠΈ 365 ΡΡΡ ΠΏΠΎΡΠ»Π΅ ΠΏΡΠΎΠ²Π΅Π΄Π΅Π½ΠΈΡ Π ΠΠ. ΠΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ ΡΠ»ΡΠΆΠΈΠ»ΠΎ ΠΎΡΡΡΡΡΡΠ²ΠΈΠ΅ ΠΏΠΎΠ΄ΡΠ΅ΠΊΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ Π² ΠΏΠΎΠΊΠΎΠ΅ ΠΈΠ»ΠΈ ΠΏΡΠΈ ΡΠΈΠ·ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π½Π°Π³ΡΡΠ·ΠΊΠ΅ ΠΈ Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ ΡΡΡΠ°Ρ
ΠΎΠ²ΠΎΡΠ½ΠΎΠΉ ΠΏΡΠΎΠΊΠ»Π°Π΄ΠΊΠΈ.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΡΡΠΎΠ²Π΅ΡΠ½ΡΡ
ΡΠ°Π·Π»ΠΈΡΠΈΠΉ Π² ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΡΡ
ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ Π½Π° 1-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ ΡΠ΄Π°Π»Π΅Π½ΠΈΡ ΡΡΠ΅ΡΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΊΠ°ΡΠ΅ΡΠ΅ΡΠ° Π² ΠΎΠ±Π΅ΠΈΡ
Π³ΡΡΠΏΠΏΠ°Ρ
Π½Π΅ Π²ΡΡΠ²Π»Π΅Π½ΠΎ (Ρ >0,05). Π 1-ΠΉ Π³ΡΡΠΏΠΏΠ΅ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»ΠΈ ΠΊΠΎΠ½ΡΠΈΠ½Π΅Π½ΡΠΈΠΈ ΡΠ΅ΡΠ΅Π· 30, 90 ΠΈ 180 ΡΡΡ ΠΏΠΎΡΠ»Π΅ Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΡ Π ΠΠ Π±ΡΠ»ΠΈ Π΄ΠΎΡΡΠΎΠ²Π΅ΡΠ½ΠΎ Π²ΡΡΠ΅ (57,7; 69,2 ΠΈ 71,1 % ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ) ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ 2-ΠΉ Π³ΡΡΠΏΠΏΠΎΠΉ (35,1; 41,9 ΠΈ 51,3 % ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ) (Ρ <0,05). ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ Π½Π°ΡΡΠΎΡΡΠ΅ΠΉ ΡΠ°Π±ΠΎΡΡ Π΄Π΅ΠΌΠΎΠ½ΡΡΡΠΈΡΡΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π° Π ΠΠ Ρ ΡΡΡΠΏΠ΅Π½Π·ΠΈΠ΅ΠΉ ΡΡΠ΅ΡΡΡ m. levator ani ΠΏΠΎ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΡΠΎ ΡΡΠ°Π½Π΄Π°ΡΡΠ½ΠΎΠΉ Π ΠΠ ΠΏΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ ΠΊΠΎΠ½ΡΠΈΠ½Π΅Π½ΡΠΈΠΈ Π½Π° 7, 14, 30, 90 ΠΈ 180-Π΅ ΡΡΡΠΊΠΈ ΠΏΠΎΡΠ»Π΅ ΠΎΠΏΠ΅ΡΠ°ΡΠΈΠΈ. Π’Π΅Ρ
Π½ΠΈΠΊΠ° ΡΡΡΠΏΠ΅Π½Π·ΠΈΠΈ ΡΡΠ΅ΡΡΡ m. levator ani ΠΏΡΠΎΡΡΠ° Π² Π²ΡΠΏΠΎΠ»Π½Π΅Π½ΠΈΠΈ ΠΈ ΠΎΠ±Π΅ΡΠΏΠ΅ΡΠΈΠ²Π°Π΅Ρ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ ΡΡΠ½ΠΊΡΠΈΠΈ ΡΠ΄Π΅ΡΠΆΠ°Π½ΠΈΡ ΠΌΠΎΡΠΈ Π² Π±ΠΎΠ»Π΅Π΅ ΡΠ°Π½Π½ΠΈΠ΅ ΡΡΠΎΠΊΠΈ ΠΏΠΎΡΠ»Π΅ Π ΠΠ
ΠΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΡΠΈ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠ΅ ΠΊΡΠ°ΡΠ½ΡΡ ΠΈ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
Introduction: Despite on mandatory vaccination againstΒ rubella, the amount of pregnant women without immunityΒ to rubella may exceed 20%. These women represent a riskΒ group for the rubella disease.Objectives: The goals of the presented work are to analyzeΒ the cases of anti-rubella IgM detection in pregnantΒ women, and to develop an algorithm for management of suchΒ patients.Materials and Methods: Screening has been performedΒ by ELISA test systems company Radim (Italy). In total 799Β patients were examined for rubella in 2013, 56 of them wereΒ pregnant women.Results. Positive IgM antibodies to rubella in 2013 haveΒ been identified in 5 cases, including 4 pregnant women. AΒ detailed analysis of medical history, clinical and laboratoryΒ data has been done. In none of these cases the diagnosis ofΒ rubella has been confirmed.Conclusions. The main criterion for the diagnosis of rubellaΒ in pregnant women with rubella markers in the absenceΒ of clinical symptoms must be a dynamic examination, includingΒ study on IgM- and IgG-antibodies to rubella virus. TheΒ study must be conducted in the same laboratory at intervalsΒ of 10β14 days. In most cases, determination of IgG-antibodiesΒ avidity helps to estimate the time of infection.Β In complicated cases it is recommended to use PCR andΒ immunoblot.ΠΠΊΡΡΠ°Π»ΡΠ½ΠΎΡΡΡ: Π½Π΅ΡΠΌΠΎΡΡΡ Π½Π° Π²Π²Π΅Π΄Π΅Π½ΠΈΠ΅ ΠΎΠ±ΡΠ·Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉΒ Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΠΈ ΠΎΡ ΠΊΡΠ°ΡΠ½ΡΡ
ΠΈ, ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
, Ρ ΠΊΠΎΡΠΎΡΡΡ
ΠΎΡΡΡΡΡΡΠ²ΡΡΡ Π·Π°ΡΠΈΡΠ½ΡΠ΅ Π°Π½ΡΠΈΡΠ΅Π»Π°, ΠΌΠΎΠΆΠ΅Ρ ΠΏΡΠ΅Π²ΡΡΠ°ΡΡ 20%. ΠΡΠΈ ΠΆΠ΅Π½ΡΠΈΠ½Ρ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»ΡΡΡ Π³ΡΡΠΏΠΏΡ ΡΠΈΡΠΊΠ° ΠΏΠΎ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ ΠΊΡΠ°ΡΠ½ΡΡ
ΠΎΠΉ.Π¦Π΅Π»Ρ ΡΠ°Π±ΠΎΡΡ: ΠΏΡΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡΠΎΠ²Π°ΡΡ ΡΠ»ΡΡΠ°ΠΈ Π²ΡΡΠ²Π»Π΅Π½ΠΈΡ IgMΒ ΠΊ ΠΊΡΠ°ΡΠ½ΡΡ
Π΅ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΈ ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°ΡΡ Π°Π»Π³ΠΎΡΠΈΡΠΌ Π²Π΅Π΄Π΅Π½ΠΈΡΒ ΡΠ°ΠΊΠΈΡ
ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠΊ.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ: ΡΠΊΡΠΈΠ½ΠΈΠ½Π³ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠΌΒ ΠΈΠΌΠΌΡΠ½ΠΎΡΠ΅ΡΠΌΠ΅Π½ΡΠ½ΠΎΠ³ΠΎ Π°Π½Π°Π»ΠΈΠ·Π° Π½Π° ΡΠ΅ΡΡ-ΡΠΈΡΡΠ΅ΠΌΠ°Ρ
ΡΠΈΡΠΌΡΒ Radim (ΠΡΠ°Π»ΠΈΡ).Β Π 2013 Π³. Π½Π° Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ ΠΊΡΠ°ΡΠ½ΡΡ
Π΅ Π±ΡΠ»ΠΎ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΎ 799Β ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΈΠ· Π½ΠΈΡ
56 Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
.Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. ΠΠΎΠ»ΠΎΠΆΠΈΡΠ΅Π»ΡΠ½ΡΠ΅ IgM Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ ΠΊΡΠ°ΡΠ½ΡΡ
Π΅ Π±ΡΠ»ΠΈ Π²ΡΡΠ²Π»Π΅Π½Ρ Π² 5 ΡΠ»ΡΡΠ°ΡΡ
, Π² ΡΠΎΠΌ ΡΠΈΡΠ»Π΅ Ρ 4 Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
.Β ΠΡΠΎΠ²Π΅Π΄Π΅Π½ ΡΡΠ°ΡΠ΅Π»ΡΠ½ΡΠΉ Π°Π½Π°Π»ΠΈΠ· Π°Π½Π°ΠΌΠ½Π΅ΡΡΠΈΡΠ΅ΡΠΊΠΈΡ
, ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠ½ΡΡ
Π΄Π°Π½Π½ΡΡ
. ΠΠΈ Π² ΠΎΠ΄Π½ΠΎΠΌ ΠΈΠ· ΡΡΠΈΡ
ΡΠ»ΡΡΠ°Π΅Π²Β Π΄ΠΈΠ°Π³Π½ΠΎΠ· ΠΊΡΠ°ΡΠ½ΡΡ
ΠΈ Π½Π΅ Π±ΡΠ» ΠΏΠΎΠ΄ΡΠ²Π΅ΡΠΆΠ΄Π΅Π½.ΠΡΠ²ΠΎΠ΄Ρ. ΠΡΠ½ΠΎΠ²Π½ΡΠΌ ΠΊΡΠΈΡΠ΅ΡΠΈΠ΅ΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΡΡΠΈΠΊΠΈ ΠΊΡΠ°ΡΠ½ΡΡ
ΠΈ Ρ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΡΡ
ΠΏΡΠΈ ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½ΠΈΠΈ ΠΌΠ°ΡΠΊΠ΅ΡΠΎΠ² ΠΊΡΠ°ΡΠ½ΡΡ
ΠΈ ΠΈΒ ΠΎΡΡΡΡΡΡΠ²ΠΈΠΈ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΡΠΈΠΌΠΏΡΠΎΠΌΠ°ΡΠΈΠΊΠΈ Π΄ΠΎΠ»ΠΆΠ½ΠΎ Π±ΡΡΡΒ Π΄ΠΈΠ½Π°ΠΌΠΈΡΠ΅ΡΠΊΠΎΠ΅ ΠΎΠ±ΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π±Π΅ΡΠ΅ΠΌΠ΅Π½Π½ΠΎΠΉ, Π²ΠΊΠ»ΡΡΠ°ΡΡΠ΅Π΅Β ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π½Π° IgM- ΠΈ IgG-Π°Π½ΡΠΈΡΠ΅Π»Π° ΠΊ Π²ΠΈΡΡΡΡ ΠΊΡΠ°ΡΠ½ΡΡ
ΠΈ.Β ΠΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠ΅ Π΄ΠΎΠ»ΠΆΠ½ΠΎ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΡΡΡΡ Π² ΠΎΠ΄Π½ΠΎΠΉ Π»Π°Π±ΠΎΡΠ°ΡΠΎΡΠΈΠΈΒ Ρ ΠΈΠ½ΡΠ΅ΡΠ²Π°Π»ΠΎΠΌ 10β14 Π΄Π½Π΅ΠΉ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ Π°Π²ΠΈΠ΄Π½ΠΎΡΡΠΈ IgG-Π°Π½ΡΠΈΡΠ΅Π» ΠΏΠΎΠΌΠΎΠ³Π°Π΅Ρ Π² Π±ΠΎΠ»ΡΡΠΈΠ½ΡΡΠ²Π΅ ΡΠ»ΡΡΠ°Π΅Π² ΠΎΠΏΡΠ΅Π΄Π΅Π»ΠΈΡΡΒ Π΄Π°Π²Π½ΠΎΡΡΡ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ. Π ΡΠ»ΠΎΠΆΠ½ΡΡ
ΡΠ»ΡΡΠ°ΡΡ
Π½Π΅ΠΎΠ±Ρ
ΠΎΠ΄ΠΈΠΌΠΎ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°ΡΡ ΠΈΠΌΠΌΡΠ½ΠΎΠ±Π»ΠΎΡ ΠΈ ΠΠ¦Π
Π Π΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠ΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ ΠΏΠΎΠ»ΠΈΠ³Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π³ΡΠ°Π½ΠΈΠ΄ΠΈΠ½ Π³ΠΈΠ΄ΡΠΎΡ Π»ΠΎΡΠΈΠ΄Π°
Polyguanidines are characterized by pronounced antimicrobial activity and are widely used as the main active substance of disinfectants. Polymers of this class possess the property of gel formation, which, together with biological activity, opens the prospect of obtaining an effective single-component agent or basis for an external preparation for the therapy of skin lesions. Earlier, we developed a method for the production of a hydrogel based on polyhexamethyleneguanidine hydrochloride, which involves the cross-linking of the terminal amino groups of the branched polymer with formaldehyde.The purpose of the study was to observe the effect of hydrogel polyhexamethyleneguanidine hydrochloride on the progression of wound healing.Materials and methods. An experiment on the evaluation of the wound healing action of hydrogel was carried out under conditions simulating a linear cutaneous wound, a muscular wound, and a thermal burn. The comparative drug was the pharmacopoeian drug Levomecol.Results. It has been established that hydrogel has a pronounced wound healing effect, as evidenced by the results of ruminant thoracic anatomy and pathomorphology of the sections, which shows accelerated ripening of granulation tissue and scar formation. By the method of vulnografiya it was shown that the daily decrease in wound area is most pronounced in the hydrogel group, which also indicates a pronounced reparative effect. It was determined that the hydrogel activates the growth of antioxidatic activity and leukocytes in the blood of animals in dynamics on the 10th, 17th and 24th day of the experiment, amounting to 56, 34 and 21%, and of leukocytes β 32, 30, 10% in relation to the intact animals.Conclusion. Thus, on the model of a linear cutaneous wound, a muscular wound, and a thermal burn, the healing effect of the hydrogel PGMGh/f is established, as evidenced by the results of the early exercise, vulnografiya and pathomorphological studies. It is noted that the hydrogel PGMG h/f has an effect on the content of antioxidants and leukocytes in the blood, contributing to the normalization of their quantity.ΠΠΎΠ»ΠΈΠ³ΡΠ°Π½ΠΈΠ΄ΠΈΠ½Ρ Ρ
Π°ΡΠ°ΠΊΡΠ΅ΡΠΈΠ·ΡΡΡΡΡ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΉ Π°Π½ΡΠΈΠΌΠΈΠΊΡΠΎΠ±Π½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΈ Π½Π°Ρ
ΠΎΠ΄ΡΡ ΡΠΈΡΠΎΠΊΠΎΠ΅ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΠΎΡΠ½ΠΎΠ²Π½ΠΎΠ³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΡΡΡΠ΅Π³ΠΎ Π²Π΅ΡΠ΅ΡΡΠ²Π° Π² ΡΠΎΡΡΠ°Π²Π΅ Π΄Π΅Π·ΠΈΠ½ΡΠΈΡΠΈΡΡΡΡΠΈΡ
ΡΡΠ΅Π΄ΡΡΠ². ΠΠΎΠ»ΠΈΠΌΠ΅ΡΡ ΡΡΠΎΠ³ΠΎ ΠΊΠ»Π°ΡΡΠ° ΠΎΠ±Π»Π°Π΄Π°ΡΡ ΡΠ²ΠΎΠΉΡΡΠ²ΠΎΠΌ Π³Π΅Π»Π΅ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΡΡΠΎ Π² ΡΠΎΠ²ΠΎΠΊΡΠΏΠ½ΠΎΡΡΠΈ Ρ Π±ΠΈΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡΡ ΠΎΡΠΊΡΡΠ²Π°Π΅Ρ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Ρ ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠ³ΠΎ ΠΎΠ΄Π½ΠΎΠΊΠΎΠΌΠΏΠΎΠ½Π΅Π½ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ΅Π΄ΡΡΠ²Π° ΠΈΠ»ΠΈ ΠΎΡΠ½ΠΎΠ²Ρ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° Π½Π°ΡΡΠΆΠ½ΠΎΠ³ΠΎ ΠΏΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΡ Π΄Π»Ρ ΡΠ΅ΡΠ°ΠΏΠΈΠΈ ΠΏΠΎΠ²ΡΠ΅ΠΆΠ΄Π΅Π½ΠΈΠΉ ΠΊΠΎΠΆΠ½ΡΡ
ΠΏΠΎΠΊΡΠΎΠ²ΠΎΠ². Π Π°Π½Π΅Π΅ Π½Π°ΠΌΠΈ Π±ΡΠ» ΡΠ°Π·ΡΠ°Π±ΠΎΡΠ°Π½ ΡΠΏΠΎΡΠΎΠ± ΠΏΠΎΠ»ΡΡΠ΅Π½ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ Π½Π° ΠΎΡΠ½ΠΎΠ²Π΅ ΠΏΠΎΠ»ΠΈΠ³Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π³ΡΠ°Π½ΠΈΠ΄ΠΈΠ½ Π³ΠΈΠ΄ΡΠΎΡ
Π»ΠΎΡΠΈΠ΄Π°, Π·Π°ΠΊΠ»ΡΡΠ°ΡΡΠΈΠΉΡΡ Π² ΡΡΠΈΠ²Π°Π½ΠΈΠΈ ΠΊΠΎΠ½ΡΠ΅Π²ΡΡ
Π°ΠΌΠΈΠ½ΠΎΠ³ΡΡΠΏΠΏ ΡΠ°Π·Π²Π΅ΡΠ²Π»Π΅Π½Π½ΠΎΠ³ΠΎ ΠΏΠΎΠ»ΠΈΠΌΠ΅ΡΠ° ΡΠΎΡΠΌΠ°Π»ΡΠ΄Π΅Π³ΠΈΠ΄ΠΎΠΌ.Π¦Π΅Π»ΡΡ ΡΠ°Π±ΠΎΡΡ ΡΠ²ΠΈΠ»ΠΎΡΡ ΠΈΠ·ΡΡΠ΅Π½ΠΈΠ΅ Π²Π»ΠΈΡΠ½ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ ΠΏΠΎΠ»ΠΈΠ³Π΅ΠΊΡΠ°ΠΌΠ΅ΡΠΈΠ»Π΅Π½Π³ΡΠ°Π½ΠΈΠ΄ΠΈΠ½ Π³ΠΈΠ΄ΡΠΎΡ
Π»ΠΎΡΠΈΠ΄Π° Π½Π° ΡΠ΅ΡΠ΅Π½ΠΈΠ΅ ΡΠ°Π½Π΅Π²ΠΎΠ³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠ°.ΠΠ°ΡΠ΅ΡΠΈΠ°Π»Ρ ΠΈ ΠΌΠ΅ΡΠΎΠ΄Ρ. ΠΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½Ρ ΠΏΠΎ ΠΎΡΠ΅Π½ΠΊΠ΅ ΡΠ°Π½ΠΎΠ·Π°ΠΆΠΈΠ²Π»ΡΡΡΠ΅Π³ΠΎ Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ ΠΏΡΠΎΠ²ΠΎΠ΄ΠΈΠ»ΡΡ Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΌΠΎΠ΄Π΅Π»ΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΊΠΎΠΆΠ½ΠΎ-ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠ°Π½Ρ ΠΈ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΆΠΎΠ³Π°. Π ΠΊΠ°ΡΠ΅ΡΡΠ²Π΅ ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π»ΡΡ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠΏΠ΅ΠΉΠ½ΡΠΉ ΠΏΡΠ΅ΠΏΠ°ΡΠ°Ρ Β«ΠΠ΅Π²ΠΎΠΌΠ΅ΠΊΠΎΠ»ΡΒ».Π Π΅Π·ΡΠ»ΡΡΠ°ΡΡ. Π£ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ, ΡΡΠΎ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ ΠΎΠ±Π»Π°Π΄Π°Π» Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌ ΡΠ°Π½ΠΎΠ·Π°ΠΆΠΈΠ²Π»ΡΡΡΠΈΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ΠΌ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΡΠ°Π½Ρ, ΠΎ ΡΠ΅ΠΌ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΡΠ°Π½ΠΎΡΠ΅Π½Π·ΠΎΠΌΠ΅ΡΡΠΈΠΈ ΡΡΠ±ΡΠ° ΠΈ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΠΈ ΡΡΠ΅Π·ΠΎΠ², ΠΏΠΎΠΊΠ°Π·Π°Π²ΡΠΈΠ΅ ΡΡΠΊΠΎΡΠ΅Π½Π½ΠΎΠ΅ ΡΠΎΠ·ΡΠ΅Π²Π°Π½ΠΈΠ΅ Π³ΡΠ°Π½ΡΠ»ΡΡΠΈΠΎΠ½Π½ΠΎΠΉ ΡΠΊΠ°Π½ΠΈ ΠΈ ΡΠΎΡΠΌΠΈΡΠΎΠ²Π°Π½ΠΈΠ΅ ΡΡΠ±ΡΠ°. ΠΠ΅ΡΠΎΠ΄ΠΎΠΌ Π²ΡΠ»ΡΠ½ΠΎΠ³ΡΠ°ΡΠΈΠΈ Π½Π° ΠΌΠΎΠ΄Π΅Π»ΠΈ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΆΠΎΠ³Π° ΠΏΠΎΠΊΠ°Π·Π°Π½ΠΎ, ΡΡΠΎ ΡΡΡΠΎΡΠ½ΠΎΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠ»ΠΎΡΠ°Π΄ΠΈ ΡΠ°Π½Ρ Π² Π½Π°ΠΈΠ±ΠΎΠ»ΡΡΠ΅ΠΉ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΠΊΡΠΏΠ»ΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΎ Ρ ΠΎΠΏΡΡΠ½ΠΎΠΉ Π³ΡΡΠΏΠΏΡ 1 (Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ), ΡΡΠΎ ΡΠ°ΠΊΠΆΠ΅ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΎ ΠΎ Π΅Π³ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠΌ ΡΠ΅ΠΏΠ°ΡΠ°ΡΠΈΠ²Π½ΠΎΠΌ Π΄Π΅ΠΉΡΡΠ²ΠΈΠΈ. ΠΠΏΡΠ΅Π΄Π΅Π»Π΅Π½ΠΎ, ΡΡΠΎ ΠΏΡΠΈ ΠΎΠΆΠΎΠ³Π΅ Π½Π°Π±Π»ΡΠ΄Π°Π»ΠΈΡΡ ΡΠ΅Π·ΠΊΠΎΠ΅ ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΡΡΠ²ΠΎΡΠΎΡΠΊΠΈ ΠΊΡΠΎΠ²ΠΈ ΠΈ Π½Π°ΡΠ°ΡΡΠ°Π½ΠΈΠ΅ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ². Π Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ΅ Π½Π° 10-, 17- ΠΈ 24-Π΅ ΡΡΡ ΡΠΊΡΠΏΠ΅ΡΠΈΠΌΠ΅Π½ΡΠ° ΡΠΌΠ΅Π½ΡΡΠ΅Π½ΠΈΠ΅ ΠΏΠ΅ΡΠ²ΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ ΡΠΎΡΡΠ°Π²ΠΈΠ»ΠΎ 56, 34 ΠΈ 21%, Π° ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ Π²ΡΠΎΡΠΎΠ³ΠΎ ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Ρ β ΡΠΎΠΎΡΠ²Π΅ΡΡΡΠ²Π΅Π½Π½ΠΎ Π½Π° 32, 30 ΠΈ 10% ΠΏΠΎ ΠΎΡΠ½ΠΎΡΠ΅Π½ΠΈΡ ΠΊ ΠΈΠ½ΡΠ°ΠΊΡΠ½ΡΠΌ ΠΆΠΈΠ²ΠΎΡΠ½ΡΠΌ. ΠΡΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ Π±ΠΎΠ»Π΅Π΅ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΠΎ, ΡΠ΅ΠΌ ΠΏΡΠ΅ΠΏΠ°ΡΠ°ΡΠ° ΡΡΠ°Π²Π½Π΅Π½ΠΈΡ, ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°Π»ΠΎ Π½ΠΎΡΠΌΠ°Π»ΠΈΠ·Π°ΡΠΈΠΈ Π΄Π°Π½Π½ΡΡ
ΠΏΠΎΠΊΠ°Π·Π°ΡΠ΅Π»Π΅ΠΉ.ΠΠ°ΠΊΠ»ΡΡΠ΅Π½ΠΈΠ΅. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, Π½Π° ΠΌΠΎΠ΄Π΅Π»ΡΡ
Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΠΉ ΠΊΠΎΠΆΠ½ΠΎ-ΠΌΡΡΠ΅ΡΠ½ΠΎΠΉ ΡΠ°Π½Ρ ΠΈ ΡΠ΅ΡΠΌΠΈΡΠ΅ΡΠΊΠΎΠ³ΠΎ ΠΎΠΆΠΎΠ³Π° ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΎ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΠΎΠ΅ ΡΠ°Π½ΠΎΠ·Π°ΠΆΠΈΠ²Π»ΡΡΡΠ΅Π΅ Π΄Π΅ΠΉΡΡΠ²ΠΈΠ΅ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ, ΠΎ ΡΠ΅ΠΌ ΡΠ²ΠΈΠ΄Π΅ΡΠ΅Π»ΡΡΡΠ²ΠΎΠ²Π°Π»ΠΈ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡΒ ΡΠ°Π½ΠΎΡΠ΅Π½Π·ΠΎΠΌΠ΅ΡΡΠΈΠΈ, Π²ΡΠ»ΡΠ½ΠΎΠ³ΡΠ°ΡΠΈΠΈ ΠΏΠ°ΡΠΎΠΌΠΎΡΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ. ΠΠΎΠ»Π΅Π΅ Π²ΡΡΠΎΠΊΠΈΠΉ ΡΠ°Π½ΠΎΠ·Π°ΠΆΠΈΠ²Π»ΡΡΡΠΈΠΉ ΡΡΡΠ΅ΠΊΡ Π³ΠΈΠ΄ΡΠΎΠ³Π΅Π»Ρ, ΠΏΠΎ-Π²ΠΈΠ΄ΠΈΠΌΠΎΠΌΡ, ΡΠ²ΡΠ·Π°Π½ Ρ ΡΠ²Π΅Π»ΠΈΡΠ΅Π½ΠΈΠ΅ΠΌ ΡΡΠΌΠΌΠ°ΡΠ½ΠΎΠΉ Π°Π½ΡΠΈΠΎΠΊΡΠΈΠ΄Π°Π½ΡΠ½ΠΎΠΉ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΠΈ ΠΈ Π±ΠΎΠ»Π΅Π΅ Π²ΡΡΠ°ΠΆΠ΅Π½Π½ΡΠΌ Π²ΠΎΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΠ΅ΠΌ ΠΊΠΎΠ»ΠΈΡΠ΅ΡΡΠ²Π° Π»Π΅ΠΉΠΊΠΎΡΠΈΡΠΎΠ² Π² ΠΊΡΠΎΠ²ΠΈ
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