PVB therapy for advanced testicular cancer

Twelve cases of advanced testicular cancer, including 5 cases of seminoma, 3 cases of teratocarcinoma, 1 case of yolk sac tumor, 1 case of embryonal carcinoma and 2 cases of mixed cell type, were treated with cisplatin-vinblastine-bleomycin (PVB) therapy. Among them, 10 cases had measurable metastatic lesions and the objective response rate was 80%. Three cases showed complete response. Ten cases showed nonexistent disease after PVB therapy and salvage operation. Though PVB therapy was useful for the treatment of advanced testicular cancer, a few cases having poor prognostic factors showed no response to the therapy

Clinical efficacy of flucytosine on urinary candidiasis

An antifungal agent (Flucytosine) was used to treat urinary candidiasis in 9 patients who had an indwelling catheter and developed fungal colony counts greater than 10(4). Among 9 patients with catheter drainage, urologic underlying diseases were benign prostatic hyperplasia in 7 and a neurogenic bladder in one patient all of whom had accompanied diabetes mellitus. Only one patient was supravesically diverted from the upper urinary tract through an indwelling catheter of bilateral ureterocutaneostomy after the removal of a tumorous bladder. All patients had previously received antimicrobials. Isolated strains of Candida were Candida albicans in 6, Candida tropicalis in 2, and Candida parapsilosis in one patient. Out of 9 patients having received daily administration of 1, 500 mg Flucytosine for 2 weeks, 7 patients subsequently had no yield of fungal colony after the treatment. Minimum inhibitory concentration (MIC) of this agent was determined at the range of 0.1 to 0.2 microgram/ml in 5 patients with C. albicans and 0.2 microgram/ml in both patients with C. tropicalis. Otherwise, a high MIC of over 100 micrograms/ml indicating resistance to this agent was observed in only 2 patients with C. albicans and C. parapsilosis. Three of the 7 patients had recurrent urinary Candida infection even 2 weeks after the discontinuation of this antifungal therapy despite rapid and excellent eradication of urinary candidiasis. From these results, Flucytosine may be one of the most promising antifungal agent with a low MIC in the treatment of compromised urinary Candida infection and should be occasionally supplemented with a topical instillation of amphotericin B without any serious complication in the prevention of recurrence

児童・生徒のサポートの互恵性とストレス反応－友人関係の発達的変化からの検討－

本稿は、谷口弘一, 田中宏二. Support Reciprocity and Stress Responses among Children: From the Viewpoint of DevelopmentalChange in Friendships.長崎大学教育学部紀要. 教育科学. 2010, Vol74, p. 17-23 に対する査読の結果、修正なしで、『研究論文集－教育系・文系の九州地区国立大学間連携論文集－. 2010，vol.4, no.1』に掲載されたものである

Performance of the Imaging Fourier Transform Spectrometer with Photoconductive Detector Arrays: An Application for the AKARI Far-Infrared Instrument

We have developed an imaging Fourier transform spectrometer (FTS) for space-based far-infrared astronomical observations. The FTS employs a newly developed photoconductive detector arrays with a capacitive trans-impedance amplifier, which makes the FTS a completely unique instrument. The FTS was installed as a function of the far-infrared instrument (FIS: Far-Infrared Surveyor) on the Japanese astronomical satellite, AKARI, which was launched on February 21, 2006 (UT) from the Uchinoura Space Center. The FIS-FTS had been operated for more than one year before liquid helium ran out on August 26, 2007. The FIS-FTS was operated nearly six hundreds times, which corresponds to more than one hundred hours of astronomical observations and almost the same amount of time for calibrations. As expected from laboratory measurements, the FIS-FTS performed well and has produced a large set of astronomical data for valuable objects. Meanwhile, it becomes clear that the detector transient effect is a considerable factor for FTSs with photoconductive detectors. In this paper, the instrumentation of the FIS-FTS and interesting phenomena related to FTS using photoconductive detectors are described, and future applications of this kind of FTS system are discussed.Comment: 10 pages, 6 figures, 2 tables, accepted for publication in PASJ AKARI special issu

Study on urinary splitting enzymes and proteins. III. Effect of non-ionic contrast medium on renal function

通常行われている尿路造影法に非イオン性造影剤(iohexol)を用い, 検査前後で尿中逸脱酵素・蛋白がどのような変化を示すかにつき検討した.正常な腎機能を有する9例を対象とし, DIPにて注入スピード10 ml/min, 総投与量100 ml (2.5 ml以下/kg)で静注した.投与前後の尿を採取し, 糸球体濾過能の指標としてアルブミンを, brush-border酵素としてγ-GTPを, lysosomal酵素としてNAGを, 尿細管性蛋白尿の指標としてα1MGおよびβ2MGを測定し, 各酵素と蛋白の尿中排泄量を尿中クレアチニン量と比較検定した.DIP後γ-GTPとNAGの尿中排泄量は有意(p<0.001, 0.02)に増加した.α1MGおよびβ2MGは有意に変化せず, アルブミンの変化は少量であった.今回の検討から, 非イオン性, 低浸透圧性造影剤であるiohexolは尿細管障害が少なく, brush-border酵素であるγ-GTPとlysosomal酵素のNAGは尿細管障害の良い指標となると考えられたRenal toxicity of non-ionic contrast medium (iohexol) for drip infused pyelography (DIP) was studied in a randomized trial of nine patients with normal renal function. Urine samples were collected before and immediately after DIP, and analyzed for albumin, an index of glomerular permeability; gamma-glutamyl transpeptidase (gamma-GTP), a brush-border enzyme; N-acetyl-beta-glucosaminidase (NAG), a lysosomal enzyme; alpha 1 microglobulin (alpha 1MG) and beta 2 microglobulin (beta 2MG), an index to tubular proteinuria; and creatinine. The urinary excretion of enzymes and proteins was compared with urinary creatinine. Urinary excretion of gamma-GTP and NAG increased significantly (P less than 0.001, 0.02) after DIP. Urinary alpha 1 MG and beta 2-MG did not change significantly. The change of urinary albumin was mild. Our data suggest that non-ionic, low osmolal radiocontrast medium ioheol shows a lower renal tubular toxicity, and the brush-border enzyme gamma-GTP and lysosomal enzyme NAG are considered as a good index for renal tubular damage

The Relationships of Support Reciprocity to Self-efficacy and Burnout among Teachers

This study examined the effects of support reciprocity in the relationships with principals and colleagues on self-efficacy and burnout among teachers. The respondents wore 122 school teachers (51 elementary school teachers, 9 junior high school teachers, 44 senior high school teachers, 17 teachers of school for the disabled, and 1 unidentified by school). They completed measures of social support exchange in the relationships with principals and colleagues, measurements of self-efficacy in student guidance, course instruction, and job relations, and a burnout assessment with a Japanese version of the Maslach Burnout Inventory. Teachers, support reciprocity in the relationships with principals related significantly to their self-efficacy in course instruction and job relations, and marginally significantly to their self-efficacy in student guidance. Results also indicated that teachers, support reciprocity in the relationships with colleagues correlated significantly with their self-efficacy in course instruction and marginally significantly with emotional exhaustion

特別展示「山里（やま）の祝祭（まつり）―神々と鬼たちの宴舞（うたげ）―」

PDF【日時】 令和4年7月14日～令和4年7月20日 【場所】 静岡文化芸術大学　ギャラリー 【共催】 浜松市無形民俗文化財保護団体連絡会 【後援】 浜松市 【協力】 佐久間神社、NPO法人みらいネット浜松 【目的・趣旨】 　天竜区佐久間町の旧山室神社に伝来した神事芸能「花の舞」の面を紹介・展示する。三遠南信地域に伝わった民俗芸能の魅力を本学の学生たちや市民にも見知っていただく機会とする。 【内容】 　1956年（昭和31）、天竜川の畔にあった山室集落は佐久間ダムの完成と引き換えに湖底へと沈んだ。その山室にもかつては「花の舞」と呼ばれる神事が伝えられていた。山室集落の解散後、「花の舞」に用いられた神々と鬼たちの面は佐久間町内の別の神社に移管され、長いあいだ収蔵庫のなかで眠ってきた。 　本事業では、浜松市無形民俗文化財保護団体連絡会と浜松市文化財課と連携し、山室集落の「花の舞」に用いられた神々と鬼たちの面を初めて展示公開した。また、公開講演会、ギャラリートーク、神楽の実演などもあわせて開催した。 　なお、本事業は「地域連携演習」のプログラムも兼ねており、10名の学生が事業の企画・運営に参画した。 【結果・成果】 　7月15日（金）からあいだに3連休をはさんで7月20日（水）までの6日間の開催となった。 　7月14日（木）の内覧会では浜松市無形民俗文化財保護団体連絡会と浜松市文化財課の関係者、学内関係者、報道各社も含めて約30名が参加。静岡新聞と中日新聞が取材に訪れ、翌日の両紙の朝刊に開催の記事が掲載された。 　また、15日（金）にはNHKが取材に訪れ、当日の昼のニュースで放送された。同ニュースは翌日には全国でも放送されたため「ニュースを見て知った」という県外からの来場者が多数あった。 　とくに、7月17日（日）の午後に催した講演会と神楽舞の実演では、当初の見込みをはるかに上まわる来聴があり、会場の南棟176大講義室が満席に近い状況となった。新型コロナウイルスに見舞われた時期でもあったので、満席に近い状況になったことはかならずしも芳しい成果とは言えず、開催と運営に課題を残した。それでも、内覧会を含む7日間で合計759人の参加があったことは、本事業における大きな成果と言えるだろう。 　「地域連携演習」として事業の企画・運営に参画した学生たちにとっても、充実した学習の機会になったようである。boo