Structure of the Energy Landscape of Short Peptides

We have simulated, as a showcase, the pentapeptide Met-enkephalin (Tyr-Gly-Gly-Phe-Met) to visualize the energy landscape and investigate the conformational coverage by the multicanonical method. We have obtained a three-dimensional topographic picture of the whole energy landscape by plotting the histogram with respect to energy(temperature) and the order parameter, which gives the degree of resemblance of any created conformation with the global energy minimum (GEM).Comment: 17 pages, 4 figure

h-deformation of Gr(2)

The $h$-deformation of functions on the Grassmann matrix group $Gr(2)$ is presented via a contraction of $Gr_q(2)$. As an interesting point, we have seen that, in the case of the $h$-deformation, both R-matrices of $GL_h(2)$ and $Gr_h(2)$ are the same

Mating type idiomorphs of Pyrenophora teres in Turkey

Pyrenophora teres f. maculata (Ptm) and Pyrenophora teres f. teres (Ptt) causes spot form and net form of net blotch diseases of barley, respectively. Although both forms of P. teres are morphologically similar, their symptoms and genetic background differ. In this study, 175 single spore (109 Ptm and 66 Ptt) isolates obtained from different regions of Turkey were evaluated for their mating type distribution and prevalence. Fungal isolates of both forms were verified using species-speci.c polymerase chain reaction (PCR) primers. For mating type determination studies, duplex PCR was performed using MAT-specific single nucleotide polymorphism primers. Sixty and 49 of 109 Ptm isolates were found as MAT1-1 and MAT1-2 types, respectively and 43 and 23 of 66 Ptt isolates were found as MAT1-1 and MAT1-2 types, respectively. These results show the possibility of sexual reproduction among the Ptm isolates in Turkey and Ptt population of Central Anatolia, Turkey. However, the overall pattern of Ptt isolates did not support the sexual reproduction hypothesis in Turkey. Sexual reproduction in the life cycle of P. teres is important since it could lead to genetic and pathogenic variation. As a result of new sexual combinations more virulent pathotypes of P. teres may occur

Laboratories of Learning: Education, Learning and Knowledge-Making in Social Movements: Insights from Colombia, Nepal, South Africa and Turkey

This synthesis report brings together cross-case insights produced from four case studies of social movements in Colombia, Nepal, South Africa and Turkey. The research that was ably carried out by a committed group of researchers in collaboration with the movements themselves, their leaders and activists, in a dynamic process of research coproduction

Genetic characterization of grape (Vitis vinifera L.) germplasm from Southeast Anatolia by SSR markers

Southeast Anatolia is located in close proximity to the center of origin of grapes and is an important grape producing area of Turkey. The important location of this region for grape genetic diversity together with its diverse ecological conditions may have led to the development of grape germplasm that is unique to this region. However, so far little has been done to genetically analyze this grape germplasm. In this study, we genetically analyzed 55 grape cultivars originating from six different provinces of this region using 14 simple sequence repeat (SSR) loci and a number of ampeolographic characteristics. Based on these analyses, one case of synonymous and four cases of homonymous grape cultivars were identified. The contribution of our results to better characterization of the grape germplasm of the region as well as future germplasm management and breeding efforts is discussed.

The European Union, borders and conflict transformation: the case of Cyprus

Much of the existing literature on the European Union (EU), conflict transformation and border dynamics has been premised on the assumption that the nature of the border determines EU intervention and the consequences that flow from this in terms of EU impact. The article aims to transcend this literature through assessing how domestic interpretations influence EU border transformation in conflict situations, taking Cyprus as a case study. Moreover, the objective is to fuse the literature on EU bordering impact and perceptions of the EU’s normative projection in conflict resolution. Pursuing this line of inquiry is an attempt to depart from the notion of borders being constructed solely by unidirectional EU logics of engagement or bordering practices to a conceptualization of the border as co-constituted space, where the interpretations of the EU’s normative projections by conflict parties, and the strategies that they pursue, can determine the relative openness of the EU border

Trace Anomaly and Quasi-Particles in Finite Temperature SU(N) Gauge Theory

We consider deconfined matter in SU(N) gauge theory as an ideal gas of transversely polarized quasi-particle modes having a temperature-dependent mass m(T). Just above the transition temperature, the mass is assumed to be determined by the critical behavior of the energy density and the screening length in the medium. At high temperature, it becomes proportional to T as the only remaining scale. The resulting (trace anomaly based) interaction measure Delta=(e - 3P)/T^4 and energy density are found to agree well with finite temperature SU(3) lattice calculations.Comment: 13 pages, 13 figures; references added for version

Properties of 42 Solar-type Kepler Targets from the Asteroseismic Modeling Portal

Recently the number of main-sequence and subgiant stars exhibiting solar-like oscillations that are resolved into individual mode frequencies has increased dramatically. While only a few such data sets were available for detailed modeling just a decade ago, the Kepler mission has produced suitable observations for hundreds of new targets. This rapid expansion in observational capacity has been accompanied by a shift in analysis and modeling strategies to yield uniform sets of derived stellar properties more quickly and easily. We use previously published asteroseismic and spectroscopic data sets to provide a uniform analysis of 42 solar-type Kepler targets from the Asteroseismic Modeling Portal (AMP). We find that fitting the individual frequencies typically doubles the precision of the asteroseismic radius, mass and age compared to grid-based modeling of the global oscillation properties, and improves the precision of the radius and mass by about a factor of three over empirical scaling relations. We demonstrate the utility of the derived properties with several applications.Comment: 12 emulateapj pages, 9 figures, 1 online-only extended figure, 1 table, ApJS accepted (typo corrected in Eq.8

Flow-based basophil activation test in immediate drug hypersensitivity. An EAACI task force position paper

Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests. Evidence has emerged that the basophil activation test (BAT), an in vitro assay that mirrors the in vivo response, can be a complementary test for many drugs. In this position paper, members of Task Force (TF) “Basophil activation test in the evaluation of Drug Hypersensitivity Reactions” from the European Academy of Allergy and Clinical Immunology (EAACI) present the data from a survey about the use and utility of BAT in IDHRs in Europe. The survey results indicate that there is a great interest for using BAT especially for diagnosing IDHRs. However, there are still main needs, mainly in the standardization of the protocols. Subsequently consensus-based recommendations were formulated for: (i) Technical aspects of BAT in IDHRs including type of sample, management of drugs, flow cytometry protocols, interpretation of the results; and (ii) Drug-specific aspects that should be taken into account when performing BAT in relation to betalactams, neuromuscular blocking agents, fluoroquinolones, chlorhexidine, opioids, radio contrast media, chemotherapeutics, biological agents, nonsteroidal anti-inflammatory drugs, COVID vaccine, and excipients. Moreover, aspects in the evaluation of pediatric population have also been considered. All this indicates that BAT offers the clinician and laboratory a complementary tool for a safe diagnostic for IDHRs, although its place in the diagnostic algorithm depends on the drug class and patient population (phenotype, geography, and age). The standardization of BAT is important for generalizing this method beyond the individual laboratory.Funding for open access charge: Universidad de Málaga/CBUA. The authors would like to thank EAACI for their financial support in the development of this Task Force Position Paper

Turner syndrome and associated problems in turkish children: A multicenter study

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population. Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014. Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosi) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto’s thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%. Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespan. © Journal of Clinical Research in Pediatric Endocrinology