İdyopatik Hirşutizm Hastalarında QT Dispersiyonu

Amaç: Çalışmada idyopatik hirşutizm tanılı hastaların QT dispersiyonu açısından değerlendirilmesi amaçlanmıştır. Metod: 28 İH hastası ve kontrol grubu olarak 35 sağlıklı kadın çalışmaya dahil edildi. Hastaların hormonal incelemeleri ile birlikte elektrokardiyografi EKG analizleri yapılarak QT dispersiyonları QTd ile düzeltilmiş QT QTc değerleri kullanılarak düzeltilmiş QT dispersiyon QTcd değerleri elde edilmiştir. Bulgular: İH ve kontrol hastalarının minimum QT 336±30; 337±32 ms , maksimum QT 358±30; 358±34 ms , minimum QTc 391 ± 24; 399 ± 25 ms ; maksimum QTc 417 ± 24; 424 ± 26 ms , QTd 22±5; 21±7, P=0.6 ve QTcd 26 ± 6, 25 ± 9 ms, P= 0.7 değerleri arasındaki fark istatistiksel olarak anlamsızdı. Hirşutizm hastalarında açlık insülin, Homeostasis model assessment HOMA indeksi ve androjen düzeyleri anlamlı olarak yüksek saptandı. Sonuç: Hormonal ve metabolik bozukluklara rağmen İH hastalarında sağlıklı kadınlara göre anlamlı QT dispersiyonu saptanmamıştı

The role of ga-68-psma pet/ct in newly diagnosed primary prostatic carcinoma (PCA)

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Oligo-Amenorrheic Polycystic Ovary Syndrome Patients Have Higher Risk For Cardiovascular Disease Compared to Hirsute Patients and Healthy Control

OBJECTIVE: To evaluate the clinical, endocrine and cardiovascular disease risk profile differences in polycystic ovary syndrome (PCOS) patients who complain of hirsutism or oligo-amenorrhea. STUDY DESIGN: A total of 129 consecutive women underwent the screening investigation at Dr. Sami Ulus Women’s Health Teaching and Research Hospital between December 2009 and June 2010. There were 48 PCOS patients with hirsutism while 49 PCOS patients with oligo-amenorrhea and 32 healthy women included in the study. Body mass index (BMI), Waist/hip ratio (WHR) serum follicle stimulating hormone (FSH), luteinizing hormone (LH), progesterone, free testosterone, glucose, low density lipoprotein (LDL), total cholesterol, high density lipoprotein (HDL), triglceride (TG), high sensitive C reactive protein (hs-CRP), insulin, insulin sensitivity and carotid intima thickness (CIMT) were compared in PCOS patients who complain of hirsutism or oligo-amenorrhea and control group. RESULTS: Mean ages were similar among groups. There were significant differences among groups in terms of BMI, WHR, total cholesterol, LDL, TG, LH, fasting glucose, hsCRP, CIMT (p<0.05) (table 1). BMI, waist-hip ratio (WHR), total cholesterol, LDL, TG, LH, estrodiol, fasting glucose adjusted mean CIMT values were 0.40±0.01 mm, 0.49±0.012mm, 0.34±0.012mm (p<0.001) in hirsute, oligo-amenorrheic and control groups respectively. CONCLUSION: PCOS patients with oligo-amenorrhea without hirsutism have higher risk for cardiovascular disease (CVD) and abnormal lipid profile than patients with hirsutism without oligo-amenorrhea

The value of Ga-68-PSMA PET/CT in biochemical recurrence of prostatic carcinoma (Pca)

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Oral glukoz tolerans testinde 1. saat glukoz seviyesi ve non-alkolik yağlı karaciğer hastalığı

Amaç: Non-alkolik yağlı karaciğer hastalığının (NAYKH) etyolojisi henüz net aydınlatılamamıştır. Prediyabetten diyabete karbohidrat metabolizma bozuklukları NAYKH'nın temelini oluşturmaktadır. Ancak, NAYKH ve glisemik bozukluklar arasındaki ilişkiye dair yayınlar yetersiz kalmaktadır. Yakın zamanda yapılan çalışmalarda alanin transaminaz (ALT) ve gama-glutamil transferaz (GGT)'nin NAYKH için belirteç olduğu gösterilmiştir. Hepatik testlerle prediabet arasındaki ilişki de yeterince tanımlanmamıştır. Bu nedenle, çalışmamızda oral glukoz tolerans testinde ara basamaklarının NAFLD ve hepatik fonksiyon testleri ile ilişkili olup olmadığı değerlendirildi. Gereç ve Yöntemler: 75 gr oral glukoz tolerans testi ve hepatik fonksiyon testleri 367 hastada değerlendirildi. Hepatosteatoz seviyesi ultrasonografi ile değerlendirildi. Bulgular: Hepatosteatoz yaş, BMI, 60. dk kan glukozu, ALT, GGT ile pozitif korelasyon göstermektedir. Açlık kan glukozu ve 0. dk kan glukozu ile zayıf pozitif korelasyon göstermektedir. Lineer regresyon analizinde, 60. dk glukoz NAYKH için bağımsız bir risk faktörü olarak saptanmıştır. Sonuç: NAYKH karbonhidrat metabolizma bozukluğu olan kişilerde sık rastlanmaktadır ve temel olarak glisemi düzeyleri ile ilişkilidir. NAYKH etyolojisinde glukoz tolerans testi 60. dk glukoz seviyelerinin rolü olabilir. ALT ve GGT seviyeleri de çalışmamızda 1.saat glukoz düzeyleri ve hepatosteatoz seviyeleri ile ilişkilendirilmiştirObjective: The etiology of non-alcoholic fatty liver disease (NAFLD) is still not clearly defined. Carbohydrate metabolism disorder including prediabetes to overt diabetes constitutes the main stone of the NAFLD. However; data on the relationship between glycemic disorders and NAFLD is scarce. Recent studies show that alanine transaminase (ALT) and gamma-glutamyl transferase (GGT) levels can be predictor factors for NAFLD. The relationship between hepatic test and prediabetes has not been defined clearly, yet. Therefore; we evaluated whether the intermediate stages of oral glucose tolerance test have association with NAFLD and with hepatic function test. Materials and Methods: 75 gr oral glucose loading test and hepatic function levels were evaluated in 367 participants. Hepatosteatosis level were assessed with ultrasonographic evaluation. Results: Grade of hepatic steatosis was positively correlated with age, body mass index (BMI), 60. min blood glucose, ALT, GGT and weakly positively correlated with fasting blood glucose, 0. min blood glucose. In lineer regression analysis, 60. min blood glucose after glucose loading were obtained to be an independent risk factor for NAFLD regardless of age, BMI. Conclusion: NAFLD is extremely common in people with carbohydrate metabolism disorder and is mainly associated with glucose levels. The 60. min blood glucose levels after post challenge test might have been a role in etiopathogenesis of NAFLD. ALT and GGT levels are also associated with glucose levelsat one-hour glucose loading and hepatosteatosis degre

Preliminary findings of our institute on initial staging of breast cancer with FDG-18 PET/CT

28th Annual Congress of the European-Association-of-Nuclear-Medicine (EANM) -- October 10-14, 2015 -- Hamburg, GermanyWOS: 000363013203107…European Association of Nuclear Medicin

Role of 18F FDG PETCT in marginal zone lymphomas

Annual Congress of the European-Association-of-Nuclear-Medicine -- OCT 15-19, 2016 -- Barcelona, SPAINWOS: 000391802400189…European Association of Nuclear Medicin

Predictors of Total Gonadotropin Dose Required for Follicular Growth in Controlled Ovarian Stimulation with Intrauterin Insemination Cycles in Patients with Unexplained Infertility or Male Subfertility

OBJECTIVE: The aim of this study was to determine the possible predictors of total gonadotropin dose (TGD) required to achieve ovulation in patients with unexplained infertility or male subfertility. STUDY DESIGN: A prospective study on 230 patients (n:178 unexplained infertility, n:52 male subfertility) scheduled for controlled ovarian stimulation (COH) and intrauterine insemination (IUI) was designed to determine the association between basal follicle stimulating hormone (FSH), luteinizing hormone (LH), estrodiol (E2) levels, antral follicle count (AFC), age and body mass index (BMI) and total gonadotropin doses needed to achieve follicular growth. RESULT: Regression analysis revealed an association between basal FSH level, BMI and AFC with total gonadotropin dose (P=0.001, P=0.002, P=0.045). BMI was positively correlated with TGD (r:0.400, P=0.001). Mean BMI of patients who required a total dosage of >1500 IUs of gonadotropin was 29.7±4.8kg/ m2 where as it was 24.9±3.2kg/ m2 for patients who received <1500 IU to achieve follicle growth (P=0.001). CONCLUSION: Our study results imply that basal BMI is the essential parameter in determining the total dose of gonadotropin used to achieve follicular growth

Polycystic Ovary Syndrome and the Relationship of Cardiovascular Disease Risk

Polycystic ovary syndrome (PCOS) is a common endocrine disorder affecting at least 5-10% of women of reproductive age. PCOS is characterized by hyperandrogenism, menstrual disturbance, anovulation, infertility and obesity and, also associated with increased number of cardiovascular risk factors and early atherosclerosis. Hyperinsulinemia is a frequent finding in PCOS patients and has cause-and-effect relationship with low-grade chronic inflammation and increased risk of cardiovascular disease. Turk Jem 2013; 17: 33-