259 research outputs found

    Targeting glucose metabolism for treatment of COVID-19

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    Covid-19 and Multiple Job Holding in Canada

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    Multiple job holding can be stimulated for various reasons, from financial difficulties to interest in a different career. Remote working, a newly dominant phenomenon in the working environment, can be a driving force for multiple job holding. This paper investigates how pandemic and remote working affects the decision to moonlight during and after the Covid-19 pandemic in Canada using data from the Labor Force Survey of Canada between 2007 and 2022. The findings suggest that, in general, the probability of taking a second job and hours spent in that have not increased during the pandemic and post-pandemic

    How Does Economic Complexity Affect Energy Demand in Iran? New Evidence from the Quantile Regression Model

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    The impact of technological advances on energy consumption is one of the topics that has been considered by many researchers and policymakers. Numerous researchers have tried to evaluate this relationship based on various technology indicators. The index of economic complexity is one of the new indicators that has been used in recent years to measure the level of knowledge and technology in the production structure. In this paper, the index of economic complexity along with energy prices and GDP have been used as determining factors of energy consumption in Iran during the period 1976 to 2018. Quantile regression results show that the coefficients of the variables are different in the deciles. The impact of economic complexity on energy consumption in all deciles has been positive, indicating the dominance of the rebound effect on energy consumption. Price elasticity is less than one in all deciles and less in the higher consumption deciles. In contrast, the income elasticity of energy demand was higher in the upper decile

    A Model Of Factors’ Effects On Brand Identification: Evidence From Iran

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    Social identification is essentially a perception of oneness with a group of persons. This study designs a model that tests and identifies social factors affecting brand identification. A convenience sample of 383 visitors to Ala Eddin Market (Mobile Market in Tehran) was surveyed. A series of linear regressions to test the hypotheses were completed using Path Analysis. The results showed that brand trust and brand attractiveness have positive effects on brand identification. The results also revealed that ideal self-congruity, brand distinctiveness and brand attractiveness have positive effects on brand trust, which in turn indirectly influence brand identification. Ideal selfcongruity and brand distinctiveness also positively affect brand attractiveness, which indirectly influence brand identification. However, the findings of the study indicate that actual self-congruity has no significant effect on brand trust and brand attractiveness

    Prevalence of idiopathic osteosclerosis on cone beam computed tomography images

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    Objectives This study was performed to investigate the prevalence of idiopathic osteosclerosis on cone beam computed tomography (CBCT) images of patients.Methods In this descriptive, cross-sectional study, 240 CBCT scans of patients (125 women, 115 men) referred to a private oral and maxillofacial radiology clinic in Tehran in 2013 were selected and evaluated. Presence of idiopathic osteosclerosis and its features including its location in the jaw, its association with teeth, presence or absence of root resorption, number, shape and size of lesions and age and gender of patients were assessed. Descriptive statistics were reported. Chi-square test and independent t-test were used for statistical analysis.Results Idiopathic osteosclerosis was seen on CBCT images of 20 patients (8.33%). The lesion was more frequent in women than men, but the difference was not significant (P = 0.50). Also, the lesion was more common in the mandible than the maxilla (95.6% vs. 4.4%). Most lesions were observed in the molar (56.5%) and premolar (34.7%) areas of the lower jaw. Most lesions did not have any association with teeth (73.9%). More than half of the lesions (56.5%) were round in shape and the rest (43.4%) were irregular. The mean size of the lesions was 5.4 ± 1.8 and 5.7 ± 1.4 mm in the mesiodistal and superior-inferior aspects, respectively.Conclusion The prevalence of idiopathic osteosclerosis of the jaws on CBCT images of an Iranian population was within the range reported by other studies. The lesions were more common in the mandibular molar region with no relation to teeth

    Assessment of Relationships Among and Within Helichrysum Mill. (Asteraceae) Species by Using ISSR Markers and Morphological Traits

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    AbstractThis study conducted to determine relationship among and within Iranian Helichrysum species (Asteraceae), using molecular analyses which are based on the inter simple sequences repeat (ISSR) technique and morphological observations of taxa which are collected in the areas of different habitats of Iran, where 20 species have been recorded within this genus. Helichrysum is a large and taxonomically difficult genus and relationships and infrageneric classification have remained largely unresolved. In this study Based on ISSR markers, ten primers generated 1145 polymorphic ISSR-PCR bands. Cluster analysis by the unweighted pair-group method (UPGMA) separated the 64 populations into two main clusters that were in agreement with the principal coordinate (PCO) analysis. Both UPGMA and the PCoA demonstrated that the highest percentage of ISSR loci polymorphism (54.7 %) occurred in populations of H. armenium. The highest gene diversity over loci (1.224), Shannon's Information Index (0.224 %) and Expected Heterozygosity (0.142 %) occurred in H. armenium (0.18) and the lowest of these parameters (0%) were observed in H. araxinum, H. graveolens, H. persicum and H. psychrophayllum. The highest genetic similarity occurred between H. armenium and H. rubicundum (0.989), while the lowest was between H.polyphyllum and H. graveolance (0.213). The analysis of molecular variance (AMOVA), showed significant genetic variation among (24%) and within (76%) species. A morphological analysis of this genus is carried out using 36 quantitative and qualitative morphological traits in 87 populations (249 individuals) of 19 species and traits such as indumentum, resting bud, achene length, achenial papillae, dimension of receptacle and form and apex of phyllaries were main diagnostic features. A high degree of similarity was revealed between H.artemisioides and H. davisianum.Results obtained from the morphological cluster were greatly consistent with the molecular data, to elucidating taxonomic relationships, as well as both attributed the higher diversity in H. armenium and H.rubicundum in comparison with other species and also indicated that H. persicum is a member of H. oocephalum species. Totally we confirmed the presence of 18 species in Iran

    Expression of let-7 family as a survival biomarker for lung cancer: A meta-analysis

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    Introduction: Lung cancer is the most common cancer among men around the world. Today, by evaluating the expression of microRNA biomarkers, cancer cells can be detected in specific tissues. However, it's still controversy that the expression of let-7 in the prognosis of patients with lung cancer is informative.Material and Methods: A meta-analysis was performed by searching Google Scholar, PubMed, Scopus, Web of Science, IranMedex, MEDLIB, IranDoc and Scientific Information Database(SID). All data were extracted from articles comparing prognosis in patients with lung cancer having low expression of let-7 with those having high expression. Pooled hazard ratios (HRs) and corresponding 95 % confidence intervals (CIs) were calculated. Subgroup analyses were conducted for ethnicity.Results: A total of 1,370 cases of lung cancer were involved for this meta-analysis. The HR of low let-7 expression was 1.32 (95 % CI 0.68–2.58). A subgroup analysis was performed on ethnicity; combined HR was 1.56 (95 % CI 0.52–4.62) for Asians and 1.08 (95%CI 0.42–2.74) for non-Asians.Conclusion: There was no significant relationship between the expression of let-7 and lung cancer, let-7 might be a biomarker in Asian patients with favourable prognosis. Furthermore, with large-scale investigations, useful prognostic microRNA biomarkers in the diagnosis, treatment and follow-up could be detected.

    SARS-CoV-2 and pancreas: a potential pathological interaction?

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    The widespread extrapulmonary complications of coronavirus disease 2019 (COVID-19) have gained momentum; the pancreas is another major target for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Here, we take a closer look into potential pathological interactions. We provide an overview of the current knowledge and understanding of SARS-CoV-2 infection of the pancreas with a special focus on pancreatic islets and propose direct, indirect, and systemic mechanisms for pancreas injury as result of the COVID-19–diabetes fatal bidirectional relationship

    The liver-derived exosomes stimulate insulin gene expression in pancreatic beta cells under condition of insulin resistance

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    Introduction: An insufficient functional beta cell mass is a core pathological hallmark of type 2 diabetes (T2D). Despite the availability of several effective pharmaceuticals for diabetes management, there is an urgent need for novel medications to protect pancreatic beta cells under diabetic conditions. Integrative organ cross-communication controls the energy balance and glucose homeostasis. The liver and pancreatic islets have dynamic cross-communications where the liver can trigger a compensatory beta cell mass expansion and enhanced hormonal secretion in insulin-resistant conditions. However, the indispensable element(s) that foster beta cell proliferation and insulin secretion have yet to be completely identified. Exosomes are important extracellular vehicles (EVs) released by most cell types that transfer biological signal(s), including metabolic messengers such as miRNA and peptides, between cells and organs. Methods: We investigated whether beta cells can take up liver-derived exosomes and examined their impact on beta cell functional genes and insulin expression. Exosomes isolated from human liver HepG2 cells were characterized using various methods, including Transmission Electron Microscopy (TEM), dynamic light scattering (DLS), and Western blot analysis of exosomal markers. Exosome labeling and cell uptake were assessed using CM-Dil dye. The effect of liver cell-derived exosomes on Min6 beta cells was determined through gene expression analyses of beta cell markers and insulin using qPCR, as well as Akt signaling using Western blotting. Results: Treatment of Min6 beta cells with exosomes isolated from human liver HepG2 cells treated with insulin receptor antagonist S961 significantly increased the expression of beta cell markers Pdx1, NeuroD1, and Ins1 compared to the exosomes isolated from untreated cells. In line with this, the activity of AKT kinase, an integral component of the insulin receptor pathway, is elevated in pancreatic beta cells, as represented by an increase in AKT’s downstream substrate, FoxO1 phosphorylation. Discussions: This study suggests that liver-derived exosomes may carry a specific molecular cargo that can affect insulin expression in pancreatic beta cells, ultimately affecting glucose homeostasis
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