6 research outputs found

    Assessment of the Antiviral Properties of Recombinant Porcine SP-D against Various Influenza A Viruses In Vitro

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    The emergence of influenza viruses resistant to existing classes of antiviral drugs raises concern and there is a need for novel antiviral agents that could be used therapeutically or prophylacticaly. Surfactant protein D (SP-D) belongs to the family of C-type lectins which are important effector molecules of the innate immune system with activity against bacteria and viruses, including influenza viruses. In the present study we evaluated the potential of recombinant porcine SP-D as an antiviral agent against influenza A viruses (IAVs) in vitro. To determine the range of antiviral activity, thirty IAVs of the subtypes H1N1, H3N2 and H5N1 that originated from birds, pigs and humans were selected and tested for their sensitivity to recombinant SP-D. Using these viruses it was shown by hemagglutination inhibition assay, that recombinant porcine SP-D was more potent than recombinant human SP-D and that especially higher order oligomeric forms of SP-D had the strongest antiviral activity. Porcine SP-D was active against a broad range of IAV strains and neutralized a variety of H1N1 and H3N2 IAVs, including 2009 pandemic H1N1 viruses. Using tissue sections of ferret and human trachea, we demonstrated that recombinant porcine SP-D prevented attachment of human seasonal H1N1 and H3N2 virus to receptors on epithelial cells of the upper respiratory tract. It was concluded that recombinant porcine SP-D holds promise as a novel antiviral agent against influenza and further development and evaluation in vivo seems warranted

    The Iowa Homemaker vol.16, no.2

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    Cover by Allene Nelson Circles on Your Calender by Vera Joyce Horswell, page 1 Manners Make You “Tops” by Peggy Schenk, page 2 Mrs. Friley Prefers Informal Entertainment by Kay Hoffman, page 3 Sportswear Dictionary by Rosemae Johnson and Stella Mae Brinkman, page 4 Alums at Work – And Some Go to Europe by Gay Starrak, page 6 Doorknobs Are Polished for Veishea by Lola Wilcox, page 7 After Graduation, What Can I Do? by Elizabeth Brann and Marian Reinke, page 8 Picnics – Sixty Campus Opinions on Them by Dorothy Fedderson, page 9 What’s New in Home Economics, page 10 Behind Bright Jackets, page 12 Should You Balance your Educational Diet? by Ida Ruth Younkin, page 13 Try Bread if You’re Food Conscious by Clara Gebhard Snyder, page 14</p

    Involvement of the Nitric Oxide Pathway in Synaptic Dysfunction Following Amyloid Elevation in Alzheimer's Disease

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