1,322 research outputs found

    Analysis of Interior and Exterior Environment Construction of Library Building and Rationalization Proposal

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    With increasingly fierce social competition, people need to constantly acquire knowledge to keep pace with the times. Thus, more and more people to resort to the library for learning, which is bound to have a huge impact on the construction and development of the library. To better reflect the function of the library, and make library provide more services, it is needed to systematically research the construction of interior and exterior environment of the library building in both reconstruction and expansion projects in the library. In this paper, the three major principles which should be followed in the construction of interior and exterior environment of the library building, namely perfect combination of applicability and artistry, giving prominence to culture and atmosphere, and green design and sustainable development. Secondly, countermeasures for problems (lack of parking space, design of the rest room, and so on) in the process of interior and exterior environment construction of a library building are put forward. Besides, deep discussions on measures for interior and exterior environment construction of a library building also are made. Thus, this paper is of certain reference value

    Search for vector-like leptons at a Muon Collider

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    A feasibility study is performed for searching vector-like leptons at a muon collider, in the context of the "4321 model", an ultraviolet-complete model with rich collider phenomenology together with potential to explain recent existing some B physics measurements or anomalies. In this paper, we perform a Monte Carlo study with various machine learning techniques, and examine the projected sensitivity on vector-like leptons over a wide mass range at a TeV-scale muon collider. We find that a 3 TeV muon collider with only 10/fb of data can already be sensitive to cover the mass range of a vector-like lepton up to 1450 GeV.Comment: CPC Published Versio

    Relationship between IL-10 gene -819C/T polymorphism and the risk of inflammatory bowel disease: A meta-analysis

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    Background: The -819C/T polymorphism in interleukin 10 (IL-10) gene has been reported to be associated with inflammatory bowel disease (IBD) ,but the previous results are conflicting.Materials and methods: The present study aimed at investigating the association between this polymorphism and risk of IBD using a meta-analysis.PubMed,Web of Science,EMBASE,google scholar and China National Knowledge Infrastructure (CNKI) databases were systematically searched to identify relevant publications from their inception to April 2016.Pooled odds ratio (OR) with 95% confidence interval (CI) was calculated using fixed- or random-effects models.Results: A total of 7 case-control studies containing 1890 patients and 2929 controls were enrolled into this meta-analysis, and our results showed no association between IL-10 gene -819C/T polymorphism and IBD risk(TT vs. CC:OR=0.81,95%CI 0.64- 1.04;CT vs. CC:OR=0.92,95%CI 0.81-1.05; Dominant model: OR=0.90,95%CI 0.80-1.02; Recessive model: OR=0.84,95%CI 0.66-1.06). In a subgroup analysis by nationality, the -819C/T polymorphism was not associated with IBD in both Asians and Caucasians. In the subgroup analysis stratified by IBD type, significant association was found in Crohn’s disease(CD)(CT vs. CC:OR=0.68,95%CI 0.48-0.97).Conclusion: In summary, the present meta-analysis suggests that the IL-10 gene -819C/T polymorphism may be associated with CD risk.Keywords: Interleukin 10, -819C/T polymorphism, inflammatory bowel diseaseDue to errors in the previous PDF especially in the 'Cite as' authors names, the PDF fulltext has been reloaded. This information is now correct

    A Group-Based Trust Model in Peer-to- Peer Environment

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    Abstract. The open and anonymous nature of peer-to-peer system makes it easy to be attacked and abused by some malicious nodes, so it is very important to establish a perfect trust mechanism in peer-to-peer environment. In this paper, we propose a novel group-based trust model in which the trust relationships between entities are divided into trust relationship in group and trust relationship between groups. This model deals with these two kinds of trust relationships in the different way and improves trust value calculation method. The model can get more real trust value at the small price, and the advantages of the model are simple structure and high reliability

    Comparative transcriptomics in Yersinia pestis: a global view of environmental modulation of gene expression

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    <p>Abstract</p> <p>Background</p> <p>Environmental modulation of gene expression in <it>Yersinia pestis </it>is critical for its life style and pathogenesis. Using cDNA microarray technology, we have analyzed the global gene expression of this deadly pathogen when grown under different stress conditions <it>in vitro</it>.</p> <p>Results</p> <p>To provide us with a comprehensive view of environmental modulation of global gene expression in <it>Y. pestis</it>, we have analyzed the gene expression profiles of 25 different stress conditions. Almost all known virulence genes of <it>Y. pestis </it>were differentially regulated under multiple environmental perturbations. Clustering enabled us to functionally classify co-expressed genes, including some uncharacterized genes. Collections of operons were predicted from the microarray data, and some of these were confirmed by reverse-transcription polymerase chain reaction (RT-PCR). Several regulatory DNA motifs, probably recognized by the regulatory protein Fur, PurR, or Fnr, were predicted from the clustered genes, and a Fur binding site in the corresponding promoter regions was verified by electrophoretic mobility shift assay (EMSA).</p> <p>Conclusion</p> <p>The comparative transcriptomics analysis we present here not only benefits our understanding of the molecular determinants of pathogenesis and cellular regulatory circuits in <it>Y. pestis</it>, it also serves as a basis for integrating increasing volumes of microarray data using existing methods.</p

    Combined use of venetoclax and azacitidine in treatment of acute myeloid leukemia complicated with disseminated Fusarium infection: a case report

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    Acute myeloid leukemia (AML) is a malignant clonal disease originating from hematopoietic stem/progenitor cells. Chemotherapy is the main treatment. If not effectively treated after 2 courses of standard treatment, these patients can be diagnosed with refractory AML. In this article, a case of refractory AML complicated with disseminated Fusarium infection receiving combined treatment of venetoclax and azacitidine was reported. The patient was diagnosed with AML (M5a) with DNMT3A, IDH2 and BCOR mutations, classified in the moderate group. Standard dose of IA regimen (deoxydaunorubicin + cytarabine) was ineffective, and additional homoharringtonine induction therapy remained ineffective. Subsequently, combined use of venetoclax and azacitidine was adopted and the severity of disease was alleviated. Complete remission was achieved after three cycles of venetoclax combined with azacitidine consolidation therapy. After the first chemotherapy, the patient presented with recurrent fever, purple induration with central necrosis in the upper and lower limbs, and visible subcutaneous liquid mass. Pathological examination suggested Fusarium infection. After amphotericin B combined with voriconazole as antifungal therapy, disseminated Fusarium infection was effectively controlled. This case prompts that combined use of venetoclax and azacitidine yields high remission rate in the treatment of refractory AML. Disseminated Fusarium infection is a rare fatal complication in AML patients after chemotherapy. Early diagnosis and effective antifungal treatment are effective interventions to improve the survival rate of patients

    Characterization of Zur-dependent genes and direct Zur targets in Yersinia pestis

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    <p>Abstract</p> <p>Background</p> <p>The zinc uptake regulator Zur is a Zn<sup>2+</sup>-sensing metalloregulatory protein involved in the maintenance of bacterial zinc homeostasis. Up to now, regulation of zinc homeostasis by Zur is poorly understood in <it>Y. pestis</it>.</p> <p>Results</p> <p>We constructed a <it>zur </it>null mutant of <it>Y. pestis </it>biovar <it>microtus </it>strain 201. Microarray expression analysis disclosed a set of 154 Zur-dependent genes of <it>Y. pestis </it>upon exposure to zinc rich condition. Real-time reverse transcription (RT)-PCR was subsequently used to validate the microarray data. Based on the 154 Zur-dependent genes, predicted regulatory Zur motifs were used to screen for potential direct Zur targets including three putative operons <it>znuA, znuCB </it>and <it>ykgM</it>-<it>RpmJ2</it>. The LacZ reporter fusion analysis verified that Zur greatly repressed the promoter activity of the above three operons. The subsequent electrophoretic mobility shift assay (EMSA) demonstrated that a purified Zur protein was able to bind to the promoter regions of the above three operons. The DNase I footprinting was used to identify the Zur binding sites for the above three operons, verifying the Zur box sequence as predicted previously in γ-Proteobacteria. The primer extension assay was further used to determine the transcription start sites for the above three operons and to localize the -10 and -35 elements. Zur binding sites overlapped the -10 sequence of its target promoters, which was consistent with the previous observation that Zur binding would block the entry of the RNA polymerase to repress the transcription of its target genes.</p> <p>Conclusion</p> <p>Zur as a repressor directly controls the transcription of <it>znuA, znuCB </it>and <it>ykgM</it>-<it>RpmJ2 </it>in <it>Y. pestis </it>by employing a conserved mechanism of Zur-promoter DNA association as observed in γ-Proteobacteria. Zur contributes to zinc homeostasis in <it>Y. pestis </it>likely through transcriptional repression of the high-affinity zinc uptake system ZnuACB and two alternative ribosomal proteins YkgM and RpmJ2.</p
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