687 research outputs found

    Probing New Physics via pp-> W+W- -> lvjj at the CERN LHC

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    TeV scale new Physics, e.g., Large Extra Dimensions or Models with anomalous triple vector boson couplings, can lead to excesses in various kinematic regions on the semi-leptonic productions of pp -> WW -> lvjj at the CERN LHC, which, although suffers from large QCD background compared with the pure leptonic channel, can benefit from larger production rates and the reconstructable 4-body mass Mlvjj. We study the search sensitivity through the lvjj channel at the 7TeV LHC on relevant new physics, via probing the hard tails on the reconstructed Mlvjj and the transverse momentum of W-boson (PTW), taking into account main backgrounds and including the parton shower and detector simulation effects. Our results show that with integrated luminosity of 5fb-1, the LHC can already discovery or exclude a large parameter region of the new physics, e.g., 95% CL. limit can be set on the Large Extra Dimensions with a cut-off scale up to 1.5 TeV, and the WWZ anomalous coupling down to, e.g. |\lambda_Z|~0.1. Brief results are also given for the 8TeV LHC.Comment: 13 pages, 6 figures, 2 table

    Quantitative Implementation of Artificial Intelligence Based on Task Completion Analysis

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    With the further development of the new generation of artificial intelligence science and technology, the new generation of artificial intelligence science and technology has been applied in many fields. AlphaGo program uses high technology of quantitative analysis to realize qualitative research and development of artificial intelligence, which has important reference significance for the research and development of a new generation of artificial intelligence in the future. From the perspective of task accessibility, this paper analyzes the defects of the disturbance, so as to achieve the quantitative implementation of the new generation of artificial intelligence task accessibility analysis method

    The association between epilepsy and COVID-19: analysis based on Mendelian randomization and FUMA

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    ObjectiveA multitude of observational studies have underscored a substantial comorbidity between COVID-19 and epilepsy. This study was aimed at establishing a conclusive causal link between these two conditions.MethodsWe employed Mendelian randomization (MR) to evaluate the causal link between COVID-19 and epilepsy, as well as its focal and generalized subtypes. The GWAS for epilepsy and its subtypes database were abstracted from both FinnGen consortium and ILAE. Additionally, we leveraged functional mapping and annotation (FUMA) to integrate information from genome-wide association studies (GWAS) results.ResultsThe MR analyses revealed that genetic liability to COVID-19 infection conferred a causal effect on epilepsy [FinnGen: OR: 1.5306; 95% confidence interval (CI): 1.1676–2.0062, PFDR (false discovery rate) = 0.0076; ILAE: OR: 1.3440; 95% CI: 1.0235–1.7649, PFDR = 0.0429], and generalized epilepsy (FinnGen: OR: 2.1155; 95% CI: 1.1734–3.8139, PFDR = 0.0327; ILAE: OR: 1.1245; 95% CI: 1.0444–1.2108, PFDR = 0.0114). Genetic liability to COVID-19 hospitalization conferred a causal effect on epilepsy (FinnGen: OR: 1.0934; 95% CI: 1.0097–1.1841, PFDR = 0.0422; ILAE: OR: 1.7381; 95% CI: 1.0467–2.8862, PFDR = 0.0451), focal epilepsy (ILAE: OR: 1.7549; 95% CI: 1.1063–2.7838, PFDR = 0.0338), and generalized epilepsy (ILAE: OR: 1.1827; 95% CI: 1.0215–1.3693, PFDR = 0.0406). Genetic liability to COVID-19 severity conferred a causal effect on epilepsy (FinnGen consortium: OR: 1.2454; 95% CI: 1.0850–1.4295, PFDR = 0.0162; ILAE: OR: 1.2724; 95% CI: 1.0347–1.5647, PFDR = 0.0403), focal epilepsy (FinnGen: OR: 1.6818; 95% CI: 1.1478–2.4642, PFDR = 0.0231; ILAE: OR: 1.6598; 95% CI: 1.2572–2.1914, PFDR = 0.0054), and generalized epilepsy (FinnGen: OR: 1.1486; 95% CI: 1.0274–1.2842, PFDR = 0.0335; ILAE: OR: 1.0439; 95% CI: 1.0159–1.0728, PFDR = 0.0086). In contrast, no causal linkage of epilepsy on COVID-19 was observed. Further, FUMA analysis identified six overlapping genes, including SMEK2, PNPT1, EFEMP1, CCDC85A, VRK2, and BCL11A, shared between COVID-19 and epilepsy. Tissue-specific expression analyses revealed that the disease-gene associations of COVID-19 were significantly enriched in lung, ovary, and spleen tissue compartments, while being significantly enriched in brain tissue for epilepsy.ConclusionOur study demonstrates that COVID-19 can be a contributing factor to epilepsy, but we found no evidence that epilepsy contributes to COVID-19

    Fabrication and characterization of Ge–Sb–Se–I glasses and fibers

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    International audienceChalcogenide glasses of the Ge20Sb5Se75−x I x (x = 0, 5, 10, 15, 20 at.%) system were prepared. This study was performed to examine some Ge–Sb–Se–I glass physical and optical properties, the structural evolution of the glass network, and the optical properties of the infrared glass fibers based on our previous studies. The variation process of the glass physical properties, such as transition temperature, glass density, and refractive index, was investigated from the glass of Ge20Sb5Se75 to the Ge20Sb5Se75−x I x glass series. The structural evolutions of these glasses were examined by Raman spectroscopy. The Ge20Sb5Se55I20 composition was selected for the preparation of the IR fiber. The Ge20Sb5Se55I20 glass was purified through distillation, and the intensity of the impurity absorption peaks caused by Ge–O, H2O, and Se–H was reduced or eliminated in the purified glasses. Then, Ge20Sb5Se55I20 chalcogenide glass fiber for mid-infrared transmission was fabricated using high-purity materials. The transmission loss of the Ge20Sb5Se55I20 fiber was greatly reduced compared with that of the Ge20Sb5Se75 glass fiber. The lowest losses obtained were 3.5 dB/m at 3.3 μm for Ge20Sb5Se75I20 fiber, which was remarkably improved compared with 48 dB/m of the unpurified Ge20Sb5Se75 fiber

    Genomic Takeover by Transposable Elements in the Strawberry Poison Frog

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    We sequenced the genome of the strawberry poison frog, Oophaga pumilio, at a depth of 127.5× using variable insert size libraries. The total genome size is estimated to be 6.76 Gb, of which 4.76 Gb are from high copy number repetitive elements with low differentiation across copies. These repeats encompass DNA transposons, RNA transposons, and LTR retrotransposons, including at least 0.4 and 1.0 Gb of Mariner/Tc1 and Gypsy elements, respectively. Expression data indicate high levels of gypsy and Mariner/Tc1 expression in ova of O. pumilio compared with Xenopus laevis. We further observe phylogenetic evidence for horizontal transfer (HT) of Mariner elements, possibly between fish and frogs. The elements affected by HT are present in high copy number and are highly expressed, suggesting ongoing proliferation after HT. Our results suggest that the large amphibian genome sizes, at least partially, can be explained by a process of repeated invasion of new transposable elements that are not yet suppressed in the germline. We also find changes in the spliceosome that we hypothesize are related to permissiveness of O. pumilio to increases in intron length due to transposon proliferation. Finally, we identify the complement of ion channels in the first genomic sequenced poison frog and discuss its relation to the evolution of autoresistance to toxins sequestered in the skin
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