59 research outputs found

    Hazard Footprint-Based Normalization of Economic Losses from Tropical Cyclones in China During 1983–2015

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    Abstract Loss normalization is the prerequisite for understanding the effects of socioeconomic development, vulnerability, and climate changes on the economic losses from tropical cyclones. In China, limited studies have been done on loss normalization methods of damages caused by tropical cyclones, and most of them have adopted an administrative division-based approach to define the exposure levels. In this study, a hazard footprint-based normalization method was proposed to improve the spatial resolution of affected areas and the associated exposures to influential tropical cyclones in China. The meteorological records of precipitation and near-surface wind speed were used to identify the hazard footprint of each influential tropical cyclone. Provincial-level and national-level (total) economic loss normalization (PLN and TLN) were carried out based on the respective hazard footprints, covering loss records between 1999–2015 and 1983–2015, respectively. Socioeconomic factors—inflation, population, and wealth (GDP per capita)—were used to normalize the losses. A significant increasing trend was found in inflation-adjusted losses during 1983–2015, while no significant trend was found after normalization with the TLN method. The proposed hazard footprint-based method contributes to a more realistic estimation of the population and wealth affected by the influential tropical cyclones for the original year and the present scenario

    Ferroptosis in hematological malignant tumors

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    Ferroptosis is a kind of iron-dependent programmed cell death discovered in recent years. Its main feature is the accumulation of lipid reactive oxygen species in cells, eventually leading to oxidative stress and cell death. It plays a pivotal role in normal physical conditions and the occurrence and development of various diseases. Studies have shown that tumor cells of the blood system, such as leukemia cells and lymphoma cells, are sensitive to the response to ferroptosis. Regulators that modulate the Ferroptosis pathway can accelerate or inhibit tumor disease progression. This article reviews the mechanism of ferroptosis and its research status in hematological malignancies. Understanding the mechanisms of ferroptosis could provide practical guidance for treating and preventing these dreaded diseases

    Association of p53 rs1042522, MDM2 rs2279744, and p21 rs1801270 polymorphisms with retinoblastoma risk and invasion in a Chinese population.

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    Single nucleotide polymorphisms (SNPs) of p53 rs1042522, MDM2 rs2279744 and p21 rs1801270, all in the p53 pathway, which plays a crucial role in DNA damage and genomic instability, were reported to be associated with cancer risk and pathologic characteristics. This case-control study was designed to analyse the association between these SNPs and retinoblastoma (RB) in a Chinese Han population. These SNPs in 168 RB patients and 185 adult controls were genotyped using genomic DNA from venous blood. No significant difference was observed in allele or genotypic frequencies of these SNPs between Chinese RB patients and controls (all P > 0.05). However, the rs1042522 GC genotype showed a protective effect against RB invasion, as demonstrated by event-free survival (HR = 0.53, P = 0.007 for GC versus GG/CC). This effect was significant for patients with a lag time >1 month and no pre-enucleation treatment (P = 0.007 and P = 0.010, respectively), indicating an interaction between p53 rs1042522 and clinical characteristics, including lag time and pre-enucleation treatment status. Thus, the rs1042522 SNP may be associated with RB invasion in the Han Chinese population; however, further large and functional studies are needed to assess the validity of this association

    A longitudinal resource for population neuroscience of school-age children and adolescents in China

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    During the past decade, cognitive neuroscience has been calling for population diversity to address the challenge of validity and generalizability, ushering in a new era of population neuroscience. The developing Chinese Color Nest Project (devCCNP, 2013–2022), the first ten-year stage of the lifespan CCNP (2013–2032), is a two-stages project focusing on brain-mind development. The project aims to create and share a large-scale, longitudinal and multimodal dataset of typically developing children and adolescents (ages 6.0–17.9 at enrolment) in the Chinese population. The devCCNP houses not only phenotypes measured by demographic, biophysical, psychological and behavioural, cognitive, affective, and ocular-tracking assessments but also neurotypes measured with magnetic resonance imaging (MRI) of brain morphometry, resting-state function, naturalistic viewing function and diffusion structure. This Data Descriptor introduces the first data release of devCCNP including a total of 864 visits from 479 participants. Herein, we provided details of the experimental design, sampling strategies, and technical validation of the devCCNP resource. We demonstrate and discuss the potential of a multicohort longitudinal design to depict normative brain growth curves from the perspective of developmental population neuroscience. The devCCNP resource is shared as part of the “Chinese Data-sharing Warehouse for In-vivo Imaging Brain” in the Chinese Color Nest Project (CCNP) – Lifespan Brain-Mind Development Data Community (https://ccnp.scidb.cn) at the Science Data Bank

    Tubeless video-assisted thoracic surgery for pulmonary ground-glass nodules: expert consensus and protocol (Guangzhou)

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    Morphological Component Analysis-Based Hidden Markov Model for Few-Shot Reliability Assessment of Bearing

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    Reliability is of great significance in ensuring the safe operation of modern industry, which mainly relies on data analysis and life tests. However, as the life of mechanical systems becomes increasingly longer with the rapid development of the manufacturing industry, the collection of historical failure data becomes progressively more time-consuming. In this paper, a few-shot reliability assessment approach is proposed in order to overcome the dependence on historical data. Firstly, the vibration response of a bearing was illustrated. Then, based on a vibration response analysis, a morphological component analysis (MCA) method based on sparse representation theory was used to decompose vibration signals and extract impulse signals. After the impulse components’ reconstruction, their statistical indexes were utilized as the input observation vector of a Mixture of Gaussians Hidden Markov Model (MoG-HMM) for a reliability estimation. Finally, the experimental dataset of an aerospace bearing was analyzed via the proposed method. The comparison results illustrate the effectiveness of the proposed method of a few-shot reliability assessment

    Promotion effect of bacteria in phycosphere on flocculation activity of Aspergillus niger on Synechocystis biomass

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    The cyanobacterium Synechocystis with high scientific research value and application potential to aquaculture is hard to harvest its biomass. Bioflocculation is an economical and efficient method for harvesting microalgal biomass. In this study, Aspergillus niger 7806F3, a fungus that showed high flocculation activity on Synechocystis cells, was selected to assess its potential for the harvest of microalgal biomass. The analyses of flocculation activity and flocculation mechanism indicated that mycelial pellets of Aspergillus niger 7806F3 exhibited high flocculation activity on Synechocystis biomass through charge neutralization mechanism, and proteins of mycelial pellets participated in the flocculation activity. The flocculation activity of strain 7806F3 on aseptic algal culture indicated that bacteria in the phycosphere can promote the flocculation effect of strain 7806F3 on algal cells. Bacterial community analysis indicated that the addition of mycelial pellets changed the bacterial community diversity in the Synechocystis phycosphere, increasing the abundance of genus Pseudomonas in the phycosphere. Finally, Pseudomonas sp. Algal4 was isolated from the Synechocystis phycosphere and confirmed with the ability to promote the flocculation activity of strain 7806F3 on Synechocystis cells. This study not only provides a method to harvest Synechocystis biomass, but also confirms the promotion effect of bacteria in phycosphere on flocculation activity, which provided a new understanding for the interaction between the algae and bacteria in the phycosphere

    Characterization of Microstructures and Tensile Properties of Recycled Al-Si-Cu-Fe-Mn Alloys with Individual and Combined Addition of Titanium and Cerium

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    Individual and combined addition of Ti and Ce on the recycled Al-Si-Cu-Fe-Mn alloy was conducted. The microstructures and tensile properties of these fabricated alloys were investigated. In the case of Ti or Ce which was individually added, the added amount was ranging from 0.03 wt.% to 0.09 wt.%. The combined addition of Ti and Ce was set at the ratios of 1 : 1, 1 : 3, and 3 : 1 with a total amount of 0.12 wt.%. Microstructures and phases of these alloys were investigated by using an optical microscope, X-ray diffraction testing, and SEM coupled with EDS. The morphologies of these alloys were quantified by analyzing the SDAS value, length of secondary phases, and phases’ distribution uniformity. Tensile testing was carried out for understanding the strengthen effect of the modification process. Results show that the addition of Ce was favorable to the strength and % elongation because the coarse needle-like phase and the polyhedral phase were effectively refined. Their SDAS values and distribution factor were remarkably declined with the increase of the Ce level. The Ti addition could also refine the secondary phases and SDAS values. But its effect was not as prominent as the addition of Ce. Combined addition of Ti and Ce elements at the ratio of 1 : 3 resulted in the samples reaching maximum comprehensive tensile properties. In this case, the short needle-like phase was uniformly distributed in the microstructure. Few polyhedral phases could be found in the Al-Si-Cu-Fe-Mn matrix. The strengthening of these fabricated materials was due to the grain refinement for α-Al and modification for coarse secondary phases. In addition, distribution uniformity of secondary phases was also changed by their modification effects

    The wet, the wild and the wondrous

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    Wet markets are an integral part of Singaporeans’ national identity. What makes seemingly mundane grocery shopping venues and experiences so important to Singapore's social space? The Wet, the Wild and the Wondrous takes a granular look at the aspects of wet markets – architectural, sociological, economic – that make up its unique character. This documentary short is a multi-sensory experience, exposing the hidden communities and social dynamics within wet markets. This report provides a chronological account of the process of making our film, from conceptualisation to production and post-production. The report also sheds light on the decisions we made, challenges we faced, and lessons we learnt along the way.Bachelor of Communication Studie
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