2,084 research outputs found

    IT Governance Mechanisms, Employees\u27 Digital Mindset, and Behavioral Outcomes

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    The disruptive nature of digitalization and the complexity and ambiguity of their technical properties require many new skills from employees today. Recent research emphasizes that the employees’ digital mindset plays an essential role in digital transformation by leveraging employee engagement. This paper aims to advance the understanding of how the behavioral outcomes of digital mindset, which encompass interpersonal interaction, focus of attention, enthusiasm for development, perspective on setbacks, and construal of effort, can be positively influenced during digital initiatives. We develop a novel research model integrating two literature streams: information technology and mindset. We conceptually link back to the behavioral outcomes of digital mindset by looking at the influence of IT governance mechanisms as potential antecedents. Our model explains how IT governance mechanisms influence the behavioral outcomes of digital mindset and helps future researchers by providing propositions on the impact of IT governance mechanisms towards more employee engagement

    Zum Zusammenhang des Beeinträchtigungsausmaßes bei primären Kopfschmerzen und Migräne mit dem Body Mass Index und regelmäßiger körperlicher Aktivität in Deutschland

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    In dieser Arbeit wird ein für Deutschland repräsentativer Datensatz einer Querschnittsbefragung der deutschsprachigen Wohnbevölkerung von 2016 im Hinblick auf mögliche Zusammenhänge des kopfschmerzbedingten Beeinträchtigungsausmaßes bei primären Kopfschmerzen generell und Migräne speziell mit dem BMI und regelmäßiger körperlicher Aktivität mithilfe ordinaler logistischer Regressionsanalysen ausgewertet. Die inhaltliche Einordnung der zugrundeliegenden Theorien orientiert sich am biopsychosozialen Krankheitsmodell

    Strength of the EpE_{\text{p}}=1.842 MeV resonance in the 40^{40}Ca(p,γ\gamma)41^{41}Sc reaction revisited

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    The strength of the Ep=1.842E_{\rm p} = 1.842 MeV resonance in the 40^{40}Ca(p,γ\gamma)41^{41}Sc reaction is determined with two different methods: First, by an absolute strength measurement using calcium hydroxide targets, and second, relative to the well-determined strength of the resonance triplet at EαE_\alpha = 4.5 MeV in the 40^{40}Ca(α\alpha,γ\gamma)44^{44}Ti reaction. The present new value of ωγ=(0.192±0.017)\omega\gamma=(0.192\pm0.017) eV is 37% (equivalent to 3.5σ3.5\sigma) higher than the evaluated literature value. In addition, the ratio of the strengths of the 1.842 MeV 40^{40}Ca(p,γ\gamma)41^{41}Sc and 4.5 MeV 40^{40}Ca(α\alpha,γ\gamma)44^{44}Ti resonances has been determined to be 0.0229±0.00180.0229\pm0.0018. The newly corrected strength of the 1.842-MeV resonance can be used in the future as a normalization point for experiments with calcium targets.Comment: Submitted to Phys. Rev.

    In Situ Transmission Electron Microscopy in Materials Science - Possibilities and Prospects

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    The development of organized, informative, robust, user-friendly, and freely accessible molecular markers is imperative to the Musa marker assisted breeding program. Although several hundred SSR markers have already been developed, the number of informative, robust, and freely accessible Musa markers remains inadequate for some breeding applications. In view of this issue, we surveyed SSRs in four different data sets, developed large-scale non-redundant highly informative therapeutic SSR markers, and classified them according to their attributes, as well as analyzed their cross-taxon transferability and utility for the genetic study of Musa and its relatives. A high SSR frequency (177 per Mbp) was found in the Musa genome. AT-rich dinucleotide repeats are predominant, and trinucleotide repeats are the most abundant in transcribed regions. A significant number of Musa SSRs are associated with pre-miRNAs, and 83% of these SSRs are promising candidates for the development of therapeutic SSR markers. Overall, 74% of the SSR markers were polymorphic, and 94% were transferable to at least one Musa spp. Two hundred forty-three markers generated a total of 1047 alleles, with 2-8 alleles each and an average of 4.38 alleles per locus. The PIC values ranged from 0.31 to 0.89 and averaged 0.71. We report the largest set of non-redundant, polymorphic, new SSR markers to be developed in Musa. These additional markers could be a valuable resource for marker-assisted breeding, genetic diversity and genomic studies of Musa and related species

    Overexpression Of Muts Alpha Complex Proteins Predicts Poor Prognosis In Oral Squamous Cell Carcinoma

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    Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)The DNA mismatch repair (MMR) system is responsible for the detection and correction of errors created during DNA replication, thereby avoiding the incorporation of mutations in dividing cells. The prognostic value of alterations in MMR system has not previously been analyzed in oral squamous cell carcinoma (OSCC). The study comprised 115 cases of OSCC diagnosed between 1996 and 2010. The specimens collected were constructed into tissue microarray blocks. Immunohistochemical staining for MutS alpha complex proteins hMSH2 and hMSH6 was performed. The slides were subsequently scanned into high-resolution images, and nuclear staining of hMSH2 and hMSH6 was analyzed using the Nuclear V9 algorithm. Univariable and multivariable Cox proportional hazard regression models were performed to evaluate the prognostic value of hMSH2 and hMSH6 in OSCC. All cases in the present cohort were positive for hMSH2 and hMSH6 and a direct correlation was found between the expression of the proteins (P<0.05). The mean number of positive cells for hMSH2 and hMSH6 was 64.44 +/- 15.21 and 31.46 +/- 22.38, respectively. These values were used as cutoff points to determine high protein expression. Cases with high expression of both proteins simultaneously were classified as having high MutS alpha complex expression. In the multivariable analysis, high expression of the MutS alpha complex was an independent prognostic factor for poor overall survival (hazard ratio: 2.75, P = 0.02). This study provides a first insight of the prognostic value of alterations in MMR system in OSCC. We found that MutS alpha complex may constitute a molecular marker for the poor prognosis of OSCC.9522Brazilian National Council for Scientific and Technological Development (CNPq)Postgraduate Research Group of the Porto Alegre University Hospital [GPPG/FIPE: 15-0210]Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
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