565 research outputs found

    Diagnosis and treatment of paraneoplastic neurological disorders

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    In about two thirds of cases, patients with paraneoplastic neurological disorders present to the neurologist without a known tumor. Due to the ongoing immune response, this tumor tends to stay biologically relatively benign, and therefore difficult to diagnose. In patients with a known tumor, the neurological symptoms often precede a tumor recurrence. In both scenarios, anti-neuronal antibodies are an invaluable diagnostic help to the clinician, and may be supplemented by other diagnostic tests such as MRI, CSF, and electrophysiology. Tumor therapy remains the mainstay of therapeutic options, although early immune therapy must be started in parallel. It is hoped that the recent fundamental advances in understanding the autoimmune pathology of these disorders, especially the role of cytotoxic T cells, will eventually lead to more effective treatment options

    Palliative Therapie in der Neurologie

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    Amyotrophe Lateralsklerose

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    Radioluminescence des milieux organiques III. Étude expĂ©rimentale des solutions aromatiques liquides

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    L'Ă©tude du dĂ©clin de la scintillation Ă©mise par des solutions aromatiques liquides irradiĂ©es par un rayonnement ÎČ a permis de montrer que la composante diffĂ©rĂ©e est due Ă  une interaction entre deux Ă©tats triplets du solutĂ© excitĂ©s par capture de l'Ă©nergie du solvant. La constante de Stern-Volmer de la rĂ©action de transfert de l'Ă©nergie des Ă©tats triplets du solvant au solutĂ© (α-NPO) a Ă©tĂ© estimĂ©e Ă  350 M -1 pour les solutions de benzĂšne et de toluĂšne. La durĂ©e de vie de l'Ă©tat triplet le plus bas du solvant est infĂ©rieure Ă  une vingtaine de ns. Par ailleurs, on a Ă©valuĂ© Ă  environ 40 Å le rayon des zones cylindriques de forte densitĂ© d'activation dans lesquelles a lieu la rĂ©action d'annihilation bimolĂ©culaire des Ă©tats triplets

    Quebra de dormĂȘncia de sementes de Mimosa daleoides.

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    Is the blue tit falling into an ecological trap in Argentine ant invaded forests?

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    Because insectivorous birds must evaluate resources for reproduction before settling into a breed- ing habitat, they can fall into an ecological trap if informative cues about habitat suitability become dissociated from their actual yield. Given their potential to affect ecological networks, invasive ant species are potential candidates for triggering such ecological traps. We combined observational and experimental approaches to examine whether the variation in food supply for nestlings resulting from the invasion of the Argentine ant, Linepithema humile, had any influence on the breeding ecology of the blue tit, Cyanistes caeruleus, an insectivorous foliage-gleaner. We inves- tigated the effects of the ant invasion on breeding performance (nesting success, clutch size, brood size and breeding success) and offspring quality (body size and condition, developmental stability and plumage colour) in replicated Mediterranean forest areas over a period of 3 years. There was no evidence that the reduction in caterpillar availability resulting from the invasion had a concurrent negative effect on the blue tit’s ability to successfully rear nestlings in optimal conditions, at least as measured here. Although the raw figures suggest an increased level of nutritional stress in blue tits breeding in invaded forests, the data analyses showed no significant alterations in terms of productiv- ity or offspring fitness. The reproductive performance of the blue tit has been shown to be remarkably resilient to the Argentine ant-mediated food shortage, either because the prey reduction following the invasion did not reach a critical threshold or because of compensa- tory activity by the progenitors. We cannot conclusively reject an ecological trap triggered by the ant invasion on blue tits, since neither fledgling recruitment nor the prospective survival of parents were assessed. Even though we could not confirm short-term consequences of the Argentine ant invasion on blue tit reproductive fitness, the long-term bottom-up effects of the invasion remain unknown and should not be ruled outPeer reviewe

    A Large-Scale FPGA-Based Trigger and Dead-Time Free DAQ System for the Kaos Spectrometer at MAMI

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    The Kaos spectrometer is maintained by the A1 collaboration at the Mainz Microtron MAMI with a focus on the study of (e,e'K^+) coincidence reactions. For its electron-arm two vertical planes of fiber arrays, each comprising approximately 10 000 fibers, are operated close to zero degree scattering angle and in close proximity to the electron beam. A nearly dead-time free DAQ system to acquire timing and tracking information has been installed for this spectrometer arm. The signals of 144 multi-anode photomultipliers are collected by 96-channel front-end boards, digitized by double-threshold discriminators and the signal time is picked up by state-of-the-art F1 time-to-digital converter chips. In order to minimize background rates a sophisticated trigger logic was implemented in newly developed Vuprom modules. The trigger performs noise suppression, signal cluster finding, particle tracking, and coincidence timing, and can be expanded for kinematical matching (e'K^+) coincidences. The full system was designed to process more than 4 000 read-out channels and to cope with the high electron flux in the spectrometer and the high count rate requirement of the detectors. It was successfully in-beam tested at MAMI in 2009.Comment: Contributed to 17th IEEE Real Time Conference (RT10), Lisbon, 24-28 May 201

    A measurable entanglement criterion for two qubits

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    We propose a directly measurable criterion for the entanglement of two qubits. We compare the criterion with other criteria, and we find that for pure states, and some mixed states, it coincides with the state's concurrency. The measure can be obtained with a Bell state analyser and the ability to make general local unitary transformations. However, the procedure fails to measure the entanglement of a general mixed two-qubit state.Comment: 5 page