4 research outputs found

    Frequ√™ncia de polimorfismos do gene TMEM18 numa popula√ß√£o de crian√ßas participantes de um estudo de coorte em Salvador ‚Äď BA

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    Introdu√ß√£o: O TMEM18 √© um gene localizado no cromossomo 2p25.3. A recente liga√ß√£o deste gene √† obesidade tem sido replicada em diversos estudos de associa√ß√£o gen√īmica para algumas variantes al√©licas. O presente artigo analisou as frequ√™ncias al√©licas e genot√≠picas de polimorfismos no gene TMEM18 numa amostra da popula√ß√£o de Salvador ‚Äď BA, e a diferen√ßa das MAFs encontradas em rela√ß√£o √†s principais popula√ß√Ķes que respondem pela composi√ß√£o √©tnica do Brasil ‚Äď amer√≠ndios, africanos e europeus. Metodologia: participaram deste estudo 1308 crian√ßas com idade entre 4 a 11 anos, integrantes de um estudo de coorte do projeto Social Changes, Asthmaand Allergy in LatinAmerica (SCAALA). Para a genotipagem dos indiv√≠duos foi utilizado o painel comercial Illumina Human Omni 2, com aproximadamente 2.5 milh√Ķes de marcadores. Utilizamos os softwares PLINK (PURCELL et al., 2007)¬† e Haploview (BROAD Institute) para controle de qualidade dos SNPs e an√°lise de agrega√ß√£o de hapl√≥tipos (Linkage Desequilibrium - LD>4.2%), respectivamente. Resultados: As variantes do gene TMEM18 encontradas localizam-se na regi√£o 3¬īUTR (rs17729501, rs17042334, rs3187671) e intr√īnica (rs73153245, rs73153246, rs4241323, rs12990777, e rs2293084). Todos os polimorfismos est√£o em equil√≠brio de Hardy-Weinberg. As frequ√™ncias dos alelos menos frequentes (MAFs) observadas (9% e 9,3%) foram para os SNPs rs17729501 ers17042334, respectivamente. ¬†Os polimorfismos com as menores MAFs - s17729501 (9%) e rs17729501 (9,3%) - apresentaram, simultaneamente, as menores frequ√™ncias genot√≠picas para homozigose, 0,5% (C/C) e 0,8% (T/T), respectivamente. As maiores taxas de heterozigose observadas na popula√ß√£o foram de 44% (A/C - rs2293084) e 47,3% (G/A -rs12990777) e correspondem √†s maiores frequ√™ncias al√©licas (rs2293084 ‚Äď 34,9%; rs12990777 - 47,3%). Os SNPs rs3187671, rs73153245 e rs73153246 est√£o em desequil√≠brio de liga√ß√£o. Conclus√£o: As frequ√™ncias al√©licas obtidas para os SNPs, de uma forma geral, diferiram das frequ√™ncias registradas para popula√ß√Ķes de refer√™ncia. O presente trabalho contribuiu com informa√ß√Ķes sobre a ocorr√™ncia de polimorfismos no TMEM18 na popula√ß√£o brasileira, bem como com as frequ√™ncias al√©licas dos SNPs analisadas para os futuros estudos do tipo GWAS.

    Educa√ß√£o em sa√ļde para usu√°rios homens de um centro municipal de sa√ļde: relato de experi√™ncia - Health education for men users from a municipal health center: experience report

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    Objetivo: Descrever a experi√™ncia de um grupo de discentes do 4¬į per√≠odo da gradua√ß√£o em enfermagem de uma universidade federal localizada no Rio de Janeiro acerca de atividades educativas em um centro municipal de sa√ļde. M√©todo: Trata-se de um relato de experi√™ncia de discentes do 4¬į per√≠odo de uma universidade federal localizada no Rio de Janeiro, acerca de uma interven√ß√£o em educa√ß√£o em sa√ļde de Homens, promovida em um centro municipal de sa√ļde. Resultados: Essa interven√ß√£o aconteceu no contexto do Est√°gio Supervisionado na Aten√ß√£o Prim√°ria e contemplou um grupo de usu√°rios homens do CMS, abordando as tem√°ticas: C√Ęncer de pr√≥stata, Exames de rotina, teste de PSA. Tais temas foram abordados em fun√ß√£o do cumprimento de a√ß√Ķes educativas previstas no calend√°rio do est√°gio. Conclus√£o: Dessa forma, observou-se que as a√ß√Ķes educativas de conscientiza√ß√£o s√£o essenciais para a dissemina√ß√£o de conhecimento acerca da sa√ļde individual e coletiva principalmente na ESF

    Overview of the order Zoantharia (Cnidaria: Anthozoa) in Brazil

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    Geoeconomic variations in epidemiology, ventilation management, and outcomes in invasively ventilated intensive care unit patients without acute respiratory distress syndrome: a pooled analysis of four observational studies

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    Background: Geoeconomic variations in epidemiology, the practice of ventilation, and outcome in invasively ventilated intensive care unit (ICU) patients without acute respiratory distress syndrome (ARDS) remain unexplored. In this analysis we aim to address these gaps using individual patient data of four large observational studies. Methods: In this pooled analysis we harmonised individual patient data from the ERICC, LUNG SAFE, PRoVENT, and PRoVENT-iMiC prospective observational studies, which were conducted from June, 2011, to December, 2018, in 534 ICUs in 54 countries. We used the 2016 World Bank classification to define two geoeconomic regions: middle-income countries (MICs) and high-income countries (HICs). ARDS was defined according to the Berlin criteria. Descriptive statistics were used to compare patients in MICs versus HICs. The primary outcome was the use of low tidal volume ventilation (LTVV) for the first 3 days of mechanical ventilation. Secondary outcomes were key ventilation parameters (tidal volume size, positive end-expiratory pressure, fraction of inspired oxygen, peak pressure, plateau pressure, driving pressure, and respiratory rate), patient characteristics, the risk for and actual development of acute respiratory distress syndrome after the first day of ventilation, duration of ventilation, ICU length of stay, and ICU mortality. Findings: Of the 7608 patients included in the original studies, this analysis included 3852 patients without ARDS, of whom 2345 were from MICs and 1507 were from HICs. Patients in MICs were younger, shorter and with a slightly lower body-mass index, more often had diabetes and active cancer, but less often chronic obstructive pulmonary disease and heart failure than patients from HICs. Sequential organ failure assessment scores were similar in MICs and HICs. Use of LTVV in MICs and HICs was comparable (42·4% vs 44·2%; absolute difference -1·69 [-9·58 to 6·11] p=0·67; data available in 3174 [82%] of 3852 patients). The median applied positive end expiratory pressure was lower in MICs than in HICs (5 [IQR 5-8] vs 6 [5-8] cm H2O; p=0·0011). ICU mortality was higher in MICs than in HICs (30·5% vs 19·9%; p=0·0004; adjusted effect 16·41% [95% CI 9·52-23·52]; p<0·0001) and was inversely associated with gross domestic product (adjusted odds ratio for a US$10 000 increase per capita 0·80 [95% CI 0·75-0·86]; p<0·0001). Interpretation: Despite similar disease severity and ventilation management, ICU mortality in patients without ARDS is higher in MICs than in HICs, with a strong association with country-level economic status
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