214 research outputs found

    Globalisation, Inequality and Health

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    As we suggested in a previous work (Borghesi and Vercelli, Sustainable globalisation, Ecological Economics, vol.44, n.1, 2003), the process of globalisation affects the sustainability of development mainly through three channels: economic growth, inequality and environmental degradation. This conceptual framework may help us to understand also the causal influence of globalisation on health that represents a fundamental dimension of the quality of life enjoyed by the people and of sustainability. For this purpose, the present paper aims to investigate both the direct and the indirect effects of post-war globalisation, with particular attention to the role played by inequality in the globalisation-health relationship. A few policy implications emerging from the analysis are also discussed, suggesting a policy strategy that can at the same time improve health and make the current globalisation process more compatible with sustainable development.globalisation, inequality, health, sustainable development

    CSR, rationality and the ethical preferences of investors in a laboratory experiment

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    This experimental study aims to clarify to what extent and in which direction investors react to CSR (Corporate Social Responsibility) initiatives meant to upgrade the ethical standards of firms beyond the minimal requirements of law. Subjects in the laboratory were invited to invest their endowment in a portfolio of financial assets. We provided information on the expected returns of each stock and on its inclusion in an ethical index, or exclusion from it. Our findings show that subjects’ behavior appears to be a function not only of their individual pay-offs but also of the information on the ethical standards of the firms issuing stocks. Most of them, however, did not show a fully irrational behavior as they consistently correlated the share of stocks with their expected returns. We may conclude that the sizeable reaction of our sample’s investors to the inclusion of a stock in the ethical index, or its exclusion from it, is the fruit of a deliberate choice

    Neuromuscular Junctions as Key Contributors and Therapeutic Targets in Spinal Muscular Atrophy

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    Spinal muscular atrophy (SMA) is a recessive autosomal neuromuscular disease, representing the most common fatal paediatric pathology. Even though, classically and in a simplistic way, it is categorized as a motor neuron (MN) disease, there is an increasing general consensus that its pathogenesis is more complex than expected. In particular, neuromuscular junctions (NMJs) are affected by dramatic alterations, including immaturity, denervation and neurofilament accumulation, associated to impaired synaptic functions: these abnormalities may in turn have a detrimental effect on MN survival.Here we provide a description of NMJ development/maintenance/maturation in physiological and pathological (SMA) conditions, focusing on pivotal molecules and on the time-course of pathological events. Moreover, since NMJs could represent an important target to be exploited for counteracting the pathology progression, we also describe several therapeutic strategies that, directly or indirectly, aim at NMJs
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