701 research outputs found

    Formulation and evaluation of transdermal delivery system of an anti-hypertensive drug

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    oai:ojs2.japtronline.com:article/1The present study was aims to formulate and evaluate transdermal drug delivery for sustained release of an anti-hypertensive drug Captopril, it is considered as drug of choice in anti hypertensive therapy and is reported for potential administration through transdermal route. The investigation was carried out to study the effect of different proportion of ethyl cellulose and PVP a hydrophobic and hydrophilic polymer respectively. Transdermal patches were prepared using different combination of the two polymers by solvent evaporation technique. Polyvinyl alcohol was used to prepare the backing membrane and dibutyl phthalate as a plasticizer. Several Physicochemical parameter like moisture content, moisture loss, thickness, film folding endurance, tensile strength, flatness were studied. For all the formulations, in vitro drug release was studied using modified diffusion cell. Formulations with highest proportion of polyvinyl pyrolidone shows faster release whereas increasing proportion of ethyl cellulose produces a prolonged regimen of sustained drug delivery through transdermal route for a period of 24 hrs

    Effect of supplementary pollination in grapes (Vitis vinifera)

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    In the variety Bharat Early, the weight of bunch and number of berries per bunch were markedly increased by supplementary pollinations with Pearl of Csaba and Pusa Seedless pollen as compared to control. However, berry weight was not altered. Shot berries were significantly reduced by all pollen including the self as compared to control. Least number of shot berries were obtained by using Pearl of Csaba and Pusa Seedless pollen.In the variety Pusa Seedless which is allied to Thompson Seedless the bunch weight was increased by Bharat Early, Beauty Seedless and Pearl of Csaba pollen. No significant increase in the number of berries per bunch resulted, but berry size was increased by these pollen

    Hazard Classification Testing of Primers used in Small Arms Ammunition.

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    Primer is a small initiating device used for ignition of propellant charge and subsequent ejection of projectile from a weapon. Hilherto, primers were classified under safely class. Recent accidents however, have raised doubts about their diversification. Field trials were therefore carried out to ascertain their correct behaviour under different conditions. It was observed that the nature of filling composition, its charge mass and the type of package had profound influence on the hazard classification which could change its classification from safety class to mass explosion hazard

    Community-engaged primary care medical education

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    BACKGROUND: Community-engaged medical education (CEME) requires medical schools to partner with local communities to help address community priorities, whilst enhancing the learning experiences of students. Current literature on CEME has focused on evaluating its effects on students; however, there remains a gap in exploring whether CEME initiatives can have a sustainable impact for communities. APPROACH: The Community Action Project (CAP) at Imperial College London, is an eight-week, community-engaged, quality improvement project for Year 3 medical students. Students initially consult with clinicians, patients and wider community stakeholders to understand local needs and assets, and identify a health priority to address. They then work with relevant stakeholders to design, implement and evaluate a project to help address their identified priority. EVALUATION: All CAPs (n = 264) completed in the 2019-2021 academic years were evaluated for evidence of several key areas, including community engagement and sustainability. 91% of projects evidenced a needs analysis, 71% demonstrated patient involvement in their development, and 64% demonstrated sustainable impacts from their projects. Analysis revealed the topics frequently addressed, and the formats used by students. Two CAPs are described in more detail to demonstrate their community impact. IMPLICATIONS: The CAP demonstrates how the principles of CEME (meaningful community engagement and social accountability) can lead to sustainable benefits for local communities through purposeful collaboration with patients and local communities. Strengths, limitations and future directions are highlighted

    Thermoelectric transport properties of a T-shaped double quantum dot system in the Coulomb blockade regime

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    We investigate the thermoelectric properties of a T-shaped double quantum dot system described by a generalized Anderson Hamiltonian. The system's electrical conduction (G) and the fundamental thermoelectric parameters such as the Seebeck coefficient (SS) and the thermal conductivity (κ\kappa), along with the system's thermoelectric figure of merit (ZT) are numerically estimated based on a Green's function formalism that includes contributions up to the Hartree-Fock level. Our results account for finite onsite Coulomb interaction terms in both component quantum dots and discuss various ways leading to an enhanced thermoelectric figure of merit for the system. We demonstrate that the presence of Fano resonances in the Coulomb blockade regime is responsible for a strong violation of the Wiedemann-Franz law and a considerable enhancement of the system's figure of merit (ZTZT).Comment: 7 pages, 10 figure