15 research outputs found

    Treatment decisions in T3N0M0 glottic carcinoma

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    Purpose: To analyze the results of T3N0M0 glottic carcinoma treated with radiotherapy, surgery, or both

    Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited

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    Aims: The purpose of this study was to review the treatment policy for locally advanced stage III and IV squamous cell carcinoma (SCC) of the tonsil at the Princess Alexandra Hospital Head and Neck Unit, Brisbane, Australia. Materials and Methods: The records of 148 patients with curable stage III and IV SCC of the tonsil were reviewed from the years 1992 to 2004 inclusive. During this period, patients were treated with surgery and postoperative radiotherapy and only offered definitive radiation if they were medically or surgically inoperable. There were 102 patients treated with surgery postoperative radiotherapy (group 1) and 46 patients treated with definitive radiotherapy chemotherapy (group 2). The endpoints of locoregional control (LRC), disease specific survival (DSS), and overall survival (OS) were studied and prognostic factors were investigated with univariate and multivariate analyses. Results. The 5-year OS, DSS, and LRC were 57%, 69%, find 84%, respectively. Univariate analyses showed that patients in group 1 had a superior OS (69% vs. 41%, P =.007), a trend toward improvement in LRC (88% vs. 73%, P =.08), and a nonsignificant improvement in DSS (75% vs. 56%, P =.14). There was a greater percentage of patients with an Eastern Cooperative Oncology Group (ECOG) score of 2 or less in group 1, suggesting selection bias toward the surgical group. Multivariate analyses, which adjusted for known prognostic factors, showed that treatment group was significant for OS but not for LRC or DSS. Conclusions. Surgery and postoperative radiotherapy continues to provide a superior outcome in locally advanced tonsil SCC in patients with surgically resectable disease, good ECOG performance status, and medically operable

    Early-stage vaginal carcinoma - an analysis of 70 patients

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    Objectives: The aims of this study were to assess outcomes and define prognostic factors for early-stage vaginal carcinoma

    A phase III study on the efficacy of topical aloe vera gel on irradiated breast tissue

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    The aim of the study was to see if topical aloe vera gel would be beneficial in reducing the identified skin side-effects of radiation therapy, including erythema, pain, itching, dry desquamation, and moist desquamation, when compared with aqueous cream. The secondary aim was to assess the effect of other factors known to predict severity of radiation skin reaction, le, breast size, smoking habit, and one or more drainages of lymphocele after surgery, on other skin side effects.A Phase III study was conducted involving 225 patients with breast cancer after lumpectomy or partial mastectomy, who required a course of radiation therapy using tangential fields. Patients were randomized to either topical aloe vera gel or topical aqueous cream to be applied 3 times per day throughout and for 2 weeks after completion of radiation treatment. Weekly skin assessments were performed by nursing staff.Aqueous cream was significantly better than aloe vera gel in reducing dry desquamotion and pain related to treatment. Subjects with D cup or larger size breasts experienced significantly more erythema, regardless of treatment arm. For subjects who had undergone lymphocele drainage, the aloe vera group experienced significantly more pain than the aqueous cream group. Within the aqueous cream arm, smokers were significantly more likely to experience itching within the treatment field than were nonsmokers. Within the aloe vera arm, subjects who had undergone one or more lymphocele drainages after surgery were significantly more likely to experience erythema and itching within the treatment field than those who did not have drainage.In this study, aloe vera gel did not significantly reduce radiation-induced skin side effects. Aqueous cream was useful in reducing dry desquamation and pain related to radiation therapy

    Australian Indigenous students: addressing equity issues in assessment

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    This article provides the background and context to the important issue of assessment and equity in relation to Indigenous students in Australia. Questions about the validity and fairness of assessment are raised and ways forward are suggested by attending to assessment questions in relation to equity and culture-fair assessment. Patterns of under-achievement by Indigenous students are reflected in national benchmark data and international testing programmes like the Trends in International Mathematics and Science Sstudy and the Program for International Student Assessment. The argument developed views equity, in relation to assessment, as more of a sociocultural issue than a technical matter. It highlights how teachers need to distinguish the "funds of knowledge" that Indigenous students draw on and how teachers need to adopt culturally responsive pedagogy to open up the curriculum and assessment practice to allow for different ways of knowing and being

    Efficacy and tolerability of concurrent weekly low dose cisplatin during radiation treatment of localised muscle invasive bladder transitional cell carcinoma: A report of two sequential phase II studies from the Trans Tasman Radiation Oncology Group

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    Background and purpose: To determine the feasibility, toxicity, and clinical effectiveness of concurrent weekly cisplatin chemotherapy in conjunction with definitive radiation in the treatment of localised muscle invasive bladder cancer

    Australian Torres Strait Islander students negotiate learning secondary school science in Standard Australian English: a tentative case for also teaching and assessing in Creole

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    [Extract] At the opening of the 42nd Australian National Parliament in early 2008, the Prime Minister of Australia, Mr Kevin Rudd, pledged to build new educational opportunity\ud for indigenous children of Torres Strait Islander and Aboriginal descent. The discourse used was that of "closing the gap" on both opportunity and academic achievement.\ud The persistent difference in educational achievement and attainment between indigenous Australians (Aboriginal and Torres Strait Islander people) and non-indigenous\ud Australians (immigrants to the continent since 1788 and their descendents) is a problem with many complexities, including tolerated failure on the part of state and\ud federal governments over many decades to vigorously address persistent educational disadvantage. Australia has been described as a "high quality-low equity" country in\ud that Australian schools, while operating under high-quality policy frameworks, have found it difficult to address equity issues in teaching, learning and assessment effectively in practice (Klenowski 2009)