28 research outputs found

    STATUS OF APPLYING OF INTERNATIONAL ENERGY MANAGEMENT STANDARDS IN UKRAINE

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    National standards harmonized with international, which are fundamental for the creation of efficient energy management systems. However, the requirements of Directive 2012/27 / EU fully expedient is to harmonize all the ISO 50000 series of standards, as well as the related series of standards EN 16247 (energy audits), ISO 11011 (evaluation of the energy efficiency of compressed air systems), ISO / ASME 14414 (evaluation energy pump installations), ISO 80000-1 and IEC 60027 series (scientific and mathematical quantities and their units, letter symbols), ISO / IEC / TS 17022 (requirements and recommendations for the content of the report of the Audit management system, conducted by a third party), ISO / IEC / TS 17023 (installation for determining the duration of the certification audits of management systems), ISO / TR 16344 (terms, definitions and symbols to assess the energy performance and energy certification of buildings), ISO 16818 (the terminology of energy efficiency in the design of engineering systems of buildings) , ISO 17747 (determination of the energy saving potential in organizations), ISO / IEC guide 98-3 (guide to the expression of uncertainty in measurement).National standards harmonized with international, which are fundamental for the creation of efficient energy management systems. However, the requirements of Directive 2012/27 / EU fully expedient is to harmonize all the ISO 50000 series of standards, as well as the related series of standards EN 16247 (energy audits), ISO 11011 (evaluation of the energy efficiency of compressed air systems), ISO / ASME 14414 (evaluation energy pump installations), ISO 80000-1 and IEC 60027 series (scientific and mathematical quantities and their units, letter symbols), ISO / IEC / TS 17022 (requirements and recommendations for the content of the report of the Audit management system, conducted by a third party), ISO / IEC / TS 17023 (installation for determining the duration of the certification audits of management systems), ISO / TR 16344 (terms, definitions and symbols to assess the energy performance and energy certification of buildings), ISO 16818 (the terminology of energy efficiency in the design of engineering systems of buildings) , ISO 17747 (determination of the energy saving potential in organizations), ISO / IEC guide 98-3 (guide to the expression of uncertainty in measurement)

    Dynamics of incidence of mental and behavior disorders in children of Ukraine: a 25-years’ observation experience.

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    Disorders of the psyche and behavior among children is an urgent problem of modern pediatric science and medical practice. The high prevalence of this pathology may be a result of the unfavorable psychological state of society, aggressive effects of the unfiltered information and negative influence of the environment (including radiatioactive factors) on the mind and body of the child. We have studied a 25-years’ trends in morbidity of mental illneses and behavior disorders among children of Ukraine in order to determine the impact of environmental factors (in particular - radioactivity after Chernobyl disaster in 1986) on their development. We have performed an analysis of the incidence and prevalence of psychiatric and behavioral disorders (PBD) among  children from different regions of Ukraine, including radioactive regions, contaminated after Chernobyl disaster. We used methods of statistical evaluation and epidemiological analysis of statistical data about the mental health of children of the country, aquired from the Ministry of Health of Ukraine. Over the past 25 years, we have observed trend of  reducing the incidence of PBD among children of Ukraine to 3.77 cases per 1,000 children (p<0.01) with prevalence of this pathology among children from large industrial and agricultural regions of the country. We have connected this trend with significant toxic influence of environmental factors on the child's organism. The incidence of PBD in the last 25 years among children from the regions of the country contaminated by the Chernobyl accident in 1986  (especially in Chernihiv and Zhytomyr regions) has exceeded the national incidence rates of PBD and its incidence among children from regions without territories of radiological control. In early 1990s the incidence of mental and behavioral disorders was high among children affected by Chornobyl accident. But over the last 25 years the incidence of PBD has become lower and now its level is even lower than among children who permanently lived in areas contaminated by radiation after the Chernobyl accident and the national incidence rate of PBD among children. The results of our 25-years’ follow-up of PBD morbidity among Ukrainian children have shown that children with prolonged exposure to ecotoxic factors, including radiation, have higher levels of prevalence and incidence of mental and behavioral disorders compared with other children. All this testify that there is a need of a proper correction programs and special attention to this cohort of children

    Особливості організації та використання засобів міні-тенісу у фізичному вихованні молодших школярів

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    Deals with the characteristics of the organization and use of mini-tennis in physical education primary school children as one of the new technologies improve sports and recreational activities during physical education. Mini-tennis in the system of sports and recreational activities and conduct training process is an effective tool in the formation of interest to younger pupils. The system of gradual development allows children to make progress in accordance with the age-related capabilities, confidence and reference-point on competitionsРассматриваются вопросы организации и использования средств мини-тенниса в физическом воспитании младших школьников как одной из новых технологий повышения эффективности физкультурно-оздоровительных занятий в процессе физического воспитания. Мини-теннис в системе физкультурно-оздоровительных занятий и проведения учебно-тренировочного процесса является эффективным средством формирования интереса к занятиям физической культурой младших школьников. Система постепенного развития позволяет детям прогрессировать в соответствии со своими возрастными способностями, уверенностью и ориентиром на соревнованияРозглядаються питання організації та використання засобів міні-тенісу у фізичному вихованні молодших школярів як однієї із нових технологій підвищення ефективності фізкультурно-оздоровчих занять у процесі фізичного виховання. Міні-теніс у системі фізкультурно-оздоровчих занять та проведення навчально-тренувального процесу є ефективним засобом формування інтересу до занять фізичною культурою молодших школярів.  Система ступеневого розвитку дозволяє дітям прогресувати у відповідності зі своїми віковими здібностями, упевненістю і орієнтиром на змаганн

    Способ получения соли олигогексаметиленгуанидина высокой степени чистоты

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    Objectives. Given that microorganisms can become resistant to certain groups of drugs and considering also their ability to form biofilms, the development of new drugs that are active against adapted microflora is required. This study focused on the development of a new method for the synthesis of a promising compound, the branched hydrosuccinate oligohexamethylene guanidine (OHMGsucc), with high purity that meets the standards of the 14th edition State Pharmacopeia of the Russian Federation (SPRF). Previously proposed methods have managed to isolate this product, which, however, complies with the requirements of the outdated SPRF. Therefore, the main aim of this study was to update the regulatory framework for the indicated OHMG salt for its further use in the pharmaceutical industry according to modern standards.Methods. To control the residual impurities of hexamethylenediamine (HMDA) and guanidine hydrochloride (GHC), high-performance liquid chromatography (HPLC) was applied using a Thermo Scientific Dionex UltiMate 3000 chromatograph, and the chromatographic signals of the test solution with those of a standard sample solution obtained by a previously published conventional method were compared.Results. The HPLC experimental data indicated a significant difference in the quantitative content of HMDA and GHC observed for the new and older preparation method of the branched OHMGsucc, suggesting that the method disclosed in this article can be used to obtain highly pure OHMGsucc.Conclusions. The specified compound was standardized with the parameter “related impurities” according to the current (14th) edition of the SPRF. The effectiveness and reproducibility of the proposed method was experimentally confirmed. In addition, a process diagram for the preparation of the indicated OHMG salt was prepared.Цели. На фоне приобретения микроорганизмами резистентности к определенным группам лекарственных средств, а также способностей образовывать биопленки, требуются новые препараты, активные против адаптированной микрофлоры. Cтатья посвящена изысканию способа получения перспективного соединения – разветвленного гидросукцината олигогексаметиленгуанидина с высокой степенью чистоты, соответствующей нормам Государственной Фармакопеи 14 издания. Так как предложенные ранее методы позволяли получить продукт, удовлетворяющий требованиям устаревшей Государственной Фармакопеи, то основной целью являлась актуализация нормативной базы в отношении указанной соли олигогексаметиленгуанидина для ее дальнейшего применения в фармацевтической отрасли согласно современным стандартам.Методы. Для контроля примесных соединений – гексаметилендиамина и гуанидина гидрохлорида применяли высокоэффективную жидкостную хроматографию, которую проводили на хроматографе Thermo Scientific Dionex UltiMate 3000 методом внешнего стандарта.Результаты. На основании экспериментальных данных, полученных с помощью высокоэффективной жидкостной хроматографии, отображена разница в количественном содержании остаточных примесей в составе субстанции разветвленного гидросукцината олигогексаметиленгуанидина, полученной двумя разными способами. Отмечено, что способ, предложенный авторами настоящей статьи, позволяет снизить их содержание по сравнению с конвенциональным методом.Выводы. Согласно представленным данным проведена стандартизация указанного соединения по параметру «Родственные примеси» в соответствии с актуальным на данный момент изданием Государственной Фармакопеи. Вследствие того, что эффективность предложенного метода экспериментально подтвердилась, на заключительном этапе работы была составлена технологическая схема получения указанной соли олигогексаметиленгуанидина

    Реализация фармацевтической разработки с применением многофакторного анализа многокритериальной оптимизации на примере этапа очистки гидросукцината олигогексаметиленгуанидина

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    Objectives. The study set out to use mathematical modeling, in particular the method of multifactorial analysis of multicriteria optimization (MAMO), in the development of a pharmaceutical product.Methods. After carrying out experimental tests based on the proposed algorithmic sequence, the obtained data were interpreted using MAMO.Results. The possibility of using MAMO to solve the applied problem of purifying oligohexamethyleneguanidine hydrosuccinate (OHMG-HS), considered as a pharmaceutical precursor for the creation of medicines, was demonstrated.Conclusions. The expediency of using the proposed algorithm as a tool for pharmaceutical development is substantiated by identifying dependencies of the influence of purification conditions on the final content of admixtures in the target product.Цели. Данное исследование посвящено использованию математического моделирования, в частности метода многофакторного анализа многокритериальной оптимизации (МАМО), в фармацевтической разработке.Методы. В ходе исследования была предложена алгоритмическая последовательность эксперимента и проведены необходимые испытания. Полученные данные были интерпретированы при помощи МАМО.Результаты. Изучена возможность применения МАМО для решения прикладной проблемы очистки гидросукцината олигогексаметиленгуанидина (ОГМГ-ГС), рассматриваемого в качестве фармацевтической субстанции для создания лекарственных средств.Выводы. Были выявлены зависимости влияния условий очистки на конечное содержание примесей в целевом продукте и доказана целесообразность использования предложенного алгоритма в качестве инструмента фармацевтической разработки

    Investigation of oncolytic potential of vaccine strains of yellow fever and tick-borne encephalitis viruses against glioblastoma and pancreatic carcinoma cell lines

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    Introduction. Flaviviruses, possessing natural neurotropicity could be used in glioblastoma therapy using attenuated strains or as a delivery system for antitumor agents in an inactivated form. Objective. To investigate the sensitivity of glioblastoma and pancreatic carcinoma cell lines to vaccine strains of yellow fever and tick-borne encephalitis viruses. Materials and methods. Cell lines: glioblastoma GL-6, T98G, LN-229, pancreatic carcinoma MIA RaCa-2 and human pancreatic ductal carcinoma PANC-1. Viral strains: 17D yellow fever virus (YF), Sofjin tick-borne encephalitis virus (TBEV). Virus concentration were determined by plaque assay and quantitative PCR. Determination of cell sensitivity to viruses by MTT assay. Results. 17D YF was effective only against pancreatic carcinoma tumor cells MIA Paca-2 and had a limited effect against PANC-1. In glioblastoma cell lines (LN229, GL6, T98G), virus had no oncolytic effect and the viral RNA concentration fell in the culture medium. Sofjin TBEV showed CPE50 against MIA Paca-2 and a very limited cytotoxic effect against PANC-1. However, it had no oncolytic effect against glioblastoma cell lines (LN229, T98G and GL6), although virus reproduction continued in these cultures. For the GL6 glioblastoma cell line, the viral RNA concentration at the level with the infection dose was determined within 13 days, despite medium replacement, while in the case of the LN229 cell line, the virus concentration increased from 1 × 109 to 1 × 1010 copies/ml. Conclusion. Tumor behavior in organism is more complex and is determined by different microenvironmental factors and immune status. In the future, it is advisable to continue studying the antitumor oncolytic and immunomodulatory effects of viral strains 17D YF and Sofjin TBEV using in vivo models

    METHODOLOGICAL FOUNDATIONS OF ANALYSIS AND FORECASTING OF GAS CONSUMPTION IN THE SYSTEM OF ENERGY BALANCE OF UKRAINE BY USING THE GROUP METHOD OF DATA HANDLING

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    This research deals with issues of gas consumption in Ukraine. The dynamics of consumption of gas is analysed and proposed guidelines for the efficient production, consumption and import of gasin Ukraine. Constructed and developed predictive models of gas consumption in Ukraine through the use of modern software and using the group method of data handling, which allowed building adequate predictive models of gas consumption in the system of Ukraine's energy balance. Researched and forecasted scenarios of gas consumption in the Ukraine. The problem of efficient use of energy resources is critical for sustainable economic development against the backdrop of energy saving national economy depends on energy imports, on the one hand, and rising prices for these resources. The basic foundation of the formation energy system of Ukraine is to build forecasting scenarios for different types of energy and different criteria for effective use of energy resources. Solving this problem is not only with ensuring energy security, but also with the level of development of regions of Ukraine and ensuring quality of life. Prediction of gas consumption in Ukraine today is an extremely important issue of strategic importance since conducted through analysis and building predictive models will be possible to develop guidelines for the efficient production and consumption of gas across Ukraine as a whole

    Методологічні основи аналізу та прогнозування споживання газу в системі енергетичного балансу України шляхом використання методу групового урахування аргументів

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    This research deals with issues of gas consumption in Ukraine. The dynamics of consumption of gas is analysed and proposed guidelines for the efficient production, consumption and import of gasin Ukraine. Constructed and developed predictive models of gas consumption in Ukraine through the use of modern software and using the group method of data handling, which allowed building adequate predictive models of gas consumption in the system of Ukraine's energy balance. Researched and forecasted scenarios of gas consumption in the Ukraine.The problem of efficient use of energy resources is critical for sustainable economic development against the backdrop of energy saving national economy depends on energy imports, on the one hand, and rising prices for these resources. The basic foundation of the formation energy system of Ukraine is to build forecasting scenarios for different types of energy and different criteria for effective use of energy resources. Solving this problem is not only with ensuring energy security, but also with the level of development of regions of Ukraine and ensuring quality of life.Prediction of gas consumption in Ukraine today is an extremely important issue of strategic importance since conducted through analysis and building predictive models will be possible to develop guidelines for the efficient production and consumption of gas across Ukraine as a whole.У даній роботі розглянуто проблемні питання споживання газу по Україні. Проаналізовано динаміку споживання газу та запропоновано методичні рекомендації щодо ефективного видобування, споживання та імпорту газу по всій Україні в цілому. Побудовано та розроблено прогнозні моделі споживання газу в Україні, завдяки використанню сучасного програмного забезпечення та з використанням методу групового урахування аргументів, який дозволив побудувати адекватні прогнозовані моделі споживання енергоресурсів у системі енергетичного балансу України. Досліджено та розроблено прогноз сценаріїв споживання газу загалом по Україні.Проблема ефективного використання паливно-енергетичних ресурсів є вкрай важливою для сталого економічного розвитку енергетики на тлі збереження залежності національної економіки від імпорту енергоносіїв, з одного боку, а також зростання цін на дані ресурси. Базовою основою формування енергосистеми України є побудова прогнозних сценаріїв за різними видами енергоресурсів та різноманітними критеріями ефективного використання паливно-енергетичних ресурсів. Вирішення даної проблеми пов’язано не лише із забезпеченням енергетичної безпеки країни, але також з підвищенням рівня розвитку регіонів України та забезпечення якості життя населення.Прогнозування споживання газу в Україні на сьогодні є вкрай важливим питанням стратегічного значення, оскільки завдяки проведеному аналізу та побудові прогнозованих моделей можливо буде розробити методичні рекомендації щодо ефективного виробництва та споживання газу по всій Україні в цілому

    The Effectiveness of Various Surgical Techniques in the Treatment of Local Knee Cartilage Lesions (Review)

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    Introduction. To restore the knee local cartilage lesions, a large number of alternative surgical techniques are used in clinical practice: isolated debridement of the lesion area, chondrogenesis stimulation, mosaic osteochondral grafting, cell technologies, collagen membranes (matrices), and a combination of the above methods. The purpose of this article was to compare the effectiveness of various surgical methods of treating patients with local cartilage lesions of the femur based on analysis of relevant publications. Materials and Methods. The review included 85 publications of domestic and foreign authors within 2005 to 2020. The search was carried out in electronic scientific databases PubMed and eLIBRARy. Results. The medium and long term outcomes of debridement and/or various options of chondrogenesis stimulating, despite their wide popularity, in terms of clinical, radiological, and histological indicators, are inferior to all other surgical techniques. Mosaic osteochondral auto- and/or allografting, as well as transplantation of autologous chondrocytes culture with a collagen membrane, are characterized by the best 15 to 20-year outcomes, allowing most patients to maintain the same level of activity as before the lesion occurred. The combination of matrices with other cellular products or microfracturing shows similar medium-term results, but it long-term efficacy remains unknown. Conclusion. The use of debridement and/or chondrogenesis stimulation should be limited to minimal defects. From both a clinical and an economic point of view, mosaic osteochondral grafting is the optimal method for the treatment of knee local cartilage lesions with an area up to 4 to 6 cm2 . The combination of membranes with various cellular products or microfracturing is indicated in case of extensive local cartilage lesions or if mosaic osteochondral grafting is not appropriate
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