2,027 research outputs found

    CREATe public lectures on the proposed EU right for press publishers

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    Presents the edited text of lectures by Hoppner and Xalabarder arguing in favour and against the proposal to extend Directive 2001/29 arts 2 and 3 to press publishers, providing them with the exclusive right to publish journalistic material online for a period of 20 years. Discusses the controversies surrounding two similar initiatives in Germany and Spain

    CERTIFICATION REPORT The Certification of the Mass Fractions of As, Br, Cd, Cl, Cr, Hg, S, Sb, Sn and Zn in Low-Density Polyethylene: ERM-EC681m

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    This report describes the production of ERM-EC681m, a low-density polyethylene material certified for the mass fraction of elements. The material was produced following ISO Guide 34:2009. An LDPE material containing certain elements was prepared from commercially sourced low-density polyethylene and organic and inorganic pigments. The material was extruded, mixed and filled into bottles. Between-bottle homogeneity was quantified and stability during dispatch and storage were assessed in accordance with ISO Guide 35:2006. The within-unit homogeneity was quantified to determine the minimum sample intake. The material was characterised by an intercomparison among laboratories of demonstrated competence and adhering to ISO/IEC 17025. Technically invalid results were removed but no outlier was eliminated on statistical grounds only. Uncertainties of the certified values were calculated in compliance with the Guide to the Expression of Uncertainty in Measurement (GUM) and include uncertainties related to possible inhomogeneity, and instability and to characterisation. The material is intended for the quality control and/or assessment of method performance. As any reference material, it can also be used for control charts, validation studies or calibration of methods. The CRM is available in glass bottles containing 100 g of polyethylene granulate. The minimum amount of sample to be used is 150 mg for the determination of Cl and 60 mg for the determination of all other elements. The CRM was accepted as European Reference Material (ERM®) after peer evaluation by the partners of the European Reference Materials consortium.JRC.D.2-Standards for Innovation and sustainable Developmen

    Hard Metal Production by ERS: Processing Parameter Roles in Final Properties

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    Cemented carbide is a hard composite material, used widely in a variety of industries. The value of the global tungsten carbide market is expected to grow by 4.4% (compound annual growth rate) from 2017 to 2022. One of the main markets is in metal cutting and wear parts, where small pieces (or inserts), a few grams in weight, are used. Field-assisted sintering technique (FAST) technologies allow for the production of small blanks in a single step from powder, which are near final dimensions. Production cycles are very short. In this paper, one of the FAST processes, the ERS technology, is applied to obtain WC10Co parts. A review of the process variable effects on the final properties of the parts is accomplished. Final properties of a range of conventionally produced inserts are obtained, using 100 MPa compacting pressure, 80 MA/m2 of current density, and processing times of around 800 ms.This research was funded by EU, grant number FoF.NMP.2013-10 608729 (7th Framework Programme) EFFIPRO

    Ethnographies of immigration detention

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    There has traditionally been a special relationship between the state, its citizens and the territory it controls, often thought of as a form of contract binding the three together. Huge shifts have occurred in recent years, however. Increased international mobility means non-citizens are showing up, legitimately or illegitimately, in unprecedented numbers. Consequently, "the immigrant" has become a new political and administrative object for (Western) states. The states, in turn, are developing new systems for the greeting, evaluation, classification and ultimately either integration or deportation of the outsiders at the border. Criminological scholarship has in recent years brought renewed attention to the transformative impact of migration on issues of crime and justice. Generally speaking, the focus has been on the impact of migration on crime practices and crime rates. Researchers have particularly focused on immigrant gangs, various forms of migration-related crime and the deepening of urban marginality. While acknowledging the importance of these contributions, we want to argue that there is also a need to describe systematically the specific impact that migratory flows have had on the everyday life of people on "both sides" in the migration control system. Migration control is, as migration itself, an intrinsically transnational phenomenon and thus challenges traditionally national footing of state policies and state laws. It involves measures within and beyond national and European territories. These practices create novel spaces and notions of territoriality: 'in between spaces', borderlands or what Saskia Sassen has called 'third spaces'. Our objective is to examine the spaces where national systems of justice meet their limits. We want to study these institutions ethnographically, "from the ground up", partly to compare different institutions in different jurisdictions and partly to explore whether it makes sense to see these institutions as part of the same development on the European level.info:eu-repo/semantics/publishedVersio

    The T3 receptor β1 isoform regulates UCP1 and D2 deiodinase in rat brown adipocytes

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    Brown adipose tissue (BAT) thermogenesis increases when uncoupling protein-1 (UCP1) is activated adrenergically and requires T3. In humans, UCP1 activation in BAT seems involved in body weight maintenance. BAT type 2 deiodinase (D2) increases in response to adrenergic agents, producing the T3 required for UCP1 expression. T3 actions are mediated by thyroid hormone nuclear T3 receptors (TR), TRα and TRβ. Studies in mice suggest that TRβ is required for UCP1 induction, whereas TRα regulates body temperature and adrenergic sensitivity. In the present study, we compare the effects of T3 vs. specific TRβ1 and TRα1 agonists [GC-1 and CO23] on the adrenergic induction of UCP1 and D2 in cultured rat brown adipocytes. T3 and GC-1 produced similar increases on UCP1, whereas CO23 increased UCP1 only at high doses (50 nM). GC-1 at low doses (0.2-10 nM) was less potent than T3, increasing the adrenergic stimulation of D2 activity and mRNA. At higher doses, GC-1 further stimulated whereas T3 inhibited D2 activity but not D2 mRNA, suggesting posttranscriptional effects. CO23 had no effect on D2 activity but increased D2 mRNA. T3, GC-1, or CO23 by themselves did not increase UCP1 or D2 mRNA. High T3 doses shortened D2 half-life and increased D2 turnover via proteasome, whereas GC-1 did not change D2 stability. The α1- and α2-adrenergic D2 responses increased using high T 3 doses. In summary, T3 increases the adrenergic stimulation of UCP1 and D2 expression mostly via the TRβ1 isoform, and in brown adipocytes, D2 is protected from degradation by the action of T 3 on TRβ1. Copyright © 2010 by The Endocrine Society.This work was supported by Research Grants SAF2006/01319 and SAF2009-09364 from Plan Nacional (Ministerio de Educación y Ciencia and Ministerio de Ciencia e Innovación) and FMM2006 from Fundación Médica Madrileña (Spain) (toM.-J.O.). Centro de Investigación Biomédica en Red de Fisiopatologia de la Obesidad y Nutrición (CIBERObn) is an initiative of Instituto de Salud Carlos III, Spain.Peer Reviewe

    Exploring Body Mass Index Changes in Left Ventricular Assist Device Patients

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    Background: Current treatment options for end-stage heart failure, such as transplantation, can be limited by obesity guidelines. Mechanical devices such as Left Ventricular Assistive Devices (LVAD) can bridge heart failure patients to transplantation, however, after implantation; some patients may experience weight gain that precludes them from transplantation. Therefore, the objective of this study was to evaluate weight changes after the implantation of an LVAD. Methods: A retrospective review of 130 patients receiving an LVAD were divided into two groups based on BMI at the time of implantation: obese (\u3e30 kg/m2) and non-obese (/m2). Patients were evaluated at three time points post LVAD implantation: 3, 6, and 12 months for changes in weight and BMI. Results: The mean BMI of the overall cohort at the time of LVAD implantation was 30.3 kg/m2. Patients who were not classified as obese at the time of LVAD implementation had a significant increase in BMI (2.1 kg/m2, p\u3c0.001) Conclusion: Weight gain after LVAD implementation is more likely in patients who are non-obese at the time of LVAD evaluation; however, obese subjects remained unlikely to lose weight one year post implantation

    Hydrogen Fluoride in High-Mass Star-forming Regions

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    Hydrogen fluoride has been established to be an excellent tracer of molecular hydrogen in diffuse clouds. In denser environments, however, the HF abundance has been shown to be approximately two orders of magnitude lower. We present Herschel/HIFI observations of HF J=1-0 toward two high-mass star formation sites, NGC6334 I and AFGL 2591. In NGC6334 I the HF line is seen in absorption in foreground clouds and the source itself, while in AFGL 2591 HF is partially in emission. We find an HF abundance with respect to H2 of 1.5e-8 in the diffuse foreground clouds, whereas in the denser parts of NGC6334 I, we derive a lower limit on the HF abundance of 5e-10. Lower HF abundances in dense clouds are most likely caused by freeze out of HF molecules onto dust grains in high-density gas. In AFGL 2591, the view of the hot core is obstructed by absorption in the massive outflow, in which HF is also very abundant 3.6e-8) due to the desorption by sputtering. These observations provide further evidence that the chemistry of interstellar fluorine is controlled by freeze out onto gas grains.Comment: accepted in Ap

    Posterior subhyaloid precipitates in cytomegalovirus retinitis

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    This study aims to report a novel finding of posterior subhyaloid precipitates (PSPs) in two patients with cytomegalovirus (CMV) retinitis. A small case series was conducted. Clinical findings, treatment, and follow-up of two patients with CMV and PSPs are presented. Inflammatory precipitates may collect in the posterior subhyaloid space in acute CMV retinitis and resolve with treatment

    2006-2007 Master Class - Qi Liu (Piano)

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