14 research outputs found

    Interaction plot reflecting significant moderation of rs16969968 on correlation between “<i>conscientiousness”</i> NEO-PI-R domain and the risk of CD and CIP in EA population.

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    <p>The Y axis represents the score of “conscientiousness” domain, while the X axis shows the phenotype examined (for cocaine and nicotine dependences zero stands for controls and one stands for cases; for cocaine induced paranoia zero stands for controls, one stands for cocaine dependent cases without CIP and two stands for cocaine dependent cases with CIP). The error bars represent standard error of calculated “<i>conscientiousness</i>” scores in each group of marital status in cases and controls. The asterisks indicate the two groups (controls and CD cases with symptoms of paranoia) that revealed significant interaction (there was no significant result observed between controls and CD cases without symptoms of paranoia or CD cases with and without symptoms of paranoia).</p

    Effect of marital status and <i>CHRNA5</i> (rs16969968) on the relationship between NEO-PI-R personality domains and CIP in AA and EA subjects.

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    <p>Reference group for marital status were subjects who have never been married. Reference group for the genotypes of rs16969968 were subjects who did not have any copies of minor allele. All odds ratios (OR) refer to 10 units change in personality scores, meaning that the presented odds of an individual developing CIP reflect the NEO-PI-R domain score change in the magnitude of 10. <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0049368#s3" target="_blank">Results</a> shown in the table are those of comparison between groups A (controls with no CIP) and C (CDs with CIP). Presented p-values are not adjusted for multiple testing. Bonferroni-corrected significance threshold was set to 1.67e-03. Significant p-values are highlighted in bold.</p

    Effect of marital status and <i>CHRNA5</i> (rs16969968) on the relationship between NEO-PI-R personality domains and CD in AA and EA subjects.

    No full text
    <p>Reference group for marital status were subjects who have never been married. Reference group for the genotypes of rs16969968 were subjects who did not have any copies of minor allele. All odds ratios (OR) refer to 10 units change in personality scores, meaning that the presented odds of an individual developing CD reflect the NEO-PI-R domain score change in the magnitude of 10. Presented p-values are not adjusted for multiple testing. Bonferroni-corrected significance threshold was set to 1.67e-03. Significant p-values are highlighted in bold.</p

    Effect of marital status and <i>CHRNA5</i> (rs16969968) on the relationship between NEO-PI-R personality domains and ND in AA and EA subjects.

    No full text
    <p>Reference group for marital status were subjects who have never been married. Reference group for the genotypes of rs16969968 were subjects who did not have any copies of minor allele. All odds ratios (OR) refer to 10 units change in personality scores, meaning that the presented odds of an individual developing ND reflect the NEO-PI-R domain score change in the magnitude of 10. Presented p-values are not adjusted for multiple testing. Bonferroni-corrected significance threshold was set to 1.67e-03. Significant p-values are highlighted in bold.</p

    Interaction plot reflecting significant moderation of marital status on correlation between “<i>openness to experience</i>” NEO-PI-R domain and the risk of CD, ND and CIP in EAs.

    No full text
    <p>The Y axis represents the score of “<i>openness to experience</i>” domain, while the X axis shows the phenotype examined (for cocaine and nicotine dependences zero stands for controls and one stands for cases; for cocaine induced paranoia zero stands for controls, one stands for cocaine dependent cases without CIP and two stands for cocaine dependent cases with CIP). The error bars represent standard error of calculated “<i>openness to experience</i>” scores in each group of marital status in cases and controls.</p

    Interaction plot reflecting significant moderation of marital status on correlation between “<i>neuroticism</i>” NEO-PI-R domain and the risk of CIP in EAs.

    No full text
    <p>The Y axis represents the score of “<i>neuroticism</i>” domain, while the X axis shows the categories of CIP: zero stands for controls, one stands for cocaine dependent cases without CIP and two stands for cocaine dependent cases with CIP. The error bars represent standard error of calculated “<i>neuroticism</i>” scores in each group of marital status in cases and controls. The asterisks indicate the two groups (controls and CD cases with symptoms of paranoia) that revealed significant interaction (there was no significant result observed between controls and CD cases without symptoms of paranoia or CD cases with and without symptoms of paranoia).</p

    DNA degradation in a subject's first mouthwash sample when analyzed as a risk-factor for DNA degradation in their second mouthwash sample.

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    <p>DNA degradation in a subject's first mouthwash sample when analyzed as a risk-factor for DNA degradation in their second mouthwash sample.</p

    Gel electrophoresis of mouthwash-extracted DNA.

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    <p>Agarose gel electrophoresis of DNA extracted from mouthwashes of 8 subjects (2 samples per subject). Subjects are identified by the figures above lanes. DNA extracted from one of the mouthwashes provided by subject 4 and both mouthwashes provided by subject 5 was found to be degraded.</p

    List of SNPs with observed association p-value being less than 1.00E-05.

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    <p>Chromosomal position is specified in Build 36 (hg18). OR refers to odds ratio and 95%CI refers to 95% confidence interval. <i>TRIM36</i> refers to tripartite motif containing 36 gene. <i>ZBTB16</i> refers to zinc finger and BTB domain containing 16 gene.</p><p>List of SNPs with observed association p-value being less than 1.00E-05.</p
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