290 research outputs found

    TRACTION DRIVE CVT TECHNOLOGIES FOR AIRCRAFT EQUIPMENT

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    ABSTRACT In 1996, research activities on traction drive CVT technologies was commenced in order to apply them to aircraft equipment. Extensive efforts have been conducted to overcome various technical barriers such as weight and severe environmental conditions with employing high speed traction drive technology, a split power mechanism and a sensorless control method using "Observer". Using these technologies, a all new concept IDG called "T-IDG ®" has been developed

    The p53 gene expression and its developmental regulation in schistosomes

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    We have studied the gene expression, especially of the oncoproteins, and its regulation in schistosomes. Schistosomes have a complex life cycle with defined dimorphic lifestyle. The parasite are so far unique in biology in expressing oncogene products in their adult stage. In order to characterize the expression and developmental regulation, a lambda gt 11 cDNA library and lambda EMBL4 genomic DNA library of each growth stage of Schistosoma mansoni and S. japonicum was constructed, and was screened with various monoclonal antibodies against ongogene products. One positive plaque reacted to anti-p53 antibody (Ab-2, Oncogene Science, Inc.) was further analyzed. This fusion protein was about 120 KDa in molecular weights, and expressed as 1.4 Kb RNA in the adult stage. P53 gene is well-known as the negative regulator of the cell cicle, and the mutations in the gene are turning out to be the most common genetic alterations in human cancers. The comparison of the gene structure among species and stages were being conducted. Chromosome structures, C-band formation, and the results of in situ hybridization using the phage probe would be discussed

    Adaptive Threonine Increase in Transmembrane Regions of Mitochondrial Proteins in Higher Primates

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    BACKGROUND: The mitochondrial (mt) gene tree of placental mammals reveals a very strong acceleration of the amino acid (AA) replacement rate and a change in AA compositional bias in the lineage leading to the higher primates (simians), in contrast to the nuclear gene tree. Whether this acceleration and compositional bias were caused by adaptive evolution at the AA level or directional mutation pressure at the DNA level has been vigorously debated. METHODOLOGY/PRINCIPAL FINDINGS: Our phylogenetic analysis indicates that the rate acceleration in the simian lineage is accompanied by a marked increase in threonine (Thr) residues in the transmembrane helix regions of mt DNA-encoded proteins. This Thr increase involved the replacement of hydrophobic AAs in the membrane interior. Even after accounting for lack of independence due to phylogeny, a regression analysis reveals a statistical significant positive correlation between Thr composition and longevity in primates. CONCLUSION/SIGNIFICANCE: Because crucial roles of Thr and Ser in membrane proteins have been proposed to be the formation of hydrogen bonds enhancing helix-helix interactions, the Thr increase detected in the higher primates might be adaptive by serving to reinforce stability of mt proteins in the inner membrane. The correlation between Thr composition in the membrane interior and the longevity of animals is striking, especially because some mt functions are thought to be involved in aging

    A Case of Moyamoya Syndrome with Subdural and Intracerebral Hematoma due to Different Bleeding Sources

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    One case with a moyamoya syndrome is reported in which each of an intracerebral and subdural hematoma was caused by different bleeding sources. At first, an intracerebral hematoma was made by rupture of moyamoya vessels per se. Then, distortion of the brain would have resulted in tearing of an aneurysm which had been formed by a overloading to its wall at one of transdural anastomotic channels. Thus a subdural hematoma was developed

    Subaru Observations for the K-band Luminosity Distribution of Galaxies in Clusters near to 3C 324 at z\sim1.2

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    We investigate the KK-band luminosity distribution of galaxies in the region of clusters at z1.2z\sim1.2 near to the radio galaxy 3C 324. The imaging data were obtained during the commissioning period of the Subaru telescope. There is a significant excess of the surface number density of the galaxies with K=K = 17--20 mag in the region within \sim 40'' from 3C 324. At this bright end, the measured luminosity distribution shows a drop, which can be represented by the exponential cut off of the Schechter-function formula; the best-fitted value of the characteristic magnitude, KK^{*}, is 18.4±0.8\sim 18.4\pm0.8. This measurement follows the evolutionary trend of the KK^* of the rich clusters observed at an intermediate redshift, which is consistent with passive evolution models with a formation redshift z_f \gtsim 2. At K \gtsim 20 mag, however, the excess of the galaxy surface density in the region of the clusters decreases abruptly, which may imply that the luminosity function of the cluster galaxies has a negative slope at the faint end. This may imply strong luminosity segregation between the inner and outer parts of the clusters, or some deficit of faint galaxies in the cluster central region of the cluster.Comment: 12 pages, 9 figures, accepted for publication in PAS

    High-Resolution Near-Infrared Imaging of the Powerful Radio Galaxy 3C 324 at z = 1.21 with the Subaru Telescope

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    We have obtained high-resolution K'-band images of the powerful z=1.206 radio galaxy 3C 324 with the Subaru telescope under seeing conditions of 0.3--0.4 arcsec. We clearly resolved the galaxy and directly compared it to the optical images obtained with the Hubble Space Telescope. The host galaxy of 3C 324 is revealed to be a moderately luminous elliptical galaxy with a smooth light profile. The effective radius of the galaxy, as determined by profile fitting, is 1.3+-0.1 arcsec (1.2 kpc), which is significantly smaller than the value of 2.2 arcsec, published in Best et al. (1998, MNRAS, 292, 758). The peak of the K'-band light coincides with the position of the radio core, which implies that the powerful AGN lies at the nucleus of the host galaxy. The peak also coincides with the gap in the optical knotty structures which may be a dust lane hiding the UV-optical emission of the AGN from our line of sight; it is very likely that we are seeing the obscuring structure almost edge-on. We clearly detected the `aligned component' in the K'-band image by subtracting a model elliptical galaxy from the observed image. The red R_F702W-K color of the outer region of the galaxy avoiding the aligned component indicates that the near infrared light of the host galaxy is dominated by an old stellar population.Comment: 21 pages (10 figures), accepted for publication in PAS

    Ambient fine and coarse particles in Japan affect nasal and bronchial epithelial cells differently and elicit varying immune response

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    Ambient particulate matter (PM) epidemiologically exacerbates respiratory and immune health, including allergic rhinitis (AR) and bronchial asthma (BA). Although fine and coarse particles can affect respiratory tract, the differences in their effects on the upper and lower respiratory tract and immune system, their underlying mechanism, and the components responsible for the adverse health effects have not been yet completely elucidated. In this study, ambient fine and coarse particles were collected at three different locations in Japan by cyclone technique. Both particles collected at all locations decreased the viability of nasal epithelial cells and antigen presenting cells (APCs), increased the production of IL-6, IL-8, and IL-1β from bronchial epithelial cells and APCs, and induced expression of dendritic and epithelial cell (DEC) 205 on APCs. Differences in inflammatory responses, but not in cytotoxicity, were shown between both particles, and among three locations. Some components such as Ti, Co, Zn, Pb, As, OC (organic carbon) and EC (elemental carbon) showed significant correlations to inflammatory responses or cytotoxicity. These results suggest that ambient fine and coarse particles differently affect nasal and bronchial epithelial cells and immune response, which may depend on particles size diameter, chemical composition and source related particles types
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