961 research outputs found

    Performance of a Large-area GEM Detector Read Out with Wide Radial Zigzag Strips

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    A 1-meter-long trapezoidal Triple-GEM detector with wide readout strips was tested in hadron beams at the Fermilab Test Beam Facility in October 2013. The readout strips have a special zigzag geometry and run along the radial direction with an azimuthal pitch of 1.37 mrad to measure the azimuthal phi-coordinate of incident particles. The zigzag geometry of the readout reduces the required number of electronic channels by a factor of three compared to conventional straight readout strips while preserving good angular resolution. The average crosstalk between zigzag strips is measured to be an acceptable 5.5%. The detection efficiency of the detector is (98.4+-0.2)%. When the non-linearity of the zigzag-strip response is corrected with track information, the angular resolution is measured to be (193+-3) urad, which corresponds to 14% of the angular strip pitch. Multiple Coulomb scattering effects are fully taken into account in the data analysis with the help of a stand-alone Geant4 simulation that estimates interpolated track errors.Comment: 30 pages, 28 figures, submitted to NIM

    Evaluating Digital Humanities Projects: Collaborative Course Assessment

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    Curatorial note from Digital Pedagogy in the Humanities: This assignment includes multiple measures, collaboration, integration of concepts outside the classroom, and modeling professional expectations. Students evaluate digital humanities projects and use digital markup tools to learn how to collaboratively evaluate and respond to digital work. This is an example of learning by doing: the form and content of the assignment and the assessment work together seamlessly. Students are assessed on how they mark up the digital work, how they work in a group collaboratively, and how they respond to digital work. The task models how they will be evaluated, and it is a precursor to how students will use technology in professional environments. The assessment design mimics professional work life, allowing students to perform and be evaluated in a more realistic context with professional stakes

    Perfil clĂ­nico-epidemiolĂłgico de pacientes com hansenĂ­ase atendidos em hospital universitĂĄrio no Rio de Janeiro entre 2008 e 2017

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    Modelo do estudo: Estudo observacional, longitudinal, retrospectivo e descritivo de uma coorte de pacientes. Objetivo: Descrever o perfil clĂ­nico e epidemiolĂłgico dos pacientes com diagnĂłstico de hansenĂ­ase, atendidos em um centro de referĂȘncia no estado do Rio de Janeiro. Metodologia: Foram incluĂ­dos todos os pacientes com diagnĂłstico de hansenĂ­ase atendidos no Hospital UniversitĂĄrio GaffrĂ©e e Guinle entre os anos de 2008 a 2017. Os dados foram coletados atravĂ©s da revisĂŁo de prontuĂĄrios e analisados atravĂ©s de estatĂ­stica descritiva, utilizando-se o software SPSS 22.0 database . Resultados: Um total de 112 pacientes foi incluĂ­do no estudo, sendo que 54,5% eram do sexo masculino. A mĂ©dia de idade foi de 49,9 anos, 62,4% eram moradores do municĂ­pio do Rio de Janeiro e 69,9% apresentaram formas clĂ­nicas multibacilares da hansenĂ­ase. Foi possĂ­vel avaliar o grau de incapacidade inicial de 36 (32,1%) dos pacientes incluĂ­dos. Desses, 25% apresentaram grau de incapacidade inicial II. Durante o tratamento poliquimioterĂĄpico, 21 (18,8%) pacientes apresentaram algum efeito colateral, sendo o mais comum a anemia relacionada Ă  dapsona. Cinquenta e nove (52,7%) pacientes apresentaram algum tipo de estado reacional da hansenĂ­ase e 10 (8,9%) apresentaram complicaçÔes sistĂȘmicas graves durante o acompanhamento. ConclusĂ”es: O presente estudo evidenciou um perfil clĂ­nico-epidemiolĂłgico diferente do descrito na literatura, com uma grande porcentagem de pacientes com grau de incapacidade inicial II, uma alta frequĂȘncia de estados reacionais e de complicaçÔes advindas do curso clĂ­nico da doença ou dos tratamentos implementados.Introduction: This was an observational, longitudinal, retrospective and descriptive study of a cohort of patients. Objectives: To describe the clinical and epidemiological profile of the patients diagnosed with leprosy admitted to a reference medical center in the State of Rio de Janeiro. Methods: All leprosy patients admitted to the dermatology clinic from the Hospital UniversitĂĄrio GaffrĂ©e and Guinle between 2008 and 2017 were included. Pertinent patients’ data were collected through medical charts review. Data were then analyzed through descriptive statistics using SPSS 22.0  software.  Results: a total of 112 patients were included in the study. Among them, 54.5% were male, the median age was 49.9 years old, 62.4% were residents in the city of Rio de Janeiro and 69.9% presented multibacillary leprosy clinical forms. We evaluated the initial disability grade of 36 from the 112 included patients,  and out of them,  25% had grade II disability. During multidrug therapy, 21 (18.8%) patients presented an adverse effect, which is the most common anemia related to Dapsone. Fifty-nine (52.7%) patients presented leprosy reaction and 10 (8.9%) patients presented severe systemic complications during the follow-up. Conclusions: In the present study, it was observed a distinctive clinical and epidemiological leprosy profile. There was a high frequency of grade II initial disability, leprosy reaction and severe clinical complications due to the progression of the disease or as adverse effects of leprosy treatment

    LC-MS and NMR Based Structural Characterization and Isotopic Abundance Ratio Analysis of Magnesium Gluconate Treated with the Consciousness Energy Healing

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    Magnesium gluconate is widely used pharmaceutical/nutraceutical compound for the prevention and treatment of magnesium deficiency diseases. The present study was designed to explore the effect of The Trivedi Effect¼ - Energy of Consciousness Healing Treatment (Biofield Energy Healing Treatment) on magnesium gluconate for the change in the structural properties and isotopic abundance ratio (PM+1/PM and PM+2/PM) using LC-MS and NMR spectroscopy. Magnesium gluconate was divided into two parts – one part was control, and another part was treated with The Trivedi Effect¼ - Energy of Consciousness Healing Treatment remotely by twenty renowned Biofield Energy Healers and defined as The Trivedi Effect¼ treated sample. The LC-MS analysis of both the control and Biofield Energy Treated samples indicated the presence of mass of the protonated magnesium gluconate at m/z 415 at the retention time of 1.52 min and fragmentation pattern of both samples were almost identical. The relative peak intensities of the fragment ions were significantly altered in the treated sample compared to the control sample. The proton and carbon signals for CH, CH2 and CO groups in the proton and carbon NMR spectra of the control and treated samples were found same. The percentage change in the isotopic abundance ratio of PM+1/PM (2H/1H or 13C/12C or 17O/16O or 25Mg/24Mg) was significantly decreased in the treated sample by 48.87% compared to the control sample. Subsequently, the isotopic abundance ratio of PM+2/PM (18O/16O or 26Mg/24Mg) in the treated sample was significantly increased by 29.18% compared with the control sample. In summary, 13C, 2H, 17O, and 25Mg contributions from (C12H23MgO14)+ to m/z 416; 18O and 26Mg contributions from (C12H23MgO14)+ to m/z 417 in the treated sample were significantly altered compared with the control sample. Thus, The Trivedi Effect¼ Treated magnesium gluconate might be helpful to design the novel potent enzyme inhibitors using its kinetic isotope effects. Consequently, The Trivedi Effect¼ Treated magnesium gluconate would be valuable for designing better pharmaceutical and/or nutraceutical formulations through its altered physicochemical and thermal properties, which might be providing better therapeutic response against various diseases such as diabetes mellitus, allergy, aging, inflammatory diseases, immunological disorders, and other chronic infections. https://www.trivedieffect.com/science/lc-ms-and-nmr-based-structural-characterization-and-isotopic-abundance-ratio-analysis-of-magnesium-gluconate-treated-with-the-consciousness-energy-healing http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=216&paperId=1002165

    Evaluation of the Physicochemical, Spectral, Thermal and Behavioral Properties of Sodium Selenate: Influence of the Energy of Consciousness Healing Treatment

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    Sodium selenate is an inorganic nutraceutical/pharmaceutical compound used for the prevention and treatment of several diseases. The current research article was aimed to explore the effect of The Trivedi Effect¼ - Energy of Consciousness Healing Treatment on the physicochemical, spectral, thermal, and behavioral properties of sodium selenate using PXRD, PSD, FT-IR, UV-vis, TGA, and DSC analysis. Sodium selenate was divided into two parts – one part was control, while another part was The Trivedi Effect¼ Treated sample which was received The Trivedi Effect¼ remotely by twenty renowned Biofield Energy Healers. A significant alteration of the crystallite size of the treated sample was observed in the range of -42.87% to 39.99% compared to the control sample. Consequently, the average crystallite size was significantly enhanced in the treated sample by 5.07% compared with the control sample. The particle size distribution of the treated sample at d10, d50, and d90 values were significantly reduced by 7.68%, 9.49%, and 4.08%, respectively compared with the control sample. Subsequently, the surface area of the treated sample was significantly increased by 8.16% compared with the control sample. The control and treated FT-IR spectra exhibited the sharp and strong vibration bands at 889 cm-1 and 888 cm-1, respectively for Se=O stretching. The control and treated samples displayed the maximum absorbance at 204.9 nm and 204.5 nm, respectively. A significant reduction of total weight loss by 6.11% in the treated sample indicated the improvement of the thermal stability of the treated sample compared with the control sample. The vaporization temperature of the treated sample (95.68°C) was higher with a significant reduced latent heat of vaporization by 60.80% compared to the control sample (95.29°C). Thus, The Trivedi Effect¼ - Energy of Consciousness Healing Treatment might produce a new polymorphic form of sodium selenate which would be more soluble, dissolution rate, bioavailable, and thermally stable compared with the untreated sample. The Trivedi Effect¼ treated sodium selenate would be very suitable to design improved nutraceutical and pharmaceutical formulations that might provide better therapeutic response against several diseases such as stress, aging, inflammatory diseases, immunological disorders, infectious diseases, cancer, etc. Source: https://www.trivedieffect.com/science/evaluation-of-the-physicochemical-spectral-thermal-and-behavioral-properties-of-sodium-selenate-influence-of-the-energy-of-consciousness-healing-treatment http://www.sciencepublishinggroup.com/journal/paperinfo?journalid=398&doi=10.11648/j.ajqcms.20170101.1

    Identification of heavy-flavour jets with the CMS detector in pp collisions at 13 TeV

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    Many measurements and searches for physics beyond the standard model at the LHC rely on the efficient identification of heavy-flavour jets, i.e. jets originating from bottom or charm quarks. In this paper, the discriminating variables and the algorithms used for heavy-flavour jet identification during the first years of operation of the CMS experiment in proton-proton collisions at a centre-of-mass energy of 13 TeV, are presented. Heavy-flavour jet identification algorithms have been improved compared to those used previously at centre-of-mass energies of 7 and 8 TeV. For jets with transverse momenta in the range expected in simulated tt‟\mathrm{t}\overline{\mathrm{t}} events, these new developments result in an efficiency of 68% for the correct identification of a b jet for a probability of 1% of misidentifying a light-flavour jet. The improvement in relative efficiency at this misidentification probability is about 15%, compared to previous CMS algorithms. In addition, for the first time algorithms have been developed to identify jets containing two b hadrons in Lorentz-boosted event topologies, as well as to tag c jets. The large data sample recorded in 2016 at a centre-of-mass energy of 13 TeV has also allowed the development of new methods to measure the efficiency and misidentification probability of heavy-flavour jet identification algorithms. The heavy-flavour jet identification efficiency is measured with a precision of a few per cent at moderate jet transverse momenta (between 30 and 300 GeV) and about 5% at the highest jet transverse momenta (between 500 and 1000 GeV)

    Evidence for the Higgs boson decay to a bottom quark–antiquark pair

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    Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

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