544 research outputs found

    Theory Into Practice: Issues To Consider When Selecting Reading Software To Meet Different Readers\u27 Needs

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    According to a report from the U.S. Congress, Office of Technology Assessment (1988), over 10,000 computer pro grams are currently being marketed. With such a large and divergent array of materials to choose from, software consumers need to understand exactly how programs they are considering for purchase function before they can be sure that any particular program will actually fit their specific classroom needs. Similarly, it is important to determine whether or not the programs are compatible with the teacher\u27s philosophy of reading — reader-based, text-based or interactive (Leu and Kinzer, 1991)

    Analysis of protrusion dynamics in amoeboid cell motility by means of regularized contour flows

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    Amoeboid cell motility is essential for a wide range of biological processes including wound healing, embryonic morphogenesis, and cancer metastasis. It relies on complex dynamical patterns of cell shape changes that pose long-standing challenges to mathematical modeling and raise a need for automated and reproducible approaches to extract quantitative morphological features from image sequences. Here, we introduce a theoretical framework and a computational method for obtaining smooth representations of the spatiotemporal contour dynamics from stacks of segmented microscopy images. Based on a Gaussian process regression we propose a one-parameter family of regularized contour flows that allows us to continuously track reference points (virtual markers) between successive cell contours. We use this approach to define a coordinate system on the moving cell boundary and to represent different local geometric quantities in this frame of reference. In particular, we introduce the local marker dispersion as a measure to identify localized membrane expansions and provide a fully automated way to extract the properties of such expansions, including their area and growth time. The methods are available as an open-source software package called AmoePy, a Python-based toolbox for analyzing amoeboid cell motility (based on time-lapse microscopy data), including a graphical user interface and detailed documentation. Due to the mathematical rigor of our framework, we envision it to be of use for the development of novel cell motility models. We mainly use experimental data of the social amoeba Dictyostelium discoideum to illustrate and validate our approach

    The Reach of CERN LEP2 and Fermilab Tevatron Upgrades for Higgs Bosons in Supersymmetric Models

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    Luminosity upgrades of the Fermilab Tevatron pbar-p collider have been shown to allow experimental detection of a Standard Model (SM) Higgs boson up to mHSM120m_{H_{SM}}\sim 120 GeV via WHSMνbbˉWH_{SM} \to \ell\nu b\bar{b} events. This limit nearly saturates the parameter space for many models of weak scale supersymmetry (SUSY) with a minimal particle content. It is therefore interesting to examine the SUSY Higgs reach of future Tevatron experiments. Contours are presented of Higgs boson reach for CERN LEP2 and Tevatron luminosity upgrades for three models of weak scale SUSY: the Minimal Supersymmetric Standard Model (MSSM), the minimal Supergravity model (mSUGRA) and a simple Gauge Mediated SUSY Breaking Model (GMSB). In each case we find a substantial gain in reach at the Tevatron with integrated luminosity increasing from 10 fb^{-1} to 25-30 fb^{-1}. With the larger integrated luminosity, a Higgs search at the Tevatron should be able to probe essentially the entire parameter space of these models. While a discovery would be very exciting, a negative result would severely constrain our ideas about how weak scale supersymmetry is realized.Comment: 12 pages + 7 figures. Uses REVTEX and epsf macros. Several references added, stated value of A-parameters corrected, note added reguarding sgn(mu) dependence in MSSM case. To appear in Physical Review

    Collider discovery limits for supersymmetric Higgs bosons

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    The prospects for discovery of the five Higgs bosons of the minimal supersymmetric standard model are assessed for existing and planned future colliders, including LEP\,I, LEP\,II, LHC and SSC. As a benchmark for comparisons, we take a top-quark mass mt=150m_t= 150\,GeV and squark mass parameter m~=1\tilde m= 1\,TeV in evaluating one-loop radiative corrections; some results for other mtm_t values are also given. Searches based on the most promising production and decay channels are taken into account. For large regions in parameter space, detectable signals are predicted for one or more of the Higgs bosons, but there remains a region for which no signals would be visible at the above colliders.Comment: 24 pages, 23 postscript figures available on request. MAD/PH/69

    Shape of a liquid front upon dewetting

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    We examine the profile of a liquid front of a film that is dewetting a solid substrate. Since volume is conserved, the material that once covered the substrate is accumulated in a rim close to the three phase contact line. Theoretically, such a profile of a Newtonian liquid resembles an exponentially decaying harmonic oscillation that relaxes into the prepared film thickness. For the first time, we were able to observe this behavior experimentally. A non-Newtonian liquid - a polymer melt - however, behaves differently. Here, viscoelastic properties come into play. We will demonstrate that by analyzing the shape of the rim profile. On a nm scale, we gain access to the rheology of a non-Newtonian liquid.Comment: 4 pages, 4 figure