3,512 research outputs found

    Scientific production on computer-assisted numerical analysis in health / Produção científica sobre análise numérica assistida por computador em saúde

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    Objective: to evaluate the scientific production on computer-assisted numerical analysis in health, based on bibliometrics. Method: bibliometric research with a quantitative approach. The data were treated in the light of descriptive statistics, with the biblioshiny tool of the RStudio software. The terms used were "management, hospital material” and “barcode”. Results: 459 documents were recovered, in 274 titles, 445(96.95%) articles, 2458 authors, 81(3.30%) as sole authors. Age average number of documents was 8.91 years, co-authorship per document was 6.15. Conclusion: journals in zone 1 cannot be considered the most devoted to the subject. It was not possible to identify an elite group of authors.Objetivo: evaluar la producción científica sobre análisis numérico asistido por computadora en salud, con base en la bibliometría. Método: investigación bibliométrica con enfoque cuantitativo. Los datos fueron tratados a la luz de estadísticas descriptivo, con la herramienta biblioshiny del software RStudio. Los términos utilizados fueron "management, hospital material” y “barcode”. Resultados: se recuperaron 459 documentos, en 274 títulos, 445 (96,95%) artículos, 2458 autores, 81 (3,30%) como autor único. La edad promedio de documentos fue de 8,91 años, la coautoría por documento fue de 6,15. Conclusión: las revistas de la zona 1 no pueden considerarse las más dedicadas al tema. No fue possible identificar un grupo élite de autores.Objetivo: avaliar a produção científica sobre análise numérica assistida por computador em saúde, a partir da bibliometria. Método: pesquisa do tipo bibliométrica com abordagem quantitativa. Os dados foram tratados à luz da estatística descritiva, com a ferramenta biblioshiny do software RStudio. Os termos utilizados foram "management, hospital material” e “barcode”. Resultados: recuperou-se 459 documentos, em 274 títulos, 445(96,95%) artigos, 2458 autores, 81(3,30%) como autoria única. A idade média dos documentos foi de 8,91 anos, a coautoria por documento foi de 6,15. Conclusão: os periódicos da zona 1 não podem ser considerados os mais devotados ao assunto. Não foi possível identificar um grupo de elite de autores na temática analisada.

    Intangible approaches to improve individual health indicators and empower caregivers

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    Populations worldwide are ageing at a faster pace than in the past, and this demographic transition will affect almost all aspects of society [1]. The number and proportion of people aged 60 years and more in the population are increasing; in 2019, the number of people aged 60 years and older was one billion; this number will increase to 1.4 billion by 2030 and 2.1 billion by 2050 [2]. Population ageing is an irreversible worldwide trend. This is the inevitable result of demographic transition, the trend towards longer lives and smaller families, which occurs even in countries with relatively young populations. In 2021, one in ten people worldwide was aged 65 and over; by 2050, this age group is forecasted to represent one in six people worldwide [3]. Globally, the number of people aged 80 years and over is increasing even faster than the number of people aged 65 years and over. By 2050, the world will have an estimated 459 million people aged 80 years and over, which is nearly triple the number in 2021, at approximately 155 million [3]. This finding was seen in all regions of the world where the number of older people increased rapidly between 1980 and 2021, a trend that is likely to continue for the next three decades [3]; even in Portugal, the proportion of older people as in other countries has been increasing steadily over the past decades. By 2050, Portugal expects an old-age dependency rate of 68.8%, which is one of the highest ratios in Europe [4]. The North interior of Portugal, namely, Terras de Trás-os-Montes, is following the same behaviour as what is being observed in the world and in Portugal. Since it is a region located in the northern interior of Portugal and is considered a region of low population density, it has been seeing an increase in the ageing index, and the ageing trends are evident. It is highlighted that in 2021, Terras de Trás-osMontes’ region presents an ageing index of 359.0.This work is funded by the European Regional Development Fund through the Regional Operational Program North 2020, within the scope of Project GreenHealth-Digital strategies in biological assets to improve well-being and promote green health, Norte-01-0145- FEDER-000042. The authors are grateful to the FCT Portugal for financial support by national funds FCT/MCTES to UNIAG, under project no. UIDB/04752/2020.info:eu-repo/semantics/publishedVersio

    Antibacterial and antiviral properties of Chenopodin-derived synthetic peptides

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    Antimicrobial peptides have been developed based on plant-derived molecular scaffolds for the treatment of infectious diseases. Chenopodin is an abundant seed storage protein in quinoa, an An-dean plant with high nutritional and therapeutic properties. Here, we used computer- and physico-chemical-based strategies and designed four peptides derived from the primary structure of Che-nopodin. Two peptides reproduce natural fragments of 14 amino acids from Chenopodin, named Chen1 and Chen2 and two engineered peptides of the same length were designed based on the Chen1 sequence. The two amino acids of Chen1 containing amide side chains were replaced by ar-ginine (ChenR) or tryptophan (ChenW) to generate engineered cationic and hydrophobic peptides. The evaluation of these 14-mer peptides on Staphylococcus aureus and Escherichia coli showed that Chen1 does not have antibacterial activity up to 512 µM against these strains, while other peptides exhibited antibacterial effects at lower concentrations. The chemical substitutions of glutamine and asparagine by amino acids with cationic or aromatic side chains significantly favoured their antibacterial effects. These peptides did not show significant hemolytic activity. Fluorescence mi-croscopy analysis highlighted the membranolytic nature of Chenopodin-derived peptides. Using molecular dynamic simulations, we found that a pore is formed when multiple peptides are as-sembled in the membrane. Whereas some of them form secondary structures when interacting with the membrane, allowing water translocations during the simulations. Finally, Chen2 and ChenR significantly reduced SARS-CoV-2 infection. These findings demonstrate that Chenopodin is a highly useful template for design, engineering, and manufacturing of non-toxic, antibacterial, and antiviral peptides

    The end of an entire biome? World's largest wetland, the Pantanal, is menaced by the Hidrovia project which is uncertain to sustainably support large-scale navigation

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    The resurgent navigation project known as the Hidrovia Paraguay-Paraná threatens the integrity of the Pantanal, the world's largest wetland, which is considered a biome of its own. Intensive barge navigation is intended to transport crops (soybean, sugar, corn) and cement, iron and manganese from areas of production in Brazil, Paraguay and Bolivia to the oceanic ports of the Plata River. This short communication assembles the information available on the potential impacts of the planned deepening of the natural channel of the Paraguay River in its ~700 km-long upper section. These river channel alterations would disconnect the river from its floodplain, shorten the inundation period, and shrink the wetland area, resulting in severe degradation of the globally outstanding biological and cultural diversity of the Pantanal. The river sediments are mostly sandy and would require perpetual dredging. The reaches needing the most intensive dredging are those of the highest ecological value, protected as a National Park, UNESCO World Heritage and Biosphere Reserves, and various Indigenous reserves and Ramsar sites. Climate change is projected to increase the occurrence of low water periods. Between 2019 and 2021, navigation was impossible even in the already-deepened reaches of the Paraguay River between Corumbá and Asuncion during long periods of the year. Thus, despite considerable financial and technical efforts, the success of the navigation project is doubtful, whereas enormous environmental, cultural, and social impacts can be anticipated. For these reasons, the Brazilian government had already turned down the project in 2000. We suggest alternative, less impactful modes of transport of commodities, e.g., via railway

    The European Reference Genome Atlas: piloting a decentralised approach to equitable biodiversity genomics

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    A global genome database of all of Earth’s species diversity could be a treasure trove of scientific discoveries. However, regardless of the major advances in genome sequencing technologies, only a tiny fraction of species have genomic information available. To contribute to a more complete planetary genomic database, scientists and institutions across the world have united under the Earth BioGenome Project (EBP), which plans to sequence and assemble high-quality reference genomes for all ∼1.5 million recognized eukaryotic species through a stepwise phased approach. As the initiative transitions into Phase II, where 150,000 species are to be sequenced in just four years, worldwide participation in the project will be fundamental to success. As the European node of the EBP, the European Reference Genome Atlas (ERGA) seeks to implement a new decentralised, accessible, equitable and inclusive model for producing high-quality reference genomes, which will inform EBP as it scales. To embark on this mission, ERGA launched a Pilot Project to establish a network across Europe to develop and test the first infrastructure of its kind for the coordinated and distributed reference genome production on 98 European eukaryotic species from sample providers across 33 European countries. Here we outline the process and challenges faced during the development of a pilot infrastructure for the production of reference genome resources, and explore the effectiveness of this approach in terms of high-quality reference genome production, considering also equity and inclusion. The outcomes and lessons learned during this pilot provide a solid foundation for ERGA while offering key learnings to other transnational and national genomic resource projects

    Hypomethylation at H19DMR in penile squamous cell carcinoma is not related to HPV infection

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    Penile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to lifestyle behaviour and human papillomavirus (HPV) infection. Environmentally induced loss of imprinting (LOI) at the H19 differentially methylated region (H19DMR) is associated with many cancers in the early events of tumorigenesis and may be involved in the pathogenesis of penile SCC. We sought to evaluate the DNA methylation pattern at H19DMR and its association with HPV infection in men with penile SCC by bisulfite sequencing (bis-seq). We observed an average methylation of 32.2% ± 11.6% at the H19DMR of penile SCC and did not observe an association between the p16INK4a+ (p = 0.59) and high-risk HPV+ (p = 0.338) markers with methylation level. The average methylation did not change according to HPV positive for p16INK4a+ or hrHPV+ (35.4% ± 10%) and negative for both markers (32.4% ± 10.1%) groups. As the region analysed has a binding site for the CTCF protein, the hypomethylation at the surrounding CpG sites might alter its insulator function. In addition, there was a positive correlation between intense polymorphonuclear cell infiltration and hypomethylation at H19DMR (p = 0.035). Here, we report that hypomethylation at H19DMR in penile SCC might contribute to tumour progression and aggressiveness regardless of HPV infection.</p

    Use of Ozonized Water in the Prevention of Surgical Site Infection in Children Undergoing Cardiovascular Surgery

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    ABSTRACT Introduction: Since the reduction of healthcare-associated infections has been a focus for quality patient care, this study aimed to evaluate the surgical site infection rate of children who underwent cardiovascular surgery after implementation of ozonized water system for hand and body hygiene allied to previously implemented preventive measures. Methods: Two uniformly comparable groups of pediatric patients underwent cardiovascular surgery. Group A (187) patients were operated prior to installation of ozonized water system (March 1 to August 31, 2019), and group B (214) patients were operated after installation of ozonized water system (October 1, 2019, to March 31, 2020). Ozonized water was used for professional hand hygiene and patient body hygiene. Results: There was statistical significance for surgical site infection reduction in group B (P=0.0289), with a relative risk of 0.560 (95% confidence interval = 0.298 to 0.920), inferring the risk of being diagnosed with surgical site infections in group B was 44% less than in group A. There was no statistical significance regarding mechanical ventilation time (P=0.1998) or mortality (P=0.4457). Conclusion: Ozonized water for professional hand hygiene and patient body hygiene was an adjuvant combined with traditional preventive methods to reduce the risk of surgical site infection, although no impact on hospital stay or mortality was observed

    Seasonal dynamics of Amblyomma cajennense (Fabricius, 1787) sensu stricto in a degraded area of the Amazon biome, with notes on Rickettsia amblyommatis infection

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    Abstract Background The tick Amblyomma cajennense sensu stricto (A. cajennense s.s.) frequently parasitizes animals and humans in the Amazon biome, in addition to being a vector of Rickettsia amblyommatis. In the present study, we evaluated both the population dynamics of A. cajennense s.s. in a degraded area of the Amazon biome and the presence of rickettsial organisms in this tick population. Methods The study was carried out in a rural area of the Santa Inês municipality (altitude: 24 m a.s.l.), Maranhão state, Brazil. Ticks were collected from the environment for 24 consecutive months, from June 2021 to May 2023. The region is characterized by two warm seasons: a rainy season (November–May) and a dry season (June–October). We characterized the temporal activity of A. cajennense s.s. on the vegetation by examining questing activity for each life stage (larvae, nymphs, adults [males and females]) in relation to the dry and rainy season. Ticks collected in this study were randomly selected and individually tested by a TaqMan real-time PCR assay that targeted a 147-bp fragment of the rickettsial gltA gene. Results Overall, 1843 (62.4%) adults (52.6% females, 47.4% males), 1110 (37.6%) nymphs and 398 larval clusters were collected. All adult females and nymphs were morphologically identified as A. cajennense s.s. Larval activity was observed from April to December, with a peak from June to September (dry season); nymph abundance peaked from September to November (transition period between dry and rainy seasons); and adult ticks were abundant from October to May (spring/summer/early autumn). The infection rate by R. amblyommatis in A. cajennense s.s. ticks was at least 7% (7/99). Conclusion Our data suggest a 1-year generation pattern for A. cajennense s.s., with a well-defined seasonality of larvae, nymphs and adults in the Amazon biome. Larvae predominate during the dry season, nymphs are most abundant in the dry-rainy season transition and adults are most abundant in the rainy season. The presence of R. amblyommatis in adult ticks suggests that animals and humans in the study region are at risk of infection by this species belonging to the spotted fever group of Rickettsia. Graphical Abstrac
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