5 research outputs found

    Cytotoxicities of effect T cells against cancer stem cells and tumor cells.

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    <p>The killing was measured by an LDH release assay as described in the <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0103193#s2" target="_blank">Materials and Methods</a>. Higher % of cytotoxicity means more cell lysis. (<b>A</b>) Cytotoxicities of CSCs mediated by the H-T, ALDH<sup>low</sup>-T and ALDH<sup>high</sup>-T are shown. (<b>B</b>) Cytotoxicities of unsorted H460 cells mediated by the H-T, ALDH<sup>low</sup>-T and ALDH<sup>high</sup>-T are shown. (C) ALDH<sup>high</sup>-T could kill much more CSCs than unsorted tumor cells.</p

    Tumorigenicity of the ALDH<sup>high</sup> and ALDH<sup>low</sup> H460 cells.

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    <p>An equal number of ALDH<sup>high</sup> and ALDH<sup>low</sup> cells were inoculated into the opposite flanks of the same individuals. The sizes of the tumors were measured 3 times per week. (A) The tumor sizes of mice subjected to ALDH<sup>high</sup> H460 cells were much more larger than the ALDH<sup>low</sup> H460 cells. (B–C) show the representative tumor growth curves from 3 different mice.</p

    The identification of ALDH<sup>high</sup> cells from the human non-small cell lung cancer cells and primary tumor cells.

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    <p>ALDEFLUOR was used as a single marker to identify the ALDH<sup>high</sup> cells from the H460 cell line (A) and freshly harvested tumor cells (B). Tumor cells incubated with both ALDH and DEAB were used as a negative control.</p

    ALDH<sup>high</sup>-CD8+ T treatment prolongs the overall survival of the tumor-bearing mice.

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    <p>The mice treated with ALDH<sup>high</sup>-CD8+ T cells survived much longer than the mice treated with PBS, H-CD8+ T, or ALDH<sup>low</sup>-CD8+ T cells.</p

    ALDH<sup>high</sup>-CD8+ T treatment inhibits subcutaneous tumor growth.

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    <p>(A) The treatment scheme. (B) The tumor sizes of the mice treated with ALDH<sup>high</sup>-CD8+ T cells were much smaller than the tumors of mice treated with PBS, H-CD8+ T, or ALDH<sup>low</sup>-CD8+ T cells.</p
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