40 research outputs found

    From Big Bang to Galactic Civilizations

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    Each scientific study emerges in its own particular time and marks a new step in the development of human thought.1 Big History materialized to satisfy the human need for a unified vision of our existence. It came together in the waning decades of the twentieth century, in part, as a reaction to the specialization of scholarship and education that had taken hold around the world. While this specialization had great results, it created barriers that stood in contrast to a growing unity among our global communities. These barriers were increasingly awkward to bridge, and, thus, Big History emerged as a successful new framework

    Cultural Trigonometry of Franco-American Stereotypes

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    The life of Franco-American Tom Plant represents a group of lost Francos who came to the United States prior to the great migrations of 1870-1920. His experience differed from that of the archetypical French-Canadians who found work in a textile mill and settled into one of New England\u27s many petits Canadas. Plant\u27s life adds another facet to a story much richer and more complex than most scholars of Franco-American have documented

    Introduction: From Big Bang to Galactic Civilizations - An Introduction to Big History

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    Each scientific study emerges in its own particular time and marks a new step in the development of human thought.1 Big History materialized to satisfy the human need for a unified vision of our existence. It came together in the waning decades of the twentieth century, in part, as a reaction to the specialization of scholarship and education that had taken hold around the world. While this specialization had great results, it created barriers that stood in contrast to a growing unity among our global communities. These barriers were increasingly awkward to bridge, and, thus, Big History emerged as a successful new framework

    University of Maine at Orono Franco Series Letter with Attachments

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    Letter from Barry H. Rodrigue, a graduate student writing on behalf of the Franco-American Centre at the University of Maine at Orono, to Giguère inviting her to participate in the series Beyond the French and Indian Wars: The impact of warfare on the Franco and Native communities of North America.https://digitalcommons.usm.maine.edu/giguere-conferences-and-presentations-1968-1997/1057/thumbnail.jp

    Nickel and platinum group metal nanoparticle production by <i>Desulfovibrio alaskensis</i> G20

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    Desulfovibrio alaskensis G20 is an anaerobic sulfate reducing bacteria. While Desulfovibrio species have previously been shown to reduce palladium and platinum to the zero-state, forming nanoparticles in the process; there have been no reports that D. alaskensis is able to form these nanoparticles. Metal nanoparticles have properties that make them ideal for use in many industrial and medical applications, such as their size and shape giving them higher catalytic activity than the bulk form of the same metal. Nanoparticles of the platinum group metals in particular are highly sought after for their catalytic ability and herein we report the formation of both palladium and platinum nanoparticles by D. alaskensis and the biotransformation of solvated nickel ions to nanoparticle form

    Reprogramming the Mycobacterium tuberculosis transcriptome during pathogenesis

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    Transcriptional profiling has revealed that Mycobacterium tuberculosis adapts both its metabolic and respiratory states during infection, utilising lipids as a carbon source and switching to alternative electron acceptors. These global gene expression datasets may be exploited to identify virulence determinants and to screen for new targets for rational drug design. Characterising the changing physiological predicament of distinct M. tb populations during infection will help expose the fundamental biology of M. tb highlighting mechanisms that influence tuberculosis pathogenicity

    Community engagement for successful COVID-19 pandemic response: 10 lessons from Ebola outbreak responses in Africa

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    Publisher's version (útgefin grein)[No abstract available]The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.Peer Reviewe

    MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks

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    The Mre11–Rad50–Nbs1 (MRN) complex functions in the repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) at postreplicative stages of the cell cycle. During HR, the MRN complex functions directly in the repair of DNA DSBs and in the initiation of DSB responses through activation of the ataxia telangiectasia-mutated (ATM) serine-threonine kinase. Whether MRN functions in DNA damage responses before DNA replication in G0/G1 phase cells has been less clear. In developing G1-phase lymphocytes, DNA DSBs are generated by the Rag endonuclease and repaired during the assembly of antigen receptor genes by the process of V(D)J recombination. Mice and humans deficient in MRN function exhibit lymphoid phenotypes that are suggestive of defects in V(D)J recombination. We show that during V(D)J recombination, MRN deficiency leads to the aberrant joining of Rag DSBs and to the accumulation of unrepaired coding ends, thus establishing a functional role for MRN in the repair of Rag-mediated DNA DSBs. Moreover, these defects in V(D)J recombination are remarkably similar to those observed in ATM-deficient lymphocytes, suggesting that ATM and MRN function in the same DNA DSB response pathways during lymphocyte antigen receptor gene assembly

    Communications and Transport: The mobility of information, people and commodities

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    In a context where the study of communications tends to focus only on the mobility of information, to the neglect of that of people and commodities, this article explores the potential for a closer integration between the fields of communications and transport studies. Against the presumption that the emergence of virtuality means that material geographies are no longer of consequence, the role of mediated ‘technologies of distance’ is considered here in the broader contexts of the construction (and regulation) of a variety of physical forms of mobility and the changing modes of articulation of the virtual and material worlds

    Voyages: A Maine Franco-American Reader

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    Dozens of voices celebrate--in essays, stories, plays, poetry, songs, and art--the Franco-American and Acadian experience in Maine. They explore subjects as diverse as Quebec-Maine frontier history, immigrant drama, work, genealogy, discrimination, women, community affairs, religion, archeology, politics, literature, language, and humor. The voices, themselves, are equally diverse, including Norman Beaupré, Michael Michaud, Ross and Judy Paradis, Susann Pelletier, John Martin, Béatrice Craig, Michael Parent, Linda Pervier, Alaric Faulkner, Ray Levasseur, Yves Frenette, Paul Paré, Yvon Labbé, Rev. Clement Thibodeau, Bob Chenard, Denis Ledoux, Josée Vachon, Greg Chabot, Jean-Paul Poulain, Stewart Doty, Rhea Côté Robbins, and many others. This is a rich resource and an engaging read, one that will resonate with many.https://digitalcommons.usm.maine.edu/facbooks/1031/thumbnail.jp
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