13 research outputs found

    Review of surgical techniques for the reconstruction of the maxillofacial region used in the Department of Maxillo-Facial Surgery in Rzesz贸w

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    Postoperative reconstruction of tissue loss within the head and neck after extensive resections due to malignant neoplasms or traumas has always been a challenge for maxillo-facial surgeons or ENT physicians. Due to the complex anatomical structure of the head and neck region, every patient requires an individual approach and there is no standard method of management appropriate for all patients. The number of patients treated for malignancy is increasing year by year. The possibility of performing extensive resections in the head and neck region are conditioned by appropriate reconstruction. Aim. The aim of the paper is to present the reconstructive methods used in the Clinical Department of Maxillofacial Surgery, F. Chopin Hospital No. 1 in Rzeszow. A short review of the most commonly used flaps is presented, taking into account their advantages, disadvantages and surgical technique in terms of their usefulness in daily clinical practice

    Drug鈥搃nduced gingival overgrowth after cyclosporin A therapy

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    Introduction. Drug鈥搃nduced gingival overgrowth is a condition caused by side effects of treatment with one of three types of drugs: phenytoin (used in epilepsy treatment), cyclosporin A (used in transplantology after allogeneic organ transplants) and calcium channel blockers (in the treatment of hypertension). Gingival overgrowth leads to the development of inflammation within the gums and periodontium, reduced comfort in a patient鈥檚 life, and consequently even loss of teeth. Aim. The aim of this study was to present the issue of drug鈥搃nduced gingival overgrowth based on a review of the literature and observations of patients treated in the Clinical Department of Maxillo-Facial Surgery, Frederic Chopin Provincial Specialist Hospital in Rzesz贸w. Case description. Massive gingival overgrowth requires surgical management. Attention should be paid to multidisciplinary cooperation in case of patients qualified for a transplant. It is also import_ant to qualify and evaluate the state of the oral cavity prior to the implementation of immunosuppressive medication, instruction of patients on oral hygiene and removal of the outbreaks of infection

    Ocena wiedzy i umiej臋tno艣ci ratownik贸w medycznych na temat post臋powania w urazach z臋b贸w

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    Introduction: Traumatic teeth and mouth injuries constitute a fixed percentage of injuries. They occur as only dental injuries or accompany fractures of craniofacial skeleton or multiorgan injuries in the body. The aim of the study was to assess the paramedics鈥 knowledge of first aid principles in cases of traumatic dental and masticatory system injuries. Material and Methods: A survey was conducted among 138 randomly selected paramedics employed in the Medical Rescue Teams and emergency departments in Rzesz贸w region, who were informed about the anonymous nature of the project. A voluntarily completed questionnaire was simultaneously assumed an informed consent to participate in the study. The questionnaire consisted of two parts. The first part covered respondents鈥 demographic and social data, while the second part focused on the first aid conduct in tooth injuries and included 18 questions. Results: The results demonstrated that the paramedics鈥 knowledge of the conduct in cases of the most common dental injuries, ie. tooth knocking and dislocation, fracture of tooth crown or tooth root is unsatisfactory. Most of the respondents gave answers intuitively. Studies and statistical analysis did not confirm a significant correlation between subjects鈥 professional experience (p = 0.5891) and education (p = 0.1093) with their skills and knowledge of the proceedings after dental injuries. The fact that about 20% of the paramedics did not consider it necessary to broaden their knowledge in this subject seems distressing. Conclusions: In the light of conducted research, systematic training in dental first aid in terms of proceeding in teeth injuries for paramedics seems justified as well as its inclusion in the curriculum of undergraduate programme for paramedics.Wst臋p: Obra偶enia urazowe z臋b贸w i okolicy jamy ustnej stanowi膮 sta艂y odsetek uraz贸w cia艂a. Mog膮 wyst臋powa膰 jako samodzielne uszkodzenia z臋b贸w lub towarzyszy膰 z艂amaniom szkieletu cz臋艣ci twarzowej czaszki lub tzw. obra偶eniom wielonarz膮dowym cia艂a. Cel pracy: Celem pracy by艂a ocena wiedzy i znajomo艣膰 zasad udzielania pomocy w przypadkach urazowych obra偶e艅 z臋b贸w i narz膮du 偶ucia przez ratownik贸w medycznych. Materia艂 i metoda: Badania ankietowe przeprowadzono w grupie 138 losowo wybranych ratownik贸w medycznych zatrudnionych w Zespo艂ach Ratownictwa Medycznego oraz Szpitalnych Oddzia艂ach Ratunkowych na terenie regionu rzeszowskiego, kt贸rych poinformowano o anonimowym charakterze projektu. Dobrowolnie wype艂nienie kwestionariusza ankiety uznano jednocze艣nie za 艣wia dom膮 zgod臋 na udzia艂 w badaniu. Kwestionariusz ankiety sk艂ada艂 si臋 z dw贸ch cz臋艣ci. Pierwsza cz臋艣膰 dotyczy艂a danych demograficzno-spo艂ecznych respondent贸w, za艣 druga cz臋艣膰 merytoryczna dotyczy艂a udzielania pierwszej pomocy w urazach z臋b贸w i obejmowa艂a 18 pyta艅. Wyniki: Przeprowadzone badania wykaza艂y, 偶e wiedza badanej grupy ratownik贸w medycznych w zakresie post臋powania w przypadkach najcz臋艣ciej wyst臋puj膮cych obra偶e艅 i uszkodze艅 z臋b贸w tj. wybicie i zwichni臋cie z臋ba, z艂amanie korony lub korzenia z臋ba jest niezadowalaj膮ca. Wi臋kszo艣膰 respondent贸w udziela艂a odpowiedzi intuicyjnie. Przeprowadzone badania i analiza statystyczna nie potwierdzi艂a istotnej zale偶no艣ci pomi臋dzy sta偶empracy (p=0,5891) oraz wykszta艂ceniem badanych (p=0,1093) a ich umiej臋tno艣ciami i wiedz膮 na temat post臋powania po urazach z臋b贸w. Niepokoj膮cy jest fakt, 偶e oko艂o 20% ratownik贸w medycznych nie widzia艂o konieczno艣ci poszerzenia wiedzy w omawianej tematyce. Wnioski: W 艣wietle przeprowadzonych bada艅 uzasadnione jest prowadzenie systematycznych szkole艅 z pierwszej pomocy stomatologicznej w aspekcie post臋powania w urazach z臋b贸w dla ratownik贸w medycznych oraz w艂膮czenia ich do programu studi贸w licencjackich ratownik贸w medycznych

    Enhanced susceptibility of SARS-CoV-2 spike RBD protein assay targeted by cellular receptors ACE2 and CD147: multivariate data analysis of multisine impedimetric response

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    Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) enters the cells through the binding of spike protein to the host cell surface-expressing angiotensin-converting enzyme 2 (ACE2) or by endocytosis mediated by extracellular matrix metalloproteinase inducer (CD147). We present extended statistical studies of the multisine dynamic electrochemical impedance spectroscopy (DEIS) revealing interactions between Spike RBD and cellular receptors ACE2 and CD147, and a reference anti-RBD antibody (IgG2B) based on a functionalised boron-doped diamond (BDD) electrode. The DEIS was supported by a multivariate data analysis of a SARS-CoV-2 Spike RBD assay and cross-correlated with the atomic-level information revealed by molecular dynamics simulations. Our approach allowed us to study and detect subtle changes in the electrical properties responsible for the susceptibility of cellular receptors to SARS-CoV-2, revealing their interactions. Changes in electrical homogeneity in the function of the RBD concentration led to the conclusion that the ACE2 receptor delivers the most homogeneous surface, delivered by the high electrostatic potential of the relevant docking regions. For higher RBD concentrations, the differences in electrical homogeneity between electrodes with different receptors vanish. Collectively, this study reveals interdependent virus entry paths involving separately ACE2, CD147, and spike protein, provided by a developed biosensing platform for the rapid screening of cellular interactions (i.e. testing various mutations of SARS-CoV-2 or screening of therapeutic drugs)

    Characterisation of Selected Materials in Medical Applications

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    Tissue engineering is an interdisciplinary field of science that has developed very intensively in recent years. The first part of this review describes materials with medical and dental applications from the following groups: metals, polymers, ceramics, and composites. Both positive and negative sides of their application are presented from the point of view of medical application and mechanical properties. A variety of techniques for the manufacture of biomedical components are presented in this review. The main focus of this work is on additive manufacturing and 3D printing, as these modern techniques have been evaluated to be the best methods for the manufacture of medical and dental devices. The second part presents devices for skull bone reconstruction. The materials from which they are made and the possibilities offered by 3D printing in this field are also described. The last part concerns dental transitional implants (scaffolds) for guided bone regeneration, focusing on polylactide鈥揾ydroxyapatite nanocomposite due to its unique properties. This section summarises the current knowledge of scaffolds, focusing on the material, mechanical and biological requirements, the effects of these devices on the human body, and their great potential for applications

    Characterisation of Selected Materials in Medical Applications

    No full text
    Tissue engineering is an interdisciplinary field of science that has developed very intensively in recent years. The first part of this review describes materials with medical and dental applications from the following groups: metals, polymers, ceramics, and composites. Both positive and negative sides of their application are presented from the point of view of medical application and mechanical properties. A variety of techniques for the manufacture of biomedical components are presented in this review. The main focus of this work is on additive manufacturing and 3D printing, as these modern techniques have been evaluated to be the best methods for the manufacture of medical and dental devices. The second part presents devices for skull bone reconstruction. The materials from which they are made and the possibilities offered by 3D printing in this field are also described. The last part concerns dental transitional implants (scaffolds) for guided bone regeneration, focusing on polylactide–hydroxyapatite nanocomposite due to its unique properties. This section summarises the current knowledge of scaffolds, focusing on the material, mechanical and biological requirements, the effects of these devices on the human body, and their great potential for applications

    Risk Factors and Clinicopathological Features for Developing a Subsequent Primary Cutaneous Squamous and Basal Cell Carcinomas

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    Background: Patients with diagnosed keratinocyte carcinomas (KCs) have an increased risk of subsequent skin cancers development. Current studies indicate that patients with subsequent tumors should be followed up regularly. However, none of the studies indicate the connection between the specific subtypes and an increased risk for further KCs development. The study assesses the differences in the risk of developing a subsequent skin cancer after a previous diagnosis of KC, especially considering individual types of skin malignances, and identifies potential factors associated with an increased risk of new cutaneous tumor describing non-invasive diagnosis and monitoring. Methods: Pathology and medical records were examined to identify the characteristics of patients with multiple KCs diagnosed between 1999 and 2019. Results: The study group comprised 13,913 KCs occurring in 10,083 patients. Multiple KCs were observed in 2300 patients (22.8%). The analysis showed aggressive subtypes, multiple tumors, and male sex as significant prognostic factors. Conclusions: The most crucial risk factors for developing subsequent KC are being of a male gender, an aggressive tumor subtype, and previous history of multiple skin cancers. Basal cell carcinoma subtypes, such as infiltrative basosquamous, with aggressive growth patterns predispose not only to increased risk for the recurrence but are also expected to be at higher risk of subsequent KCs

    The incidence and clinical analysis of non-melanoma skin cancer

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    Abstract Non-melanoma skin cancers (NMSCs) are the most common malignancies diagnosed in Caucasian populations. Basal cell carcinoma (BCC) is the most frequent skin cancer, followed by squamous cell carcinoma (SCC). Unfortunately, most European cancer registries do not record individual types of NMSC. To evaluate the incidence of primary BCCs and SCCs regarding age, sex, tumour site and tumour subtype to determine trends in epidemiology of both cancers. Retrospective analysis of BCCs and SCCs diagnosed and treated across seven sites in Poland from 1999 to 2019. We recorded 13,913 NMSCs occurring in 10,083 patients. BCC represented 85.2% of all cases. SCC patients were older than BCC patients (77.1鈥壜扁11.3聽years vs. 70.1鈥壜扁12.3聽years, p鈥<鈥0.01). The nodular subtype was the most common subtype of BCC, followed by the superficial and infiltrative subtypes. The superficial BCC subtype was more common on photoprotected areas (p鈥<鈥0.01), whereas the nodular BCC subtype occurred on the face (p鈥<鈥0.01). The high-risk SCC subtypes were more common on face compared to low-risk SCC subtypes (p鈥<鈥0.01). BCC and SCC are common malignancies developing at various ages and anatomical sites. These data underline the need for better registration policies regarding NMSC in order to improve prevention and treatment strategies for these tumours
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