257 research outputs found

    Integrität im Managementalltag

    Get PDF
    Geschenke und Gef√§lligkeiten, Entlassungen, Mobbing, Billiglohnproduktion oder Einsatz von Cookies oder Pers√∂nlichkeitsprofilen ‚Äď Das Spektrum an m√∂glichen Spannungsfeldern im Unternehmensalltag ist gro√ü. Mit der Digitalisierung sind die ethischen Herausforderungen noch gr√∂√üer. Dieses Open Access Buch f√ľhrt F√ľhrungskr√§fte in die Erfassung und L√∂sung ethischer Dilemmas im Unternehmensalltag ein. Praxisnah und konkret stellt es sieben Leitideen als ethisches Fundament und ein Ablaufschema zur L√∂sung ethischer Dilemmas vor. 32 h√§ufige Spannungsfelder werden anhand von kurzen Fallbeispielen analysiert und diskutiert. Das Buch pr√§sentiert zudem einfache, aber auch umfassende Good Practices eines modernen Integrit√§tsmanagements. In Zeiten, in denen der Ruf nach der Wahrnehmung von sozialer, gesellschaftlicher und digitaler Verantwortung von Unternehmen immer lauter wird, gibt dieses Lehrmittel den F√ľhrungskr√§ften einen Leitfaden an die Hand, wie sie ethische Dilemmas im Unternehmensalltag strukturiert angehen k√∂nnen. Die zweite Auflage enth√§lt ein v√∂llig neues Kapitel mit sieben Fallbeispielen zur Corporate Digital Responsibility (CDR), das hei√üt, zur Verantwortung von Unternehmen im Zeitalter der Digitalisierung. Der Inhalt Grundbegriffe der Ethik Spannungsfelder in Organisationen Ethische Dilemmas Leitideen guter Zusammenarbeit Fallbeispiele zum Integrit√§tsmanagement Fallbeispiele zur Corporate Digital Responsibility (CDR) Good Practices im Integrit√§tsmanagement Dies ist ein Open-Access-Buch.

    Integrität im Managementalltag

    Get PDF

    Over-the-scope clip (OTSC (R)) closure of a recto-acetabular fistula

    Get PDF
    A 25-year-old male Syrian refugee presented in our hospital with recurrent hip infections after having undergone hip arthroplasty abroad following destruction of his right hip joint by shell splinters in the Syrian civil war. The patient underwent hip arthroplasty revision with implantation of a cement spacer. CT-scan with rectal contrast media filling revealed a rectoacetabular fistula. Consecutively, the patient underwent ileostomy formation. The fistula was then successfully closed by endoscopic over-the-scope clipping (OTSC (R)). Fistulas between intestines and joints rarely develop and in the few cases published mostly extensive abdominal rescue surgery has been performed. Here, we present a case of a traumatic rectoacetabular fistula that was successfully closed by OTSC. This innovative method could represent a safe and suitable option to effectively close fistulas between joints and intestines thereby avoiding extensive rescue surgery with bowel resection or permanent ostomy

    Human pluripotent stem cell-derived acinar/ductal organoids generate human pancreas upon orthotopic transplantation and allow disease modelling

    Get PDF
    Objective The generation of acinar and ductal cells from human pluripotent stem cells (PSCs) is a poorly studied process, although various diseases arise from this compartment. Design We designed a straightforward approach to direct human PSCs towards pancreatic organoids resembling acinar and ductal progeny. Results Extensive phenotyping of the organoids not only shows the appropriate marker profile but also ultrastructural, global gene expression and functional hallmarks of the human pancreas in the dish. Upon orthotopic transplantation into immunodeficient mice, these organoids form normal pancreatic ducts and acinar tissue resembling fetal human pancreas without evidence of tumour formation or transformation. Finally, we implemented this unique phenotyping tool as a model to study the pancreatic facets of cystic fibrosis (CF). For the first time, we provide evidence that in vitro, but also in our xenograft transplantation assay, pancreatic commitment occurs generally unhindered in CF. Importantly, cystic fibrosis transmembrane conductance regulator (CFTR) activation in mutated pancreatic organoids not only mirrors the CF phenotype in functional assays but also at a global expression level. We also conducted a scalable proof-of-concept screen in CF pancreatic organoids using a set of CFTR correctors and activators, and established an mRNA-mediated gene therapy approach in CF organoids. Conclusions Taken together, our platform provides novel opportunities to model pancreatic disease and development, screen for disease-rescuing agents and to test therapeutic procedures.This study was funded by the Deutsche Forschungsgemeinschaft (DFG, K.L. 2544/1-1 and 1-2), the Forschungskern SyStaR to AK, BIU (B√∂hringer Ingelheim Ulm to AK), the Fritz-Thyssen Foundation (Az. 10.15.2.040), the German Cancer Aid (111879) and the Else-Kr√∂ner-Fresenius-Stiftung (2011_A200). AK is indebted to the Baden-W√ľrttemberg Stiftung for the financial support of this research project by the Eliteprogramme for Postdocs. AK is also an Else-Kr√∂ner-Fresenius Memorial Fellow. LP is supported by a research fellowship of the Else-Kr√∂ner-Fresenius-Stiftung. MH was supported by the International Graduate School in Molecular Medicine and the Bausteinprogramme (L.SBN. 110), Ulm University. MM is supported by a grant of Ulm University (Baustein for Senior Clinician Scientists). IGC is funded by the Interdisciplinary Center for Clinical Research (IZKF Aachen) and Start Program, RWTH Aachen University Medical School, Aachen, German

    Search for a Higgs Boson Produced in Association with a W Boson in pbar-p Collisions at sqrt{s} = 1.96 TeV

    Get PDF
    We present a search for a standard model Higgs boson produced in association with a W boson using 2.7 1/fb of integrated luminosity of pbar-p collision data taken at sqrt{s} = 1.96 TeV. Limits on the Higgs boson production rate are obtained for masses between 100 GeV and 150 GeV. Through the use of multivariate techniques, the analysis achieves an observed (expected) 95% confidence level upper limit of 5.6 (4.8) times the theoretically expected production cross section for a standard model Higgs boson with a mass of 115 GeV.Comment: submitted to Phys. Rev. Let

    Search for the standard model Higgs boson decaying to a bb pair in events with one charged lepton and large missing transverse energy using the full CDF data set

    Get PDF
    We present a search for the standard model Higgs boson produced in association with a W boson in sqrt(s) = 1.96 TeV p-pbar collision data collected with the CDF II detector at the Tevatron corresponding to an integrated luminosity of 9.45 fb-1. In events consistent with the decay of the Higgs boson to a bottom-quark pair and the W boson to an electron or muon and a neutrino, we set 95% credibility level upper limits on the WH production cross section times the H->bb branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125 GeV/c2 we observe (expect) a limit of 4.9 (2.8) times the standard model value.Comment: Submitted to Phys. Rev. Lett (v2 contains clarifications suggested by PRL

    Search for the standard model Higgs boson decaying to a bbňČb\bar{b} pair in events with no charged leptons and large missing transverse energy using the full CDF data set

    Get PDF
    We report on a search for the standard model Higgs boson produced in association with a vector boson in the full data set of proton-antiproton collisions at s=1.96\sqrt{s} = 1.96 TeV recorded by the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45 fb‚ąí1^{-1}. We consider events having no identified charged lepton, a transverse energy imbalance, and two or three jets, of which at least one is consistent with originating from the decay of a bb quark. We place 95% credibility level upper limits on the production cross section times standard model branching fraction for several mass hypotheses between 90 and 150GeV/c2150 \mathrm{GeV}/c^2. For a Higgs boson mass of 125GeV/c2125 \mathrm{GeV}/c^2, the observed (expected) limit is 6.7 (3.6) times the standard model prediction.Comment: Accepted by Phys. Rev. Let

    Search for the standard model Higgs boson decaying to a bb pair in events with two oppositely-charged leptons using the full CDF data set

    Get PDF
    We present a search for the standard model Higgs boson produced in association with a Z boson in data collected with the CDF II detector at the Tevatron, corresponding to an integrated luminosity of 9.45/fb. In events consistent with the decay of the Higgs boson to a bottom-quark pair and the Z boson to electron or muon pairs, we set 95% credibility level upper limits on the ZH production cross section times the H -> bb branching ratio as a function of Higgs boson mass. At a Higgs boson mass of 125 GeV/c^2 we observe (expect) a limit of 7.1 (3.9) times the standard model value.Comment: To be submitted to Phys. Rev. Let