280 research outputs found

    Security feature measurement for frequent dynamic execution paths in software system

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    © 2018 Qian Wang et al. The scale and complexity of software systems are constantly increasing, imposing new challenges for software fault location and daily maintenance. In this paper, the Security Feature measurement algorithm of Frequent dynamic execution Paths in Software, SFFPS, is proposed to provide a basis for improving the security and reliability of software. First, the dynamic execution of a complex software system is mapped onto a complex network model and sequence model. This, combined with the invocation and dependency relationships between function nodes, fault cumulative effect, and spread effect, can be analyzed. The function node security features of the software complex network are defined and measured according to the degree distribution and global step attenuation factor. Finally, frequent software execution paths are mined and weighted, and security metrics of the frequent paths are obtained and sorted. The experimental results show that SFFPS has good time performance and scalability, and the security features of the important paths in the software can be effectively measured. This study provides a guide for the research of defect propagation, software reliability, and software integration testing

    PI3K/AKT/mTOR pathway-derived risk score exhibits correlation with immune infiltration in uveal melanoma patients

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    Uveal melanoma (UVM) is a rare but highly aggressive intraocular tumor with a poor prognosis and limited therapeutic options. Recent studies have implicated the PI3K/AKT/mTOR pathway in the pathogenesis and progression of UVM. Here, we aimed to explore the potential mechanism of PI3K/AKT/mTOR pathway-related genes (PRGs) in UVM and develop a novel prognostic-related risk model. Using unsupervised clustering on 14 PRGs profiles, we identified three distinct subtypes with varying immune characteristics. Subtype A demonstrated the worst overall survival and showed higher expression of human leukocyte antigen, immune checkpoints, and immune cell infiltration. Further enrichment analysis revealed that subtype A mainly functioned in inflammatory response, apoptosis, angiogenesis, and the PI3K/AKT/mTOR signaling pathway. Differential analysis between different subtypes identified 56 differentially expressed genes (DEGs), with the major enrichment pathway of these DEGs associated with PI3K/AKT/mTOR. Based on these DEGs, we developed a consensus machine learning-derived signature (RSF model) that exhibited the best power for predicting prognosis among 76 algorithm combinations. The novel signature demonstrated excellent robustness and predictive ability for the overall survival of patients. Moreover, we observed that patients classified by risk scores had distinguishable immune status and mutation. In conclusion, our study identified a consensus machine learning-derived signature as a potential biomarker for prognostic prediction in UVM patients. Our findings suggest that this signature is correlated with tumor immune infiltration and may serve as a valuable tool for personalized therapy in the clinical setting

    China-EU Energy Cooperation Roadmap 2020 _ Concept Note

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    The process for the definition of an Energy Cooperation Roadmap between the EU and China was officially initiated at the first meeting of the Energy Security Working Group held in Beijing in February 2013, following the China-EU Joint Declaration on Energy Security of May 2012 that stated the formal establishment of the relationships between China and the EU as energy consumers and strategic partners. This Concept Note on China-EU Energy Cooperation Roadmap 2020 has been elaborated by the Europe-China Clean Energy Centre (EC2) and it provides suggestions on cooperation goals and recommendations for a Roadmap to 2020
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