29 research outputs found

    Agenda Ambiental na Administração Pública (A3P) como instrumento de gestão de inservíveis em Escola Pública Estadual de Salvador, Bahia

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    Environmental management in solid waste is fundamental for sustainable development. The solid waste generated in schools requires proper care and management to protect the environment. The federal government has a rule for public companies to practice sustainability: the Environmental Agenda in Public Administration (A3P), that is an instrument which includes the proper management of waste generated by public agencies. This paper analyzes the A3P rule as a contribution to think about the management of waste materials in state public schools, aiming to obtain elements for sustainable school practices. This is an exploratory and bibliographic study based on academic papers, on Brazil federal norms and laws and on behavior description of furniture disposal at one Salvador’s public school. It uses photography as a qualitative research tool.  The results pointed to an inadequate environmental management of classroom desks and chairs disposal. The application of the A3P could contribute to incorporate principles, responsibility and sustainable environmental practices in Bahia’s public schools.A gestão ambiental é fundamental para o desenvolvimento sustentável e deve contemplar cuidados no gerenciamento de resíduos sólidos (RS) gerados em escolas, considerando os instrumentos de políticas públicas para a viabilização desses processos. Este artigo tem como principal objetivo analisar o papel da Agenda Ambiental na Administração Pública (A3P) como contribuição para se pensar a gestão de materiais inservíveis em escolas públicas estaduais, visando obter elementos para práticas sustentáveis. Trata-se de um estudo exploratório, delineado por levantamento fotográfico e observação in loco da disposição e armazenamento de cadeiras e carteiras escolares em uma escola pública. Esta pesquisa documental tem como base legal a Lei nº 12.305/10 e como instrumento principal de análise a Cartilha Agenda Ambiental na Administração Pública (A3P), além da Portaria Conjunta SAEB/SEC, nº 036 de 24 de abril de 2015, que orienta sobre a retirada de bens móveis inservíveis em órgãos públicos. Os resultados apontaram uma gestão ambiental inadequada durante o descarte e a disposição interna de bens móveis escolares. A A3P pode contribuir com elementos para incorporação de princípios sobre responsabilidade socioambiental e práticas ambientais sustentáveis, que incluem a política dos RS e a Educação Ambiental para uma gestão e gerenciamento adequado dos resíduos gerados nas escolas públicas estaduais

    Oral health profile in patients infected with HTLV-1: Clinical findings, proviral load, and molecular analysis from HTLV-1 in saliva

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    Human T-lymphotropic virus type 1 (HTLV-1) is associated with adult T-cell leukemia (ATL) and HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP) and has also been implicated in several disorders, including periodontal disease. The proviral load is an important biological marker for understanding HTLV-1 pathogenesis and elucidating whether or not the virus is related to the clinical manifestation of the disease. This study describes the oral health profile of HTLV-1 carriers and HAM/TSP patients in order to investigate the association between the proviral load in saliva and the severity of the periodontal disease and to examine virus intra-host variations from peripheral blood mononuclear cells and saliva cells. It is a cross-sectional analytical study of 90 individuals carried out from November 2006 to May 2008. Of the patients, 60 were HTLV-1 positive and 30 were negative. Individuals from the HTLV-1 positive and negative groups had similar mean age and social-economic status. Data were analyzed using two available statistical software packages, STATA 8.0 and SPSS 11.0 to conduct frequency analysis. Differences of P?<?0.05 were considered statistically significant. HTLV-1 patients had poorer oral health status when compared to seronegative individuals. A weak positive correlation between blood and saliva proviral loads was observed. The mean values of proviral load in blood and saliva in patients with HAM/TSP was greater than those in HTLV-1 carriers. The HTLV-1 molecular analysis from PBMC and saliva specimens suggests that HTLV-1 in saliva is due to lymphocyte infiltration from peripheral blood. A direct relationship between the proviral load in saliva and oral manifestations was observed. J. Med. Virol. 84:1428-1436, 2012. (c) 2012 Wiley Periodicals, Inc.FAPESB [303/03]Brazilian Ministry of Health [306/04, 307/04

    Seroprevalence and molecular epidemiology of HTLV-1 isolates from HIV-1 co-infected women in Feira de Santana, Bahia, Brazil.

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    Submitted by Ana Maria Fiscina Sampaio ([email protected]) on 2014-11-18T18:27:05Z No. of bitstreams: 1 Rego FFA Seroprevalence.pdf: 397297 bytes, checksum: 8c2a0e5d43fba73bfd997f12e8d5a67e (MD5)Approved for entry into archive by Ana Maria Fiscina Sampaio ([email protected]) on 2014-11-18T18:27:16Z (GMT) No. of bitstreams: 1 Rego FFA Seroprevalence.pdf: 397297 bytes, checksum: 8c2a0e5d43fba73bfd997f12e8d5a67e (MD5)Made available in DSpace on 2014-11-18T18:41:00Z (GMT). No. of bitstreams: 1 Rego FFA Seroprevalence.pdf: 397297 bytes, checksum: 8c2a0e5d43fba73bfd997f12e8d5a67e (MD5) Previous issue date: 2010HTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, BrasilHTLV Center. Bahia School of Medicine and Public Health. Bahia Foundation for Science Development. Salvador, BA, Brasil / HTLV Center/ Bahia School of Medicine and Public Health/Bahia Foundation for Science Development. Salvador, Bahia, Brasil / National Cancer Institute. National Institutes of Health. Bethesda, MarylandHTLV–1/HIV-1 co-infection is associated with severe clinical manifestations, marked immunodeficiency, and opportunistic pathogenic infections, as well as risk behavior. Salvador, the capital of the State of Bahia, Brazil, has the highest HTLV-1 prevalence (1.74%) found in Brazil. Few studies exist which describe this co-infection found in Salvador and its surrounding areas, much less investigate how these viruses circulate or assess the relationship between them. To describe the epidemiological and molecular features of HTLV in HIV coinfected women. To investigate the prevalence of HTLV/HIV co-infection in surrounding areas, as well as the molecular epidemiology of HTLV, a cross sectional study was carried out involving 107 women infected with HIV-1 from the STD/HIV/AIDS Reference Center located in the neighboring City of Feira de Santana. Patient samples were submitted to ELISA, and HTLV infection was confirmed using Western Blot and Polymerase Chain Reaction (PCR). Phylogenetic analysis using Neighbor-Joining (NJ) and Maximum Likelihood (ML) was performed on HTLV LTR sequences in order to gain further insights about molecular epidemiology and the origins of this virus in Bahia. Four out of five reactive samples were confirmed to be infected with HTLV-1, and one with HTLV-2. The seroprevalence of HTLV among HIV-1 co-infected women was 4.7%. Phylogenetic analysis of the LTR region from four HTLV-1 sequences showed that all isolates were clustered into the main Latin American group within the Transcontinental subgroup of the Cosmopolitan subtype. The HTLV-2 sequence was classified as the HTLV-2c subtype. It was also observed that four HTLV/HIV-1 co-infected women exhibited risk behavior with two having parenteral exposure, while another two were sex workers. This article describes the characteristics of co-infected patients. This co-infection is known to be severe and further studies should be conducted to confirm the suggestion that HTLV-1 is spreading from Salvador to surrounding area

    Genetic characterisation of Langerin gene in human immunodeficiency virus-1-infected women from Bahia, Brazil

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    Studies on human genetic variations are a useful source of knowledge about human immunodeficiency virus (HIV)-1 infection. The Langerin protein, found at the surface of Langerhans cells, has an important protective role in HIV-1 infection. Differences in Langerin function due to host genetic factors could influence susceptibility to HIV-1 infection. To verify the frequency of mutations in the Langerin gene, 118 samples from HIV-1-infected women and 99 samples from HIV-1-uninfected individuals were selected for sequencing of the promoter and carbohydrate recognition domain (CRD)-encoding regions of the Langerin gene. Langerin promoter analysis revealed two single nucleotide polymorphisms (SNPs) and one mutation in both studied groups, which created new binding sites for certain transcription factors, such as NFAT5, HOXB9.01 and STAT6.01, according to MatInspector software analysis. Three SNPs were observed in the CRD-encoding region in HIV-1-infected and uninfected individuals: p.K313I, c.941C>T and c.983C>T. This study shows that mutations in the Langerin gene are present in the analysed populations at different genotypic and allelic frequencies. Further studies should be conducted to verify the role of these mutations in HIV-1 susceptibility
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