8 research outputs found

    Novel hybrid organic/inorganic poly(thiourethane) covalent adaptable networks

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    Organic-inorganic hybrid materials combine the advantages of both phases: hardness and strength of inorganic phase and elasticity and toughness of the organic matrix. In the present study, we have prepared nanocomposites with a poly(thiourethane) polymeric matrix and silsesquioxane-type structures, with thiols as reactive groups (POSS-A or POSS-B, synthesized in different pressure conditions), looking for a covalent interaction between both phases, and good dispersion. Due to the click behavior of the reaction between the isocyanate and the thiol groups, highly homogeneous materials are obtained. Both monomers, catalyst (dibutyltin dilaurate, DBTDL), and the POSS precursor (3-mercaptopropyl trimethoxysilane, MPTMS), are commercially available, which present the advantage of being industrially scalable. The incorporation of POSS leads to an increase in glassy and rubbery storage moduli and the temperature of the maximum of tan delta curve. The vitrimeric behavior of the poly(thiourethanes) improved with the POSS incorporation, getting lower relaxation times. With a higher proportion of closed cages, POSS-B leads to the most significant improvements. All the materials prepared showed high transparency and the fracture of POSS modified materials indicates an improved toughness.This work is part of the R & D projects PID2020-115102RB-C21 and PID2020-115102RB-C22 funded by MCINAEI/10.13039/501100011033. We acknowledge these grants and the Generalitat de Catalunya (2017-SGR-77 and BASE3D) . The authors declare the following financial interests/personal re-lationships which may be considered as potential competing interests: Angels Serra reports financial support was provided by Spain Ministry of Science and Innovation

    Role of age and comorbidities in mortality of patients with infective endocarditis

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    [Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65‚ÄĮyears,65 to 80‚ÄĮyears,and‚ÄĮ‚Č•‚ÄĮ80‚ÄĮyears.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327‚ÄĮ<‚ÄĮ65‚ÄĮyears;1291 65-80‚ÄĮyears;502‚ÄĮ‚Č•‚ÄĮ80‚ÄĮyears) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ‚Č•80‚ÄĮyears who underwent surgery were significantly lower compared with other age groups (14.3%,65‚ÄĮyears; 20.5%,65-79‚ÄĮyears; 31.3%,‚Č•80‚ÄĮyears). In-hospital mortality was lower in the <65-year group (20.3%,<65‚ÄĮyears;30.1%,65-79‚ÄĮyears;34.7%,‚Č•80‚ÄĮyears;p‚ÄĮ<‚ÄĮ0.001) as well as 1-year mortality (3.2%, <65‚ÄĮyears; 5.5%, 65-80‚ÄĮyears;7.6%,‚Č•80‚ÄĮyears; p‚ÄĮ=‚ÄĮ0.003).Independent predictors of mortality were age‚ÄĮ‚Č•‚ÄĮ80‚ÄĮyears (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32‚Äď3.34), CCI‚ÄĮ‚Č•‚ÄĮ3 (HR:1.62; 95% CI:1.39‚Äď1.88),and non-performed surgery (HR:1.64;95% CI:11.16‚Äď1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65‚ÄĮyears(p‚ÄĮ<‚ÄĮ0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age‚ÄĮ‚Č•‚ÄĮ80‚ÄĮyears, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

    'The Good, the Bad and the Double-Sword' Effects of Microplastics and Their Organic Additives in Marine Bacteria

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    [eng] Little is known about the direct effects of microplastics (MPs) and their organic additives on marine bacteria, considering their role in the nutrient cycles, e.g., N-cycles through the N2-fixation, or in the microbial food web. To fill this gap of knowledge, we exposed marine bacteria, specifically diazotrophs, to pure MPs which differ in physical properties (e.g., density, hydrophobicity and/or size), namely, polyethylene, polypropylene, polyvinyl chloride and polystyrene, and to their most abundant associated organic additives (e.g., fluoranthene, 1,2,5,6,9,10-hexabromocyclododecane and dioctyl-phthalate). Growth, protein overproduction, direct physical interactions between MPs and bacteria, phosphorus acquisition mechanisms and/or N2-fixation rates were evaluated. Cyanobacteria were positively affected by environmental and high concentrations of MPs, as opposed to heterotrophic strains, that were only positively affected with high concentrations of ~120 ¬Ķm-size MPs (detecting the overproduction of proteins related to plastic degradation and C-transport), and negatively affected by 1 ¬Ķm-size PS beads. Generally, the organic additives had a deleterious effect in both autotrophic and heterotrophic bacteria and the magnitude of the effect is suggested to be dependent on bacterial size. Our results show species-specific responses of the autotrophic and heterotrophic bacteria tested and the responses (beneficial: the 'good', deleterious: the 'bad' and/or both: the 'double-sword') were dependent on the type and concentration of MPs and additives. This suggests the need to determine the threshold levels of MPs and additives concentrations starting from which significant effects can be observed for key microbial populations in marine systems, and these data are necessary for effective environmental quality control management

    Indocilidad reflexiva : el pensamiento crítico como forma de creación y resistencia

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    Este libro recoge fundamentalmente (aunque no s√≥lo) las intervenciones en el ¬ďCuarto encuentro de la Red Internacional de Pensamiento Cr√≠tico¬Ē que tuvo lugar durante los d√≠as 21 al 23 de Septiembre de 2016 en la Universidad Complutense de Madrid, bajo el t√≠tulo: La (in)actualidad del pensamiento cr√≠tico. Un t√≠tulo que pretende recoger, benjaminiamente, el doble significado que sugiere la part√≠cula ¬ďin¬Ē: tanto presencia del tiempo en que le toca vivir como su desubicaci√≥n en el presente por situarse en un futuro ut√≥pico que realice, que mejore al actual. A ninguna de las dos perspectivas puede renunciar un aut√©ntico pensamiento cr√≠tico

    Indocilidad reflexiva : el pensamiento crítico como forma de creación y resistencia

    No full text
    Este libro recoge fundamentalmente (aunque no sólo) las intervenciones en el Cuarto encuentro de la Red Internacional de Pensamiento Crítico que tuvo lugar durante los días 21 al 23 de Septiembre de 2016 en la Universidad Complutense de Madrid, bajo el título: La (in)actualidad del pensamiento crítico. Un título que pretende recoger, benjaminiamente, el doble significado que sugiere la partícula in: tanto presencia del tiempo en que le toca vivir como su desubicación en el presente por situarse en un futuro utópico que realice, que mejore al actual. A ninguna de las dos perspectivas puede renunciar un auténtico pensamiento crítico

    Role of age and comorbidities in mortality of patients with infective endocarditis.

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    The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups: A total of 3120 patients with IE (1327‚ÄĮ There were no differences in the clinical presentation of IE between the groups. Age‚ÄĮ‚Č•‚ÄĮ80‚ÄĮyears, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in th

    Infective Endocarditis in Patients With Bicuspid Aortic Valve or Mitral Valve Prolapse

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    Mural Endocarditis: The GAMES Registry Series and Review of the Literature

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