220 research outputs found

    Fasi finali e riutilizzo di etĂ  storica nel Nuraghe Cuccurada di Mogoro (OR)

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    Nel sito archeologico in località Cuccurada, in territorio comunale di Mogoro, le ricerche hanno evidenziato un insediamento pluristratificato, con fasi di occupazione del Neolitico recente (cultura di Ozieri), dell’Eneolitico (cultura di Monte Claro) e delle Età del Bronzo e del Ferro, con un riutilizzo dell’area in epoca romana e medievale. Il complesso è già abbastanza noto in letteratura, ma ancora parzialmente inedito per quanto riguarda i materiali e i dati di scavo. Nel presente contributo si vuole presentare nel dettaglio le diverse fasi di occupazione del sito, soprattutto in relazione ai momenti finali della frequentazione protostorica (Bronzo Finale/I Ferro) ed alla rioccupazione del complesso in età romana e medievale.In the archaeological site of Cuccurada, in the territory of Mogoro, the researches have evidenced a pluristratified settlement, with phases of occupation of the recent Neolithic (culture of Ozieri), of the Eneolithic age (culture of Monte Claro) and of the Bronze and Iron Ages, with a re-use of the area in roman and medieval period. The complex is already enough famous in literature, but still partially unknown regarding the materials and the excavation data. In the present work we want to present in detail the different occupation phases of the site, especially in relationship to the final moments of the proto-historic frequentation (Final Bronze/I Iron Age) and to the last re-use of the complex in Roman and medieval age

    Evaluation of corneal distortion characteristics in different eyes using Scheimpflug camera device

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    Objective. To study the correlations between corneal distortion and morphological features in different kinds of eyes such as healthy ones (HE), ones previously undergone myopic PRK (PRKE), ones affected by keratoconus (KCE) and keratoconus eyes previously undergone corneal collagen crosslinking (CCCE). Materials and Methods. In this retrospective comparative study, a total of 106 HE of 106 patients, 58 PRKE of 58 patients, 33 KCE of 33 patients, 28 CCCE of 28 patients were included. A complete examination of all eyes was followed by tomographic (Pentacam, Oculus, Wetzlar, Germany) and biomechanical (Corvis ST, Oculus, Wetzlar, Germany) evaluation. Differences among Corvis ST (CST) parameters in the different groups have been analyzed. Linear regressions between central corneal thickness (CCT), intraocular pressure (IOP) and anterior corneal curvature measured with Simulated Keratometry (SK), versus corneal deformation parameters measured with Corvis ST in the different groups, have been run using SPSS software version 18.0. Results, HE showed a significant correlation between main curvature power of the cornea within the central 3 mm expressed in Diopters (KM) and 6 CST parameters; between CCT and 4 CST parameters and between IOP and 5 CST parameters. PRKE showed a significant correlation between KM and 3 CST parameters; between IOP and 4 CST parameters and none between CCT and CST parameters. KCE showed a significant correlation between SK and 3 CST parameters; between IOP and 3 CST parameters and none between CCT and CST parameters. CCCE showed a significant correlation between KM and 5 CST parameters; between CCT and 1 CST parameters and between IOP and 5 CST parameters. Discussion. Data of this study suggest that both corneal curvature and IOP could have a greater influence on the corneal deformation, compared to central corneal thickness (CCT). These results should be taken into account by further studies aiming to assess biomechanical corneal characteristics

    Noninvasive Ultrasound Monitoring of Embryonic and Fetal Development in Chinchilla lanigera to Predict Gestational Age: Preliminary Evaluation of This Species as a Novel Animal Model of Human Pregnancy

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    Ultrasound is a noninvasive routine method that allows real-time monitoring of fetal development in utero to determine gestational age and to detect congenital anomalies and multiple pregnancies. To date, the developmental biology of Chinchilla lanigera has not yet been characterized. This species has been found to undergo placentation, long gestation, and fetal dimensions similar to those in humans. The aim of this study was to assess the use of high-frequency ultrasound (HFUS) and clinical ultrasound (US) to predict gestational age in chinchillas and evaluate the possibility of this species as a new animal model for the study of human pregnancy. In this study, 35 pregnant females and a total of 74 embryos and fetuses were monitored. Ultrasound examination was feasible in almost all chinchilla subjects. It was possible to monitor the chinchilla embryo with HFUS from embryonic day (E) 15 to 60 and with US from E15 to E115 due to fetus dimensions. The placenta could be visualized and measured with HFUS from E15, but not with US until E30. From E30, the heartbeat became detectable and it was possible to measure fetal biometrics. In the late stages of pregnancy, stomach, eyes, and lenses became visible. Our study demonstrated the importance of employing both techniques while monitoring embryonic and fetal development to obtain an overall and detailed view of all structures and to recognize any malformation at an early stage. Pregnancy in chinchillas can be confirmed as early as the 15th day postmating, and sonographic changes and gestational age are well correlated. The quantitative measurements of fetal and placental growth performed in this study could be useful in setting up a database for comparison with human fetal ultrasounds. We speculate that, in the future, the chinchilla could be used as an animal model for the study of US in human pregnancy

    Therapy of age-related exudative macular degeneration with anti-vascular endothelial growth factor drugs: An Italian real life study

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    Aim: To evaluate the real utilization of ranibizumab and aflibercept in the daily management of patients with neovascular age-related macular degeneration (nAMD) treated at the Eye Clinic of Campania University L.Vanvitelli. Background: Therapy with anti-vascular endothelial growth factor represents the gold standard in wet age-related macular degeneration. There are nonreal life italian studies of this therapy in the literature. Objective: To analyze in our sample the post-therapy variations of best-corrected visual acuity (BCVA) and central retinal thickness (CRT) observed at the end of a 12-month follow-up period. Methods: This real-life study analyzes 109 patients that underwent monthly checks for the first 4 months and then every 2 months until the end of the 12-month follow-up. The sample was first analyzed in its entirety, subsequently subdivided into 3 groups based on baseline BCVA, age, and the number of intravitreal injections performed, in order to identify possible predictive elements of the anti-VEGF response. Results: On average, patients underwent 4.16 ± 1.58 intravitreal anti-VEGF injections in 1 year. At the end of the 12-month follow-up, the patients’ average BCVA increased from 33.01 letters to 33.75 letters (+0.74 ± 9,4 letters), while the average CRT decreased from 346.86 µm to 265.39 µm (-81.47 ± 121 µm). Conclusion: The study shows the efficacy of anti-VEGF therapy in the stabilization of BCVA in nAMD, confirming the differences in visual outcomes compared to clinical trials, mainly for economic-organizational reasons

    INSTRUCTIONAL DESIGN AND ASSESSMENT A Peer Review Process for Classroom Teaching

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    Objective. Describe the planning, implementation, and faculty perceptions of a classroom peer-review process, including an evaluation tool. Design. A process for peer evaluation of classroom teaching and its evaluation tool were developed and implemented by a volunteer faculty committee within our department. At the end of the year, all faculty members were asked to complete an online anonymous survey to evaluate the experience. Assessment. The majority of faculty members either agreed or strongly agreed that the overall evaluation process was beneficial for both evaluators and for those being evaluated. Some areas of improvement related to the process and its evaluation tool also were identified. Summary. The process of developing and implementing a peer-evaluation process for classroom teaching was found to be beneficial for faculty members, and the survey results affirmed the need and continuation of such a process

    Head and Neck Veins of the Mouse. A Magnetic Resonance, Micro Computed Tomography and High Frequency Color Doppler Ultrasound Study.

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    To characterize the anatomy of the venous outflow of the mouse brain using different imaging techniques. Ten C57/black male mice (age range: 7-8 weeks) were imaged with high-frequency Ultrasound, Magnetic Resonance Angiography and ex-vivo Microcomputed tomography of the head and neck. Under general anesthesia, Ultrasound of neck veins was performed with a 20MHz transducer; head and neck Magnetic Resonance Angiography data were collected on 9.4T or 7T scanners, and ex-vivo Microcomputed tomography angiography was obtained by filling the vessels with a radiopaque inert silicone rubber compound. All procedures were approved by the local ethical committee. The dorsal intracranial venous system is quite similar in mice and humans. Instead, the mouse Internal Jugular Veins are tiny vessels receiving the sigmoid sinuses and tributaries from cerebellum, occipital lobe and midbrain, while the majority of the cerebral blood, i.e. from the olfactory bulbs and fronto-parietal lobes, is apparently drained through skull base connections into the External Jugular Vein. Three main intra-extracranial anastomoses, absent in humans, are: 1) the petrosquamous sinus, draining into the posterior facial vein, 2) the veins of the olfactory bulb, draining into the superficial temporal vein through a foramen of the frontal bone 3) the cavernous sinus, draining in the External Jugular Vein through a foramen of the sphenoid bone. The anatomical structure of the mouse cranial venous outflow as depicted by Ultrasound, Microcomputed tomography and Magnetic Resonance Angiography is different from humans, with multiple connections between intra- and extra- cranial veins

    Free amino acid profile of Bubalus bubalis L. meat from the Campania region

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    ABSTRACT In this study, we determined the amount of carnosine and anserine in water buffalo meat without hanging treatment and the free amino acid profile by using amino acid analyser with post-column ninhydrin derivatization procedure. The main free amino acids present in samples were glutamic acid (>60 mg/100 g), followed by alanine, glycine, and arginine. Other protein amino acids were detected in minor amounts (less than 2 mg/100 g). Among the non-protein amine-containing compounds, taurine and urea were the most abundant. The analysis showed that 50% of the total free amino acids was represented by dipeptides carnosine (average ~130.3 mg/100 g) and anserine (average ~17.9 mg/100 g). Thus, this study for the first time reports the free amino acids profile of water buffalo meat and the content of carnosine and anserine, potentially involved in the darkening meat process and their ratio, that could be used to estimate the water buffalo meat portion in mixed meat products

    Accertamento sintetico e giudizio

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    La disciplina sull'accertamento sintetico introdotta dalla Manovra 2010 impone all'Ufficio procedente l'> di invitare il contribuente a fornire dati e notizie rilevanti ai fini dell'accertamento, e, subito dopo, di tentarne la definizione mediante adesione. A tale fattispecie \ue8 impropriamente attribuito un carattere >, che si concretizzerebbe nel divieto di utilizzazione in giudizio di fatti e documenti non prodotti. Simile interpretazione non appare condivisibile perch\ue8 in contrasto, sia con i principi costituzionali a garanzia del diritto di difesa e del >, sia con la > del contraddittorio. Infatti quando assume il carattere di garanzia, tale istituto risponde a una facolt\ue0 del contribuente di anticipare difese la cui sede naturale \ue8 il giudizio; facolt\ue0 che se \ue8 veramente tale non pu\uf2 essere limitata o condizionata dalla prospettiva di incorrere in decadenze, se non esercitata

    Il principio di legalit\ue0 tributaria impone l'irrilevanza dell'iscrizione nel registro del CONI per l'accesso ai benefici fiscali degli enti sportivi dilettantistici

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    La mancata iscrizione nel "nuovo" registro istituito presso il CONI non impedisce all'ente sportivo dilettantistico che soddisfi i requisiti indicati dalla disciplina agevolativa di accedere ai regimi tributari agevolati da essi previsti. Contro la tesi contraria, condivisibilmente rigettata dalla Commissione tributaria provinciale di Macerata, si oppongono il principio di legalit\ue0 tributaria e i suoi corollari della certezza del diritto e della separazione e autonomia dei poteri
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