5,476 research outputs found

    Tools and techniques for AIS Strategic Planning.

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    AIS went through and will continue to undergo evolution and revolution as it grows. This article analyzes the current state of AIS and concludes it is in or approaching a crisis of priorities. Planning is the recommended path for solving this crisis. Four planning methods are proposed: stakeholder analysis, service matrix analysis, missions matrix analysis, and a four-year budget cycle.AIS, planning, planning methods, priority setting, stakeholder analysis, service matrix analysis, missions matrix analysis, budget cycleAssociation of Information Systems Planning; Planning method; Stakeholder analysis; Service matrix analysis; Missions matrix analysis; Planification stratégique;

    Base pair opening within B-DNA: free energy pathways for GC and AT pairs from umbrella sampling simulations.

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    The conformational pathways and the free energy variations for base opening into the major and minor grooves of a B-DNA duplex are studied using umbrella sampling molecular dynamics simulations. We compare both GC and AT base pair opening within a double-stranded d(GAGAGAGAGAGAG). d(CTCTCTCTCTCTC) oligomer, and we are also able to study the impact of opening on the conformational and dynamic properties of DNA and on the surrounding solvent. The results indicate a two-stage opening process with an initial coupling of the movements of the bases within the perturbed base pair. Major and minor groove pathways are energetically comparable in the case of the pyrimidine bases, but the major groove pathway is favored for the larger purine bases. Base opening is coupled to changes in specific backbone dihedrals and certain helical distortions, including untwisting and bending, although all these effects are dependent on the particular base involved. Partial opening also leads to well defined water bridging sites, which may play a role in stabilizing the perturbed base pairs

    Root optimization of polynomials in the number field sieve

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    The general number field sieve (GNFS) is the most efficient algorithm known for factoring large integers. It consists of several stages, the first one being polynomial selection. The quality of the chosen polynomials in polynomial selection can be modelled in terms of size and root properties. In this paper, we describe some algorithms for selecting polynomials with very good root properties.Comment: 16 pages, 18 reference

    Passive scalar mixing downstream of a synthetic jet in crossflow

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    An experimental investigation on passive scalar mixing due to the interaction of a synthetic jet with a thermal boundary layer is presented. From velocity measurements, performed by particle image velocimetry, two jet behaviours were identified. For jet to crossflow velocity ratios less than 1.2, the velocity fluctuations due to the jet/crossflow interaction stayed close to the wall. At higher ratios, the fluctuations moved away from the wall. The thermal mixing was examined using laser induced fluorescence. During expulsion, the thickness of the downstream thermal boundary layer increased whilst the thermal boundary layer was annihilated immediately downstream of the jet during entrainment

    Regular and First Order List Functions

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    We define two classes of functions, called regular (respectively, first-order) list functions, which manipulate objects such as lists, lists of lists, pairs of lists, lists of pairs of lists, etc. The definition is in the style of regular expressions: the functions are constructed by starting with some basic functions (e.g. projections from pairs, or head and tail operations on lists) and putting them together using four combinators (most importantly, composition of functions). Our main results are that first-order list functions are exactly the same as first-order transductions, under a suitable encoding of the inputs; and the regular list functions are exactly the same as MSO-transductions

    Linking public investment programs and SPAHD macro models : methodology and application to aid requirements

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    The authors propose a"bottom up"approach to link public investment programs with a class of macro models recently developed to quantify Strategy Papers for Human Development (SPAHD) in low-income countries. The methodology involves establishing constant-price projections of investment outlays (disaggregated into infrastructure, education, and health), spending on maintenance and other goods and services, salaries, and user charges. These estimates are incorporated in a SPAHD macro framework to calculate, under alternative scenarios, domestic financing, foreign borrowing, and aid requirements. The authors also evaluate the impact on growth and indicators associated with the Millennium Development Goals. They use illustrative applications, based on a SPAHD model for Niger, to highlight the link between tax reform and aid requirements.Public Sector Economics&Finance,Economic Theory&Research,Public Sector Expenditure Analysis&Management,Investment and Investment Climate,Population Policies