128 research outputs found

    Aspectos motivacionales relacionados con el teletrabajo

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    El presente estudio trata de explicar c贸mo han influido las Tecnolog铆as de la Informaci贸n y la Comunicaci贸n en el 谩mbito laboral. Cada vez son m谩s las empresas que aplican la flexibilidad y la conciliaci贸n laboral del teletrabajo como principales elementos de motivaci贸n, para captar trabajadores con talento aunque se encuentren geogr谩ficamente distanciados. Sin embargo, el teletrabajo tambi茅n tiene unos inconvenientes importantes como son el aislamiento, la p茅rdida de trabajo en equipo o la falta de regulaci贸n, que hacen que en Espa帽a surja la desconfianza hacia esta modalidad laboral y, por lo tanto, ocupe un lugar muy por debajo de la media europea.Grado en Relaciones Laborales y Recursos Humano

    An谩lisis de los determinantes de la inversi贸n privada en el sector minero en Per煤 durante el periodo 2002-2017

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    El objetivo de esta investigaci贸n es analizar los principales factores que determinan la inversi贸n privada en el sector minero en Per煤 durante el periodo de 2002-2017, la metodolog铆a empleada en este estudio es la siguiente: el m茅todo empleado es sint茅tico anal铆tico, el tipo de investigaci贸n que se emplea es descriptivo y explicativa, su dise帽o es no experimental. Las variables consideradas son: la inversi贸n privada minera, el Producto Bruto Interno de EEUU, la inversi贸n p煤blica, cotizaci贸n internacional de los minerales, la tasa de inter茅s interbancario y la tasa impositiva, la data es trimestral obtenida de la p谩gina web Banco Central de Reserva del Per煤, Ministerio de Energ铆a y Minas del Per煤, la Reserva Federal y de otras instituciones gubernamentales. Se hace uso de la econometr铆a para realizar pruebas de estacionariedad de cada una de las variables, adem谩s de las metodolog铆as de cointegraci贸n de Johansen y Pesaran para encontrar una relaci贸n a largo plazo. Los resultados muestran que un incremento de 1% en el PBI de los EEUU y en el precio del cobre, incrementa la inversi贸n privada minera en 3.22% y 2.64% respectivamente, mientras que un incremento de 1% en la tasa de inter茅s interbancaria disminuye la inversi贸n privada en -3.60% con un coeficiente de correcci贸n de errores de 10.38%. La principal conclusi贸n que se desprende del an谩lisis de los resultados es que la inversi贸n privada en el sector minero esta explicada en forma positiva por el PBI de los EEUU y en el precio del cobre y en forma negativa por la tasa de inter茅s interbancaria en el largo plazo.Tesi

    Efecto del tipo tinta y de las propiedades del papel estucado de alta gama en la calidad de impresi贸n

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    En los 煤ltimos a帽os, el gran desarrollo tecnol贸gico experimentado por el sector de la impresi贸n offset, unido a que cada vez los costes de producci贸n son m谩s ajustados, ha producido un aumento de la exigencia de la calidad del papel. La calidad de impresi贸n de un papel estucado se eval煤a mediante la densidad, las coordenadas colorim茅tricas y el brillo de la impresi贸n. El objetivo del estudio fue determinar la influencia de las propiedades del papel estucado y de la tinta sobre las propiedades que definen la calidad de la impresi贸n. Para ello se seleccionaron ocho papeles estucados (5 brillantes y 3 mates) y se determinaron la rugosidad y la energ铆a libre de superficie de los mismos. Posteriormente se imprimieron con cantidades crecientes de tinta en un IGT, con dos tintas de color negro y dos cian. Por 煤ltimo se determinaron la densidad, el brillo y las coordenadas CIELAB de la impresi贸n. La variaci贸n de densidad, brillo, L* a* y b* de la impresi贸n con la tinta transferida presenta tendencias similares en todos los papeles, existiendo diferencias en la impresi贸n en funci贸n del tipo de tinta. Las propiedades de impresi贸n dependen principalmente de la lisura Bekk y de la componente polar de la energ铆a de superficie

    Espectroscopia de infrarrojo: una herramienta 煤til para evaluar la penetraci贸n de la tinta en el papel prensa

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    La impresi贸n del papel prensa se realiza principalmente mediante el proceso cold-set, donde el secado de la tinta tiene lugar por la penetraci贸n de 茅sta en el papel. La excesiva penetraci贸n del pigmento o del veh铆culo en la estructura del papel, produce una p茅rdida de eficiencia para alcanzar la densidad 贸ptica deseada y una disminuci贸n del coeficiente de dispersi贸n de la luz. En este trabajo se eval煤a si la espectrometr铆a de infrarrojo por transformada de Fourier (FTIR) es una herramienta 煤til para determinar la penetraci贸n de la tinta cold-set. Se imprimieron algunos papeles prensa con 3 g/m2 de tinta azul en un equipo de laboratorio Pr眉fbau. Las hojas impresas se separaron en capas y se registr贸 el espectro FTIR de cada una ellas. El estudio del espectro FTIR de los papeles prensa, de la tinta y de sus componentes demostr贸 que aparecen bandas asignables a los distintos componentes de la tinta que pueden diferenciarse con suficiente claridad de las del papel. Se ha establecido una nueva metodolog铆a basada en la espectrometr铆a FTIR para determinar la penetraci贸n de distintos componentes de la tinta en el papel

    Estudio de la relaci贸n entre las propiedades del papel prensa reciclado y el print through

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    Uno de los problemas m谩s frecuentes en la impresi贸n de papel prensa es el denominado print through, que consiste en la percepci贸n visual de la imagen impresa por la cara contraria del papel. En la impresi贸n cold-set, el print through es debido a las caracter铆sticas f铆sicas y 贸pticas del papel y a las interacciones tinta-papel. El objetivo del trabajo ha sido evaluar la influencia de las propiedades superficiales, 贸pticas y estructurales del papel prensa sobre el print through, as铆 como obtener un modelo que lo prediga en funci贸n de las propiedades del papel. Para el estudio se han seleccionado diversos papeles prensa fabricados con fibra reciclada, siguiendo un dise帽o experimental donde las variables independientes son: la porosidad Bendtsen, la rugosidad Bendtsen y la luminosidad (L*). Se determinaron las propiedades f铆sicas y 贸pticas, antes y despu茅s de la impresi贸n a densidad comercial. La cuantificaci贸n del print through se realiz贸 utilizando diversos 铆ndices obtenidos en base a c谩lculos experimentales y bibliogr谩ficos. Los diferentes 铆ndices empleados no consiguen explicar satisfactoriamente el efecto visual que genera la impresi贸n sobre un observador. El print through se puede minimizar mejorando las propiedades 贸pticas del papel y consiguiendo impresiones uniformes

    Chlorinated Guaiane-Type Sesquiterpene Lactones as Cytotoxic Agents against Human Tumor Cells

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    This article belongs to the Section Bioactives and Nutraceuticals.Guaiane-type sesquiterpene lactones are naturally occurring compounds which have attracted attention due to their array of biological activities. In this study, chlorinated guaianolides 1鈥8, isolated from plants of the genus Centaurea, were evaluated against the human leukemia cell lines HL-60, U-937, a specific U-937 cell line that overexpresses the anti-apoptotic Bcl-2 protein and the human melanoma cell line SK-MEL-1. This established the relevant structure-growth inhibition relationships. Chlorohyssopifolins A (1), C (3) and D (4) and linichlorin A (6) were the most potent compounds in terms of inducing growth inhibition in the four cell lines. IC50 values were below 10 渭M in all cases. Chlorohyssopifolins A (1) and D (4) and linichlorin A (6) were potent apoptotic inducers in human U-937 leukemia cells, as determined by fluorescent microscopy and flow cytometry, and their mechanism of action was associated with cytochrome c release, caspase activation and poly(ADP-ribose)polymerase cleavage. Overall this study shows that guaianolides induce cytotoxicity against human tumor cells and provides important insights into the cell death pathways that are involved.This research was funded by FEDER and AGENCIA CANARIA DE INVESTIGACI脫N, INNOVACI脫N Y SOCIEDAD DE LA INFORMACI脫N (PROID2017010095 FEDER/ACIISI) and in part by the Spanish Ministry of Science, Innovation and Universities and the European Regional Development Fund (PGC2018-094503-B-C21)

    Routine cerebrospinal fluid parameters as biomarkers in first-episode psychosis: A prospective observational study

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    In recent years, multiple studies have investigated the role of biomarkers in first-episode psychosis (FEP) to facilitate early diagnosis, disease stratification, therapeutic choice and outcome prediction. Few studies have focused on cerebrospinal fluid (CSF) investigations. In this prospective observational study, 95 FEP inpatients were followed up for one year. A lumbar puncture was performed at index admission (baseline) to study the CSF parameters (glucose, total proteins, lactate dehydrogenase [LDH], and pleocytosis). At the baseline visit, the clinical assessment included prodromal (psychotic and non-psychotic) symptoms before the psychotic outbreak and psychopathology at admission. The SCID-I was administered to obtain a clinical diagnosis at baseline and at 12 months. The relationship between prodromal and psychopathology symptoms at the baseline visit was tested with multiple linear regression. Multinomial logistic regression was also used to explore the association between CSF biomarkers and longitudinal diagnoses at follow-up (schizophrenia/schizoaffective disorder vs unipolar/bipolar depression vs other psychoses). Higher CSF glucose was associated with depressive (Standardized beta = 0.27, p = 0.041) and disorganized/concrete symptoms (Standardized beta = 0.33, p = 0.023) and lower CSF LDH was associated with prodromal symptoms (Standardized beta = 鈭0.25, p = 0.042). Lower LDH concentrations were also associated with social withdrawal (r = 鈭0.342, p = 0.001). CSF glucose was a predictor of the long-term diagnosis (lower CSF concentrations were associated with schizophrenia or schizoaffective disorder diagnoses [OR = 0.88, CI95%: 0.77鈥0.99). Our study suggests that CSF biomarkers that involve bioenergetic systems are associated with prodromal symptoms and the phenotype of psychotic disorders during the early stages of the disease

    Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment

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    Alternative splicing; Soluble receptors; IFNAR; Interferon beta; Multiple sclerosisEmpalmament alternatiu; Receptors solubles; IFNAR; Interfer贸 beta; Esclerosi m煤ltipleSplicing alternativo; Receptores solubles; IFNAR; Interfer贸n beta; Esclerosis m煤ltiplePurpose: Interferon beta receptor 2 subunit (IFNAR2) can be produced as a transmembrane protein, but also as a soluble form (sIFNAR2) generated by alternative splicing or proteolytic cleavage, which has both agonist and antagonist activities for IFN-尾. However, its role regarding the clinical response to IFN-尾 for relapsing-remitting multiple sclerosis (RRMS) is unknown. We aim to evaluate the in vitro short-term effects and after 6 and 12 months of IFN-尾 therapy on sIFNAR2 production and their association with the clinical response in MS patients. Methods: Ninety-four RRMS patients were included and evaluated at baseline, 6 and 12 months from treatment onset. A subset of 41 patients were classified as responders and non-responders to IFN-尾 therapy. sIFNAR2 serum levels were measured by ELISA. mRNA expression for IFNAR1, IFNAR2 splice variants, MxA and proteases were assessed by RT-PCR. The short-term effect was evaluated in PBMC from RRMS patients after IFN-尾 stimulation in vitro. Results: Protein and mRNA levels of sIFNAR2 increased after IFN-尾 treatment. According to the clinical response, only non-responders increased sIFNAR2 significantly at both protein and mRNA levels. sIFNAR2 gene expression correlated with the transmembrane isoform expression and was 2.3-fold higher. While MxA gene expression increased significantly after treatment, IFNAR1 and IFNAR2 only slightly increased. After short-term IFN-尾 in vitro induction of PBMC, 6/7 patients increased the sIFNAR2 expression. Conclusions: IFN-尾 administration induces the production of sIFNAR2 in RRMS and higher levels might be associated to the reduction of therapeutic response. Thus, levels of sIFNAR2 could be monitored to optimize an effective response to IFN-尾 therapy.This research was funded by grants from the Instituto de Salud Carlos III and co-funded by European Regional Development Fund (ERDF), Technological Development Project in health DTS/1800045 to BO-M. BO-M holds a contract from Red Andaluza de Investigacion Cl铆nica y Traslacional en Neurolog铆a (Neuro-reca) (RIC-0111-2019). PA-G is supported by Promoci贸n de Empleo Joven e Implantaci贸n de la Garant铆a Juvenil 2018 (PEJ2018-002719-A). JR-B is supported by grants from Red Tem谩tica de Investigaci贸n Cooperativa, Red Espa帽ola de Esclerosis Multiple REEM (RD16/0015/0010). LL holds a Nicol谩s Monardes research contract (RC-002-2019) from the Andalusian Ministry of Health and Family. IB-M holds a pFIS contract (FI19/00139) from the Spanish Science and Innovation Ministry

    Identification of the Immunological Changes Appearing in the CSF During the Early Immunosenescence Process Occurring in Multiple Sclerosis

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    Immunitat adaptativa; Envelliment; Esclerosi m煤ltipleInmunidad adaptativa; Envejecimiento; Esclerosis m煤ltipleAdaptive immunity; Aging; Multiple sclerosisPatients with multiple sclerosis (MS) suffer with age an early immunosenescence process, which influence the treatment response and increase the risk of infections. We explored whether lipid-specific oligoclonal IgM bands (LS-OCMB) associated with highly inflammatory MS modify the immunological profile induced by age in MS. This cross-sectional study included 263 MS patients who were classified according to the presence (M+, n=72) and absence (M-, n=191) of LS-OCMB. CSF cellular subsets and molecules implicated in immunosenescence were explored. In M- patients, aging induced remarkable decreases in absolute CSF counts of CD4+ and CD8+ T lymphocytes, including Th1 and Th17 cells, and of B cells, including those secreting TNF-alpha. It also increased serum anti-CMV IgG antibody titers (indicative of immunosenescence) and CSF CHI3L1 levels (related to astrocyte activation). In contrast, M+ patients showed an age-associated increase of TIM-3 (a biomarker of T cell exhaustion) and increased values of CHI3L1, independently of age. Finally, in both groups, age induced an increase in CSF levels of PD-L1 (an inductor of T cell tolerance) and activin A (part of the senescence-associated secretome and related to inflammaging). These changes were independent of the disease duration. Finally, this resulted in augmented disability. In summary, all MS patients experience with age a modest induction of T-cell tolerance and an activation of the innate immunity, resulting in increased disability. Additionally, M- patients show clear decreases in CSF lymphocyte numbers, which could increase the risk of infections. Thus, age and immunological status are important for tailoring effective therapies in MS.This work was supported by grants FIS-PI15/00513, FIS-PI18/00572 and RD16/0015/0001 from the Instituto de Salud Carlos III. Ministerio de Ciencia e Innovacio虂n, Spain and FEDER: "Una manera de hacer Europa"

    Clozapine and paliperidone palmitate antipsychotic combination in treatment-resistant schizophrenia and other psychotic disorders: A retrospective 6-month mirror-image study

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    Background: Around 30% of patients with schizophrenia are considered treatment resistant (TRS). Only around 40% of TRS patients respond to clozapine. Long acting injectable antipsychotics could be a useful augmentation strategy for nonresponders. Methods: We conducted a multicenter, observational, naturalistic, retrospective, 6-month mirror-image study to evaluate the efficacy and tolerability of clozapine and paliperidone palmitate association in 50 patients with TRS and other psychotic disorders. Clinical outcomes and side effects were systematically assessed. Results: Six months after starting the combined treatment, participants showed a significant relief of symptoms, decreasing the Brief Psychiatric Rating Scale total score from 18.32 卤 7.71 to 7.84 卤 5.16 (p < 0.001). The number of hospitalizations, the length of hospital stays and the number of visits to emergency services also decreased, while an increase of the functionality was observed (Personal and Social Performance total score increased from 46.06 卤 118.7 to 60.86 卤 18.68, p < 0.001). There was also a significant decrease in the number and severity of side effects with the combination therapy, decreasing the Udvalg for Kliniske Undersogelser total score from 10.76 卤 8.04 to 8.82 卤 6.63 (p = 0.004). Conclusions: This study provides the first evidence that combining clozapine with paliperidone palmitate in patients with TRS and other psychotic disorders could be effective and safe, suggesting further research with randomized controlled trials of augmentation strategies for clozapine nonresponder patients. Policy Significance Statement: Patients with psychotic disorders such as schizophrenia show a variable response to antipsychotic treatments. Around 30% of patients are considered treatment resistant, indicated by insufficient symptom control to at least two different drugs. In these resistant cases, clozapine should be indicated, as it has shown to be superior to other options. However, only 40% of patients respond to clozapine, being necessary to establish which treatments could best potentiate clozapine action. Combining clozapine with long acting injectable antipsychotics, and particularly paliperidone palmitate, could be a useful strategy. We conducted a multicenter study of 50 patients with treatment-resistant schizophrenia and other psychotic disorders comparing the efficacy and tolerability in the 6 month-period prior and after starting the clozapine and paliperidone palmitate association. Our study suggests that this combination could be effective and safer, laying the groundwork for future clinical trials with this combination
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