37 research outputs found

    Iodine-based contrast media, multiple myeloma and monoclonal gammopathies: literature review and ESUR Contrast Media Safety Committee guidelines

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    Objectives Many radiologists and clinicians still consider multiple myeloma (MM) and monoclonal gammopathies (MG) a contraindication for using iodine-based contrast media. The ESUR Contrast Media Safety Committee performed a systematic review of the incidence of post-contrast acute kidney injury (PC-AKI) in these patients. Methods A systematic search in Medline and Scopus databases was performed for renal function deterioration studies in patients with MM or MG following administration of iodine-based contrast media. Data collection and analysis were performed according to the PRISMA statement 2009. Eligibility criteria and methods of analysis were specified in advance. Cohort and case-control studies reporting changes in renal function were included. Results Thirteen studies were selected that reported 824 iodine-based contrast medium administrations in 642 patients withMMorMG, in which 12 unconfounded cases of PC-AKIwere found (1.6 %). The majority of patients had intravenous urography with high osmolality ionic contrast media after preparatory dehydration and purgation. Conclusions MM and MG alone are not risk factors for PCAKI. However, the risk of PC-AKI may become significant in dehydrated patients with impaired renal function. Hypercalcaemia may increase the risk of kidney damage, and should be corrected before contrast medium administration. Assessment for Bence-Jones proteinuria is not necessary. Key Points \u2022 Monoclonal gammopathies including multiple myeloma are a large spectrum of disorders. \u2022 In monoclonal gammopathy with normal renal function, PCAKI risk is not increased. \u2022 Renal function is often reduced in myeloma, increasing the risk of PC-AKI. \u2022 Correction of hypercalcaemia is necessary in myeloma before iodine-based contrast medium administration. \u2022 Bence-Jones proteinuria assessment in myeloma is unnecessary before iodine-based contrast medium administration

    Superhydrophobic surfaces fabricated by nanoimprint lithography

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    none8Superhydrophobic surfaces were fabricated on silicon by nanoimprint lithography and wet chemical etching. Glass molds were used to imprint a positive photoresist layer. The residual layer in imprinted regions was removed by UV-ozone exposure and subsequent developing of the photoresist. The pattern is transferred to a thin SiO2 layer by buffered hydrofluoric acid etching and then to Si by isotropic hydrofluoric-nitric-acetic acid (HNA) or by anisotropic KOH etching. After coating the samples with a hydrophobic self-assembled monolayer of octadecyltriclorosilane contact angles of water drops were measured and compared to model predictions.Physics, AppliedmixedPOZZATO A; DAL ZILIO S; FOIS G; VENDRAMIN D; MISTURA G.; BELOTTI M; CHEN Y; NATALI MPozzato, A; DAL ZILIO, S; Fois, G; Vendramin, D; Mistura, Giampaolo; Belotti, M; Chen, Y; Natali, M

    MDM4 (MDMX) is overexpressed in chronic lymphocytic leukaemia (CLL) and marks a subset of p53wild-type CLL with a poor cytotoxic response to Nutlin-3

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    In the present study, moving from the gene expression signature that identified a a subgroup of p53wt CLL showing a lack of response to the in-vitro treatment with Nutlin-3, we eventually identified MDM4 as a gene that, despite its peculiar over-expression in a subset of Nutlin-3 \u2018non-responder\u2019 p53wt CLL, turned out to be universally over-expressed by CLL cells compared to normal B cells. This observation is in keeping with studies describing the over-expression of MDM4 in primary samples from several solid tumours, including glioblastoma, retinoblastoma, breast, colon, and lung cancers, and may contribute to identify MDM4 as a potentially useful new therapeutic target also for CLL. Preclinical studies indicating the anti-neoplastic effects of MDM4 down-regulation in murine lymphoma models are of further support for this hypothesis
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