5 research outputs found

    Features of the immunotropic effects of partial components of the balneotherapeutic complex of SPA Truskavets’

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    Background. The arsenal of therapeutic factors of the spa Truskavets’ is not limited to bioactive water Naftussya, but also includes ozokerite applications and mineral baths. The purpose of this study is to quantify the partial immunotropic effects of these balneofactors and also the organic substances and microbiota of Naftussya water. Material and methods. The object of observation were 41 men and 10 women aged 24-70 years old, who came to the spa Truskavets’ for the treatment of chronic pyelonephritis combined with cholecystitis in remission. Immune status evaluated on a set of I and II levels recommended by the WHO. The survey was conducted twice, before and after 7-10-days balneotherapy. 23 patients drinked bioactive water Naftussya (BAWN) by 3,2 mL/kg for 1 hour before meals three times a day, while 7 others volunteers drinked Ozokerite extract by 2 mL dissolved in sweet water (2,5-2,6 mL/kg) one time daily. 8 patients in the third group received BAWN and baths with mineral water (Cl--SO42--Na+-Mg2+ containing salt concentration 25 g/L) and for the other 13 patients in the balneotherapeutic complex included additionally application of Ozokerite on the lumbar region. Results. The most pronounced as stimulating (blood level of total, active and cytolytic T-lymphocytes, Circulating Immune Complexes, IgA and Microbial Count for Staph. aureus) and suppressor (blood level of helper T-lymphocytes and Neutrophils, theirs Killing Index and Bactericydity vs both Staph. aureus and E. coli) action are the organic substances of Ozokerite that contact the surface of the skin, whereas their contact with the mucous of the digestive tract causes less pronounced immunotropic effect. Naftussya water has a stronger effect than the water solution of Ozokerite, apparently due to the additional effects of microbes and organic matter produced by them. In contrast, the bath factors affect the immune parameters of the opposite influences. Microbiota has the most pronounced enhancing effects on the Phagocytose Index of Neutrophils vs. Staph. aureus and blood level of Natural Killers as well as Entropy of Leukocytogram. Instead, organic substances of Ozokerite have the same tangible but opposite effects on these parameters

    Features of the neurotropic effects of partial components of the balneotherapeutic complex of SPA Truskavets’

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    Background. In the previous article we outlined the results of comparative evaluation of immunotropic effects of partial components of the balneotherapeutic complex of spa Truskavets’. In the previous article we outlined the results of comparative evaluation of neurotropic effects of partial components of the complex. Material and methods. The object of observation were the same 41 men and 10 women aged 24-70 years old, who came to the spa Truskavets’ for the treatment of chronic pyelonephritis combined with cholecystitis in remission. We recorded simultaneously parameters of HRV and EEG before and after course of balneotherapy. 23 patients drank bioactive water Naftussya (BAWN); 7 others volunteers drank Ozokerite extract; 8 patients in the third group received BAWN and baths with mineral water and for the other 13 patients in the balneotherapeutic complex included additionally application of Ozokerite on the lumbar region Results. It has been shown that the use of the water solution of Ozokerite dramatically increases the vagus tone and reduces the reciprocally the sympathetic tone, which is accompanied by an increase in the Amplitude of both β- and δ-rhythms as well as in the Frequency of the latter, on the one hand, and a decrease in the Index and the Deviation of θ-rhythm as well as the Amplitude of α-rhythm, on the other hand. At the same time, there is a left-sided shift in the Laterality of β- and α-rhythms. Instead, the Microbiota of Naftussya water, together with the transformed by microbes of organic substances that are related to Ozokerite, have the same pronounced but opposite effect on the listed parameters of HRV and EEG. As a result, BAWN, which contains both neurogenic antipodes in its composition, has a very moderate neurotropic effect on the listed parameters of HRV and EEG. Mineral baths activate other vagus tone markers and suppress the sympathetic marker, coupled with a decrease in the Entropy of HRV bands and β-rhythm Frequency, as well as a significant left-sided shift in Laterality both θ- and δ-hythms. The consistent use of BAWN somewhat weakens the listed effects of Baths due to the slight opposite effect of its organic substances, but not Microbes. Instead, the application of organic substances to the skin causes a much more pronounced opposing neurotropic action. Organic substances of Ozokerite, applied to the skin, causes a increase in Bayevskiy's ARS Index as well as vagal tone and a decline in Bayevskiy's Stress Index coupled with a decrease in Indexes both β- and α-rhythms. A similar, but much weaker effect makes contact with the skin of mineral water, while, as native and transformed by microbes organic matter on the side of the mucous of the digestive tract has the opposite effects on the listed parameters of HRV and EEG. Conclusion. The hypothesis that as native and transformed by microbes organic matter related to Ozokerite on the side of the gut activate chemoreceptors of vagus terminals and/or TL-Receptors of Macrophages of GALT. Activated Macrophages release cytokines, which too activate vagus afferents. When applying Ozokerite or taking Baths, organic substances and mineral salts activate the skin nerve terminals and/or TL-Receptors of Langerhans cells (as variety of Macrophages of SALT) which also release cytokines

    Interrelations between changes in parameters of HRV, EEG and phagocytosis at patients with chronic pyelonephritis and cholecystitis

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    Background. Previously we have shown within the immunological homunculus conception that take place causal relationships between induced by balneotherapy changes in parameters of EEG and HRV, on the one hand, and the parameters of humoral and cellular immunity, on the other hand. The purpose of this study is to find out the relationships between induced by balneotherapy changes in parameters of EEG and HRV, on the one hand, and the parameters of phagocytosis , on the other hand. Material and methods. In basal conditions in 33 men and 10 women with chronic pyelonephritis and cholecystitis in remission, we recorded twice, before and after balneotherapy at the spa Truskavets’, EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood estimated parameters of phagocytic function of neutrophils against Staphylococcus aureus and Escherichia coli. Results. Judging by the coefficients of canonical correlation, the maximal subordinate nervous regulation is the completeness of phagocytosis of E. coli (R=0,944), whereas the influence of the nervous system on the completeness of phagocytosis Staph. aur. is minimal (R=0,607). With regard to the intensity of phagocytosis, the differences in the strength of nerve influence are expressed less (0,893 vs 0,744), and in relation to the activity of phagocytosis as well as the bactericidal ability of neutrophils, there are no differences between R (0,858 vs 0,857 and 0,831 vs 0,834, respectively). However, significant differences were found between profiles of correlation coefficients between EEG and HRV parameters, on the one hand, and phagocytosis parameters, on the other hand, for representatives of Gram-negative and Gram-positive microbes. Conclusion. In the nervous regulation of phagocytosis by neutrophils of the Gram-negative and Gram-positive microbes are involved the structures that are localized in different parts of the CNS

    Mineral waters, metabolism, neuro-endocrine-immune complex, s. 252.

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    Dedicated to the 75th anniversary of Volodymyr Illich Kozyavkin with gratitude for the support of the Truskavetsian Scientific School of BalneologyThe monograph systematizes these writers and highlights the results of their own priority experimental and clinical-physiological studies of the impact of drinking mineral waters of Ukraine on neuroendocrine regulation, metabolism and immunity of healthy rats and patients in the process of rehabilitation of chronic pyelonephritis and cholecystitis in remission. In line with the concepts of functional-metabolic continuum and neuroendocrine-immune complex using the methods of factor, discriminant and canonical correlation analysis, it is demonstrated that mineral waters have both similar and specific physiologically favorable modulating effects on the parameters of the studied body systems. For specialists in medical rehabilitation, endocrinologists, immunologists, biochemists, pathophysiologists

    Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and immunogram

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    Kul’chyns’kyi Andriy B, Gozhenko Anatoliy I, Zukow Walery, Popovych Igor L. Neuro-immune relationships at patients with chronic pyelonephrite and cholecystite. Communication 3. Correlations between parameters EEG, HRV and immunogram. Journal of Education, Health and Sport. 2017;7(3):53-71. eISSN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.265228 http://ojs.ukw.edu.pl/index.php/johs/article/view/4209 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26.01.2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author (s) 2017; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.01.2017. Revised 21.01.2017. Accepted: 31.01.2017. NEURO-IMMUNE RELATIONSHIPS AT PATIENTS WITH CHRONIC PYELONEPHRITE AND CHOLECYSTITE. Communication 3. CORRELATIONS BETWEEN PARAMETERS EEG, HRV AND IMMUNOGRAM Andriy B Kul’chyns’kyi1, Anatoliy I Gozhenko2, Walery Zukow3, Igor L Popovych4 1Communal Hospital, Truskavets’, Ukraine [email protected] 2Ukrainian Scientific Research Institute of Transport Medicine Ministry of Health, Odesa [email protected] 3Faculty of Physical Education, Health and Tourism, Kazimierz Wielki University, Bydgoszcz, Poland [email protected] 4Department of Immunophysiology, OO Bohomolets’ Institute of Physiology, Kyiv, Ukraine [email protected] Abstracts Background. The immunological homunculus conception considers somatotopic organization to СNS regulation of immune system. We set a goal to analyze the causal relationships between parameters of EEG and HRV, on the one hand, and the parameters of immunity, on the other hand. Methods. In basal conditions in 23 men with chronic pyelonephrite and cholecystite in remission, we recorded EEG (“NeuroCom Standard”) and HRV (“Cardiolab+VSR”). In blood estimated routine parameters of Immunity on a set of I and II levels recommended by the WHO. Results. Maximal coefficient canonical correlation (R) parameters of EEG and HRV detected with relative level CD22+ B-Lymphocytes: 0,94 (p<10-4), maximal relationships take place with Spectral Power Density (SPD) absolute (a) Fp1-α (r=-0,64) and relative (r) PSD Fp1-β (r=0,60). R with serum level IgM takes 0,90 (p<10-4), maximal relationships with rSPD O1-θ (r=0,60) and rHF HRV (r=0,52), with serum level IgG takes 0,86 (p<10-3), maximum with rSPD of β-rhythm in loci T6, O1 and O2 (r for all makes 0,40), with serum level IgA takes 0,84 (p<10-4), maximum with Asymmetry of δ-rhythm (r=0,59) and aSPD T4-θ (r=-0,50) as well as with Circulating Immune Complexes: R=0,84 (p<10-4), maximum with Bayevskiy’s Stress Index HRV (r=0,45) and rSPD T3-α (r=0,39). R with relative level CD8+ T-Lymphocytes makes 0,81 (p<10-4), maximal relationships take place with aSPD of α-rhythm in loci P4 (r=-0,38) and P3 (r=-0,31) as well as with rVLF HRV (r=-0,29). R with relative level CD4+ T-Lymphocytes makes 0,79 (p<10-3), maximum with aSPD of β-rhythm in loci F4 (r=0,40) and T3 (r=0,39). R with level CD16+ NK-Lymphocytes makes 0,71 (p=0,009), maximal relationships take place with Index of α-rhythm (r=-0,36) and Entropy SPD in locus C3. Minimal R detected with level “active” T-Lymphocytes: 0,57 (p=0,029). Conclusion. Take place neuro-immune causal relationships in bounds of immunological homunculus conception. Keywords: HRV, EEG, T-, NK-, B-Lymphocytes, Immunoglobulines M,G,A, Circulating immune complexes, correlations
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