20 research outputs found

    Elogio da Europa : o sonho de Jean Monnet : Estados Unidos da Europa?

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    Disserta√ß√£o de Mestrado em Estudos sobre a Europa apresentada √† Universidade AbertaEsta disserta√ß√£o tem como finalidade fazer uma incurs√£o pela hist√≥ria da Europa atrav√©s de factos hist√≥ricos e historiogr√°ficos, conjuntamente com fontes bibliogr√°ficas, em conhecer o sonho de Jean Monnet sobre o elogio √† Europa. Nesta perspetiva, importa analisar de forma cient√≠fica as representa√ß√Ķes pol√≠ticas, econ√≥micas, sociais e culturais do passado europeu que levaram a Jean Monnet, conjuntamente com outros homens do seu tempo, pensarem no projeto Europa. As diversas fontes de investiga√ß√£o evidenciam quest√Ķes diversas como qual a raz√£o de querer uma Europa √ļnica, comum nos ideais morais e filos√≥ficos, pol√≠ticos, econ√≥micos, sociais e sobretudo, esse sonho da arquitectura dos Estados Unidos da Europa. As mem√≥rias de Jean Monnet, a hist√≥ria da Europa, os factos beligerantes das duas Grandes Guerras, a constru√ß√£o de um sonho ou a utopia, pretende ser um elogio √† Europa, a Jean Monnet e sobretudo, a todos aqueles que padeceram nos caminhos da (des)constru√ß√£o da Uni√£o Europeia.This essay aims at making an incursion by European history through historical and historiographical facts, together with bibliographical sources, to know Jean Monnet's dream on the praise to Europe. Therefore, it is important to analyze scientifically the political, economic, social and cultural representations of Europe's past that led Jean Monnet, together with other men of his time, think about Europe project. The various research sources show different issues as the reason to want a single Europe, common in its moral, philosophical, political, economic and social ideals but, above all, the dream of the United States of Europe architecture. Jean Monnet's memoirs, the history of Europe, the belligerent facts of the two World Wars, the construction of a dream or utopia, aims at being a compliment to Europe, to Jean Monnet and to all those who suffered in the paths of the (de)construction of the European Union

    Ordo AB Chao: di√°logos sobre os direitos humanos

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    A presente investiga√ß√£o procede a uma incurs√£o pela Hist√≥ria, Antropologia, Filosofia, Pol√≠tica e Direito, a fim de discutir a import√Ęncia dos Direitos Humanos como gram√°tica e fundamento do Estado de Direito e da Democracia na Europa, assim como tamb√©m no mundo com o qual a Europa se relaciona. Dando-se especial aten√ß√£o ao que se passa na Uni√£o Europeia, procura definir-se uma f√≥rmula que possibilite responder ao objetivo pol√≠tico e cultural de uma Europa unida, em torno de valores e princ√≠pios, permitindo-lhe dar respostas eficazes aos problemas complexos que enfrenta e que fazem as pessoas, mais do que crer, descrer da viabilidade do projeto de constru√ß√£o europeia. Nesta investiga√ß√£o, discutem-se as diferentes conce√ß√Ķes de Direitos Humanos, dentro e fora da Europa (em particular da Uni√£o Europeia) e da civiliza√ß√£o ocidental, dando-se especial aten√ß√£o √† discuss√£o sobre o car√°ter universal ou particular dos Direitos Humanos, assim como aos grandes desafios colocados pelo multiculturalismo e perspetivas afins ou concorrentes. O ponto central da investiga√ß√£o passa por perceber que tipo de respostas podem ser dadas ao desejo de constru√ß√£o de uma Europa unida, pr√≥spera e solid√°ria.The present investigation makes an incursion into History, Anthropology, Philosophy, Politics and Law, in order to discuss the importance of Human Rights as a grammar and foundation of the Rule of Law and Democracy in Europe, as well as in the world with which Europe is related. Paying special attention to what is happening in the European Union, it seeks to define a formula that makes it possible to respond to the political and cultural objective of a united Europe, around values and principles, allowing it to give effective answers to the complex problems it faces and that make people, more than believe, disbelieve the viability of the European construction project. In this investigation, the different conceptions of Human Rights are discussed, inside and outside Europe (in particular the European Union) and Western civilization, paying special attention to the discussion about the universal or particular character of Human Rights, as well as to the major challenges posed by multiculturalism and related or competing perspectives. The central point of the investigation is to understand what kind of answers can be given to the desire to build a united, prosperous and solidary Europe

    F√≥rmula de Erasmo para a Europa no sec. XXI: a constru√ß√£o da paz, da toler√Ęncia e da fraternidade

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    Esta comunica√ß√£o tem como finalidade fazer uma incurs√£o pela hist√≥ria, antropologia e filosofia, pela pol√≠tica e pelo direito, discutir a quest√£o da educa√ß√£o enquanto coluna de um templo das democracias e dos Direitos Humanos, cujo espa√ßo limite √© a Europa e o mundo. A discuss√£o dos DH assentes nos princ√≠pios do humanismo e do Iluminismo, na rela√ß√£o entre sistemas de valores, como o universalismo, o particular e o relativismo, as tens√Ķes provocadas ou n√£o pelas migra√ß√Ķes que a Europa hoje vive e sente, num debate entre multiculturalismo e interculturalismo, dos movimentos prospetivos do DH e os seus instrumentos de negocia√ß√£o e de prote√ß√£o, tem como objetivo mor a procura da f√≥rmula alquimista que resolva o confronto das identidades, da liberdade vs. seguran√ßa, do profano vs. sagrado, da √©tica e da moral, tendo como inspira√ß√£o o humanista holand√™s Desid√©rio Erasmo (1467-1536), mais conhecido com Erasmo de Roterd√£o. S√£o caminhos de utopia?This communication aims to make an incursion into history, anthropology and philosophy, through politics and law, to discuss the issue of education as a pillar of a temple of democracies and Human Rights (HR) , whose boundary is Europe and the world. In this regard, we will look at the HR debate based on the principles of humanism and enlightenment. On the relationship between systems of values, such as universalism, particularism and relativism. The tensions, resulting or not, from migrations that Europe now lives and feels, in a debate between multiculturalism and interculturalism. The proletarian movements of the HR and its instruments of negotiation and protection, as a purpo se for the search of the alchemist formula that solves the confrontation of identities, freedom vs. security, of the profane vs. sacred, of ethics and morals, as inspired by the Dutch humanist Desiderius Erasmus (1467-1536), better known as Erasmus of Rott erdam. A re these the paths of utopia?info:eu-repo/semantics/publishedVersio

    Toxicological and anti-tumor effects of a linden extract (Tilia platyphyllos Scop.) in a HPV16-transgenic mouse model

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    Tilia platyphyllos Scop. is a popular broad-leaved tree, native to Central and Southern Europe. Hydroethanolic extracts rich in phenolic compounds obtained from T. platyphyllos Scop. have shown in vitro antioxidant, anti-inflammatory and antitumor properties. The aim of this work was to evaluate the therapeutic properties of a hydroethanolic extract obtained from T. platyphyllos in HPV16-transgenic mice. The animals were divided into eight groups according to their sex and phenotype. Four groups of female: HPV+ exposed to linden (HPV linden; n = 6), HPV+ (HPV water; n = 4), HPV- exposed to linden (WT linden; n = 5) and HPV- (WT water; n = 4) and four groups of male: HPV+ exposed to linden (HPV linden; n = 5), HPV+ (HPV water; n = 5), HPV- exposed to linden (WT linden; n = 5) and HPV- (WT water; n = 7). The linden (Tilia platyphyllos Scop.) extract was orally administered at a dose of 4.5 mg/10 mL per animal (dissolved in water) and changed daily for 33 days. The hydroethanolic extract of T. platyphyllos consisted of protocatechuic acid and (-)-epicatechin as the most abundant phenolic acid and flavonoid, respectively, and was found to be stable during the studied period. In two male groups a significant positive weight gain was observed but without association with the linden extract. Histological, biochemical, and oxidative stress analyses for the evaluation of kidney and liver damage support the hypothesis that the linden extract is safe and well-tolerated under the present experimental conditions. Skin histopathology does not demonstrate the chemopreventive effect of the linden extract against HPV16-induced lesions. The linden extract has revealed a favourable toxicological profile; however, additional studies are required to determine the chemopreventive potential of the linden extract. This journal isThis work was supported by the project IBERPHENOL, project number 0377_IBERPHENOL_6_E; Interact R&D project, operation number NORTE-01-0145-FEDER-000017, National Funds by FCT ‚Äď Portuguese Foundation for Science and Technology, under the project UIDB/04033/2020 (CITAB), and project UIDB/ CVT/00772/2020 (CECAV) and the post-graduation grant SFRH/ BD/136747/2018 and 2020.04789.BD; the authors are also grateful to FCT, Portugal and FEDER under programme PT2020 for financial support to CIMO (UIDB/00690/2020) and L. Barros acknowledges the national funding by FCT, P. I., through the institutional scientific employment program-contract. The authors would like to thank Cantinho das Arom√°ticas organic farmers from Vila Nova de Gaia (Portugal) for providing the samples. This work was financially supported by: Base Funding - UIDB/00511/2020 of the Laboratory for Process Engineering, Environment, Biotechnology and Energy ‚Äď LEPABE - funded by national funds through the FCT/MCTES (PIDDAC).info:eu-repo/semantics/publishedVersio

    Decavanadate interactions with actin: inhibition of G-actin polymerization and stabilization of decameric vanadate

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    Decameric vanadate species (V10) inhibit the rate and the extent of G-actin polymerization with an IC50 of 68 ¬Ī 22 lM and 17 ¬Ī 2 lM, respectively, whilst they induce F-actin depolymerization at a lower extent. On contrary, no effect on actin polymerization and depolymerization was detected for 2 mM concentration of ‚Äė‚Äėmetavanadate‚Äô‚Äô solution that contains ortho and metavanadate species, as observed by combining kinetic with 51V NMR spectroscopy studies. Although at 25 C, decameric vanadate (10 lM) is unstable in the assay medium, and decomposes following a first-order kinetic, in the presence of G-actin (up to 8 lM), the half-life increases 5-fold (from 5 to 27 h). However, the addition of ATP (0.2 mM) in the medium not only prevents the inhibition of G-actin polymerization by V10 but it also decreases the half-life of decomposition of decameric vanadate species from 27 to 10 h. Decameric vanadate is also stabilized by the sarcoplasmic reticulum vesicles, which raise the half-life time from 5 to 18 h whereas no effects were observed in the presence of phosphatidylcholine liposomes, myosin or G-actin alone. It is proposed that the ‚Äė‚Äėdecavanadate‚Äô‚Äô interaction with G-actin, favored by the G-actin polymerization, stabilizes decameric vanadate species and induces inhibition of G-actin polymerization. Decameric vanadate stabilization by cytoskeletal and transmembrane proteins can account, at least in part, for decavanadate toxicity reported in the evaluation of vanadium (V) effects in biological systems

    Features of Neutrophils From Atopic and Non-Atopic Elite Endurance Runners

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    We collected peripheral blood from thirty-nine elite male endurance runners at rest (24 hours after the last exercise session) and used the Allergy Questionnaire for Athletes score and plasma specific IgE level to separate them into atopic and non-atopic athletes. Neutrophils obtained from atopic and non-atopic athletes were subsequently stimulated in vitro with fMLP (N-formyl-methionyl-leucyl-phenylalanine), LPS (lipopolysaccharide), or PMA (phorbol 12-myristate 13-acetate). Neutrophils from non-atopic runners responded appropriately to LPS, as evidenced by the production of pro (IL-8, TNF-őĪ, and IL-6) and anti-inflammatory (IL-10) cytokines. Neutrophils from atopic elite runners exhibited lower responses to LPS stimulus as indicated by no increase in IL-1ő≤, TNF-őĪ, and IL-6 production. Neutrophils from non-atopic and atopic runners responded similarly to fMLP stimulation, indicating that migration function remained unaltered. Both groups were unresponsive to PMA induced reactive oxygen species (ROS) production. Training hours and training volume were not associated with neutrophil IgE receptor gene expression or any evaluated neutrophil function. Since non-atopic runners normally responded to LPS stimulation, the reduced neutrophil response to the stimuli was most likely due to the atopic state and not exercise training. The findings reported are of clinical relevance because atopic runners exhibit a constant decline in competition performance and are more susceptible to invading microorganisms

    MAMMALS IN PORTUGAL : A data set of terrestrial, volant, and marine mammal occurrences in P ortugal

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    Mammals are threatened worldwide, with 26% of all species being includedin the IUCN threatened categories. This overall pattern is primarily associatedwith habitat loss or degradation, and human persecution for terrestrial mam-mals, and pollution, open net fishing, climate change, and prey depletion formarine mammals. Mammals play a key role in maintaining ecosystems func-tionality and resilience, and therefore information on their distribution is cru-cial to delineate and support conservation actions. MAMMALS INPORTUGAL is a publicly available data set compiling unpublishedgeoreferenced occurrence records of 92 terrestrial, volant, and marine mam-mals in mainland Portugal and archipelagos of the Azores and Madeira thatincludes 105,026 data entries between 1873 and 2021 (72% of the data occur-ring in 2000 and 2021). The methods used to collect the data were: live obser-vations/captures (43%), sign surveys (35%), camera trapping (16%),bioacoustics surveys (4%) and radiotracking, and inquiries that represent lessthan 1% of the records. The data set includes 13 types of records: (1) burrowsjsoil moundsjtunnel, (2) capture, (3) colony, (4) dead animaljhairjskullsjjaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8),observation in shelters, (9) photo trappingjvideo, (10) predators dietjpelletsjpine cones/nuts, (11) scatjtrackjditch, (12) telemetry and (13) vocalizationjecholocation. The spatial uncertainty of most records ranges between 0 and100 m (76%). Rodentia (n=31,573) has the highest number of records followedby Chiroptera (n=18,857), Carnivora (n=18,594), Lagomorpha (n=17,496),Cetartiodactyla (n=11,568) and Eulipotyphla (n=7008). The data setincludes records of species classified by the IUCN as threatened(e.g.,Oryctolagus cuniculus[n=12,159],Monachus monachus[n=1,512],andLynx pardinus[n=197]). We believe that this data set may stimulate thepublication of other European countries data sets that would certainly contrib-ute to ecology and conservation-related research, and therefore assisting onthe development of more accurate and tailored conservation managementstrategies for each species. There are no copyright restrictions; please cite thisdata paper when the data are used in publications.info:eu-repo/semantics/publishedVersio

    Mammals in Portugal: a data set of terrestrial, volant, and marine mammal occurrences in Portugal

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    Mammals are threatened worldwide, with ~26% of all species being included in the IUCN threatened categories. This overall pattern is primarily associated with habitat loss or degradation, and human persecution for terrestrial mammals, and pollution, open net fishing, climate change, and prey depletion for marine mammals. Mammals play a key role in maintaining ecosystems functionality and resilience, and therefore information on their distribution is crucial to delineate and support conservation actions. MAMMALS IN PORTUGAL is a publicly available data set compiling unpublished georeferenced occurrence records of 92 terrestrial, volant, and marine mammals in mainland Portugal and archipelagos of the Azores and Madeira that includes 105,026 data entries between 1873 and 2021 (72% of the data occurring in 2000 and 2021). The methods used to collect the data were: live observations/captures (43%), sign surveys (35%), camera trapping (16%), bioacoustics surveys (4%) and radiotracking, and inquiries that represent less than 1% of the records. The data set includes 13 types of records: (1) burrows | soil mounds | tunnel, (2) capture, (3) colony, (4) dead animal | hair | skulls | jaws, (5) genetic confirmation, (6) inquiries, (7) observation of live animal (8), observation in shelters, (9) photo trapping | video, (10) predators diet | pellets | pine cones/nuts, (11) scat | track | ditch, (12) telemetry and (13) vocalization | echolocation. The spatial uncertainty of most records ranges between 0 and 100‚ÄČm (76%). Rodentia (n =31,573) has the highest number of records followed by Chiroptera (n = 18,857), Carnivora (n = 18,594), Lagomorpha (n = 17,496), Cetartiodactyla (n = 11,568) and Eulipotyphla (n = 7008). The data set includes records of species classified by the IUCN as threatened (e.g., Oryctolagus cuniculus [n = 12,159], Monachus monachus [n = 1,512], and Lynx pardinus [n = 197]). We believe that this data set may stimulate the publication of other European countries data sets that would certainly contribute to ecology and conservation-related research, and therefore assisting on the development of more accurate and tailored conservation management strategies for each species. There are no copyright restrictions; please cite this data paper when the data are used in publications

    Homenagem Casa dos Estudantes do Império - 50 Anos | Testemunhos, Vivências, Documentos

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    Os textos inclu√≠dos nesta obra s√£o transcri√ß√Ķes das interven√ß√Ķes feitas pelos participantes nas diversas sess√Ķes da homenagem √† Casa dos Estudantes do Imp√©rio, realizadas entre 2014 e 2015. Estas interven√ß√Ķes foram gravadas atrav√©s de meios audiovisuais e posteriormente editadas para efeitos de publica√ß√£o. A presente edi√ß√£o segue a grafia do Acordo Ortogr√°fico, exceto nos casos em que os autores quiseram manter a antiga grafia.CML ‚Äď C√Ęmara Municipal de Lisboa; Cam√Ķes ‚Äď Instituto da Coopera√ß√£o e da L√≠ngua; Funda√ß√£o Calouste Gulbenkianinfo:eu-repo/semantics/publishedVersio

    Characterisation of microbial attack on archaeological bone

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    As part of an EU funded project to investigate the factors influencing bone preservation in the archaeological record, more than 250 bones from 41 archaeological sites in five countries spanning four climatic regions were studied for diagenetic alteration. Sites were selected to cover a range of environmental conditions and archaeological contexts. Microscopic and physical (mercury intrusion porosimetry) analyses of these bones revealed that the majority (68%) had suffered microbial attack. Furthermore, significant differences were found between animal and human bone in both the state of preservation and the type of microbial attack present. These differences in preservation might result from differences in early taphonomy of the bones. © 2003 Elsevier Science Ltd. All rights reserved
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