146 research outputs found

    Implementação de ferramenta genérica para suporte de diversas bases de dados de medicamentos

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    Estágio realizado na ALERT Life Sciences Computing, S. ATese de mestrado integrado. Engenharia Informátca e Computação. Faculdade de Engenharia. Universidade do Porto. 200

    Planeamento otimizado de movimento de rob√ī submarino

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    The antiageing efficacy of donkey milk in combination with pomegranate extract and UV protection: A traditional ingredient in a modern formulation.

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    Donkey milk, allegedly used by Cleopatra, is a complex, traditional cosmetic ingredient composed of hydrating substances. In this work, donkey milk was mixed with pomegranate extract and an optimised blend of UV filters in a cosmetic O/W emulsion. The antiageing efficacy of this synergistic blend was assessed by imaging, biomechanical and electrometric methods on 32 volunteers, after 28 days of application. The wrinkle count decreased by 32.9% and the wrinkle length was reduced by 9.6%. Skin hydration increased by 11.4%, while skin firmness and elasticity increased by 9.6% and 16.1%, respectively. Furthermore, skin colour homogeneity was enhanced. Thus, this product was proven to have antiageing effects, both by preventing photoageing and by diminishing existing signs of ageing

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    This work will demonstrate a new flavor of the RA-TDMA set of protocols, namely RA-TDMAs+, which uses IEEE-802.11 (WiFi) COTS hardware in ad-hoc mode to set up a dynamic mesh network of mobile nodes with highbandwidth. The protocol uses topology tracking to configure the TDMA frame and robust relative synchronization to define the TDMA slots without resorting to a global clock and in the presence of interfering traffic. The demo will set up a small-scale testbed using COTS hardware, thus evidencing the feasibility of the approach, and it will show 1clive plots 1d of the temporal (synchronization) and topological views of the network.This work was partially supported by National Funds through FCT/MCTES (Portuguese Foundation for Science and Technology), within the CISTER Research Unit (UIDB/04234/2020); by the Operational Competitiveness Programme and Internationalization (COMPETE 2020) under the PT2020 Agreement, through the European Regional Development Fund (ERDF); also by FCT and the ESF (European Social Fund) through the Regional Operational Programme (ROP) Norte 2020, under PhD grant 2020.06685.BD; and within the AQUAMON project (PTDC/CCI-COM/30142/2017).info:eu-repo/semantics/publishedVersio

    Mechanical Behaviour of Human and Porcine Urethra: Experimental Results, Numerical Simulation and Qualitative Analysis

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    Low urinary tract dysfunctions and symptoms (LUTS) affect both men and woman, with the incidence increasing with age. Among the LUTS, urinary incontinence (UI) is a common dysfunction, characterised by the involuntary loss of urine. These medical conditions become debilitating, with a severe impact on patients‚Äô routines and overall well-being. To mitigate LUTS-associated symptoms, the mechanical behaviour of both normal and LUTS-affected urethrae can be an important tool. The current work approaches the porcine urethra as a mechanical replacement candidate for the human urethra. It aims to provide a framework based on in silico (numerical) simulations and experimental data, to compare the candidate‚Äôs mechanical behaviour against the human urethra. Porcine urethral samples were mechanically evaluated through low-cycle fatigue tests in both circumferential and longitudinal orientations. The specimens were collected from porcine urethrae from crossbred pigs raised for human consumption. The experimental results were compared with human references found in the literature, with similar experimental conditions. The experimental data were used as the input for the mechanical properties estimation (nonlinear fitting to hyperelastic constitutive models) and for the simulation of the urethral tensile behaviour, using those models. In the longitudinal orientation, the results for the porcine and human urethra were in good agreement, while in the circumferential direction, the differences increased with deformation. Previous data on the mechanical behaviour of the equine urethra is in line with these findings. The nonlinear mechanical behaviour of a porcine urethra was modelled using the finite element method (FEM) and hyperelastic constitutive models. For the longitudinal urethra, the simulation results approximate experimental data for stretches up to őĽ‚Čą1.5 (50% deformations), whereas for the circumferential urethra, the same was true for stretches up to őĽ‚Čą1.35 (35% deformations). The hyperelastic models with a higher number of parameters performed better with the third-order Ogden model (six parameters), displaying the best performance among the studied models. The pig urethra is a suitable candidate for an implant targeted at human urethra replacement or as a model to study the human urinary system. Nevertheless, the data available on the circumferential mechanical behaviour need to be consolidated with additional mechanical tests. The tensile behaviour of the porcine urethra over large deformations can be modelled using the third-order Ogden model; however, to extend the modelling capabilities to larger deformations requires the use of hyperelastic models more adequate to soft tissue behaviour
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