73 research outputs found

    Developing teamwork skills beyond cross-cultural barriers: a case study for engineering students in higher education

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    In 2013, our university has implemented a new educational model that puts team projects at the core of all BSc programmes, requiring that students develop teamwork skills. On top of this, in 2018, our Chemical Science & Engineering BSc has become an English-taught, international programme. In consideration of this challenging transition, we have developed additional training to facilitate students' acquisition of knowledge, skills, tools, and attitudes to aid conscientious intercultural teamwork. For this, it is paramount that students become aware of, and learn to appreciate, differences in the educational and cultural backgrounds of themselves and their peers. Concurrently, students should practice what they have learned and adjust their behaviour when appropriate. In this paper, we share our experiences, best practices, and lessons learned. More specifically, our study: i) explores which factors are key to a successful intercultural team, ii) investigates how diversity in teams can be cherished and used for the benefit of the team, its members, and its goals, and iii) how these teamwork skills can effectively be taught in engineering programmes. Building on this, the paper describes how the new curricular education has been designed, what is taught, and how an inclusive, regardful, and pleasant atmosphere has been created for the intercultural project teams

    Burden of disease resulting from chronic mountain sickness among young Chinese male immigrants in Tibet

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    BACKGROUND: In young Chinese men of the highland immigrant population, chronic mountain sickness (CMS) is a major public health problem. The aim of this study was to measure the disease burden of CMS in this population. METHODS: We used disability-adjusted life years (DALYs) to estimate the disease burden of CMS. Disability weights were derived using the person trade-off methodology. CMS diagnoses, symptom severity, and individual characteristics were obtained from surveys collected in Tibet in 2009 and 2010. The DALYs of individual patients and the DALYs/1,000 were calculated. RESULTS: Disability weights were obtained for 21 CMS health stages. The results of the analyses of the two surveys were consistent with each other. At different altitudes, the CMS rates ranged from 2.1-37.4%; the individual DALYs of patients ranged from 0.13-0.33, and the DALYs/1,000 ranged from 3.60-52.78. The age, highland service years, blood pressure, heart rate, smoking rate, and proportion of the sample working in engineering or construction were significantly higher in the CMS group than in the non-CMS group (p < 0.05). These variables were also positively associated with the individual DALYs (p < 0.05). Among the symptoms, headaches caused the largest proportion of DALYs. CONCLUSION: The results show that CMS imposes a considerable burden on Chinese immigrants to Tibet. Immigrants with characteristics such as a higher residential altitude, more advanced age, longer highland service years, being a smoker, and working in engineering or construction were more likely to develop CMS and to increase the disease burden. Higher blood pressure and heart rate as a result of CMS were also positively associated with the disease burden. The authorities should pay attention to the highland disease burden and support the development and application of DALYs studies of CMS and other highland diseases

    ILT4 drives B7-H3 expression via PI3K/AKT/mTOR signalling and ILT4/B7-H3 co-expression correlates with poor prognosis in non-small cell lung cancer

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    AbstractImmunoglobulin-like transcript (ILT) 4 is critical for the inhibitory function of certain immune cells. We previously demonstrated that ILT4 is over-expressed in human non-small cell lung cancer (NSCLC) cells and is involved in tumour evasion via an unknown mechanism. In this report, we demonstrate that ILT4 increases the expression of the co-inhibitory molecule B7-H3 through PI3K/AKT/mTOR signalling. In primary human NSCLC tissues, a significant positive relationship is observed between ILT4 and B7-H3 expression. ILT4/B7-H3 co-expression is significantly associated with a reduction in T infiltrating lymphoid cells and lower overall survival. In summary, ILT4 increases B7-H3 expression and ILT4/B7-H3 co-expression may be involved in NSCLC progression
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