130 research outputs found

    Emotional intelligence and psychological well-being in nursing professionals from southern Chile

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    Foundation: Health professionals and specialy those related to caring, are under certain situations which produce professional stress that affect their psychological state.Objective: to identify the levels of emotional intelligence and psychological wellbeing, respectively, in nursing professionals of the Los Lagos Region, Chile.Methods: Descriptive study with non-experimental design. A number of 97 nurses from the Los Lagos region were included. A Trait Meta-Mood Scale and the Ryff scale of psychological wellbeing were applied to evaluate the emotional intelligence and psychological wellbeing respectively, both with good levels of reliability and composed by a series of sub-scales or dimensions.Results: regarding emotional intelligence, high levels of of emotional perception were observed (35 %), emotional comprehension (36,1 %) and emotional regulation (42,7 %). A 57,5 % of the professionals had a high level of psychological wellbeing, although 33,7 % showed  low level of positive relations.Conclusion: there is a direct and significant relation between the scales of emotional intelligence and psychological wellbeing.</p

    Emotional intelligence and psychological well-being in nursing professionals from southern Chile

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    Foundation: Health professionals and specialy those related to caring, are under certain situations which produce professional stress that affect their psychological state.Objective: to identify the levels of emotional intelligence and psychological wellbeing, respectively, in nursing professionals of the Los Lagos Region, Chile.Methods: Descriptive study with non-experimental design. A number of 97 nurses from the Los Lagos region were included. A Trait Meta-Mood Scale and the Ryff scale of psychological wellbeing were applied to evaluate the emotional intelligence and psychological wellbeing respectively, both with good levels of reliability and composed by a series of sub-scales or dimensions.Results: regarding emotional intelligence, high levels of of emotional perception were observed (35 %), emotional comprehension (36,1 %) and emotional regulation (42,7 %). A 57,5 % of the professionals had a high level of psychological wellbeing, although 33,7 % showed  low level of positive relations.Conclusion: there is a direct and significant relation between the scales of emotional intelligence and psychological wellbeing.</p

    New 8-nitroquinolinone derivative displaying submicromolar in vitro activities against both Trypanosoma brucei and cruzi

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    International audienceAn antikinetoplastid pharmacomodulation study was conducted at position 6 of the 8-nitroquinolin-2(1H)-one pharmacophore. Fifteen new derivatives were synthesized and evaluated in vitro against L. infantum, T. brucei brucei, and T. cruzi, in parallel with a cytotoxicity assay on the human HepG2 cell line. A potent and selective 6-bromo-substituted antitrypanosomal derivative 12 was revealed, presenting EC50 values of 12 and 500 nM on T. b. brucei trypomastigotes and T. cruzi amastigotes respectively, in comparison with four reference drugs (30 nM ‚ȧ EC50 ‚ȧ 13 őľM). Moreover, compound 12 was not genotoxic in the comet assay and showed high in vitro microsomal stability (half life >40 min) as well as favorable pharmacokinetic behavior in the mouse after oral administration. Finally, molecule 12 (E¬į = ‚ąí0.37 V/NHE) was shown to be bioactivated by type 1 nitroreductases, in both Leishmania and Trypanosoma, and appears to be a good candidate to search for novel antitrypanosomal lead compounds

    Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer

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    Background: Impairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (&lt;50 years) is rising, there is little data on functional outcomes in this group. Methods: The REACCT international collaborative database was reviewed and data on eligible patients analysed. Inclusion criteria comprised patients with a histologically confirmed rectal cancer, &lt;50 years of age at time of diagnosis and with documented follow-up including functional outcomes. Results: A total of 1428 (n=1428) patients met the eligibility criteria and were included in the final analysis. Metastatic disease was present at diagnosis in 13%. Of these, 40% received neoadjuvant therapy and 50% adjuvant chemotherapy. The incidence of post-operative major morbidity was 10%. A defunctioning stoma was placed for 621 patients (43%); 534 of these proceeded to elective restoration of bowel continuity. The median follow-up time was 42 months. Of this cohort, a total of 415 (29%) reported persistent impairment of functional outcomes, the most frequent of which was bowel dysfunction (16%), followed by bladder dysfunction (7%), sexual dysfunction (4.5%) and infertility (1%). Conclusion: A substantial proportion of patients with early-onset rectal cancer who undergo surgery report persistent impairment of functional status. Patients should be involved in the discussion regarding their treatment options and potential impact on quality of life. Functional outcomes should be routinely recorded as part of follow up alongside oncological parameters

    Search for dark matter produced in association with bottom or top quarks in ‚ąös = 13 TeV pp collisions with the ATLAS detector

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    A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb‚ąí1 of proton‚Äďproton collision data recorded by the ATLAS experiment at ‚ąös = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

    Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study