1,583 research outputs found

    New Physics signals from measurable polarization asymmetries at LHC

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    We propose a new type of Z polarization asymmetry in bottom-Z production at LHC that should be realistically measurable and would provide the determination of the so-called AbA_b parameter, whose available measured value still appears to be in disagreement with the Standard Model prediction. This polarization can be measured independently of a possible existence of Supersymmetry. If Supersymmetry is found, a second polarization, i.e. the top longitudinal polarization in top-charged Higgs production, would neatly identify the tan‚Ā°ő≤\tan \beta parameter. In this case, the value of AbA_b should be in agreement with the Standard Model. If Supersymmetry does not exist, a residual disagreement of AbA_b from the Standard Model prediction would be a clean signal of New Physics of "non Supersymmetric" origin.Comment: typo correcte

    A top-quark mass measurement feasibility study in the tt \uaf dilepton channel at LHC and at future hadronic colliders

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    This contribution documents the first efforts being taken to study the feasibility of a measurement of the top-quark mass at the Large Hadron Collider and future hadron colliders in pair production events in the dilepton channel

    Prospects of searches for long-lived charged particles with MoEDAL

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    We study the prospects of searches for exotic long-lived particles with the MoEDAL detector at the LHC, assuming the integrated luminosity of 30 fb‚ąí1^{-1} that is expected at the end of Run 3. MoEDAL incorporates nuclear track detectors deployed a few metres away from the interaction point, which are sensitive to any highly-ionizing particles. Hence MoEDAL is able to detect singly- or doubly-charged particles with low velocities ő≤<0.15\beta < 0.15 or <0.3< 0.3, respectively, and lifetimes larger than O(1)‚ÄČm/c{\cal O}(1) \,{\rm m}/c. We examine the MoEDAL sensitivity to various singly-charged supersymmetric particles with long lifetimes and to several types of doubly-charged long-lived particles with different spins and SU(2) charges. We compare the prospective MoEDAL mass reaches to current limits from ATLAS and CMS, which involve auxiliary analysis assumptions. MoEDAL searches for doubly-charged fermions are particularly competitive.Comment: 19 pages, 5 figure

    Expanding the role of bitter taste receptor in extra oral tissues : TAS2R38 is expressed in human adipocytes

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    Increasing evidence indicates that taste receptors mediate a&nbsp;variety of functions in extra-oral&nbsp;tissues.&nbsp;The present study investigated the expression of bitter taste receptor TAS2R38 in human adipocytes, the possible link with genetic background and the role of TAS2R38 in cell delipidation and lipid accumulation rate&nbsp;in vitro. Subcutaneous (SAT) and visceral (VAT) adipose tissues were collected in 32 obese and 18 lean subjects. The TAS2R38 gene expression and protein content were examined in whole tissues,&nbsp;differentiated adipocytes and&nbsp;stroma-vascular&nbsp;fraction cells (SVF). The P49A&nbsp;SNP of TAS2R38 gene was determined in each collected sample. The effect of two bitter agonists (6-n-propylthiouracil and quinine) was tested.&nbsp;TAS2R38 mRNA was more expressed in&nbsp;SAT and VAT of obese than&nbsp;lean subjects&nbsp;and the expression/protein content&nbsp;was greater in mature adipocytes.&nbsp;The expression levels were not linked to P49A variants. In&nbsp;in&nbsp;vitro&nbsp;differentiated adipocytes, bitter agonists induced a&nbsp;significant delipidation.&nbsp;Incubation with 6-n-propylthiouracil induced an inhibition of lipid accumulation rate&nbsp;together with an&nbsp;increase in TAS2R38 and a&nbsp;decrease in genes involved in&nbsp;adipocyte&nbsp;differentiation. In conclusion, TAS2R38 is more expressed in adipocytes of obese than lean subjects&nbsp;and&nbsp;is involved in differentiation and delipidation processes

    The relevance of polarized bZ production at LHC

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    We consider the Z polarization asymmetry A_Z=(sigma(Z_R)-sigma(Z_L))/(sigma(Z_R)+sigma(Z_L)) in the process of associated bZ production at the LHC. We show that in the Standard Model (SM) this quantity is essentially given by its Born approximation, remaining almost unaffected by QCD scales and parton distribution functions variations as well as by electroweak corrections. The theoretical quantity that appears in A_Z is the same that provides the LEP1 Z -> b bbar forward-backward asymmetry, the only measured observable still in some contradiction with the SM prediction. In this sense, A_Z would provide the possibility of an independent verification of the possible SM discrepancy, which could reach, if consistency with LEP1 measurements is imposed, values of the relative ten percent size.Comment: 10 pages, 5 eps figure

    Cardiac tamponade occurred after endoscopic submucosal dissection : conservative management of the esophagopericardial fistula

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    Key Clinical Message We describe the case of an esophagopericardial fistula generated after endo- scopic submucosal dissection in a patient affected by a superficial esophageal squamous cell carcinoma immediately treated with percutaneous pericardial drainage and placement of a partially covered self-expanding metal stent that has been removed using the stent-in-stent technique after 35 days

    Laparoscopic paraesophageal hernia repair with absorbable mesh: a systematic review

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    Background: Laparoscopic repair is the standard of care for patients with paraesophageal hernia (PEH). Different prosthetic materials have been proposed to bolster the hiatus thus theoretically minimizing the probability for hernia recurrence. The use of non-absorbable mesh has been reported however, their safety profile has been questioned because the noteworthy mesh-related complication rate. Opposite, absorbable mesh (synthetic and biologic) seems associated with mitigated mesh-related complications and comparable hernia recurrence in the short- and medium-term. Methods: PubMed, MEDLINE, EMBASE, Scopus, Google Scholar, and ClinicalTrials.gov were executed according to the PRISMA statement until May 2022. Primary endpoints were technical details and surgical outcomes of adult patients (&gt;= 18 years old) that underwent laparoscopic PEH repair and crural reinforcement with absorbable mesh. The ROBINS-I tool was used to assess the methodological quality of included studies. Results: Thirty-nine studies (3,103 patients) were included. The age of the patient population ranged from 18 to 93 years old and 62.8% were females. Posterior cruroplasty was performed in all patients. U-shape (83.7%), circumferential (8.1%), keyhole (5.4%) and starburst (2.8%) mesh configuration were described. Different methods for mesh fixation (sutures vs. fibrin glue vs. absorbable tacks) were adopted while Nissen (75.1%) and Toupet (21.1%) fundoplication were mainly fashioned. The overall postoperative complication rate was 2.5%. Pulmonary and cardiac complication rates were 1.8% and 0.9%, respectively while in-hospital mortality was 0.2%. Postoperative follow-up ranged from 12 to 166 months. Mesh-related complication rate was 0.06% (esophageal stricture related to fibrosis). Hernia recurrence rate was 12.7% while re-do surgery was required in 1.9% of patients. Postoperative dysphagia rate was 5.1%. Discussion: Consensus concerning the optimal mesh material for crural buttressing is lacking. Given the potential for tissue ingrowth rather than encapsulation and reduced degree of perivisceral inflammation, absorbable meshes are mostly preferred over non-absorbable meshes. The use of absorbable mesh seems safe and effective with low overall and mesh-related complications, acceptable recurrence rate and low need for re-do surgery in the short/medium-term. Because heterogeneity related to different hernia characteristics, intraoperative technical variations (i.e., method for mesh fixation, etc.), definition of hernia recurrence and diverse follow-up, a conclusive evidence is still to be defined

    Using novel palaeolimnological techniques to define lake conservation objectives for three Cheshire meres

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    This is the final report to Natural England on the project ‚ÄěUsing novel palaeolimnological techniques to define lake conservation objectives for three Cheshire meres‚Äü: Melchett Mere, Tatton Mere and Comber Mere. The aim is to use existing and recently developed palaeoecological techniques to define reference conditions and assess the condition of selected Sites of Special Scientific Interest (SSSIs) in the Cheshire meres, and thereby assist in the setting of conservation objectives and management goals

    Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies

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    Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised. Gadolinium(III) complexes of these three ligands have been prepared as potential monomers for the synthesis of polymeric MRI contrast agents. To assess the potential of these monomers as MRI contrast agents, their relaxation enhancement properties and cytotoxicity have been determined. A europium(III) complex of one of these ligands (with propargyl substituents) is also presented together with its PARACEST properties. In addition, to gain further insight into the coordination chemistry of the tetra-propargyl substituted ligand, the corresponding zinc(II) and cadmium(II) complexes have been prepared. The X-ray crystal structures of the tetra-propargyl ligand and its corresponding gadolinium(III), zinc(II) and cadmium(II) complexes are also presented

    Laparoscopic trans-abdominal right adrenalectomy for a large primitive adrenal oncocytic carcinoma:a case report and review of literature

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    Rare disease Background: Adrenocortical oncocytic neoplasms (AONs) are extremely rare tumors. AONs are classified as: oncocytoma (AO), oncocytic neoplasm of uncertain malignant potential (AONUMP), and oncocytic carcinoma (AOC). Among the 162 reported cases of AONs in the literature, 30 cases were classified as malignant. Adrenalectomy is the treatment of choice for AON. Case Report: We report the case of a 48-year-old man with a primitive 12-cm mass affecting the right adrenal gland, detected by ultrasonography during follow-up for alcoholic liver cirrhosis. Computed tomography (CT) scan and magnetic resonance imaging (MRI) showed a mass of the right adrenal gland compressing the inferior vena cava (IVC) and dislocating the right lobe of the liver, with no invasion of kidney, liver, or IVC. Preoperative blood tests showed mild transaminase increase. Laparoscopic right adrenalectomy with lateral transperitoneal approach was performed. The postoperative course was uneventful. The lesion was diagnosed as a primitive adrenal oncocytic carcinoma (AOC). No recurrence was evidenced during 24-month follow-up. Conclusions: Although AONs are very rare, they must be considered in the differential diagnosis of adrenal masses due to their prognostic difference compared to non-oncocytic tumors. AOCs are a rare presentation of AONs. Only 30 cases are described in the literature. Laparotomic adrenalectomy is the treatment of choice for AOC. We report the first case of laparoscopic lateral trans-abdominal adrenalectomy for a voluminous AOC (120 795 7110 mm) and we review the literature regarding AOCs. Laparoscopy in experienced hands is safe and effective for the treatment of AONs. Despite the rarity of AOC, a case series should be performed to confirm the results of our case report
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