1,625 research outputs found

    Table_2_Retrospective cohort study to evaluate the continuous use of anticholesterolemics and diuretics in patients with COVID-19.DOCX

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    PurposeThe purpose of this study is to evaluate the interference of the continuous use of drug classes in the expression of biomarkers during the first week of hospitalization and in the prognosis of patients with COVID-19.MethodsThe patients diagnosed with COVID-19 and confirmed with SARS-CoV-2 by RT-qPCR assay underwent the collection of fasting whole blood samples for further analysis. Other data also extracted for this study included age, sex, clinical symptoms, related comorbidities, smoking status, and classes of continuous use. Routine serum biochemical parameters, including alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, N-terminal fragment of B-type natriuretic peptide, and cardiac troponin, were measured.ResultsIn this cross-sectional study, a total of 176 patients with COVID-19 hospitalizations were included. Among them, 155 patients were discharged (88.5%), and 21 patients died (12%). Among the drug classes evaluated, we verified that the continuous use of diuretic 4.800 (1.853‚Äď11.67) (p‚ÄČ=‚ÄČ0.0007) and antihypercholesterolemic 3.188 (1.215‚Äď7.997) (p‚ÄČ=‚ÄČ0.0171) drug classes presented a significant relative risk of death as an outcome when compared to the group of patients who were discharged. We evaluated biomarkers in patients who used continuous antihypercholesterolemic and diuretic drug classes in the first week of hospitalization. We observed significant positive correlations between the levels of CRP with cardiac troponin (r‚ÄČ=‚ÄČ0.714), IL-6 (r‚ÄČ=‚ÄČ0.600), and IL-10 (r‚ÄČ=‚ÄČ0.900) in patients who used continuous anticholesterolemic and diuretic drug classes and were deceased. In these patients, we also evaluated the possible correlations between the biomarkers AST, NT-ProBNP, cardiac troponin, IL-6, IL-8, and IL-10. We observed a significantly negative correlations in AST levels with NT-ProBNP (r‚ÄČ=‚ÄČ‚ąí0.500), cardiac troponin (r‚ÄČ=‚ÄČ‚ąí1.00), IL-6 (r‚ÄČ=‚ÄČ‚ąí1.00), and IL-10 (r‚ÄČ=‚ÄČ‚ąí1.00) and a positive correlation with IL-8 (r‚ÄČ=‚ÄČ0.500). We also observed significant negative correlation in the levels of NT-ProBNP with IL-10 (r‚ÄČ=‚ÄČ‚ąí0.800) and a positive correlation with cardiac troponin (r‚ÄČ=‚ÄČ0.800). IL-6 levels exhibited positive correlations with cardiac troponin (r‚ÄČ=‚ÄČ0.800) and IL-10 (r‚ÄČ=‚ÄČ0.700).ConclusionIn this study, we observed that hospitalized COVID-19 patients who continued using anticholesterolemic and diuretic medications showed a higher number of correlations between biomarkers, indicating a poorer clinical prognosis. These correlations suggest an imbalanced immune response to injuries caused by SARS-CoV-2.</p

    Cocriando com o Boi da Floresta: design para autonomia e superação da sazonalidade da produção artesanal

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    The article presents the results of research that aimed to produce alternatives for the autonomy and economic sustainability of a Bumba Meu Boi Group in the State of Maranh√£o. Based on a critical view of co-creation and the production and circulation of craft products, the action research undertaken uses co-creation tools to come up with products that can be produced by the group, which is idle from embroidery practice during the second half of the year, often falling into a situation of social vulnerability. The co-creation carried out took place through workshops and the use of tools, and the results of the research, in addition to the co-created products, provide a reflection through triangulations, involving the methodological path, the statements of the co-researchers and the theory used, generating a reflection on the subject.O artigo apresenta resultados de uma pesquisa que teve como objetivo produzir alternativas para a autonomia e sustentabilidade econ√īmica de um grupo de Bumba Meu Boi do Estado do Maranh√£o. A partir de uma vis√£o cr√≠tica sobre a cocria√ß√£o, a produ√ß√£o e circula√ß√£o de produtos artesanais, a pesquisa-a√ß√£o empreendida utiliza ferramentas de cocria√ß√£o para chegar a produtos poss√≠veis de serem produzidos pelo grupo, que ficam ociosos da pr√°tica do bordado durante o segundo semestre do ano, muitas vezes em situa√ß√£o de vulnerabilidade econ√īmica e social. A cocria√ß√£o realizada aconteceu a partir de oficinas e usos de ferramentas, e como resultados da pesquisa, al√©m dos produtos cocriados, traz a reflex√£o por meio de triangula√ß√Ķes, envolvendo o percurso metodol√≥gico, as falas dos copesquisadores e a teoria acionada, gerando uma reflex√£o sobre o tema

    Unraveling the genetic background of individuals with a clinical familial hypercholesterolemia phenotype

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    Familial hypercholesterolemia (FH) is a common genetic disorder of lipid metabolism caused by pathogenic/likely pathogenic variants in LDLR, APOB, and PCSK9 genes. Variants in FH-phenocopy genes (LDLRAP1, APOE, LIPA, ABCG5, and ABCG8), polygenic hypercholesterolemia, and hyperlipoprotein (a) [Lp(a)] can also mimic a clinical FH phenotype. We aim to present a new diagnostic tool to unravel the genetic background of clinical FH phenotype. Biochemical and genetic study was performed in 1,005 individuals with clinical diagnosis of FH, referred to the Portuguese FH Study. A next-generation sequencing panel, covering eight genes and eight SNPs to determine LDL-C polygenic risk score and LPA genetic score, was validated, and used in this study. FH was genetically confirmed in 417 index cases: 408 heterozygotes and 9 homozygotes. Cascade screening increased the identification to 1,000 FH individuals, including 11 homozygotes. FH-negative individuals (phenotype positive and genotype negative) have Lp(a) >50 mg/dl (30%), high polygenic risk score (16%), other monogenic lipid metabolism disorders (1%), and heterozygous pathogenic variants in FH-phenocopy genes (2%). Heterozygous variants of uncertain significance were identified in primary genes (12%) and phenocopy genes (7%). Overall, 42% of our cohort was genetically confirmed with FH. In the remaining individuals, other causes for high LDL-C were identified in 68%. Hyper-Lp(a) or polygenic hypercholesterolemia may be the cause of the clinical FH phenotype in almost half of FH-negative individuals. A small part has pathogenic variants in ABCG5/ABCG8 in heterozygosity that can cause hypercholesterolemia and should be further investigated. This extended next-generation sequencing panel identifies individuals with FH and FH-phenocopies, allowing to personalize each person’s treatment according to the affected pathway

    Table_1_Retrospective cohort study to evaluate the continuous use of anticholesterolemics and diuretics in patients with COVID-19.DOCX

    No full text
    PurposeThe purpose of this study is to evaluate the interference of the continuous use of drug classes in the expression of biomarkers during the first week of hospitalization and in the prognosis of patients with COVID-19.MethodsThe patients diagnosed with COVID-19 and confirmed with SARS-CoV-2 by RT-qPCR assay underwent the collection of fasting whole blood samples for further analysis. Other data also extracted for this study included age, sex, clinical symptoms, related comorbidities, smoking status, and classes of continuous use. Routine serum biochemical parameters, including alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, N-terminal fragment of B-type natriuretic peptide, and cardiac troponin, were measured.ResultsIn this cross-sectional study, a total of 176 patients with COVID-19 hospitalizations were included. Among them, 155 patients were discharged (88.5%), and 21 patients died (12%). Among the drug classes evaluated, we verified that the continuous use of diuretic 4.800 (1.853‚Äď11.67) (p‚ÄČ=‚ÄČ0.0007) and antihypercholesterolemic 3.188 (1.215‚Äď7.997) (p‚ÄČ=‚ÄČ0.0171) drug classes presented a significant relative risk of death as an outcome when compared to the group of patients who were discharged. We evaluated biomarkers in patients who used continuous antihypercholesterolemic and diuretic drug classes in the first week of hospitalization. We observed significant positive correlations between the levels of CRP with cardiac troponin (r‚ÄČ=‚ÄČ0.714), IL-6 (r‚ÄČ=‚ÄČ0.600), and IL-10 (r‚ÄČ=‚ÄČ0.900) in patients who used continuous anticholesterolemic and diuretic drug classes and were deceased. In these patients, we also evaluated the possible correlations between the biomarkers AST, NT-ProBNP, cardiac troponin, IL-6, IL-8, and IL-10. We observed a significantly negative correlations in AST levels with NT-ProBNP (r‚ÄČ=‚ÄČ‚ąí0.500), cardiac troponin (r‚ÄČ=‚ÄČ‚ąí1.00), IL-6 (r‚ÄČ=‚ÄČ‚ąí1.00), and IL-10 (r‚ÄČ=‚ÄČ‚ąí1.00) and a positive correlation with IL-8 (r‚ÄČ=‚ÄČ0.500). We also observed significant negative correlation in the levels of NT-ProBNP with IL-10 (r‚ÄČ=‚ÄČ‚ąí0.800) and a positive correlation with cardiac troponin (r‚ÄČ=‚ÄČ0.800). IL-6 levels exhibited positive correlations with cardiac troponin (r‚ÄČ=‚ÄČ0.800) and IL-10 (r‚ÄČ=‚ÄČ0.700).ConclusionIn this study, we observed that hospitalized COVID-19 patients who continued using anticholesterolemic and diuretic medications showed a higher number of correlations between biomarkers, indicating a poorer clinical prognosis. These correlations suggest an imbalanced immune response to injuries caused by SARS-CoV-2.</p

    Caratterizzazione e analisi del contenuto dei post Instagram sull'integrazione sportiva

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    Supplementation in sports has become popular and social media plays an important role in facilitating access and speeding up the dissemination of health information to society. However, at the same time, supplements represent a significant exposure source to health misinformation, which can directly impact the health of individuals who consume this information. The objective of the study was to characterize and analyze the quality of content published on Instagram on the subject of sports supplementation. Thus, the top 10 posts on Instagram were collected from the search for key hashtags on the subject over 5 weeks, 2 times a week, and content analysis was quantitatively and qualitatively performed from the Descending Hierarchical Classification, word cloud and the DISCERN instrument. As a result, 112 posts composed the analyzed textual corpus, with mentions of 154 supplements; moreover, 39.4% of the authors were nutritionists, followed by content creators (23.2%) and nutrition students (16.9%), with greater female representation (66.9%), and the hashtag ‚Äúsupplementation‚ÄĚ was responsible for 60.5% of the analyzed posts. The main themes present in the posts involve aspects of creatine supplementation, predetermining factors for supplementation, benefits and characteristics of protein supplementation. The average DISCERN score was 2.77, representing a low reliability of the posts; however, professionals and students in the nutrition area had higher averages. The results show that publications on the subject of sports supplementation have low quality of scientific reliability, but that quality may vary depending on the education level of the author of the publication.La suplementaci√≥n en los deportes se ha vuelto popular y las redes sociales desempe√Īan un papel importante a la hora de facilitar el acceso y acelerar la difusi√≥n de informaci√≥n sanitaria a la sociedad. El objetivo del estudio fue caracterizar y analizar la calidad del contenido publicado en Instagram sobre el tema de la suplementaci√≥n deportiva. A lo largo de 5 semanas, se recogieron las diez publicaciones principales en Instagram dos veces por semana mediante la b√ļsqueda de hashtags clave sobre el tema y el an√°lisis de contenido se realiz√≥ de forma cuantitativa y cualitativa utilizando la Clasificaci√≥n Jer√°rquica Descendente, la nube de palabras y el DISCERNIR. instrumento. Ciento doce posts conformaron el corpus textual analizado, con menciones a 154 suplementos, el 39,4% de los autores fueron nutricionistas, seguidos de creadores de contenidos (23,2%) y estudiantes de nutrici√≥n (16,9%), con mayor representaci√≥n femenina (66,9%) y el hashtag ‚Äúsuplementa√ß√£o‚ÄĚ, responsable del 60,5% de las publicaciones analizadas. Los temas principales de las publicaciones involucran la suplementaci√≥n con creatina, los factores predeterminados para la suplementaci√≥n, los beneficios y las caracter√≠sticas de la suplementaci√≥n proteica. El puntaje DISCERN promedio fue de 2,77, representando baja confiabilidad de los mensajes, sin embargo, los profesionales y estudiantes del √°rea de nutrici√≥n tuvieron promedios m√°s altos. Los resultados muestran que las publicaciones sobre suplementaci√≥n deportiva tienen una baja calidad de fiabilidad cient√≠fica, pero que esta calidad puede variar en funci√≥n del nivel de formaci√≥n del autor de la publicaci√≥n.A suplementa√ß√£o no esporte vem se popularizando e as m√≠dias sociais tem papel importante na facilita√ß√£o do acesso e na velocidade da dissemina√ß√£o de informa√ß√Ķes em sa√ļde para a sociedade. O objetivo do estudo foi caracterizar e analisar a qualidade dos conte√ļdos publicados no Instagram acerca da tem√°tica de suplementa√ß√£o esportiva. Ao longo de 5 semanas, 2 vezes por semana foram coletadas as dez principais postagens no Instagram a partir da busca por hashtags chaves sobre a tem√°tica e a an√°lise do conte√ļdo foi realizada de forma quanti-qualitativa a partir da Classifica√ß√£o Hier√°rquica Descendente, nuvem de palavras e o instrumento DISCERN. Cento e doze postagens compuseram o corpus textual analisado, com men√ß√Ķes a 154 suplementos, 39,4% dos autores eram nutricionistas, seguido de criadores de conte√ļdo (23,2%) e estudantes de nutri√ß√£o (16,9%), com maior representa√ß√£o feminina (66,9%) e da hashtag ‚Äúsuplementa√ß√£o‚ÄĚ, respons√°vel por 60,5% das postagens analisadas. As principais tem√°ticas nas postagens envolvem a suplementa√ß√£o da creatina, fatores predeterminantes para a suplementa√ß√£o, benef√≠cios e caracter√≠sticas da suplementa√ß√£o de prote√≠nas. A pontua√ß√£o m√©dia do DISCERN foi de 2.77, representando uma baixa confiabilidade das postagens, por√©m, profissionais e estudantes da √°rea de nutri√ß√£o tiveram m√©dias superiores. Os resultados evidenciam que as publica√ß√Ķes sobre suplementa√ß√£o esportiva apresentam baixa qualidade de confiabilidade cient√≠fica, mas que, essa qualidade pode sofrer varia√ß√Ķes a depender do grau de instru√ß√£o do autor da publica√ß√£o.A suplementa√ß√£o no esporte vem se popularizando e as m√≠dias sociais tem papel importante na facilita√ß√£o do acesso e na velocidade da dissemina√ß√£o de informa√ß√Ķes em sa√ļde para a sociedade. O objetivo do estudo foi caracterizar e analisar a qualidade dos conte√ļdos publicados no Instagram acerca da tem√°tica de suplementa√ß√£o esportiva. Ao longo de 5 semanas, 2 vezes por semana foram coletadas as dez principais postagens no Instagram a partir da busca por hashtags chaves sobre a tem√°tica e a an√°lise do conte√ļdo foi realizada de forma quanti-qualitativa a partir da Classifica√ß√£o Hier√°rquica Descendente, nuvem de palavras e o instrumento DISCERN. Cento e doze postagens compuseram o corpus textual analisado, com men√ß√Ķes a 154 suplementos, 39,4% dos autores eram nutricionistas, seguido de criadores de conte√ļdo (23,2%) e estudantes de nutri√ß√£o (16,9%), com maior representa√ß√£o feminina (66,9%) e da hashtag ‚Äúsuplementa√ß√£o‚ÄĚ, respons√°vel por 60,5% das postagens analisadas. As principais tem√°ticas nas postagens envolvem a suplementa√ß√£o da creatina, fatores predeterminantes para a suplementa√ß√£o, benef√≠cios e caracter√≠sticas da suplementa√ß√£o de prote√≠nas. A pontua√ß√£o m√©dia do DISCERN foi de 2.77, representando uma baixa confiabilidade das postagens, por√©m, profissionais e estudantes da √°rea de nutri√ß√£o tiveram m√©dias superiores. Os resultados evidenciam que as publica√ß√Ķes sobre suplementa√ß√£o esportiva apresentam baixa qualidade de confiabilidade cient√≠fica, mas que, essa qualidade pode sofrer varia√ß√Ķes a depender do grau de instru√ß√£o do autor da publica√ß√£o.L‚Äôintegrazione nello sport √® diventata popolare e i social media svolgono un ruolo importante nel facilitare l‚Äôaccesso e accelerare la diffusione delle informazioni sanitarie nella societ√†. L'obiettivo dello studio era caratterizzare e analizzare la qualit√† dei contenuti pubblicati su Instagram sul tema dell'integrazione sportiva. Nel corso di 5 settimane, i primi dieci post su Instagram sono stati raccolti due volte a settimana ricercando gli hashtag chiave sull'argomento e l'analisi dei contenuti √® stata effettuata in modo quantitativo e qualitativo utilizzando la classificazione gerarchica discendente, word cloud e il DISCERN strumento. Centododici post compongono il corpus testuale analizzato, con menzioni di 154 integratori, il 39,4% degli autori erano nutrizionisti, seguiti da creatori di contenuti (23,2%) e studenti di nutrizione (16,9%), con una maggiore rappresentanza femminile (66,9%) e l'hashtag ‚Äúsuplementa√ß√£o‚ÄĚ, responsabile del 60,5% dei post analizzati. I temi principali nei post riguardano l'integrazione di creatina, i fattori predeterminanti per l'integrazione, i benefici e le caratteristiche dell'integrazione proteica. Il punteggio DISCERN medio √® stato di 2,77, che rappresenta una bassa affidabilit√† dei post, tuttavia, professionisti e studenti nel settore della nutrizione hanno avuto medie pi√Ļ alte. I risultati mostrano che le pubblicazioni sull‚Äôintegrazione sportiva hanno una bassa qualit√† di affidabilit√† scientifica, ma che tale qualit√† pu√≤ variare a seconda del livello di istruzione dell‚Äôautore della pubblicazione

    Image_1_Retrospective cohort study to evaluate the continuous use of anticholesterolemics and diuretics in patients with COVID-19.TIF

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    PurposeThe purpose of this study is to evaluate the interference of the continuous use of drug classes in the expression of biomarkers during the first week of hospitalization and in the prognosis of patients with COVID-19.MethodsThe patients diagnosed with COVID-19 and confirmed with SARS-CoV-2 by RT-qPCR assay underwent the collection of fasting whole blood samples for further analysis. Other data also extracted for this study included age, sex, clinical symptoms, related comorbidities, smoking status, and classes of continuous use. Routine serum biochemical parameters, including alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, C-reactive protein, N-terminal fragment of B-type natriuretic peptide, and cardiac troponin, were measured.ResultsIn this cross-sectional study, a total of 176 patients with COVID-19 hospitalizations were included. Among them, 155 patients were discharged (88.5%), and 21 patients died (12%). Among the drug classes evaluated, we verified that the continuous use of diuretic 4.800 (1.853‚Äď11.67) (p‚ÄČ=‚ÄČ0.0007) and antihypercholesterolemic 3.188 (1.215‚Äď7.997) (p‚ÄČ=‚ÄČ0.0171) drug classes presented a significant relative risk of death as an outcome when compared to the group of patients who were discharged. We evaluated biomarkers in patients who used continuous antihypercholesterolemic and diuretic drug classes in the first week of hospitalization. We observed significant positive correlations between the levels of CRP with cardiac troponin (r‚ÄČ=‚ÄČ0.714), IL-6 (r‚ÄČ=‚ÄČ0.600), and IL-10 (r‚ÄČ=‚ÄČ0.900) in patients who used continuous anticholesterolemic and diuretic drug classes and were deceased. In these patients, we also evaluated the possible correlations between the biomarkers AST, NT-ProBNP, cardiac troponin, IL-6, IL-8, and IL-10. We observed a significantly negative correlations in AST levels with NT-ProBNP (r‚ÄČ=‚ÄČ‚ąí0.500), cardiac troponin (r‚ÄČ=‚ÄČ‚ąí1.00), IL-6 (r‚ÄČ=‚ÄČ‚ąí1.00), and IL-10 (r‚ÄČ=‚ÄČ‚ąí1.00) and a positive correlation with IL-8 (r‚ÄČ=‚ÄČ0.500). We also observed significant negative correlation in the levels of NT-ProBNP with IL-10 (r‚ÄČ=‚ÄČ‚ąí0.800) and a positive correlation with cardiac troponin (r‚ÄČ=‚ÄČ0.800). IL-6 levels exhibited positive correlations with cardiac troponin (r‚ÄČ=‚ÄČ0.800) and IL-10 (r‚ÄČ=‚ÄČ0.700).ConclusionIn this study, we observed that hospitalized COVID-19 patients who continued using anticholesterolemic and diuretic medications showed a higher number of correlations between biomarkers, indicating a poorer clinical prognosis. These correlations suggest an imbalanced immune response to injuries caused by SARS-CoV-2.</p

    AVALIA√á√ÉO DA DISPONIBILIDADE DE MEDICAMENTOS PARA TRATAMENTO DA ENDOMETRIOSE NO SUS EM COMPARA√á√ÉO COM AS RECOMEDA√á√ēES DO MINIST√ČRIO DA SA√öDE

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    Endometriosis affects 7 million women in Brazil, mainly between 25 and 29 years old. This disease occurs when there are parts of the endometrial tissue in extrauterine locations. Its pathophysiological mechanism can be explained by three theories, with retrograde menstruation being the main cause of ectopic implantation of endometrial tissue, which produces local irritation and a series of symptoms. Goals. This article aims to evaluate the treatment for endometriosis available in the National Network of Essential Medicines (RENAME) in comparison with the Clinical Protocol and Therapeutic Guidelines of the Ministry of Health. Methods. This article's methodology is bibliographic research, in which the bibliographic material was based on the use of the Clinical Protocol and Therapeutic Guidelines of the Ministry of Health and the National List of Essential Medicines (RENAME). Results. The 2022 National List of Essential Medicines (RENAME) provides four medicines for the treatment of endometriosis, which are analogues of GnRH and Danazol. While the Clinical Protocol and Therapeutic Guidelines of the Ministry of Health describes six medications as treatment possibilities, being GnRH analogues, progestins, oral contraceptives and Danazol. Conclusion. Given the information collected and the comparisons made, it was possible to identify that the Clinical Protocol and Therapeutic Guidelines of the Ministry of Health on Endometriosis covers a more complete treatment given the many specificities of endometriosis, encompassing treatment for mild and moderate cases with milder adverse effects.A endometriose acomete 7 milh√Ķes de mulheres no Brasil, principalmente entre 25 e 29 anos. Essa doen√ßa ocorre quando h√° partes do tecido endometrial em locais extra√ļtero. Seu mecanismo fisiopatol√≥gico pode ser explicado por tr√™s teorias, sendo a menstrua√ß√£o retr√≥gada a principal causa da implanta√ß√£o do tecido endometrial de maneira ect√≥pica, o que produz irrita√ß√£o local e uma s√©rie de sintomas. Objetivos. Esse artigo tem como objetivo avaliar o tratamento para endometriose dispon√≠vel na Rede Nacional de Medicamentos Essenciais (RENAME) em compara√ß√£o com o Protocolo Cl√≠nico e Diretrizes Terap√™uticas do Minist√©rio da Sa√ļde. M√©todos. Esse artigo tem como metodologia a pesquisa bibliogr√°fica, em que o material bibliogr√°fico teve como base a utiliza√ß√£o do Protocolo Cl√≠nico e Diretrizes Terap√™uticas do Minist√©rio da Sa√ļde e a Rela√ß√£o Nacional de Medicamentos Essenciais (RENAME). Resultados. A Rela√ß√£o Nacional de Medicamentos Essenciais (RENAME) de 2022 disponibiliza quatro medicamentos para o tratamento da endometriose, que s√£o an√°logos do GnRH e o Danazol. Enquanto que o Protocolo Cl√≠nico e Diretrizes Terap√™uticas do Minist√©rio da Sa√ļde descreve seis medicamentos como possibilidades de tratamento, sendo an√°logos do GnRH, progest√°genos, anticoncepcionais orais e o Danazol. Conclus√£o. Diante das informa√ß√Ķes coletadas e das compara√ß√Ķes realizadas, foi poss√≠vel identificar que o Protocolo Cl√≠nico e Diretrizes Terap√™uticas do Minist√©rio da Sa√ļde sobre Endometriose abrange um tratamento mais completo diante de tantas especificidades da endometriose, englobando tratamento para casos leves e moderados com efeitos adversos mais leves

    The Psychological Science Accelerator's COVID-19 rapid-response dataset

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    In response to the COVID-19 pandemic, the Psychological Science Accelerator coordinated three large-scale psychological studies to examine the effects of loss-gain framing, cognitive reappraisals, and autonomy framing manipulations on behavioral intentions and affective measures. The data collected (April to October 2020) included specific measures for each experimental study, a general questionnaire examining health prevention behaviors and COVID-19 experience, geographical and cultural context characterization, and demographic information for each participant. Each participant started the study with the same general questions and then was randomized to complete either one longer experiment or two shorter experiments. Data were provided by 73,223 participants with varying completion rates. Participants completed the survey from 111 geopolitical regions in 44 unique languages/dialects. The anonymized dataset described here is provided in both raw and processed formats to facilitate re-use and further analyses. The dataset offers secondary analytic opportunities to explore coping, framing, and self-determination across a diverse, global sample obtained at the onset of the COVID-19 pandemic, which can be merged with other time-sampled or geographic data

    Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study

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    Background Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave. Methods This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs. Results Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p‚ÄČ=‚ÄČ0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p‚ÄȂȧ‚ÄČ0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p‚ÄČ=‚ÄČ0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p‚ÄČ=‚ÄČ0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p‚ÄČ=‚ÄČ0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI ‚ąí 0.47, 1.37, p‚ÄČ=‚ÄČ0.34) and hospital (adj. difference 1.4 days; 95% CI ‚ąí 0.62, 2.35, p‚ÄČ=‚ÄČ0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p‚ÄČ=‚ÄČ0.24) when adjusted for covariates. Conclusions Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility. Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)

    INCID√äNCIA DE SEPSE TARDIA ENTRE R√ČCEM-NASCIDOS PREMATUROS EM UMA MATERNIDADE NO INTERIOR DA BAHIA

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    Introdu√ß√£o/Objetivo: A sepse neonatal √© uma s√≠ndrome cl√≠nica caracterizada por sinais sist√™micos de infec√ß√£o, quando iniciada ap√≥s 48 horas de vida √© considerada como tardia1. Esse estudo objetivou avaliar o efeito da Imunoterapia Orofar√≠ngea de Colostro (IOC) na redu√ß√£o da incid√™ncia de sepse dos Rec√©m-nascidos Pr√©-Termo (RNPT) de Muito Baixo Peso (MBP) em hospital p√ļblico do interior da Bahia. M√©todo: Trata-se de uma coorte, ambispectivo realizado com grupo interven√ß√£o composto por RNPT de MBP em uso de IOC e grupo controle sem uso de IOC. O grupo interven√ß√£o foi tratado com a IOC, 4 gotas (0,2 mL) na mucosa orofar√≠ngea direita e esquerda do RN, totalizando 8 administra√ß√Ķes a cada 24 horas at√© 7¬į dia de vida completo e grupo controle constitu√≠do por RNPT de MBP nascidos nos tr√™s √ļltimos anos antes da implementa√ß√£o da terapia (controle hist√≥rico). Dados coletados em 156 prontu√°rios de m√£e/filho (70 grupo tratamento/86 grupo controle). As vari√°veis consideradas foram sepse tardia, peso ao nascer, idade gestacional, tempo de uso de cateteres de inser√ß√£o perif√©rica (PICC) e tempo de ventila√ß√£o mec√Ęnica (VM) invasiva. An√°lise dos dados feita com SPSS 24.0. Realizadas an√°lises descritiva e bivariada. Aprovado pelo Comit√™ de √Čtica sob o CAAE:93056218.0.0000.0053 e registrado no ReBEC. Resultados: A incid√™ncia de sepse tardia foi de 20,0% no grupo controle e 22,9% no grupo tratamento (OR bruto‚ÄĮ=‚ÄĮ0,844; 0,390-1,823; p-valor 0,697). As menores taxas de sepse podem ser explicadas a partir das caracter√≠sticas neonatais de idade gestacional maior que 28 semanas (72,6% vs 60,9%, p-valor 0,139) e peso ao nascer maior que 1.000 gramas (60,5% vs 58,6%, p-valor 0,801) no grupo controle e tratamento, respectivamente. Neste estudo, o grupo tratamento apresentou maior tempo de uso PICC e tempo de VM invasiva com medianas de 14 (4-23, p-valor 0,002) e 6 (1-24, p-valor 0,280) dias, respectivamente, em rela√ß√£o ao controle. Conclus√£o: De todo o exposto, n√£o foi comprovado redu√ß√£o de sepse em rec√©m-nascidos em uso de imunoterapia orofar√≠ngea de colostro. Foi observado maior tempo de uso de PICC dos pacientes em uso de IOC. Novos estudos podem ajudar a avaliar o papel de terapia com colostro para os RNPT
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