24 research outputs found

    A Design Science Research Approach to Smart and Collaborative Urban Supply Networks

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    Urban supply networks are facing increasing demands and challenges and thus constitute a relevant field for research and practical development. Supply chain management holds enormous potential and relevance for society and everyday life as the flow of goods and information are important economic functions. Being a heterogeneous field, the literature base of supply chain management research is difficult to manage and navigate. Disruptive digital technologies and the implementation of cross-network information analysis and sharing drive the need for new organisational and technological approaches. Practical issues are manifold and include mega trends such as digital transformation, urbanisation, and environmental awareness. A promising approach to solving these problems is the realisation of smart and collaborative supply networks. The growth of artificial intelligence applications in recent years has led to a wide range of applications in a variety of domains. However, the potential of artificial intelligence utilisation in supply chain management has not yet been fully exploited. Similarly, value creation increasingly takes place in networked value creation cycles that have become continuously more collaborative, complex, and dynamic as interactions in business processes involving information technologies have become more intense. Following a design science research approach this cumulative thesis comprises the development and discussion of four artefacts for the analysis and advancement of smart and collaborative urban supply networks. This thesis aims to highlight the potential of artificial intelligence-based supply networks, to advance data-driven inter-organisational collaboration, and to improve last mile supply network sustainability. Based on thorough machine learning and systematic literature reviews, reference and system dynamics modelling, simulation, and qualitative empirical research, the artefacts provide a valuable contribution to research and practice

    Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020

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    We show the distribution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) genetic clades over time and between countries and outline potential genomic surveillance objectives. We applied three genomic nomenclature systems to all sequence data from the World Health Organization European Region available until 10 July 2020. We highlight the importance of real-time sequencing and data dissemination in a pandemic situation, compare the nomenclatures and lay a foundation for future European genomic surveillance of SARS-CoV-2

    Search for dark matter produced in association with bottom or top quarks in ‚ąös = 13 TeV pp collisions with the ATLAS detector

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    A search for weakly interacting massive particle dark matter produced in association with bottom or top quarks is presented. Final states containing third-generation quarks and miss- ing transverse momentum are considered. The analysis uses 36.1 fb‚ąí1 of proton‚Äďproton collision data recorded by the ATLAS experiment at ‚ąös = 13 TeV in 2015 and 2016. No significant excess of events above the estimated backgrounds is observed. The results are in- terpreted in the framework of simplified models of spin-0 dark-matter mediators. For colour- neutral spin-0 mediators produced in association with top quarks and decaying into a pair of dark-matter particles, mediator masses below 50 GeV are excluded assuming a dark-matter candidate mass of 1 GeV and unitary couplings. For scalar and pseudoscalar mediators produced in association with bottom quarks, the search sets limits on the production cross- section of 300 times the predicted rate for mediators with masses between 10 and 50 GeV and assuming a dark-matter mass of 1 GeV and unitary coupling. Constraints on colour- charged scalar simplified models are also presented. Assuming a dark-matter particle mass of 35 GeV, mediator particles with mass below 1.1 TeV are excluded for couplings yielding a dark-matter relic density consistent with measurements

    A Design Science Research Approach to Smart and Collaborative Urban Supply Networks

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    Urban supply networks are facing increasing demands and challenges and thus constitute a relevant field for research and practical development. Supply chain management holds enormous potential and relevance for society and everyday life as the flow of goods and information are important economic functions. Being a heterogeneous field, the literature base of supply chain management research is difficult to manage and navigate. Disruptive digital technologies and the implementation of cross-network information analysis and sharing drive the need for new organisational and technological approaches. Practical issues are manifold and include mega trends such as digital transformation, urbanisation, and environmental awareness. A promising approach to solving these problems is the realisation of smart and collaborative supply networks. The growth of artificial intelligence applications in recent years has led to a wide range of applications in a variety of domains. However, the potential of artificial intelligence utilisation in supply chain management has not yet been fully exploited. Similarly, value creation increasingly takes place in networked value creation cycles that have become continuously more collaborative, complex, and dynamic as interactions in business processes involving information technologies have become more intense. Following a design science research approach this cumulative thesis comprises the development and discussion of four artefacts for the analysis and advancement of smart and collaborative urban supply networks. This thesis aims to highlight the potential of artificial intelligence-based supply networks, to advance data-driven inter-organisational collaboration, and to improve last mile supply network sustainability. Based on thorough machine learning and systematic literature reviews, reference and system dynamics modelling, simulation, and qualitative empirical research, the artefacts provide a valuable contribution to research and practice

    Pulmonary artery to ascending aorta ratio by echocardiography: A strong predictor for presence and severity of pulmonary hypertension.

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    BACKGROUND:The pulmonary artery (PA) to ascending aorta diameter ratio (PA:A) has been evaluated in numerous studies analyzing cardiac magnetic resonance (CMR) and computed tomography (CT) data. Previously, no transthoracic echocardiography (TTE) cutoffs have been published. We sought to evaluate (1) the feasibility to image the pulmonary trunk in a prospective cohort, and (2) the ability of PA:A derived by TTE to predict pulmonary hypertension (PH). METHODS:We performed a post-hoc analysis of a prospectively recruited consecutive cohort of patients referred to our tertiary center cardiology department due to suspicion for PH. Invasive hemodynamic assessment and quasi-simultaneous TTE was performed in all participants. RESULTS:A total of 84 patients were included in the analysis, median age was 70.5 years (IQR 58-75), 46 (55%) were female. The PA was significantly wider in the PH group (28mm vs. 22.5mm, p<0.001) with a resulting median PA:A of 0.84 vs. 0.66 (p<0.001). Both PA diameter (r = 0.524 and r = 0.44, both p<0.001) and PA:A (r = 0.652 and 0.697, both p<0.001) significantly correlated with mPAP and with PVR, respectively. Area under the curve for the detection of PH was 0.853 (95%CI 0.739-0.967, p<0.001). CONCLUSION:The PA can be visualized in almost all echocardiographic exams, especially when it is dilated. A view showing the pulmonary trunk should be included in every routine TTE. An increased PA:A should raise suspicion for PH and prompt further evaluation and follow-up examinations of these patients

    Aplicaci√≥n de musicomovigramas en la educaci√≥n de ni√Īos con TEA

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    Con el paso de los a√Īos, la sociedad en la que vivimos y, por tanto, la educaci√≥n, han ido evolucionando. En la ense√Īanza tradicional, eran los docentes los que tomaban todas y cada una de las decisiones, es decir, ten√≠an un papel totalmente activo. Sin embargo, poco a poco, y debido a los m√ļltiples cambios que se han ido produciendo, los alumnos, han ido cobrando un papel mucho menos pasivo, siendo ahora, los √ļnicos protagonistas de su proceso de ense√Īanza-aprendizaje. Por otra parte, los docentes, se han convertido en gu√≠as y mediadores de las aulas. Como consecuencia de esto, los m√©todos de ense√Īanza, tambi√©n se han visto sometidos a un gran cambio y en este sentido, numerosos estudios demuestran los m√ļltiples beneficios que tanto la m√ļsica, como las TIC, est√°n teniendo en la sociedad que nos rodea. A lo largo del presente Trabajo Fin de Grado (TFG) se har√° una revisi√≥n exhaustiva de diferentes autores, gracias a los cuales, es posible asegurar la necesidad de incorporar en las aulas ambos recursos desde edades muy tempranas. Vivimos en un mundo en el que continuamente estamos en contacto con ruidos y sonidos. Son muchas las personas que recomiendan hablar al feto, y poner m√ļsica junto al vientre de la madre durante los meses de gestaci√≥n. Adem√°s, desde el d√≠a de nuestro nacimiento, comenzamos a estar en contacto con ruidos que poco a poco se ir√°n convirtiendo en algo muy familiar para nosotros. En cuanto a las TIC, actualmente est√°n presentes en todas nuestras actividades diarias, nos encontramos en la era digital en la que las nuevas tecnolog√≠as cobran un papel fundamental. Frecuentemente, escuchamos la expresi√≥n ‚Äúhoy en d√≠a los ni√Īos nacen con una Tablet debajo del brazo‚ÄĚ, sin embargo, ¬Ņes adecuado el uso que se est√° dando a este tipo de recursos? Tal y como se indicar√° en el apartado siguiente, la m√ļsica nos permite desarrollarnos de manera hol√≠stica a nivel social, cognitivo y emocional. Tambi√©n, incide en nuestro estado de √°nimo, nuestro desarrollo f√≠sico, etc. Adem√°s, en el caso de los Alumnos con Necesidades Educativas Especiales (ACNEE), como son aquellos que presentan Trastorno del Espectro Autista (TEA), la m√ļsica los permite sentirse seguros, c√≥modos y tranquilos. Por otra parte, los ni√Īos con TEA se ver√°n muy beneficiados a nivel social y en el desarrollo de la comunicaci√≥n, gracias a las TIC. Sin embargo, se ha podido comprobar que, en la etapa de Educaci√≥n Infantil, no existe un momento espec√≠fico dedicado a la educaci√≥n musical, lo que nos lleva pensar c√≥mo poder transmitir diferentes contenidos del curr√≠culum, a trav√©s de recursos did√°ctico-musicales que, a su vez, incorporen las TIC, como son los musicomovigramas. A lo largo de este TFG, nos centraremos en la influencia tan positiva que tanto la m√ļsica como las TIC, tienen en todos los ni√Īos desde edades muy tempranas y de forma m√°s concreta, en c√≥mo afectan a los ni√Īos que presentan TEA. Adem√°s, se plasmar√°n una serie de objetivos que pretenden ser conseguidos, mediante la elaboraci√≥n del presente documento, as√≠ como la metodolog√≠a que se seguir√° para alcanzarlos. Igualmente, se elaborar√° una programaci√≥n did√°ctica que contar√° con un apartado de justificaci√≥n, en el que se se√Īalar√°n los motivos por los que se ha creado este musicomovigrama en concreto. Del mismo modo, habr√° una secci√≥n de objetivos (generales y espec√≠ficos), contenidos (conceptuales, procedimentales y aptitudinales), competencias, metodolog√≠a, recursos materiales y evaluaci√≥n (del alumno y docente). A continuaci√≥n, nos centraremos en c√≥mo elaborar un musicomovigrama, para lo que se crear√° un videotutorial, as√≠ como en los programas que se han utilizado para la creaci√≥n de este, sus ventajas y sus inconvenientes. El paso siguiente, ser√° la puesta en pr√°ctica y, por tanto, en el punto 8, se enmarcar√°n los resultados obtenidos tras la aplicaci√≥n del musicomovigrama, as√≠ como las conclusiones. Por √ļltimo, habr√° un apartado de referencias bibliogr√°ficas en el que quedar√°n reflejados, todos y cada uno de los art√≠culos, libros, programas, videos, etc. que se han consultado para la elaboraci√≥n del TFG, as√≠ como los anexos, donde que recoger√° todo aquello que no se haya considerado oportuno incluir en los puntos anteriores
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